• Overexpression of TCF21 greatly inhibited the proliferation, migration, and invasion in both TE10 and KYSE510 cell lines. (medscimonit.com)
  • Our results show that ADAM12 overexpression enhanced proliferation, inhibited apoptosis, and acted as a positive regulator of cell cycle progression in CRC cells. (mdpi.com)
  • These agents inhibit cell growth and proliferation. (medscape.com)
  • Trifluridine is a thymidine-based nucleoside analog that incorporates into DNA, interferes with DNA synthesis, and inhibits cell proliferation. (medscape.com)
  • Genes differentially expressed as a result of in utero ETS exposure are involved in regulation of biological processes (immune response, cell proliferation, apoptosis, cell metabolism) through altered cytoskeleton, adhesion, transcription, and enzyme molecules. (nih.gov)
  • Therefore, exogenous DKK‑3 protein may inhibit the proliferation of KPK1 cells via inactivating Wnt/β‑catenin signaling. (spandidos-publications.com)
  • TEAD3 inhibits the proliferation and metastasis of prostate cancer via suppressing ADRBK2. (nih.gov)
  • 6]-gingerol inhibited cell proliferation and induced apoptosis as evidenced by externalization of phosphatidyl serine in SW-480, while the normal colon cells were unaffected. (amrita.edu)
  • These results suggest that human gastric cancer cells express PPARgamma and that activation of PPARgamma inhibits cell growth and induces apoptosis in gastric cancer cells. (nih.gov)
  • TTDA inhibited apoptosis by regulating the p53-Bax/Bcl2 axis in glioma. (nih.gov)
  • Chicken erythrocyte histone H5 has been suggested repeatedly to be a general suppressor of transcription and replication. (biologists.com)
  • By pulse-labelling of the injected cells with [ 3 H] uridine and [ 3 H] thymidine it was shown that H5 blocked both transcription and replication substantially, and that the chromatin of the injected cells became densely compacted. (biologists.com)
  • It inhibits DNA replication and transcription. (medscape.com)
  • SN-38 binds to and stabilizes the topoisomerase I-DNA complex and prevents the relegation of DNA after it has been cleaved by topoisomerase I, inhibiting DNA replication. (medscape.com)
  • The invention provides a "transgenic wheat cell or wheat plant … comprising a chimeric DNA molecule [that] encodes a dsRNA molecule which is capable of inhibiting wheat streak mosaic virus replication," the patent's abstract states. (genomeweb.com)
  • RVFV's nucleocapsid protein (N) is an RNA-binding protein that is necessary for viral transcription, replication, and the production of nascent viral particles. (mdpi.com)
  • thus inhibiting downstream covalent alterations of the donors mediated by structure-selective endonucleases (SSEs). (elifesciences.org)
  • It was revealed that the expression of transcription factor (TCF) 1 and c‑Myc, the downstream transcription factors of the Wnt/β‑catenin signaling pathway, was inhibited following treatment with DKK‑3. (spandidos-publications.com)
  • This results in the stabilization of cytosolic β-catenin and facilitates its translocation into the nucleus to activate downstream transcription factors ( 6 ). (spandidos-publications.com)
  • In addition to a constitutively occupied E2F1-Sp1 site immediately upstream of the cyclin E transcription start region, there is downstream a cell cycle-regulated site (termed CERM) that may function as a cyclin E-repressor module. (nih.gov)
  • So far, there is a small set of curated known interactions between transcription factors and their downstream genes. (hindawi.com)
  • It was demonstrated that EPO inhibited hepatic ER stress and steatosis in vivo and in vitro. (spandidos-publications.com)
  • SIRT1 can deacetylate protein kinase-like ER kinase (PERK) and inhibit the PERK-eukaryotic initiation factor 2α (eIF2α) axis of the UPR pathway, thereby suppressing hepatic steatosis in mice ( 18 - 20 ). (spandidos-publications.com)
  • scavenger dimethyl sulfoxide (DMSO) was found to dose-dependently inhibit interleukin 8 (IL-8) production in LPS-stimulated human whole blood. (jci.org)
  • IK-175 dose dependently blocks ligand-stimulated AHR activation of Cyp1a1 transcription in mouse liver and spleen, demonstrating on-target in vivo activity. (aacrjournals.org)
  • CITED4, a recently identified member of the CITED family, binds p300/CBP via the CH1 domain and functions as a coactivator for transcription factor AP-2. (ox.ac.uk)
  • 10. Meng L S. Transcription coactivator Arabidopsis ANGUSTIFOLIA3 modulates anthocyanin accumulation and light-induced root elongation through transrepression of Constitutive Photomorphogenic1[J]. Plant,Cell and Environment,2015,38(4):838-851. (nefu.edu.cn)
  • Proximity ligation assay analysis revealed a marked reduction in the interaction of YAP with TEA domain (TEAD) transcription factors in the nuclei of insulin-treated cells. (nih.gov)
  • Ethylene-insensitive3(EIN3) and EIN3-like1(EIL1) proteins are important nuclear transcription factors in ethylene signal transduction pathways in higher plants. (nefu.edu.cn)
  • found that expression of the miR-30 family was downregulated in mouse preosteoblast differentiation and further found that miR-30 targeted the important transcription factors SMAD1 and RUNX2 [ 9 ]. (hindawi.com)
  • A great deal of our effort is now devoted to studies aimed at understanding factors that promote Th17-mediated uveitis and mechanisms by which anti-inflammatory cytokines including IL-27 and IL-35 inhibit uveitis and mitigate ocular pathology. (nih.gov)
  • Instead, they act as molecular adaptors to either redirect the normal function of the host factors for virus-specific purposes or to inhibit their normal physiological function by targeting proteins for degradation or by altering their intracellular localization. (nih.gov)
  • This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. (nih.gov)
  • The diagram describes the eukaryotic preinitiation complex which includes the general transcription factors and RNA Polymerase II. (wikiversity.org)
  • Mechano-transcription of inflammatory molecules, pain mediators, pro-fibrotic and growth factors has been shown to play a key role in the development of motility dysfunction, visceral hypersensitivity, inflammation, and fibrosis in the gut. (frontiersin.org)
  • The lack of experimental information regarding the regulation of the whole set of transcription factors and their targets in different cell types is one of the main reasons to this incompleteness. (hindawi.com)
  • On the other hand, a reduced set of genes, called transcription factors (TFs), has the role of regulating the transcriptional program of the cells. (hindawi.com)
  • Spilanthol Inhibits Inflammatory Transcription Factors and iNOS Expression in Macrophages and Exerts Anti-inflammatory Effects in Dermatitis and Pancreatitis. (dife.de)
  • Here, we show that CITED4 blocks the binding of hypoxia-inducible factor 1alpha to p300 in vitro and inhibits hypoxia-inducible factor-1alpha transactivation and hypoxia-mediated reporter gene activation. (ox.ac.uk)
  • The finding that curcuminoid extract inhibits activation of NF-KB suggests that turmeric dietary supplements share the same mechanism of action as anti-arthritic pharmaceuticals under development that target NF-KB. (sciencedaily.com)
  • Hl° accumulates in contact-inhibited cultured cells ( Pehrson & Cole, 1980 ), and in murine erythroleukaemia cells after induction of erythroid differentiation ( Osborne & Chabanas, 1984 ). (biologists.com)
  • In conclusion, miR-155 inhibited osteoblast differentiation by downregulating the translation of SMAD5 in mouse preosteoblast cells. (hindawi.com)
  • Osteogenic differentiation of caspase-8 deficient cells was inhibited as these cells displayed a decreased level of mineralization and lower activity of alkaline phosphatase. (frontiersin.org)
  • Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. (abcam.com)
  • Disruption of histone modification and CARM1 recruitment by arsenic represses transcription at glucocorticoid receptor-regulated promoters. (nih.gov)
  • From a teleological standpoint, this arrangement [of focused promoters] is consistent with the notion that it would be easier to regulate the transcription of a gene with a single transcription start site than one with multiple start sites. (wikiversity.org)
  • We found that HIV-1 virus production from infected macrophages is inhibited by mannose receptor 1 (MRC1). (nih.gov)
  • Reverse transcription-polymerase chain reaction, Northern blot and Western blot analyses showed that a human gastric cancer cell line, MKN45, expressed PPARgamma mRNA and protein. (nih.gov)
  • In contrast, sequence-specific binding of AP-2 to SV40 and hMT IIA DNA is inhibited by the viral repressor protein T antigen. (psu.edu)
  • This means that the presence of this substance triggers the transcription of the gene, leading to the production of the corresponding protein. (proprofs.com)
  • A repressible gene is controlled by a regulatory protein that inhibits transcription. (proprofs.com)
  • This regulatory protein binds to the gene's promoter region and prevents the RNA polymerase enzyme from binding and initiating transcription. (proprofs.com)
  • In addition, as low‑density lipoprotein receptor‑related protein 6 (LRP6) is a receptor of DKK‑1 and DKK‑2 and their interaction on the cell surface inhibits Wnt/β‑catenin signaling, it was examined whether the exogenous DKK‑3 protein affects LRP6‑mediated Wnt/β‑catenin signaling. (spandidos-publications.com)
  • This effect was inhibited by the HIV-1 Vpr protein, which caused degradation of gelsolin. (nih.gov)
  • See the reference protein sequence for general transcription factor IIH subunit 5 (NP_997001.1). (nih.gov)
  • A transcription factor is a protein that controls when genes are switched on or off. (sciencedaily.com)
  • Arabidopsis thaliana Transcription Factor Ethylene-insensitive3(EIN3) Inhibits the Synthesis of Anthocyanins[J]. Bulletin of Botanical Research, 2018, 38(1): 148-154. (nefu.edu.cn)
  • Thus, A.thaliana transcription factor EIN3 as well as EIL1 is involved in the suppression of the anthocyanin synthesis. (nefu.edu.cn)
  • 5-FU inhibits tumor cell growth through at least 3 different mechanisms that ultimately disrupt DNA synthesis or cellular viability. (medscape.com)
  • 5-FdUMP inhibits thymidylate synthase (key enzyme in DNA synthesis), which leads to accumulation of dUMP, which then gets misincorporated into the DNA in the form of 5-FdUTP resulting in inhibition of DNA synthesis and function with cytotoxic DNA strand breaks. (medscape.com)
  • CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha. (ox.ac.uk)
  • Interestingly, pseudotyping studies revealed that gelsolin was also able to inhibit the expression and packaging of the VSVg glycoprotein into HIV-1 particles. (nih.gov)
  • DMSO was found to directly inhibit IL-8 expression at the level of transcription. (jci.org)
  • Although it is harder to regulate the transcription of genes with multiple transcription start sites, "variations in the expression of a constitutive gene would be minimized by the use of multiple start sites. (wikiversity.org)
  • [37] Angiogenesis Co-culture experiment of 2 cell lines Electrolyzed reduced H2 water inhibited lumen formation via suppression of VEGF expression in cultured cells. (researchgate.net)
  • The SCP is the strongest core promoter observed in vitro and in cultured cells and yields high levels of transcription in conjunction with transcriptional enhancers. (wikiversity.org)
  • Transcription factor 21 (TCF21), a member of the class A of basic helix-loop-helix family, has been widely identified as a tumor suppressor. (medscimonit.com)
  • RNA polymerase II holoenzyme complex may also have to search for one or more transcription start sites. (wikiversity.org)
  • The transcription factor CITED2 binds p300/CBP at the CH1 domain and functions as a negative regulator of hypoxia signaling by competing with hypoxia-inducible factor 1alpha. (ox.ac.uk)
  • Aryl hydrocarbon receptor (AHR) is a transcription factor that regulates the activity of multiple innate and adaptive immune cells subsequent to binding to numerous endogenous and exogenous ligands. (aacrjournals.org)
  • Endocrine therapies for prostate cancer inhibit the androgen receptor (AR) transcription factor. (nki.nl)
  • A Fab fragment of the chimeric monoclonal antibody 7E3 that binds to the glycoprotein IIb-IIIa receptor of human platelets, and blocks PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX, potently inhibiting PLATELET AGGREGATION. (nih.gov)
  • Binding of c-Abl to p53 inhibits the Mdm2-mediated degradation of p53 (Sionov et al. (nih.gov)
  • This program includes upregulation of basic leucine transcription factor, ATF-like (BATF), a transcription factor in the AP-1 family. (nih.gov)
  • This gene encodes a subunit of transcription/repair factor TFIIH, which functions in gene transcription and DNA repair. (nih.gov)
  • Mechano-transcription of pain mediators such as nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) may lead to visceral hypersensitivity. (frontiersin.org)
  • Here, we built a transcription factor network for human monocytic THP-1 myeloid cells based on the experimentally curated FANTOM4 database where nodes are genes and the experimental interactions correspond to links. (hindawi.com)
  • We present the topological parameters which define the network as well as some global structural features and introduce a relative inuence parameter to quantify the relevance of a transcription factor in the context of induction of a phenotype. (hindawi.com)
  • Here, we demonstrate the stem cell transcription factor Krüppel-like factor 5 (KLF5) is low or absent in prostate cancers prior to endocrine therapy, but induced in a subset of CRPC, including CRPC displaying lineage plasticity. (nki.nl)
  • The researchers found that the curcuminoid extract inhibits a transcription factor called NF-KB from being activated in the joint. (sciencedaily.com)
  • Once the transcription factor NF-KB is activated, or turned on, it binds to genes and enhances production of inflammatory proteins, destructive to the joint. (sciencedaily.com)
  • Contaminants such as phenol will inhibit reverse transcription reactions, consequently, we request that you DO NOT USE TRIZOL to extract your RNA unless you are confident you can remove all contaminants through subsequent chloroform extraction and ethanol precipitation. (nih.gov)
  • Troglitazone or pioglitazone, selective ligands for PPARgamma, inhibited the growth of MKN45 cells in a dose-dependent manner. (nih.gov)
  • Consistent with these findings, insulin significantly impaired YAP/TEAD-mediated transcription as measured by quantitative PCR in both HepG2 and C2C12 muscle cells. (nih.gov)
  • Luciferase assay in MKN45 cells showed that troglitazone, a selective ligand for PPARgamma, transactivated the transcription of a peroxisome proliferator response element-driven promoter. (nih.gov)
  • We established that Th17 cells might be the etiologic agents of uveitis by studies showing that blood of patients with uveitis contain more Th17 cells than that of healthy individuals and the expansion of Th17 is inhibited in part by immunosuppressive cytokines. (nih.gov)
  • 2007). TH17 cells are expanded by IL-2 in Uveitis or Scleritis and inhibited by IL-27/STAT1-dependent mechanisms. (nih.gov)
  • We believe that an approach, such as the one shown here, could help to understand the one regulation of transcription in eukaryotic cells. (hindawi.com)
  • 2015) Topical administration of a suppressor of cytokine signaling-1 (SOCS1) mimetic peptide inhibits ocular inflammation and mitigates ocular pathology during mouse uveitis. (nih.gov)
  • These findings suggest novel mechanisms for mediating positive and negative regulation of transcription. (psu.edu)
  • Insulin alters transcription of numerous genes relevant to energy homeostasis, and we observed that knockdown of YAP alters gexpression of genes in gluconeogenesis pathway. (nih.gov)
  • Recent studies have revealed that persistent mechanical stress is present in obstructive, functional, and inflammatory disorders and alters gene transcription in these conditions. (frontiersin.org)
  • A metabolite of estradiol that lacks estrogenic activity and inhibits TUBULIN polymerization. (nih.gov)
  • IK-175 inhibits AHR activity in experimental systems derived from multiple species including mouse, rat, monkey, and humans. (aacrjournals.org)
  • Phosphorylation of PGC-1α at Ser 570 is required for Akt to inhibit recruitment of PGC-1α to chromatin. (nature.com)
  • The core promoter includes the transcription start site(s) (TSS). (wikiversity.org)
  • antiviral gene transcription and inhibits melanin production in skin cutaneous melanoma. (bvsalud.org)
  • Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood. (jci.org)
  • There are "nearly 50,000 acetylated sites [punctate sites of modified histones] in the human genome that correlate with active transcription start sites and CpG islands and tend to cluster within gene-rich loci. (wikiversity.org)
  • Genes contain the instructions for building proteins, and these instructions are transcribed into mRNA through a process called transcription. (proprofs.com)
  • [6] Or, transcription factories are present and the euchromatin is brought within the nearest transcription factory and A1BG messenger RNA (mRNA) is transcribed. (wikiversity.org)
  • catalyzes the transcription of DNA to synthesize precursors of mRNA and most snRNA and microRNA . (wikiversity.org)
  • We will also evaluate potential therapeutic targets of mechano-transcription process for the management of these disorders. (frontiersin.org)
  • Subtyping was conducted by avian virus, it is the most avianlike of all mammalian reverse transcription (RT)-PCR with subtype-specific influenza viruses ( 2,3 ). (cdc.gov)
  • Undergoes hydrolysis in liver and tissues to form the active moiety (fluorouracil), inhibiting thymidylate synthetase, which in turn blocks methylation of deoxyuridylic acid to thymidylic acid. (medscape.com)
  • For a gene under positive repressible control, the normal state is transcription of a gene, stimulated by a transcriptional activator. (proprofs.com)
  • Here, we show that Rdh54/Tid1 inhibits D-loop formation by Rad51 and Rad54 in an ATPase-independent manner. (elifesciences.org)