Inhibits the ubiquitin ligase anaphase promoting complex cyclosome. Medical search. Frequent questions

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Anatomy27

Spindle Apparatus HeLa Cells Cell Line HEK293 Cells Chromatids Oocytes Microtubules Kinetochores Cell Line, Tumor Chromosomes Centromere Cell Nucleus Centrosome Cells, Cultured COS Cells Spermatocytes Embryo, Nonmammalian Endoplasmic Reticulum Chromatin Cytoplasm Cell Nucleolus NIH 3T3 Cells Endosomes Lysosomes Fibroblasts Chromosomes, Fungal Chromosomes, Human

Organisms13

Schizosaccharomyces Saccharomyces cerevisiae Xenopus Drosophila Caenorhabditis elegans Bivalvia Cercopithecus aethiops Drosophila melanogaster Mice, Knockout Arabidopsis Saccharomycetales Macropodidae Mice, Inbred C57BL

Diseases5

Genomic Instability Angelman Syndrome Lafora Disease Chromosomal Instability Nondisjunction, Genetic

Chemicals and Drugs123

Ubiquitin-Protein Ligase Complexes Anaphase-Promoting Complex-Cyclosome Ubiquitin Ubiquitin-Protein Ligases Cdc20 Proteins Cdh1 Proteins F-Box Proteins Cell Cycle Proteins Ligases Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome Cullin Proteins SKP Cullin F-Box Protein Ligases Ubiquitins Ubiquitin-Conjugating Enzymes Securin Cyclin B Proteasome Endopeptidase Complex Cyclin B1 Mad2 Proteins Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome Cyclin A2 Ubiquitin Thiolesterase RNA Ligase (ATP)Saccharomyces cerevisiae Proteins Nuclear Proteins Polyubiquitin CDC2 Protein Kinase Endosomal Sorting Complexes Required for Transport S-Phase Kinase-Associated Proteins Schizosaccharomyces pombe Proteins Geminin Protein-Serine-Threonine Kinases Carrier Proteins Cyclin A Fungal Proteins beta-Transducin Repeat-Containing Proteins Proto-Oncogene Proteins c-cbl Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome Nocodazole Separase Aurora Kinases Xenopus Proteins Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome Repressor Proteins RNA, Small Interfering Recombinant Fusion Proteins Proto-Oncogene Proteins c-mos DNA Ligases Drosophila Proteins Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome Calcium-Binding Proteins Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome Multiprotein Complexes Ubiquitin-Activating Enzymes DNA-Binding Proteins Proto-Oncogene Proteins c-mdm2 Protein Kinases Endopeptidases Polynucleotide Ligases Cyclins Chromosomal Proteins, Non-Histone Receptors, Autocrine Motility Factor Lysine Cadherins Cyclin-Dependent Kinases Adaptor Proteins, Signal Transducing Protein Subunits Transcription Factors Ubiquitin C Leupeptins Proteasome Inhibitors Cysteine Endopeptidases Microtubule-Associated Proteins Apc7 Subunit, Anaphase-Promoting Complex-Cyclosome Multienzyme Complexes SUMO-1 Protein Von Hippel-Lindau Tumor Suppressor Protein Small Ubiquitin-Related Modifier Proteins Peptide Synthases Proteins Ubiquitin-Specific Proteases Tumor Suppressor Proteins Intracellular Signaling Peptides and Proteins Ubiquitinated Proteins Glutamate-Cysteine Ligase Tumor Suppressor Protein p53 Cyclin-Dependent Kinase Inhibitor Proteins Kinesin Aurora Kinase B Tubulin Green Fluorescent Proteins Recombinant Proteins Membrane Proteins Proto-Oncogene Proteins Arabidopsis Proteins Mutant Proteins Caenorhabditis elegans Proteins Histones Peptide Hydrolases Adenosine Triphosphatases Proliferating Cell Nuclear Antigen Chromatin Fanconi Anemia Complementation Group L Protein Cyclin-Dependent Kinase Inhibitor p27 BRCA1 Protein Immediate-Early Proteins Protein Inhibitors of Activated STAT Cyclin E DNA Primers RNA, Messenger HSC70 Heat-Shock Proteins Carbon-Nitrogen Lyases TNF Receptor-Associated Factor 6 Adenovirus E4 Proteins Cysteine Proteinase Inhibitors Phosphoproteins DNA, Complementary Nerve Tissue Proteins Casein Kinase I vif Gene Products, Human Immunodeficiency Virus Glutathione Transferase Inhibitor of Apoptosis Proteins

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Models, Biological Two-Hybrid System Techniques Immunoprecipitation Sequence Alignment Transfection Microscopy, Fluorescence Immunoblotting Blotting, Western Models, Molecular Protein Interaction Mapping Ligase Chain Reaction Gene Knockdown Techniques Fluorescent Antibody Technique Cloning, Molecular Mutagenesis, Site-Directed Precipitin Tests Crystallography, X-Ray

Phenomena and Processes77

Anaphase Ubiquitination Mitosis Metaphase M Phase Cell Cycle Checkpoints Chromosome Segregation Cell Cycle Protein Binding RING Finger Domains Mutation Amino Acid Sequence Proteolysis Prometaphase Meiosis Amino Acid Motifs Protein Structure, Tertiary Protein Stability RNA Interference Protein Processing, Post-Translational Substrate Specificity G1 Phase Phosphorylation Genes, cdc Telophase Chromatids S Phase Kinetochores G2 Phase Sequence Homology, Amino Acid Signal Transduction Cytokinesis Chromosomes Protein Transport Centromere Sumoylation DNA Damage Transfection Base Sequence Binding Sites Protein Interaction Domains and Motifs Down-Regulation Prophase DNA Repair F-Box Motifs Endoreduplication Gene Expression Regulation Cell Division Endoplasmic Reticulum-Associated Degradation Interphase Cell Cycle Checkpoints Enzyme Activation Phenotype Gene Expression Regulation, Fungal Plasmids Gene Deletion Zinc Fingers Endocytosis Genomic Instability Chromatin Protein Folding Conserved Sequence Apoptosis Transcription, Genetic Time Factors Mutagenesis Ultraviolet Rays Chromosomal Instability Gene Silencing Catalysis Protein Conformation Cell Proliferation Chromosomes, Fungal Mitochondrial Degradation Nondisjunction, Genetic Chromosomes, Human Protein Multimerization Genes, Fungal

Information Science3

Amino Acid Sequence Molecular Sequence Data Base Sequence

Health Care1

Ultraviolet Rays

Anatomy Organisms Diseases Chemicals and Drugs Analytical, Diagnostic and Therapeutic Techniques and Equipment Phenomena and Processes Information Science

Ubiquitin-Protein Ligase Complexes Anaphase Anaphase-Promoting Complex-Cyclosome Ubiquitin Ubiquitin-Protein Ligases Cdc20 Proteins Cdh1 Proteins Ubiquitination F-Box Proteins Cell Cycle Proteins Mitosis Ligases Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome Cullin Proteins SKP Cullin F-Box Protein Ligases Ubiquitins Ubiquitin-Conjugating Enzymes Securin Cyclin B Spindle Apparatus Proteasome Endopeptidase Complex Metaphase M Phase Cell Cycle Checkpoints HeLa Cells Cyclin B1 Mad2 Proteins Apc5 Subunit, Anaphase-Promoting Complex-Cyclosome Cyclin A2 Chromosome Segregation Cell Cycle Protein Binding Ubiquitin Thiolesterase RNA Ligase (ATP)Saccharomyces cerevisiae Proteins Nuclear Proteins RING Finger Domains Mutation Polyubiquitin Amino Acid Sequence Proteolysis Molecular Sequence Data CDC2 Protein Kinase Prometaphase Endosomal Sorting Complexes Required for Transport Meiosis S-Phase Kinase-Associated Proteins Schizosaccharomyces pombe Proteins Amino Acid Motifs Geminin Schizosaccharomyces Protein-Serine-Threonine Kinases Saccharomyces cerevisiae Protein Structure, Tertiary Carrier Proteins Cyclin A Protein Stability Fungal Proteins beta-Transducin Repeat-Containing Proteins RNA Interference Cell Line Proto-Oncogene Proteins c-cbl Protein Processing, Post-Translational Apc2 Subunit, Anaphase-Promoting Complex-Cyclosome Nocodazole Substrate Specificity Separase Aurora Kinases G1 Phase Xenopus Proteins Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome Repressor Proteins RNA, Small Interfering Phosphorylation Models, Biological Recombinant Fusion Proteins Proto-Oncogene Proteins c-mos Genes, cdc HEK293 Cells Telophase DNA Ligases Chromatids Drosophila Proteins S Phase Oocytes Microtubules Xenopus Two-Hybrid System Techniques Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome Calcium-Binding Proteins Apc11 Subunit, Anaphase-Promoting Complex-Cyclosome Kinetochores G2 Phase Sequence Homology, Amino Acid Signal Transduction Multiprotein Complexes Cytokinesis Immunoprecipitation Cell Line, Tumor Ubiquitin-Activating Enzymes

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