• and v) 5 drug candidates obtained clinical trial approvals in China, namely irinotecan liposome injection, docetaxel for injection (albumin-bound), SYHA1805 tablets, SYHA1815 tablets, recombinant anti-IgE monoclonal antibody for injection, ALMB-0168 in Australia and Y150 (CD38/CD3 bispecific antibody) developed by Wuhan YZY in the U.S. (pharmiweb.com)
  • Merrimack Pharmaceuticals, Inc. (Nasdaq: MACK) [("Merrimack" or the "Company")] announced that Ipsen, SA ("Ipsen") issued a press release today reporting its primary analysis of the results of its Phase III NAPOLI 3 trial of Onivyde® (irinotecan liposome injection) plus 5 fluorouracil/leucovorin and oxaliplatin (NALIRIFOX regimen) as a treatment of first line metastatic pancreatic ductal adenocarcinoma (mPDAC). (biospace.com)
  • Merrimack Pharmaceuticals, Inc. (Nasdaq: MACK) [("Merrimack" or the "Company")] announced that Ipsen, SA ("Ipsen") has issued a press release today reporting its primary analysis of the results of its Phase 3 trial of Onivyde® (irinotecan liposomal injection) as a treatment of second line small cell lung cancer (SCLC). (biospace.com)
  • The Food and Drug Administration (FDA) accepted a supplemental new drug application for Onivyde (irinotecan liposome injection) plus 5-fluorouracil/leucovorin and oxaliplatin (NALIRIFOX regimen) as a potential first-line treatment for patients with metastatic pancreatic ductal adenocarcinoma, according to a press release from biopharmaceutical company, Ipsen. (curetoday.com)
  • In Onivyde, irinotecan is enclosed in tiny fat particles called liposomes, which accumulate in the tumor and release slowly over time. (curetoday.com)
  • Various nanocarriers are being introduced and assessed, such as polymer nanoparticles, liposomes, and micelles. (hindawi.com)
  • The nanoparticles were stable upon injection and gave excellent contrast enhancement when used for in vivo imaging, compared to microbubbles with an equivalent shell composition. (whiterose.ac.uk)
  • Stealth liposome nanoparticles have been used as an effective strategy for improving drug delivery and limiting systemic toxicity, but can still suffer from inconsistencies in formulation, sub-optimal drug release and poor detection in vivo . (confex.com)
  • We hypothesized that it would be possible to use a solvent injection method to create novel nanocomposite systems that consist of encapsulated gold nanoparticles within liposomes to improve drug delivery while also permitting non-invasive imaging. (confex.com)
  • Intravenous injections of PEGylated liposomes like Doxil are already on the market, and high dosages of glutathione are also being used as supportive therapy for cancer. (genengnews.com)
  • Owing to their nano size and special properties, the engineered NPs can enter the human body through different routes such as dermal penetration, intravenous injection and inhalation. (blogspot.com)
  • Marqibo® (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine. (nih.gov)
  • The U.S. Food and Drug Administration today approved Marqibo (vincristine sulfate liposome injection) to treat adults with a rare type of leukemia called Philadelphia chromosome negative (Ph-) acute lymphoblastic leukemia (ALL). (news-medical.net)
  • Polymersomes are similar to liposomes, which are vesicles formed from naturally occurring lipids. (wikipedia.org)
  • Liposomes are lipid vesicles in which supplements can be encapsulated and through this be protected against the harsh environment of the GI tract. (relax-uk.com)
  • The team first used an ultrasound imaging technique to follow the movement of drug-free 'acoustic liposomes', vesicles containing gas bubbles, through the lymphatic system in mice. (reachmd.com)
  • Vincristine liposome injection is used to treat Philadelphia chromosome-negative acute lymphoblastic leukemia (Ph- ALL) that has worsen or come back or in patients who have received at least 2 previous cancer treatments that did not work well. (mayoclinic.org)
  • Vincristine liposome is an antineoplastic agent (cancer medicine). (mayoclinic.org)
  • DepoCyte (cytarabine liposome injection) and DepoDur (morphine sulfate extended-release liposome injection). (medscape.com)
  • Its marketed products include Xyrem (sodium oxybate) oral solution, Sunosi (solriamfetol), Erwinaze (asparaginase erwinia chrysanthemi), Defitelio (defibrotide sodium), Vyxeos (daunorubicin and cytarabine) liposome for injection, and others. (pharmaceutical-technology.com)
  • These particles are readily taken up even by aggressive, hormone-refractory prostate cancer cells and the data suggest that they possess similar tumor deposition properties in vivo compared to traditional long-circulating sterically stabilized liposome (SSL) formulations. (confex.com)
  • AmBisome(R) (amphotericin B) liposome for injection sales for the third quarter of 2004 were $49.8 million, a decrease of 3 percent compared to the third quarter of 2003. (gilead.com)
  • and Vyxeos liposome for injection, a product for the treatment of adults with newly-diagnosed therapy-related acute myeloid leukemia. (bamagazine.com)
  • October 31, 2011 - The US Food and Drug Administration today approved a novel long-acting nonopioid anesthetic/analgesic for postsurgical pain: bupivacaine extended-release liposome injection ( Exparel , Pacira Pharmaceuticals). (medscape.com)
  • bupivacaine extended-release liposome injection ( Exparel , Pacira Pharmaceuticals). (medscape.com)
  • We have developed and characterized a novel gold-lipid nanocomposite consisting of 2-nm AuNP entrapped within liposomes. (confex.com)
  • Liposomes serve as promising active carriers of drugs to posterior segment eye disorders due to improvement in intravitreal half-life and targeted sustained drug delivery to the retina. (benthamscience.com)
  • Liposomes act as drug carriers for entrapment of hydrophilic and hydrophobic drugs. (benthamscience.com)
  • To examine cancer cell capture and killing in vivo , mice were injected with ES/TRAIL retro-orbitally, followed by injection of FL-labeled COLO 205 cells via tail vein injection. (aiche.org)
  • Tumor and tissue biodistribution in vivo was performed in athymic NCR mice using a human xenograft model by labeling the nanocomposites with DiR and dosing via tail vein injection, followed by imaging 48 hours post-treatment. (confex.com)
  • This medication is given by injection into a vein over 30-60 minutes or longer by a health care professional. (webmd.com)
  • It was shown that the AuNP could be stably entrapped within conventional liposomes to form nanocomposites while maintaining a narrow liposome size distribution- profile around 100 nm and a zeta potential near 30 mV, indicating good colloidal stability. (confex.com)
  • The liposomes were nearly spherical in shape with zeta potential varied from -14.2±4.48 to -11.7±5.26 mV. (ijpsonline.com)
  • Methods: Sitagliptin liposomes were prepared by the ethanol injection method and were evaluated for various physicochemical properties such as visual appearance, particle size distribution, zeta potential, % drug entrapment efficiency, % drug loading capacity and in vitro drug release studies. (benthamscience.com)
  • Thus present study concludes that flexible liposome enriched thermoreversible, mucoadhesive in situ intranasal gel of rizatriptan benzoate is a safe and effective drug delivery system for treatment of migraine. (ijpsonline.com)
  • Recent applications of liposomes in ophthalmic drug delivery. (benthamscience.com)
  • Notify your doctor right away if redness, pain, or swelling occur at or near the injection site. (webmd.com)
  • Through the use of nanotechnology in the form of liposomes whose building blocks, the phospholipids, naturally occur in our cell membranes. (relax-uk.com)
  • Allos Therapeutics, Inc. today announced that it has submitted a request to the European Medicines Agency (EMA) for a re-examination of the negative opinion issued in January by the EMA's Committee For Medicinal Products for Human Use (CHMP) for conditional approval of FOLOTYN (pralatrexate injection) for the treatment of patients with peripheral T-cell lymphoma (PTCL) whose disease has progressed after at least one prior systemic therapy. (news-medical.net)
  • The flexible liposomes were formulated (F1-F9) and optimized with respect to percentage of ethanol and phospholipid to get optimum vesicle size and entrapment efficiency. (ijpsonline.com)
  • In vitro ultrasound characterisation from these nanoparticle populations showed strong backscattering compared to aqueous filled liposomes of a similar size. (whiterose.ac.uk)
  • Similar to coating liposomes with polyethylene glycol, polymersomes can be made invisible to the immune system if the hydrophilic block consists of polyethylene glycol. (wikipedia.org)
  • Active ingredients are encapsulated in nanoscopically small liposomes and safely delivered through the digestive system. (relax-uk.com)
  • Film rehydration, direct injection method or dissolution method. (wikipedia.org)
  • Further investigations will be needed to determine the optimal injection rate and volume of the treatment to prevent lymphatic complications. (reachmd.com)
  • In the case of diblock, comb and dendronized copolymers the polymersome membrane has the same bilayer morphology of a liposome, with the hydrophobic blocks of the two layers facing each other in the interior of the membrane. (wikipedia.org)
  • High-intensity sound waves were applied to the armpit area on the same and third days following the injection to rupture the liposomes and release the drug. (reachmd.com)
  • To determine leukocyte functionalization with ES/TRAIL, fluorescent (FL) liposomes were exposed to human blood under shear flow, and leukocytes were isolated and analyzed for ES/TRAIL attachment using FC and confocal microscopy. (aiche.org)
  • Upon exposure to shear flow, ES/TRAIL liposomes in human blood were functionalized to the surface of leukocytes, as confirmed by confocal microscopy (Fig. 1A) and FC. (aiche.org)
  • was conducted in UK to evaluate the safety and immunogenicity of EN41-UGR7C in Alum (3 IM injections, 3 months of F-U) in 24 healthy female volunteers. (europa.eu)