Inhibits the egfr tyrosine kinase. Medical search. Frequent questions

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Anatomy15

Cell Line, Tumor Tumor Cells, Cultured Cell Line Cells, Cultured 3T3 Cells Epithelial Cells Cell Membrane Fibroblasts Cell Line, Transformed Jurkat Cells COS Cells PC12 Cells HeLa Cells NIH 3T3 Cells Cell Nucleus

Organisms6

Mice, Nude Mice, Inbred BALB C Mice, Knockout Rats, Sprague-Dawley Mice, Inbred C57BL Cricetinae

Diseases10

Lung Neoplasms Carcinoma, Non-Small-Cell Lung Adenocarcinoma, Bronchiolo-Alveolar Adenocarcinoma Carcinoma, Squamous Cell Head and Neck Neoplasms Breast Neoplasms Disease Progression Cell Transformation, Neoplastic Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Chemicals and Drugs156

Receptor, Epidermal Growth Factor Quinazolines Tyrosine Protein Kinase Inhibitors Protein-Tyrosine Kinases Tyrphostins Antineoplastic Agents Phosphatidylinositol 3-Kinases Epidermal Growth Factor Receptor Protein-Tyrosine Kinases src-Family Kinases Enzyme Inhibitors Transforming Growth Factor alpha Proto-Oncogene Proteins Proto-Oncogene Proteins c-akt Protein-Serine-Threonine Kinases Mitogen-Activated Protein Kinase 3 Protein Tyrosine Phosphatases Phosphotyrosine Mitogen-Activated Protein Kinase 1 Protein Kinases Mitogen-Activated Protein Kinases Calcium-Calmodulin-Dependent Protein Kinases Antibodies, Monoclonal, Humanized Receptor, erbB-2 Extracellular Signal-Regulated MAP Kinases Antibodies, Monoclonal Genistein Lymphocyte Specific Protein Tyrosine Kinase p56(lck)Protein Kinase C Pyrimidines Tyrosine 3-Monooxygenase Proto-Oncogene Proteins c-abl Phosphoproteins RNA, Small Interfering Proto-Oncogene Proteins pp60(c-src)p38 Mitogen-Activated Protein Kinases ras Proteins Receptors, Vascular Endothelial Growth Factor Cyclic AMP-Dependent Protein Kinases Focal Adhesion Kinase 2 Intracellular Signaling Peptides and Proteins RNA, Messenger Proto-Oncogene Proteins c-met Proto-Oncogene Proteins c-fyn Mitogen-Activated Protein Kinase Kinases Ligands fms-Like Tyrosine Kinase 3 JNK Mitogen-Activated Protein Kinases Benzamides Focal Adhesion Protein-Tyrosine Kinases Focal Adhesion Kinase 1 Janus Kinase 2 Piperazines Adaptor Proteins, Signal Transducing p21-Activated Kinases Recombinant Fusion Proteins Isoenzymes Vanadates Recombinant Proteins CDC2 Protein Kinase MAP Kinase Kinase Kinases Phosphotransferases (Alcohol Group Acceptor)Protein Tyrosine Phosphatase, Non-Receptor Type 11 MAP Kinase Kinase 1 Quinones Indoles Cyclin-Dependent Kinases Ribosomal Protein S6 Kinases Proto-Oncogene Proteins c-kit Phospholipase C gamma Creatine Kinase Proteins Lactams, Macrocyclic Casein Kinase II Casein Kinases Benzoquinones eIF-2 Kinase Receptor, Insulin DNA, Neoplasm Type C Phospholipases MAP Kinase Kinase 4 Protein Kinase C-delta GRB2 Adaptor Protein Pyruvate Kinase Membrane Proteins Fusion Proteins, bcr-abl Protein Tyrosine Phosphatase, Non-Receptor Type 6 1-Phosphatidylinositol 4-Kinase Calcium Protein Tyrosine Phosphatase, Non-Receptor Type 1 TYK2 Kinase Thymidine Kinase Glycogen Synthase Kinase 3 rho-Associated Kinases Janus Kinase 1 Isoflavones Receptors, Platelet-Derived Growth Factor DNA-Binding Proteins Protein Kinase C-alpha Intercellular Signaling Peptides and Proteins Androstadienes I-kappa B Kinase Janus Kinase 3 Nitriles Serine CDC2-CDC28 Kinases Oncogene Proteins v-abl Pyridines Enzyme Precursors Pyrroles Staurosporine DNA Primers Receptor, trkA Proto-Oncogene Proteins c-hck Proto-Oncogene Proteins c-yes Receptors, Cell Surface Aurora Kinases Proto-Oncogene Proteins c-ret Proto-Oncogene Proteins c-cbl Tetradecanoylphorbol Acetate Shc Signaling Adaptor Proteins Morpholines Chromones Diacylglycerol Kinase Carrier Proteins Flavonoids ZAP-70 Protein-Tyrosine Kinase Receptors, Growth Factor Receptor, Platelet-Derived Growth Factor beta DNA, Complementary Hepatocyte Growth Factor Platelet-Derived Growth Factor AMP-Activated Protein Kinases Cell Cycle Proteins MAP Kinase Kinase 2 Receptor Tyrosine Kinase-like Orphan Receptors TOR Serine-Threonine Kinases Cytoskeletal Proteins Trans-Activators Oncogene Proteins Receptor, EphA2 Transcription Factors STAT3 Transcription Factor Ribosomal Protein S6 Kinases, 90-kDa Myosin-Light-Chain Kinase Phosphoserine Protein Kinase C-epsilon Insulin Cyclic AMP MAP Kinase Kinase Kinase 1 Paxillin Threonine Receptor, EphB2 Peptides Adenosine Triphosphate

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Blotting, Western DNA Mutational Analysis Xenograft Model Antitumor Assays Transfection Immunohistochemistry Drug Screening Assays, Antitumor Reverse Transcriptase Polymerase Chain Reaction In Situ Hybridization, Fluorescence Precipitin Tests Treatment Outcome Antineoplastic Combined Chemotherapy Protocols Immunoblotting Models, Biological Mutagenesis, Site-Directed Cloning, Molecular Prognosis Neoplasm Staging Electrophoresis, Polyacrylamide Gel Models, Molecular Peptide Mapping

Phenomena and Processes44

Genes, erbB-1 Phosphorylation Signal Transduction Mutation MAP Kinase Signaling System Drug Resistance, Neoplasm Enzyme Activation Cell Proliferation Apoptosis Cell Division Transfection Dose-Response Relationship, Drug Amino Acid Sequence Gene Expression Regulation, Neoplastic Drug Synergism Cell Survival Protein Binding src Homology Domains Time Factors Exons Sequence Deletion Kinetics Genes, ras Gene Dosage Base Sequence Protein Structure, Tertiary Binding Sites Cell Movement Down-Regulation Substrate Specificity Sequence Homology, Amino Acid Transcriptional Activation Gene Expression Gene Expression Regulation Gene Expression Regulation, Enzymologic Cell Adhesion Genes, src Protein Processing, Post-Translational Cell Differentiation Protein Transport Cell Cycle Up-Regulation Transcription, Genetic Structure-Activity Relationship

Disciplines and Occupations1

Immunohistochemistry

Information Science3

Molecular Sequence Data Amino Acid Sequence Base Sequence

Health Care1

Treatment Outcome

Anatomy Organisms Diseases Chemicals and Drugs Analytical, Diagnostic and Therapeutic Techniques and Equipment Phenomena and Processes Disciplines and Occupations Information Science Health Care

Receptor, Epidermal Growth Factor Quinazolines Tyrosine Protein Kinase Inhibitors Genes, erbB-1 Protein-Tyrosine Kinases Tyrphostins Phosphorylation Lung Neoplasms Signal Transduction Carcinoma, Non-Small-Cell Lung Antineoplastic Agents Cell Line, Tumor Mutation Phosphatidylinositol 3-Kinases MAP Kinase Signaling System Epidermal Growth Factor Drug Resistance, Neoplasm Receptor Protein-Tyrosine Kinases src-Family Kinases Enzyme Inhibitors Transforming Growth Factor alpha Enzyme Activation Proto-Oncogene Proteins Proto-Oncogene Proteins c-akt Protein-Serine-Threonine Kinases Mitogen-Activated Protein Kinase 3 Protein Tyrosine Phosphatases Phosphotyrosine Mitogen-Activated Protein Kinase 1 Protein Kinases Mitogen-Activated Protein Kinases Blotting, Western Mice, Nude Cell Proliferation Adenocarcinoma, Bronchiolo-Alveolar Calcium-Calmodulin-Dependent Protein Kinases Tumor Cells, Cultured Antibodies, Monoclonal, Humanized Receptor, erbB-2 Extracellular Signal-Regulated MAP Kinases Antibodies, Monoclonal Apoptosis DNA Mutational Analysis Cell Division Cell Line Adenocarcinoma Genistein Molecular Sequence Data Xenograft Model Antitumor Assays Lymphocyte Specific Protein Tyrosine Kinase p56(lck)Protein Kinase C Pyrimidines Tyrosine 3-Monooxygenase Transfection Dose-Response Relationship, Drug Amino Acid Sequence Proto-Oncogene Proteins c-abl Phosphoproteins Gene Expression Regulation, Neoplastic Drug Synergism RNA, Small Interfering Cell Survival Cells, Cultured Proto-Oncogene Proteins pp60(c-src)Carcinoma, Squamous Cell Head and Neck Neoplasms p38 Mitogen-Activated Protein Kinases ras Proteins Receptors, Vascular Endothelial Growth Factor Protein Binding src Homology Domains Cyclic AMP-Dependent Protein Kinases Immunohistochemistry Focal Adhesion Kinase 2 Intracellular Signaling Peptides and Proteins RNA, Messenger Proto-Oncogene Proteins c-met Proto-Oncogene Proteins c-fyn Drug Screening Assays, Antitumor Mitogen-Activated Protein Kinase Kinases Ligands Time Factors fms-Like Tyrosine Kinase 3 JNK Mitogen-Activated Protein Kinases Benzamides Exons Focal Adhesion Protein-Tyrosine Kinases Focal Adhesion Kinase 1 Janus Kinase 2 Piperazines Sequence Deletion Kinetics 3T3 Cells Adaptor Proteins, Signal Transducing Genes, ras p21-Activated Kinases Gene Dosage Base Sequence Recombinant Fusion Proteins

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