• The results demonstrated that TEOA inhibited proliferation and induced apoptosis in time-and dose-dependent manners. (figshare.com)
  • The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. (mdpi.com)
  • Melphalan inhibits the proliferation of cancer cells by damaging DNA and interfering with its replication. (aacr.org)
  • Several hallmarks of cellular senescence, such as cell cycle arrest, expression of cyclin-dependent kinase inhibitors, DNA damages, and senescence-associated secretory profile were evaluated. (aging-us.com)
  • SnCs exhibit irreversible growth arrest accompanied by increased expression of cyclin-dependent kinase inhibitors (CDKi) such as p16 INK4a , and p21 Cip1 , accumulation of DNA damages, and secretion of diverse bioactive molecules known as the senescence-associated secretory phenotype (SASP). (aging-us.com)
  • The cyclin-dependent kinase (CDK) inhibitors p21 and p16 inhibit the activity of CDKs, such as CDK4. (medscape.com)
  • SIGNIFICANCE: Inhibiting protein elongation with SVC112 reduces tumor growth in head and neck squamous cell carcinoma and increases the effects of radiation by targeting the cancer stem cell pool. (nih.gov)
  • In addition, we showed that treatment with TMZ (100 mg·kg−1·d−1, ip) for 12 days in C6 cell xenograft mice markedly inhibited tumor growth accompanied by inducing FOXO3a upregulation, oxidative stress and BNIP3-mediated mitophagy in tumor tissues. (chinaphar.com)
  • In summary, these data demonstrate that SVC112 suppresses CSC-related proteins, enhances the effects of radiation, and blocks growth of HNSCC PDXs by inhibiting CSCs. (nih.gov)
  • During their study, the two scientists found that the spike protein appeared to interfere with our own DNA repair proteins: "Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. (techstartups.com)
  • Epirubicin was reported to block DNA replication either through direct DNA damage or indirectly through inhibition of replication proteins such as topoisomerase. (nature.com)
  • UV can be directly absorbed by cellular macromolecules, thus leading to photochemical modification of DNA and proteins ( 4 ). (spandidos-publications.com)
  • In addition, UV induces the generation of reactive oxygen species (ROS), which overwhelm the antioxidant defense system, resulting in oxidative stress and damage to cell structure, DNA, proteins and lipids ( 5 ). (spandidos-publications.com)
  • Among these cell-signaling proteins, activation of p53 is important in cells with UV radiation-induced DNA damage ( 4 , 7 ). (spandidos-publications.com)
  • The binding activity expressed in embryos was apparently unrelated to human DNA repair damage-recognition proteins XPA、RPA-70 and RPA-32, since those polypeptides recognized by an anti-human XPA、RPA-70 and RPA-32 antibody were detected only in 84-h-old zebrafish extracts. (ncl.edu.tw)
  • DNA lesion-recognizing proteins and the p53 connection. (ncl.edu.tw)
  • Drinking alcohol and smoking cigarettes results in the formation of reactive aldehydes in the lung, which are capable of forming adducts with several proteins and DNA. (cdc.gov)
  • These aldehydes react with nucleophilic targets in cells such as DNA, lipids and proteins to form both stable and unstable adducts. (cdc.gov)
  • This adduction may disturb cellular functions as well as damage proteins, nucleic acids and lipids. (cdc.gov)
  • In addition, chronic diagnostic test for follow-up of patients cy and for biochemical determination inflammation associated with the infec- with H. pylori gastritis and were able of tissue COX-2 activity using COX tion leads to damage in proteins, the to predict the risk of development of Activity Assay Kit (Cayman Chemical production of reactive oxygen species stomach cancer. (who.int)
  • In addition, TEOA induced the activation of the p38 MAPK pathway and pretreated with p38 inhibitor SB20358 or ROS scavenger could block TEOA-induced DNA damage. (figshare.com)
  • Pretreatment of cells with SB202190, a p38 inhibitor, may inhibit the DNA binding activity of p53 and suppress p53-dependent transcription ( 10 ). (spandidos-publications.com)
  • The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
  • This, in turn, establishes chronic inflammation and tissue pathology in mice with important ramifications for DNA repair-deficient, progeroid syndromes and aging. (nature.com)
  • Using mice with an engineered ERCC1-XPF defect in tissue-infiltrating macrophages, we provide evidence for a fundamental mechanism by which irreparable DNA damage triggers an exosome-based, metabolic reprogramming that leads to chronic inflammation and tissue pathology in NER progeroid syndromes and likely also during aging. (nature.com)
  • This study used etoposide, to induce DNA damage-related senescence or chronic exposure to IL-1β to entail inflammation-related senescence in human OA chondrocytes. (aging-us.com)
  • Studies have shown that it can inhibit inflammatory molecules and reduce inflammation in various parts of the body, easing joint pain and swelling. (ugandacoffee.org)
  • The ageing process is thought to contribute to tumorigenesis via aberrant genome maintenance and systemic inflammation that result in tissue damage and occurrence of unfavourable genome modifications ( 6 ). (frontiersin.org)
  • Over lifetime, due to the action of several stressors such as DNA damage and telomere shortening, senescent cells accumulate in the organism and release a variety of pro-inflammatory cytokines responsible for low-grade inflammation. (frontiersin.org)
  • This age-related inflammation, also referred to as inflammaging, increases the risk for tissue damage and genetic aberrations that cause cellular transformation and cancer development ( 8 , 9 ). (frontiersin.org)
  • 1-4) ROS react with cells initiating chain reactions that result in tissue damage causing inflammation, spasm, pain and disease. (life-enthusiast.com)
  • Loss of cell and tissue function results in further inability to repair damage, leading to increased tendency to bruising, excessive inflammation, spasm, joint stiffness, digestive abnormalities and respiratory distress. (life-enthusiast.com)
  • MDA-DNA adducts are pre-mutagenic in mammalian cells and induce frame shift and base-pair substitution mutations, whereas MAA protein adducts have been shown to induce inflammation and inhibit wound healing. (cdc.gov)
  • Here, by using an in vitro cell line, we report that the SARS-CoV-2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. (aquarius-technologies.de)
  • CpG-ODNs mediated the inhibition of PARP1, thereby suppressing DNA damage and oxidative stress response in vitro in HK-2 cells . (bvsalud.org)
  • Moreover, Sparstolonin B downregulated the expression of NLRP3, inhibited ASC formation in vivo and in vitro , and reduced the levels of IL-18 and IL-1 β . (hindawi.com)
  • The present study evaluated the protective effects of PF on UV‑induced skin damage in vitro, and demonstrated that the effects were mediated via the ROS‑p38‑p53 pathway. (spandidos-publications.com)
  • BRCA1 gene mutations impair homologous recombination (HR) DNA repair, resulting in cellular senescence and embryonic lethality in mice. (nih.gov)
  • When exposed to UVB radiation from the sun, the body's first response is to protect itself against cellular DNA damage. (express.co.uk)
  • inevitably, damage to membranes diminishes cellular ability to repair damaged tissue. (life-enthusiast.com)
  • 1, 7) Membrane and extra-cellular matrix damage leads to decreased ideal first-intention healing involving parenchyma. (life-enthusiast.com)
  • Epirubicin, a DNA damaging anticancer agent and CoCl 2 , which was used to imitate hypoxia condition, was applied to induce DNA damage in TIGAR knockdown HepG2 cells. (nature.com)
  • We showed that TMZ dosage-dependently inhibited the viability of human U87, U251, T98G, LN18 and rat C6 glioma cells with IC 50 values of 135.75, 128.26, 142.65, 155.73 and 111.60 μM, respectively. (chinaphar.com)
  • SVC112 increased cell-cycle progression delay and slowed DNA repair following radiation, enhancing colony and sphere formation radiation effects. (nih.gov)
  • Knockdown of TIGAR exacerbated DNA damage and the effects were partly reversed by the supplementation of PPP products NADPH, ribose, or the ROS scavenger NAC. (nature.com)
  • DNA damage in HepG2 cells after TIGAR knockdown with or without treatment of epirubicin or CoCl 2 was detected by Comet assay. (nature.com)
  • Knockdown of FOXO3a aggravated TMZ-induced DNA DSBs and mitochondrial damage, as well as glioma cell death. (chinaphar.com)
  • Moreover, FOXO3a knockdown inhibited TMZ-induced BNIP3 upregulation and autophagy activation. (chinaphar.com)
  • SVC112 preferentially inhibited cancer cells compared with patient-matched cancer-associated fibroblasts, whereas HHT was equally toxic to both. (nih.gov)
  • To counteract DNA damage, mammalian cells have evolved partially overlapping DNA repair systems to remove DNA lesions and restore their DNA back to its native form 1 , 2 . (nature.com)
  • Additionally, PARP1 promoted the formation of the PARP1 and XRCC1 complex by recruiting XRCC1, which in turn facilitated DNA damage and oxidative stress response in renal tubular cells . (bvsalud.org)
  • CpG-ODNs may mitigate cervical cancer RKI by blocking the activation of the PARP1/XRCC1 signaling axis, inhibiting DNA damage and oxidative stress response in renal tubule epithelial cells . (bvsalud.org)
  • Scientists from two major Swedish universities recently released a worrisome paper that used a series of complex scientific techniques to look for the full-length coronavirus spike protein (the one the mRNA and DNA/AAV vaccines cause your body to produce) inside the nucleus of our cells. (techstartups.com)
  • To prevent this, human cells have mechanisms to repair their own DNA. (techstartups.com)
  • This study investigated the role of TIGAR in DNA damage response (DDR) induced by genotoxic drugs and hypoxia in tumor cells. (nature.com)
  • To define a role of TIGAR in DNA damage, TIGAR expression was knocked down with siRNA in HepG2 cells. (nature.com)
  • Sparstolonin B was showed to alleviate joint swelling in RA rats, inhibited inflammatory cell infiltration and the release of ROS, reduced damage caused by oxidative stress, and suppressed the rate of apoptosis in synovial cells. (hindawi.com)
  • The administration of Sparstolonin B inhibited the secretion of IL-17 from Th17 cells and triggered the secretion of TGF- β from Treg cells, thus leading to the reduced expression of TLR4, MyD88, and NF- κ B, and the suppression of TNF- α secretion. (hindawi.com)
  • Since chemotherapy drugs like melphalan do not discriminate between normal cells and cancer cells, normal cells that divide frequently can also be damaged, resulting in side effects. (aacr.org)
  • In particular, CAP contains highly reactive oxygen and nitrogen species (RONS), and it can induce cell death by causing oxidative damage to cancer cells. (hindawi.com)
  • Our group has previously reported that the DNA damage ratio and cell death were increased by treating cancer cells directly with oxygen-containing CAP [ 24 ]. (hindawi.com)
  • Plus, turmeric is packed with antioxidants, which protect cells from free radical damage. (ugandacoffee.org)
  • It may help inhibit the growth of cancer cells and prevent the spread of tumors. (ugandacoffee.org)
  • Marjoram, a closely-related herb, inhibited breast cancer cells in the lab. (postindependent.com)
  • Oxidative damage of DNA molecules associated with electron-transfer reactions is an important phenomenon in living cells, which can lead to mutations and contribute to carcinogenesis and the aging processes. (intechopen.com)
  • Based on the results they found out that e-smoke both causes DNA damage and inhibits repair (both increase cancer risk) in human urothelial cells by the following chemicals : nicotine, formaldehyde, and nitrosamines. (mysite2.com)
  • In U87 and U251 cells, TMZ (200 μM) induced DNA double strand breaks (DSBs) and nuclear translocation of apoptosis inducing factor (AIF), which was accompanied by BNIP3-mediated mitophagy and FOXO3a accumulation in nucleus. (chinaphar.com)
  • TMZ treatment induced intracellular ROS accumulation in U87 and U251 cells via enhancing mitochondrial superoxide, which not only contributed to DNA DSBs and exacerbated mitochondrial dysfunction, but also upregulated FOXO3a expression. (chinaphar.com)
  • These results demonstrate that FOXO3a attenuates temozolomide-induced DNA double strand breaks in human glioma cells via promoting BNIP3-mediated mitophagy. (chinaphar.com)
  • Inhibiting BRAF Oncogene-Mediated Radioresistance Effectively Radiosensitizes BRAFV600E-Mutant Thyroid Cancer Cells by Constraining DNA Double-Strand Break Repair. (cityofhope.org)
  • Lycopene is a powerful antioxidant that might help protect cells from damage. (medlineplus.gov)
  • The nanotube bundles are similar to the potential of nanotubes to induce genetic damage size of microtubules that form the mitotic spindle in normal lung cells, cultured primary and immor- and may be incorporated into the mitotic spindle talized human airway epithelial cells were apparatus. (cdc.gov)
  • SIGNIFICANCE: This study explores the concept that homologous recombination DNA repair is not an all-or-nothing concept, but a spectrum, and that where a tumor stands on this spectrum may have therapeutic relevance. (nih.gov)
  • Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. (aquarius-technologies.de)
  • Here, we show that persistent DNA damage accumulation in tissue-infiltrating macrophages carrying an ERCC1-XPF DNA repair defect ( Er1 F/− ) triggers Golgi dispersal, dilation of endoplasmic reticulum, autophagy and exosome biogenesis leading to the secretion of extracellular vesicles (EVs) in vivo and ex vivo. (nature.com)
  • XPF-ERCC1 is a highly conserved, heterodimeric, structure-specific endonuclease complex required for lesion excision in NER 26 , 27 that is thought to play an analogous role in the repair of DNA interstrand crosslinks (ICLs) that covalently link both DNA strands preventing transcription and replication 28 . (nature.com)
  • p53 is a transcription factor whose expression is increased by DNA damage and blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
  • As part of their research, they also examine how the spike protein might impact the repair of damaged DNA in the nucleus. (techstartups.com)
  • Together, these data demonstrate that the spike protein directly affects DNA repair in the nucleus . (techstartups.com)
  • However, it remains unexplored if TIGAR plays an important role in DNA damage and repair. (nature.com)
  • Here, we present our findings on a novel role of TIGAR in DNA damage and repair. (nature.com)
  • The DNA repair mechanism essentially tells all the other mechanisms in the cell, 'Stop everything, and let me work in peace. (express.co.uk)
  • UV-B-induced DNA damage can trigger cell signaling pathways to activate defense systems, leading to DNA repair and/or apoptosis ( 6 ). (spandidos-publications.com)
  • This study claims that that vapor is potentially carcinogenic because it prevents DNA repair and induces tumorigenic DNA adducts. (mysite2.com)
  • Inhibiting DNA repair causes damage to accumulate faster over time. (mysite2.com)
  • DDB, a putative DNA repair protein, can function as a transcriptional partner of E2F1. (ncl.edu.tw)
  • Dr. Shen's research has been focused on the roles for cell growth signaling pathways (including RAS-MAPK and PI3K-mTOR) in the regulation of cell cycle progression and DNA damage repair. (cityofhope.org)
  • In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
  • DNA damage increases TP53 levels through an ATM-dependent pathway. (medscape.com)
  • MDM2 binds to and inhibits TP53 activity. (medscape.com)
  • The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
  • Treatment with PF markedly reduced the production of ROS, and inhibited the activation of p38 and p53 in human keratinocytes, thus suggesting that the ROS‑p38‑p53 pathway has a role in UV‑B‑induced skin damage. (spandidos-publications.com)
  • On the other hand, etoposide treatment reliably induces DNA damage-related senescence in human articular chondrocytes evidenced by loss of proliferative capacity, DNA damage accumulation, and expression of some SASP components. (aging-us.com)
  • Sparstolonin B improved inflammatory responses and oxidative stress by inhibiting the NLRP3 inflammasome, inhibiting the expression of FucT-V and downregulating the TLR4/MYD88/NF-𝜅B signaling pathway in order to rescue RA. (hindawi.com)
  • Nutricol reinforces membrane and matrix structures (halts damage that initiates inflammatory and spasmodic reactions). (life-enthusiast.com)
  • These fermentation inhibitors damage cell growth, reduce enzymatic and biological activities, break down DNA, and inhibit protein and RNA synthesis. (usda.gov)
  • Cell death resulted from the recruitment of 53BP1 to DNA break sites and inhibition of DNA end resection. (nih.gov)
  • This resulted in significantly decreased levels of BUN and creatinine in RKI mice , as well as reduced renal tubular and glomerular damage, lower apoptosis rate, decreased DNA damage index (8-OHdG), and increased levels of antioxidant factors associated with oxidative stress (SOD, CAT , GSH, GPx). (bvsalud.org)
  • Antioxidants provide protection to living organisms from damage caused by uncontrolled production of ROS and concomitant lipid peroxidation, protein damage and DNA stand breaking. (intechopen.com)
  • The phosphopentose pathway (PPP), which converts glucose-6-phosphate to ribose-5-phosphate for synthesis of nucleotides and NADPH to reduce DNA damage caused by ROS was reported to be activated in DDR 2 . (nature.com)
  • Oregano has been shown in the lab to reduce DNA damage caused by radiation. (postindependent.com)
  • DNA damage and metabolic disorders are intimately linked with premature disease onset but the underlying mechanisms remain poorly understood. (nature.com)
  • A urinary marker of oxidative DNA damage was significantly decreased in urine from men consuming green tea compared with controls. (lesliebeck.com)
  • These previous results indicated that the ROS-p38-p53 pathways are involved in UV-induced cell damage. (spandidos-publications.com)
  • Interestingly, these protective effects of Sparstolonin B could be blocked in RA rats by inhibiting the activation of the NLRP3 inflammasome. (hindawi.com)
  • Since the pandemic started over 18 months ago, health and medical experts have insisted that mRNA vaccines are NOT gene therapies because they supposedly have no impact on the nucleus of the cell and do not get inside the nucleus of the cell , where our DNA is stored. (techstartups.com)
  • However, as opposed to DNA vaccines, RNA vaccines only have to cross the plasma membrane, but not the nuclear envelope which may improve the probability of successful in vivo transfection. (techstartups.com)
  • Researchers have also found it causes membrane and DNA damage, and inhibits cell respiration. (farmwars.info)
  • Cytosine-phosphate-guanine oligodeoxynucleotides alleviate radiation-induced kidney injury in cervical cancer by inhibiting DNA damage and oxidative stress through blockade of PARP1/XRCC1 axis. (bvsalud.org)
  • Curcumin , its active compound, can inhibit cancer cell growth. (ugandacoffee.org)
  • Any sort of tan - whether it be from the sun or a sunbed - is indicative of skin damage, the Skin Cancer Foundation notes. (express.co.uk)
  • DNA damage is related to both aging and cancer. (mysite2.com)
  • RÉSUMÉ Des données de plus en plus nombreuses indiquent que les antioxydants alimentaires ont des effets favorables sur la réduction du risque de cancer. (who.int)
  • Taken together, these results suggest that ROS mediated activation of the p38 MAPK signal pathway plays an important role in initiating TEOA-induced DNA damage. (figshare.com)
  • He Z, Houghton PJ, Williams TM, Shen C* . Regulation of DNA duplication by the mTOR signaling pathway. (cityofhope.org)
  • Among several adducts formed in the lung, malondialdehyde DNA (MDA-DNA) adduct and hybrid malondialdehyde-acetaldehyde (MAA) protein adducts have been shown to initiate several pathological conditions in the lung. (cdc.gov)
  • They are notable for their unusual mechanism of action, in which they irreversibly inhibit their target protease by undergoing a large conformational change to disrupt the target's active site. (wikipedia.org)
  • Thus, one mechanism of epirubicin combined TACE treatment for HCC was through induction of synergistic DNA damage. (nature.com)
  • The mechanism of action of DNA photolyases. (ncl.edu.tw)
  • Macrophage-derived EVs accumulate in Er1 F/− animal sera and are secreted in macrophage media after DNA damage. (nature.com)
  • SVC112 alone inhibited the growth of patient-derived xenografts (PDX), and SVC112 combined with radiation resulted in tumor regression in HPV-positive and HPV-negative HNSCC PDXs. (nih.gov)
  • As such, any environmental assault on the DNA in the form of chemicals or radiation may result in damage to the DNA. (techstartups.com)
  • Excess ROS can damage a cell's lipids, protein or DNA, inhibiting normal function. (nih.gov)
  • RNF168-mediated ubiquitination of γH2AX at K13/15 (ub-H2AX) serves as a recruitment module for the localization of 53BP1 to DNA break sites. (nih.gov)
  • As we all know, DNA is the repository of genetic information in each living cell, its integrity and stability are essential to life. (techstartups.com)
  • Modulation of DNA damage by XPF, XPG and ERCC1 gene polymorphisms in pesticide-exposed agricultural workers of Punjab, North-West India. (cdc.gov)
  • Whether the elevated TIGAR expression protects DNA damage induced by chemotherapeutic agents or hypoxia has not been explored. (nature.com)
  • The expression levels of FucT-V, E-Selectin, and P-Selectin were also inhibited. (hindawi.com)
  • The expression of distorted DNA-binding factors was studied in developing zebrafish using UV-damaged DNA as the binding target. (ncl.edu.tw)
  • RHAMM regulates MMTV-PyMT-induced lung metastasis by connecting STING-dependent DNA damage sensing to interferon/STAT1 pro-apoptosis signaling. (medscape.com)