Inhibits receptors glucagon. Medical search. Frequent questions

Objective To determine whether treatment with agonists of glucagon-like peptide-1 receptor (GLP-1R) result in weight loss in overweight or obese patients with or without type 2 diabetes mellitus. (bmj.com)
Adenylate cyclase is inhibited by agonists of adenylate cyclase inhibitory G ( G i )-protein-coupled receptors. (wikipedia.org)
Glucagon-like peptide 1 receptor (or GLP-1R) agonists are a frontline treatment for diabetes - improving glycaemic control by reducing glucose concentrations in the blood. (cureparkinsons.org.uk)
Other agents include amylin, melanocortin-4 receptor agonists, neuropeptide Y antagonists, beta(3) adrenergic agonists and glucagon-like peptide-1 agonists. (drugbank.com)
The present disclosure relates to glucagon-like peptide-1 receptor (GLP-1R) agonists and methods of treating or preventing allergic inflammation and/or methods of treating or preventing respiratory syncytial virus (RSV) infection. (justia.com)
GLP-1 receptor (GLP-1R) agonists, such as liraglutide and exenatide are approved by the Food and Drug Administration (FDA) for treatment of type 2 diabetes (T2D). (justia.com)
The inventors found that GLP-1R agonists inhibited IL-33 expression and release from the lungs of mice in response to an airway challenge the allergen extract of the aeroallergen Alternaria alternata , an aeroallergen which has protease activity and which is associated with severe asthma exacerbations. (justia.com)
Prolactin levels are often adequately suppressed with dopamine-receptor agonists. (medscape.com)
Dopamine-receptor agonists make up another pharmacologic option. (medscape.com)
GH-receptor agonists are the newest class of drugs used to decrease excessive GH effect. (medscape.com)
Sleep disorders are treated using anti-insomnia drugs that target ionotropic and G protein-coupled receptors (GPCRs), including g -aminobutyric acid (GABA) agonists, melatonin agonists, and orexin receptor antagonists. (vdocuments.mx)
Semaglutide belongs to a class of drugs known as GLP-1 receptor agonists. (liverpoolstar.com)
The glucagon-like peptide-1 receptor agonists (GLP-1RAs) were recommended as a monotherapy or combination therapy with oral hypoglycemic agents or basal insulin in the position statement of the Korean Diabetes Association 2017 for pharmacological therapy. (e-dmj.org)
GLP-1s, or glucagon-like peptide-1 receptor agonists, are a class of medications commonly used in the treatment of type 2 diabetes. (bodyspec.com)

SAN DIEGO - Survodutide, a dual glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist, led to "striking" weight loss in a phase 2 dosing trial in people with overweight/ obesity but without type 2 diabetes. (medscape.com)
Disclosed herein are methods of treating allergic disorders and respiratory syncytial virus (RSV) infections with a glucagon-like peptide-1 receptor (GLP-1R) agonist. (justia.com)
In some aspects, disclosed herein is a method of treating or preventing an allergic disease in a subject who has, or is at risk of developing an allergic disease, comprising administering to the subject a therapeutically effective amount of a glucagon-like peptide-1 receptor (GLP-1Rt) agonist. (justia.com)
After transsphenoidal surgery, these agents are generally a first-line treatment, followed by a dopamine-receptor agonist or GH receptor antagonist. (medscape.com)
This is the dopamine-receptor agonist that is most often used to treat GH and prolactin excess. (medscape.com)
Cabergoline is a potent dopamine-receptor agonist with a prolonged duration of action. (medscape.com)
Altimmune Inc.'s peptide-based glucagon-like peptide-1/glucagon dual receptor agonist pemvidutide hiccupped in a phase I study earlier this year but has bounced. (bioworld.com)
Lixisenatide is a selective glucagon-like peptide-1 (GLP-1) receptor, an agonist. (ziprx.ca)
Mounjaro (tirzepatide) is a dual agonist for glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. (patsnap.com)
Semaglutide is a GLP-1 receptor agonist that stimulates the production of insulin and inhibits the secretion of glucagon, thereby reducing appetite and food intake. (patsnap.com)
It is a dual GIP/GLP-1 receptor agonist, which means it works on two different receptors in the body to lower blood sugar levels. (1stopsite.com)
As a dual glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) receptor agonist, and glucagon receptor antagonist, tirzepatide exerts its effects on multiple fronts. (blissfusion.com)
As a dual GIP and GLP-1 receptor agonist, tirzepatide helps to regulate blood sugar levels by stimulating insulin secretion, reducing glucagon release, and improving glucose uptake by cells. (blissfusion.com)

Acts as an antagonist at the human GLP-1 receptor. (tocris.com)
Pegvisomant is a recombinant deoxyribonucleic acid (DNA) analogue of human GH that has been structurally altered to act as a GH receptor antagonist. (medscape.com)
As a glucagon receptor antagonist, tirzepatide inhibits the effects of glucagon, leading to decreased glucose production and blood sugar levels. (blissfusion.com)

GLP-1 is a hormone that stimulates insulin production while blocking glucagon release. (cureparkinsons.org.uk)
Glucagon like peptide-1 (or GLP-1) is a hormone in the body that stimulates insulin production. (cureparkinsons.org.uk)
In pancreatic islets and INS-1 cells it inhibits glucose-mediated glucagon release and stimulates insulin production. (stemcell.com)
This hormone stimulates insulin production and inhibits the release of glucagon, effectively lowering blood sugar levels. (liverpoolstar.com)
The drug stimulates the release of insulin and inhibits the release of glucagon, which helps to lower blood sugar levels, and slows down the absorption of glucose in the gut, which helps to reduce post-meal spikes in blood sugar levels. (1stopsite.com)
The drug stimulates the release of insulin and inhibits the release of glucagon, which helps to lower blood sugar levels. (1stopsite.com)
GLP-1 stimulates glucose-dependent insulin release, inhibits glucagon release, delays gastric emptying, and suppresses the appetite through GLP-1 receptor binding. (e-dmj.org)

Secretion of glucagon is directly controlled by the level of blood sugar via a negative feedback system. (ashfordstpeters.nhs.uk)
Regarding the secretion of glucagon, orexin B shows a clear inhibiting effect on the pancreatic function of the rat. (uni-marburg.de)

Exendin-4, however, was found to be resistant to this deactivation, meaning that could last longer in the body stimulating insulin production and blocking glucagon release. (cureparkinsons.org.uk)

Further, GABA-deficient islets did not show appropriate glucagon inhibition in response to increasing glucose concentrations in vitro 22 , suggesting that GABA is directly involved in the suppression of glucagon secretion in pancreatic alpha cells. (nature.com)
Such novel pathways include induction of mitochondrial stress, inhibition of mitochondrial shuttles, alteration of intestinal microbiota, suppression of glucagon signaling, activation of autophagy, attenuation of inflammasome activation, induction of incretin receptors and reduction of terminal endoplasmic reticulum stress. (cyberleninka.org)
It also has a multitude of other endocrine and nonendocrine effects, including inhibition of glucagon, VIP, and gastrointestinal peptides. (medscape.com)

The beta-2 adrenergic receptor (β2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that binds epinephrine (adrenaline), a hormone and neurotransmitter whose signaling, via adenylate cyclase stimulation through trimeric Gs proteins, increases cAMP, and, via downstream L-type calcium channel interaction, mediates physiologic responses such as smooth muscle relaxation and bronchodilation. (wikipedia.org)
The hormone Glucagon has the opposite effect - it tells the body to release glucose into the blood to raise sugar levels. (cureparkinsons.org.uk)
Leptin, a hormone produced by adipocytes that inhibits food intake, has undergone clinical trials and analogues are currently being developed. (drugbank.com)
Glucagon-like peptide-1 (GLP-1) is a peptide hormone synthesized and released by enteroendocrine L-cells in the ileum and large intestine following oral food intake. (justia.com)
Octreotide also inhibits prolactin release by means of vasoactive intestinal peptide (VIP) ̶ and thyrotropin-releasing hormone (TRH) ̶ mediated secretion of prolactin. (medscape.com)
Alpha cells which secrete the hormone glucagon which raises the blood sugar level. (ashfordstpeters.nhs.uk)
Delta cells which secrete Samatastatin which inhibits the secretion of insulin, glucagon and growth hormone. (ashfordstpeters.nhs.uk)
Acting on the same receptor as the endogenous hormone incretin, Lixisenatide increases glucose-dependent insulin secretion, decreases inappropriate glucagon secretion, and slows gastric emptying. (ziprx.ca)
The identification of the orexin-receptors in the digestive system as well as increased hints to a possible peripheral effect of the orexins led to the aim of this study: the peripheral influence of orexin B on the hormone secretion of the pancreas should be examined. (uni-marburg.de)
The receptors on cells become less sensitive to the hormone or down-regulated. (dogzone.com)
This hormone triggers extra insulin to lower blood sugar levels, and inhibits glucagon, a hormone that raises blood sugar levels. (babyjourney.net)
GLP-1 for weight loss activates the receptors in the body that respond to said hormone. (babyjourney.net)
Incretin hormone includes glucagon-like peptide-1 (GLP-1) from L-cells and glucose-dependent insulinotrophic polypeptide from K-cells of the small intestine. (e-dmj.org)
This insulin then inhibits the action of glucagon, a hormone that raises blood sugar levels. (regenerativerevival.com)

It inhibits basal secretion of motilin, gastric inhibitory peptide, and pancreatic polypeptide and markedly inhibits meal-induced increases in superior mesenteric artery blood flow and portal venous blood flow. (medscape.com)

FGF-21 expression is regulated by tissue-specific peroxisome proliferator-activated receptors (PPARs). (stemcell.com)

G protein-coupled receptors (GPCRs) belong to the largest class of drug targets. (mdpi.com)

Aside from miRNA and lncRNA, other exosomal molecules for example gastrokine 1 inhibited gastric carcinogenesis [54]. (glucagon-receptor.com)
Exosomal miR-139 derived from cancer-associated fibroblasts inhibited gastric cancer progression by suppressing matrix metallopeptidaseBioengineering 2021, 8,4 ofexpression [55]. (glucagon-receptor.com)
Perhaps the most infamous is the combination drug Roux-en-Y gastric bypass, biliopancreatic diversion with duo- Fen-Phen. (eddoctor24h.com)

4] MG is caused by autoantibodies to postsynaptic nicotinic acetylcholine receptors (anti-AChRs) at the neuromuscular junction, causing weakness of skeletal muscles. (medscape.com)

The 3D crystallographic structure (see figure and links to the right) of the β2-adrenergic receptor has been determined by making a fusion protein with lysozyme to increase the hydrophilic surface area of the protein for crystal contacts. (wikipedia.org)
The crystal structure of the β2Adrenergic Receptor-Gs protein complex was solved in 2011. (wikipedia.org)
citation needed] This receptor-channel complex is coupled to the Gs G protein, which activates adenylyl cyclase, catalysing the formation of cyclic adenosine monophosphate (cAMP) which then activates protein kinase A, and counterbalancing phosphatase PP2A. (wikipedia.org)
The adrenergic receptors are metabolic G protein-coupled receptors. (proteopedia.org)
The human β2 adrenergic receptor bound to a G-protein ( 3sn6 ) is featured in a scene above, and additional structures are on the Adrenergic receptor page . (proteopedia.org)
For G s see Beta2 adrenergic receptor-Gs protein complex updated . (proteopedia.org)
Dopamine receptors are a class of metabotropic G protein-coupled receptors that are important in the central nervous system. (proteopedia.org)
[1] Adenylate cyclase is activated by a range of signaling molecules through the activation of adenylate cyclase stimulatory G ( G s )-protein-coupled receptors. (wikipedia.org)
AMPK pathways inhibit biosynthetic pathways with energy consumption, such as protein, fatty acid and glycogen synthesis. (springer.com)
However, there have been no reports identifying pharmacologic agents which inhibit lung IL-33 protein release or expression. (justia.com)
AMP molecules can then bind to the y subunit of AMPK and activate AMPK activity directly or by inhibiting dephosphorylation of AMPK phosphorylated by liver kinase B1 (LKB1) or calcium/calmodulin-dependent protein kinase kinase-ß (CAMKKß)10. (cyberleninka.org)
Patients with this form of the disease become hypoglycemic when fasting and also after a protein-rich meal, likely due to the glutamine in the protein stimulating the amplification of glucagon-like peptide-1 (GLP-1) receptor signaling on the beta-cell. (chop.edu)
Of note, while the effect of exendin-(9-39) on fasting glucose seems to be mediated by suppression of insulin secretion, the effect on protein-induced hypoglycemia may be mediated by exendin-(9-39)-mediated increase on glucagon, suggesting the treatment might induce multiple mechanisms of blood sugar control. (chop.edu)
It blocks GH binding to receptors, thus decreasing IGF-I, IGF binding protein 3 (IGFBP-3), and acid-labile subunit. (medscape.com)
The preservation of lean mass in the GLP-1 group was attributed to the hormone's ability to enhance protein synthesis and inhibit protein breakdown. (bodyspec.com)

Lanreotide elicits high affinity for human somatostatin receptors 2, 3, and 5. (medscape.com)
Pasireotide is a cyclohexapeptide somatostatin analog that binds to human somatostatin receptors 1, 2, 3, 4 and 5. (medscape.com)

There must be 5 molecules of cobra toxin (red) to block the receptor (blue) as each molecule binds with an individual alpha chain on the acetylcholine receptor. (proteopedia.org)
The most extensively studied and used somatostatin analogue, octreotide, binds to the somatostatin receptor subtypes II and V, inhibiting GH secretion. (medscape.com)
It selectively binds to GH receptors on cell surfaces, blocking endogenous GH binding. (medscape.com)
After the process of insulin release has been stimulated insulin binds to receptors on the surface of cells and this allows them to take in glucose and store it either as glycogen or fat which can be used as a future energy source. (dogzone.com)

noticeably induce cell apoptosis and inhibit cell migration and invasion. (biosemiotics2013.org)

The β-1 adrenergic receptor (B1AR) increases cardiac output and secretion of rennin and ghrelin. (proteopedia.org)
Glucagon receptor agonism increases energy expenditure, and GLP-1 receptor agonism inhibits appetite, both part of the mechanism of action, Le Roux, a professor at University College in Dublin, Ireland, explained. (medscape.com)
Insulin, after binding its receptor, induces the phosphorylation of receptor substrates in the liver and muscles, and induces several steps toward the transactivation of GLUT-4, which increases glucose uptake by cells and its storage as glycogen, and inhibits the net production of glucose by the liver, thus blocking glycogenolysis and neoglycogenesis. (isciii.es)
Glucagon Suppression - Glucagon increases blood sugar levels by promoting the release of glucose. (blissfusion.com)
These cell lines reported on the levels of ARX, an alpha-cell master regulator that appears to be inhibited when Pax4 activity increases. (medscape.com)

Once they reach their destination in the anterior pituitary, these hormones bind to specific receptors located on the surface of pituitary cells. (sciencebeta.com)

Beta-2 adrenergic receptors have also been found to couple with Gi, possibly providing a mechanism by which response to ligand is highly localized within cells. (wikipedia.org)
In contrast, Beta-1 adrenergic receptors are coupled only to Gs, and stimulation of these results in a more diffuse cellular response. (wikipedia.org)

Acts on GLP-1 receptors, reducing appetite and increasing feelings of fullness. (muscleandbrawn.com)
When tirzepatide activates GIP and GLP-1 receptors, it enhances feelings of fullness and reduces appetite, leading to reduced food intake. (blissfusion.com)

Liver adenylate cyclase responds more strongly to glucagon, and muscle adenylate cyclase responds more strongly to adrenaline. (wikipedia.org)
Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
In view of the marked changes in the COOH-terminal of GP glucagon, receptor binding studies were performed using both rat and GP liver membranes. (diabetesjournals.org)

cAMP is a second messenger , used for intracellular signal transduction, such as transferring into cells the effects of hormones like glucagon and adrenaline , which cannot pass through the plasma membrane. (wikipedia.org)
It synthesizes and secretes certain neurohormones, called releasing hormones or hypothalamic hormones, and these in turn stimulate or inhibit the secretion of pituitary hormones. (sciencebeta.com)
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are hormones that help regulate blood sugar levels by stimulating the release of insulin. (1stopsite.com)

Corticosteroids and, obviously, glucagon and also the tone of autonomic nervous system via peripheral M-cholinoreactive and α- and β-adrenoreactive structures take part in the activation of calcitonin secretion under insulin hypoglycemia. (scirp.org)

Inhibits hepatic glucose production in vivo and is a weak insulinotropic agent. (tocris.com)

Tirzepatide achieves its effects by stimulating both the GLP-1 and GIP receptors in the body, leading to the release of insulin from the pancreas. (regenerativerevival.com)

Labeled synthetic porcine glucagon has similar binding in the two systems and its binding is inhibited to a similar degree by synthetic porcine glucagon, whereas GP glucagon is 10-fold less potent at inhibiting binding in both systems. (diabetesjournals.org)
We found that arginine which is a well-known potent stimulator of the glucagon-secretion is lightly limited in its effect by orexin B. The orienting investigations regarding the influence of the secretion of somatostatin showed no recognizable effect of orexin B to the secretory function of the endocrine pancreas. (uni-marburg.de)

In addition to these autoantibodies, patients with thymoma-associated MG produce autoantibodies to various neuromuscular antigens, including antibodies to the skeletal muscle calcium release channel (ryanodine receptor of sarcoplasmic reticulum) and antibodies to cytoplasmic filamentous proteins (particularly titin) or neurofilaments. (medscape.com)
M1, M3, M5 receptors are coupled with G q proteins, while M2 and M4 receptors are coupled with G i/o proteins. (proteopedia.org)
The phosphorylated proteins may act directly on the cell's ion channels, or may become activated or inhibited enzymes. (wikipedia.org)
Insulin acts via specific membrane-bound receptors on target tissues to regulate the metabolism of carbohydrates, proteins, and fats. (ziprx.ca)

In prior studies, CHOP researchers have shown that administering exendin-(9-39), which blocks the GLP-1 receptor, through an intravenous infusion significantly increased fasting glucose levels in adolescents and adults with the K ATP HI form of the disease. (chop.edu)

This appears to be mediated by cAMP induced PKA phosphorylation of the receptor. (wikipedia.org)

It works as a postsynaptic neurotoxin binding to the receptor as an extracellular ligand by interacting with OH group leaving the acetylcholine channel open which releases ions used in creating an action potential. (proteopedia.org)

This is the first study to identify an FDA approved pharmacologic agent that inhibits lung IL-33 release, providing an alternative to biologic therapies that target IL-33-mediated diseases. (justia.com)

Interestingly, Beta-2 adrenergic receptor was observed to localize exclusively to the T-tubular network of adult cardiomyocytes, as opposed to Beta-1 adrenergic receptor, which is observed also on the outer plasma membrane of the cell Activation of the β2 adrenoreceptor with long-acting agents such as oral clenbuterol and intravenously-infused albuterol results in skeletomuscular hypertrophy and anabolism. (wikipedia.org)

Pancreatic cancer CB1 Activator supplier cell-derived exosomes inhibited immune response through miR-203 and hence downregulated Toll-like receptors, and downstream cytokines like tumor necrosis factor-alpha (TNF-) and IL-12 in dendritic cells (DC) [27]. (glucagon-receptor.com)
Other exosomal miRNAs like miR-144 [49] and miR-520b [50] inhibited non-small cell lung cancer (NSCLC) progression by means of the downregulation of cyclin E1 and E2 migration of pancreatic cancer cells, respectively. (glucagon-receptor.com)
Exosomal miR-375 inhibited cell proliferation and the invasive properties of colon cancer cells [53]. (glucagon-receptor.com)
These cells can be characterized in their developmental progression by changes in expression of 3 cell surface markers: CD4, CD8, and the T-cell receptor (TCR)-CD3 complex. (medscape.com)
Regarding Type 1 diabetes(T1D), animal/islet-cell studies found that GABA promotes insulin secretion, inhibits α-cell glucagon and dampens immune inflammation, while GAD immunization may also preserve β-cells. (nature.com)
GLP-1 has a role in glycemic control by inducing glucose-dependent insulin secretion from β-cells and inhibiting glucagon release from α-cells in the pancreas. (justia.com)
Occurs abruptly, characterised by an absolute deficiency of insulin due to a marked decline in the number of insulin producing beta cells (perhaps caused by the auto immune destruction of beta cells) even though target cells contain insulin receptors. (ashfordstpeters.nhs.uk)
Some type II diabetes have sufficient amounts of insulin in the blood, but they have defects in the molecular machinery that mediates the action of insulin on its target cells, cells can become less sensitive to insulin because they have fewer insulin receptors. (ashfordstpeters.nhs.uk)
When the blood sugar level falls below a certain level chemical sensors in the alpha cells of the inlets stimulate the cells to secrete glucagon. (ashfordstpeters.nhs.uk)
Glucose entry into cells depends on the presence of insulin receptors on the surface of the target cells. (ashfordstpeters.nhs.uk)
Moreover, studies concerning the receptor density on the pancreatic cells, which identify the exact function as well as the numerical and regional distribution of the OX-2-receptors, should follow. (uni-marburg.de)
By acting on the GLP-1 receptor, it reduces fat cells and promotes fat breakdown, which are key mechanisms in weight loss. (regenerativerevival.com)
[ 7 , 8 ] As background, in 2009, Collombat and colleagues [ 9 ] showed that pancreatic misexpression of the gene Pax4 led to the conversion of glucagon -producing alpha cells into functional beta cells. (medscape.com)

Deacon et al (1995) Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo . (tocris.com)

Of the secondary outcomes, the combination GABA/GAD reduced fasting and meal-stimulated serum glucagon, while the safety/tolerability of GABA was confirmed. (nature.com)

Its formula approaches weight loss from all sides, inhibiting fat buildup, increasing energy levels, and making you feel full much longer after you eat. (dallasnews.com)
If blood glucose levels are too low its secretion is inhibited. (dogzone.com)
The release and production of glucose from tissues continues where it would normally be inhibited by insulin and this, combined with glucose from the diet causes the excessively high blood sugar levels seen in diabetes mellitus. (dogzone.com)
GLP-1 plays a crucial role in regulating blood sugar levels by stimulating insulin secretion and inhibiting glucagon release. (bodyspec.com)
Tirzepatide is a medication utilized to manage type 2 diabetes and is designed to work by stimulating the GLP-1 receptors in the body, thereby boosting insulin production and regulating blood sugar levels. (regenerativerevival.com)
The investigators showed that a class of antimalarial drugs known as artemisinins, typified by the FDA-approved drug artemether , were capable of inhibiting ARX levels, reducing glucagon, and increasing insulin in an in vitro alpha-cell model. (medscape.com)

In vitro experiments found that isolated human islets treated with GABA receptor blockade have decreased insulin secretion at physiologic glucose concentrations 18 . (nature.com)

5 The anorexigenic effect of monoamine serotonin is also mediated by the 5HT-2C receptor in POMC neurons. (nature.com)

Approximately half of the members of the human GPCR superfamily are chemosensory receptors, including odorant receptors (ORs), trace amine-associated receptors (TAARs), bitter taste receptors (TAS2Rs), sweet and umami taste receptors (TAS1Rs). (mdpi.com)
at Human A2A receptor. (proteopedia.org)
Glucagons from pig, cow, human, rat, and hamster have identical amino acid sequences, whereas the amino acid contents of rabbit and camel glucagons are consistent with this 29-amino acid sequence. (diabetesjournals.org)
The top image represents a single neuron in an average human brain, highlighting an enlarged section showing the receptors and the neurotransmitters in the circled region. (hormonesmatter.com)

Moreover, insulin promotes lipid storage by inhibiting lipolysis. (isciii.es)

The Antitumorigenic Activity of Exosomes Regardless of obtaining many pro-tumor effects, exosomal cargoes are also involved in inhibiting tumor progression. (glucagon-receptor.com)
Effects of glucagon. (bmj.com)

Anatomy6

Organisms2

Diseases5

Chemicals and Drugs32

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Psychiatry and Psychology1

Phenomena and Processes5

Agonists14

Agonist13

Antagonist3

Stimulates7

Secretion of glucagon2

Blocking glucagon release1

Inhibition3

Hormone14

Pancreatic polypeptide1

Peroxisome prolifera1

GPCRs1

Gastric3

Nicotinic acetylcho1

Protein15

Somatostatin receptors2

Binds4

Induce1

Increases5

Pituitary cells1

Adrenergic receptors2

Appetite2

Liver3

Hormones3

Corticosteroids1

Glucose production1

Release of insulin1

Potent2

Proteins4

Intravenous1

Phosphorylation1

Postsynaptic1

Pharmacologic1

Interestingly1

Cells13

Endogenous1

Serum1

Levels6

Vitro1

Neurons1

Human4

Promotes1

Effects2