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Erythrocyte MembraneErythrocytesMembrane LipidsLipid PeroxidationLipidsAnion Exchange Protein 1, ErythrocyteCell MembraneMembrane FluidityLipid PeroxidesLipid MetabolismSpectrinErythrocyte AgingLipid BilayersMembranesErythrocyte DeformabilityHemolysisGlycophorinPhospholipidsIntracellular MembranesMalondialdehydeMembranes, ArtificialLipid AMembrane PotentialsMembrane ProteinsPhosphatidylcholinesOsmotic FragilityCell Membrane PermeabilityLiposomesThiobarbituric Acid Reactive SubstancesFatty AcidsAntioxidantsBlood ProteinsKineticsCholesterolAldehydesPlasmodium falciparumSpherocytosis, HereditaryOxidative StressElectrophoresis, Polyacrylamide GelBlood Group AntigensTemperatureMicroscopy, ElectronPhosphatidylethanolaminesProtein BindingAnkyrinsProtozoan ProteinsMembrane MicrodomainsPhosphatidylserinesOxidation-ReductionFatty Acids, UnsaturatedGlutathioneHydrogen-Ion ConcentrationFree RadicalsMolecular WeightErythrocytes, AbnormalDetergentsAcholeplasma laidlawiiMolecular Sequence DataVitamin EModels, BiologicalTurkeysAnemia, HemolyticRabbitsMNSs Blood-Group SystemDiphenylhexatrieneElliptocytosis, HereditaryGlycolipidsAmino Acid SequencePeroxidesCarrier ProteinsFreeze FracturingTime FactorsBasement MembraneGalactolipidsErythrocyte AggregationAscorbic AcidCells, CulturedErythrocyte CountBinding SitesLiverCell LineThiobarbituratesGlutathione PeroxidaseFluorescent DyesSuperoxide DismutaseErythrocyte VolumeCalciumCatalaseFluorescence PolarizationSpherocytesChromatography, Thin LayerSphingomyelinsMembrane GlycoproteinsHemagglutinationRh-Hr Blood-Group SystemProtein TransportCattleFreeze EtchingBiological TransportBiological Transport, Active
OxidationModel membranesPermeabilityProteinAmino acidsReactive oxygenAntioxidantsHemolysisBilayerVitro0.052002ExposureLiverRadicalsMetabolismSignificantlyInhibitionConcentrations of oxygenExtracellular MatrixEnzymeMalondialdehydePotentOxidative injuryCellSpeciesOxygenDamageCholesterolRatsFlavonoidsHumanBiologicalProductionCalciumCapacityReleaseDecreaseEffectsCrossPlasmaContent
Oxidation5
  • Hence, the present study was designed to examine the effect of T. chebula on erythrocyte oxidation products level, antioxidant status, membrane ATPases and glycoproteins in aged rats compared with young rats. (scialert.net)
  • Buege, J.A. and Aust, S.D. (1978) Microsomal lipid per- oxidation. (scirp.org)
  • Vitamin A as antioxidants works by weakening peroxyl radicals and inhibiting lipid oxidation [12]. (manuscriptscientific.com)
  • A number of naturally occurring benzofurans that differ in their substitution pattern and oxidation state have been investigated for their ability to inhibit insect feeding by a bioassay with the common cutworm ( Spodoptera litura F. Noctuidae) that applies the leaf disk method. (go.jp)
  • However, MTF reduces oxidative stress by constraining the protein oxidation and lipid peroxidation, and increases antioxidant reserve by increasing the ferric reducing ability of plasma and reducing glutathione levels. (ac.ir)
Model membranes3
  • I. viscosa and F. suspensa protected against enzymatic and non-enzymatic lipid peroxidation in model membranes and also showed scavenging property on the superoxide radical. (nih.gov)
  • Sticholysins I and II, cytolysins purified from the sea anemone Stichodactyla helianthus, act by lysing biological and model membranes. (bvsalud.org)
  • Different aspects of the interaction between peptides from the toxins' N-termini (StI1-31 and StI12-31 SELAGTIIDGASLTFEVLDKVLGELGKVSRK, and StII1-30 and StII11-30 ALAGTIIAGASLTFQVLDKVLEELGKVSRK) and model membranes - micelles and bilayers - have been studied to contribute to the elucidation of the toxins mechanism of action at the molecular level. (bvsalud.org)
Permeability3
  • Countering NADH production, calcium action on the mitochondrial permeability transition pores increases inner membrane permeability thereby reducing proton potential, causing the matrix to swell and ultimately releasing cytochrome c (an initiator of apoptosis). (benbest.com)
  • E. coli -induced increases in blood-brain barrier permeability and inflammatory neutrophilic infiltration were also inhibited [ 5876 ], suggesting that the C 60 compound could be a useful therapeutic agent in some cases of bacterial meningitis [ 738 ]. (nanomedicine.com)
  • Cell membrane permeability increases so that absorption is impaired and leads to a clinical symptom that is diarrhea [20]. (manuscriptscientific.com)
Protein11
  • The alkaloids fraction (ALK) regulated cholinergic function by inhibiting AChE activity, activating choline acetyltransferase activity, and protein expression. (bvsalud.org)
  • O 2 − release, protein kinase C (PKC) activity, and translocation of PKC-α and -βII and p47phox were increased in THP-1 cells (human monocytic cell line) under HG (15 mmol/l glucose) conditions, whereas AT supplementation inhibited these changes. (diabetesjournals.org)
  • Lu, C., Chan, S.L., Fu, W. and Mattson, M.P. (2002) The lipid peroxidation product 4-Hydroxyneal facilitates op- ening of voltage dependent Ca2+ channels in neurons by increasing protein tyrosine phosphorylation. (scirp.org)
  • Chowdhury, T.D., Das, N., Chattopadhyay, A. and Datta, A.G. (1999) Effect of oxidative stress and erythropoietin on cytoskeletal protein and lipid organization in human erythrocytes. (scirp.org)
  • The blood glucose level, liver function enzymes, total protein, lipid, and cholesterol levels were significantly normalized by extract treatment. (hindawi.com)
  • The effects of eleven flavonoids on lipid peroxidation, protein degradation, deformability and osmotic fragility of human erythrocytes exposed in vitro to 10 mM H 2 O 2 for 60 min at 37˚C have been studied. (scirp.org)
  • quercetin, 3,5,7-trihydroxy-4'-methoxy flavone-7-rutinoside and 3-hydroxy flavone significantly protected erythrocytes against protein degradation. (scirp.org)
  • Quercetin and 3,5,7-trihydroxy-4'-methoxy flavone-7-rutinoside significantly protected erythrocytes against loss of deformability and increased osmotic fragility, indicating that the loss of erythrocyte deformability and the increase in osmotic fragility of erythrocytes exposed to H 2 O 2 are related to protein degradation rather than to lipid peroxidation. (scirp.org)
  • In vitro exposure of erythrocytes to oxygen radical generating systems (such as H 2 O 2 , ascorbate/Fe 3+ , cumene hydroperoxide, tert-butyl hydroperoxide, etc.) was shown to induce lipid peroxidation, protein degradation, loss of deformability, an increase in osmotic fragility, membrane lipid bilayer perturbation, inhibition of enzymes and hemolysis [5-12]. (scirp.org)
  • The presence of antioxidant compounds and an increase in ROS, which is imbalanced will lead to oxidative stress and cause the damage on DNA, lipid, and protein [8]. (manuscriptscientific.com)
  • Org/network/7227.FBpp0072081) online tool analysis, there may be interaction between Initiation factor 5A (elf-5A) protein and Eukaryotic translation, which may be involved in oxidative stress response and cell membrane integrity16. (solamonrenewableenergy.com)
Amino acids2
  • As their name suggests, these reactive molecules provoke the deterioration of membranes, lipids, amino acids, and DNA . (meliponinibeehoney.com)
  • Specifically, NMR metabonomics profiling of serum revealed that centenarians are characterized by a metabolic phenotype distinct from that of elderly subjects, in particular regarding amino acids and lipid species. (aging-us.com)
Reactive oxygen3
  • Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
  • In 2012, Dixon 1 first proposed the concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS). (nature.com)
  • Under HG conditions, reactive oxygen species release from monocytes was not inhibited by agents affecting mitochondrial metabolism but was inhibited in human endothelial cells. (diabetesjournals.org)
Antioxidants6
Hemolysis4
Bilayer1
  • In contrast to autophagy, ferroptosis does not have the formation of classical closed bilayer membrane structures (autophagic vacuoles). (nature.com)
Vitro2
  • Carboxyfullerene directly inhibits in vitro growth of Streptococcus pyogenes and enhances bactericidal activity of neutrophils in mice in vivo [ 5874 ], suggesting that the fullerene derivative "can be considered an antimicrobial agent for group A streptococcus infection. (nanomedicine.com)
  • In vitro cytotoxicity against the HeLa S3 cell line has been evaluated by studying the inhibited growth rate [ 922 ], and some C 60 derivatives have shown promise as anti-cancer agents [ 1090 - 1092 ]. (nanomedicine.com)
0.051
20021
  • 2002). However, during aging an oxidant challenge exceeds the capacity of the cell s defense system, membrane damage may occur. (scialert.net)
Exposure2
  • Exposure to high level of nitrogen dioxide may lead to inflammation of the mucous membrane and the lower and upper respiratory tracts. (wikipedia.org)
  • 2000). The high polyunsaturated fatty acid content of the erythrocyte membrane and the continuous exposure to high concentrations of oxygen and iron in heamoglobin are factors that make erythrocytes very sensitive to oxidative injury (Bernabucci et al . (scialert.net)
Liver3
  • Although S. baicalensis inhibited the lipid peroxidation in rat liver microsomes and red blood cells, the extract showed inhibitory actions on aminopyrine N-demethylase and xanthine oxidase activities as well as an pro-oxidant effect observed in the Fe3+-EDTA-H2O2 system. (nih.gov)
  • There is a report that the use of NAC has also been associated with a significant reduction in lipid peroxidation and a significant increase in GSH levels in the liver and erythrocytes of mice15. (solamonrenewableenergy.com)
  • When CCl 4 gets into the liver, it acts as a xenobiotic and converted into free radicals CCl 3 and CCl 3 O 2 by the P-450 monooxygenase-dependent microsome system and causes liver damage through membrane lipid peroxidation [ 10 ]. (biomedcentral.com)
Radicals2
Metabolism1
  • Bioactive sphingolipids in health and disease: lipidomic analysis, metabolism and roles in membrane signaling and autophagy. (sphingolipidclub.com)
Significantly1
Inhibition2
  • HG-induced O 2 − release is triggered by PKC-α, and AT inhibits O 2 − release via inhibition of PKC-α. (diabetesjournals.org)
  • This inhibition of lipid peroxidation could be explained by the presence of at least two hydroxyl groups in ring B of the flavonoid structure, regardless of their positions. (scirp.org)
Concentrations of oxygen1
  • Erythrocytes are susceptible to oxidative damage as a result of the high polyunsaturated fatty acid content of their membranes and the high cellular concentrations of oxygen and haemoglobin [1]. (scirp.org)
Extracellular Matrix1
  • Organisms usually contain large numbers of sphingolipid subspecies (for a pathway based compilation, see www.sphingomap.org) and knowledge about the types and amounts is imperative because they influence membrane structure, interactions with the extracellular matrix and neighboring cells, vesicular traffic and the formation of specialized structures such as phagosomes and autophagosomes, as well as participate in intracellular and extracellular signaling. (sphingolipidclub.com)
Enzyme1
  • RÉSUMÉ L'objectif de la présente étude était d'évaluer l'efficacité d'un programme d'exercice sur tapis roulant électronique sur le malondialdéhyde, en tant que marqueur de la peroxydation lipidique et sur une enzyme antioxydante, le glutathion peroxydase, chez des adolescents atteints du Syndrome de Down. (who.int)
Malondialdehyde1
Potent2
  • A C 60 molecule covalently linked to peptide T, like peptide T, displays potent human monocyte chemotaxis while weakly inhibiting HIV-1 protease [ 693 ]. (nanomedicine.com)
  • Imperatorin and 5-methoxypsoralen showed the most potent inhibiting power. (hindawi.com)
Oxidative injury1
  • The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. (researchgate.net)
Cell10
  • It does not have the morphological characteristics of typical necrosis, such as swelling of the cytoplasm and organelles and rupture of the cell membrane, nor does it have the characteristics of traditional cell apoptosis, such as cell shrinkage, chromatin condensation, formation of apoptotic bodies and disintegration of the cytoskeleton. (nature.com)
  • Most of the metabolic energy of neurons is expended on maintaining ion gradients across the cell membrane. (benbest.com)
  • Potassium ions rush out of the cell while sodium & chloride ions rush inward as the cell membranes depolarize. (benbest.com)
  • Voltage-gated ion channels and ion-exchangers in the cell membrane also regulate ion concentrations. (benbest.com)
  • Postsynaptic membranes contain two voltage-gated calcium channels (L-type & T-type) as well as a sodium/calcium exchanger, but the NMDA channel is particularly adept at allowing large amounts of calcium ion to enter the cell. (benbest.com)
  • Subsequent work [ 5875 ] by this research group found that the antibacterial action of carboxyfullerene on Gram-positive bacteria is achieved by insertion into the cell wall and destruction of membrane integrity. (nanomedicine.com)
  • ROS can cause membrane lipid peroxidation so fatty acid chains in cell membranes are broken and then it causes injury in cells [4]. (manuscriptscientific.com)
  • Because of its soluble characteristics, elemental mercury is highly diffusible and is able to pass through cell membranes as well as the blood-brain and placental barriers to reach target organs. (hindawi.com)
  • Inorganic mercury has low lipophilicity and thus has a limited ability to cross cell membranes [ 9 ]. (hindawi.com)
  • The CG8005 gene in Drosophila S2 embryonic cells could regulate the proliferation and apoptosis of S2 embryonic cells by disrupting the redox homeostasis, and antioxidant NAC could inhibit cell apoptosis and promotes cell proliferation by scavenging ROS in Drosophila S2 embryonic cells, which is expected to provide novel insights for the pathogenesis of male infertility and spermatogenesis. (solamonrenewableenergy.com)
Species1
  • Shot- gun lipidomics approach displays unique changes in lipids biosynthesis in centenarians, with 41 differently abundant lipid species with respect to elderly subjects. (aging-us.com)
Oxygen2
  • CO readily crosses capillary membranes in the lungs and binds the heme moiety on the erythrocyte hemoglobin complex with an affinity 200-300 times greater than that of oxygen. (medscape.com)
  • CO also shifts the oxyhemoglobin dissociation curve to the left, inhibiting the release of bound oxygen to tissues. (medscape.com)
Damage2
  • The results suggest that oxidative damage of erythrocyte caused by phenyl hydrazine could be prevented by calcium channel antagonist, diltiazem, which may act as antioxidant also. (scirp.org)
  • In healthy erythrocytes, significant oxidative damage is prevented by a very efficient antioxidant system, consisting of a number of antioxidant compounds and enzymes [2]. (scirp.org)
Cholesterol1
Rats2
  • These results indicate that the administration of T. chebula acts as a free radical scavenger with potential antioxidant effects in erythrocytes of aged rats. (scialert.net)
  • Pre-administration of rats with the crude palm oil and its extracts modulated cadmium mediated depletion of the antioxidant capacities of rats acutely exposed to cadmium and rising lipid peroxidation profile. (springeropen.com)
Flavonoids2
  • Western blot results further confirmed that flavonoids and saponins attenuated neuroinflammation by inhibiting the phosphorylation of IκB and NF-κB p65. (bvsalud.org)
  • The other flavonoids (chrysin, 2-carboxy ethyl dihydroxy flavone, apigenin, cirsimaritin, α-naphto flavone and flavanone) failed to protect erythrocytes against the observed oxidative damages. (scirp.org)
Human1
  • Human, bovine and rat Cu-SODS were purified from erythrocytes according to the method of McCord and Fridovich [4], with a slight modification. (docksci.com)
Biological1
  • Erythrocytes have been used as a biological probe in exploring the aging process (Bernabucci et al . (scialert.net)
Production1
  • Is iron necessary to promote the production of lipid peroxides, or can other substances take the place of iron in ferroptosis? (nature.com)
Calcium1
  • Postsynaptic membranes contain several types of glutamate receptors, notably NMDA & AMPA receptors, which allow calcium ion entry. (benbest.com)
Capacity2
  • The corolla of F4-1-4 and F1-34-1 cultivars, and bracts of F1-1-1, F1-19-4, and F4-37-1 cultivars revealed the greatest capacity to inhibit the thiobarbituric acid reactive substances formation (IC50 of 38 and 40.4 µg/mL, respectively). (bvsalud.org)
  • Considering the particular actions of these metabolites, these data are suggestive of a better counteractive antioxidant capacity and a well-developed membrane lipid remodelling process in the healthy aging phenotype. (aging-us.com)
Release2
  • Depolarization of presynaptic membranes results in release of the neurotransmitter glutamate (glutamic acid) . (benbest.com)
  • Antisense oligodeoxynucleotides to PKC-α and p47phox but not to PKC-βII inhibited HG-induced O 2 − release and p47phox translocation in THP-1 cells. (diabetesjournals.org)
Decrease1
  • Insecticides can cause necrosis, which leads to hypermotility and malabsorption due to a decrease in the number of erythrocyte cells [17]. (manuscriptscientific.com)
Effects1
  • Silymarin protects against its toxic principle α-amanitin by preventing its uptake through hepatocyte membranes and inhibiting the effects of tumour necrosis factor-α, which exacerbates lipid peroxidation. (springer.com)
Cross1
  • For example, CO dissolved in plasma is known to cross capillary membranes and bind myoglobin, reduced cytochromes, guanylate cyclase, and nitric oxide (NO) synthase. (medscape.com)
Plasma3
  • 1. Discuss how the fluidity of plasma membrane largely depends on its lipid composition. (medical-junction.com)
  • Describe how the macro molecules are transported across the plasma membrane. (medical-junction.com)
  • Mention their specific role in maintaining the fluidity of plasma membrane. (medical-junction.com)
Content1