Inhibits diacylglycerol kinase regulators diacylglycerol kinase. Medical search. Frequent questions

This atypical mitogen-activated protein kinase (MAPK) has a unique structure which includes a C34 domain and C-terminus and about which relatively little is known. (wright.edu)
A chemical or drug that inhibits the mitogen-activated protein kinase kinase enzymes MEK1 and/or MEK2. (mek-inhibitors.com)
Globally, mGluRI can activate a multifaceted list of effectors, including phospholipase D (PLD), protein kinases pathways such as mitogen-activated protein kinase/extracellular receptor kinase (MAPK/ERK), the mammalian target of rapamycin (mTOR)/p70S6 kinase pathway, casein kinase 1, cyclin-dependent protein kinase 5, and Jun kinase (JUNK) [ 1 ] [ 2 ] ( Figure 1 ). (encyclopedia.pub)
MAPK is a mitogen-activated protein kinase, a class of protein kinases with dual phosphorylation of serine and tyrosine in the cytosol. (cusabio.com)

Studies in animals have revealed the intracellular signaling pathways activated by stress exposure that induce profound prefrontal cortical impairment: Excessive dopamine stimulation of D1 receptors impairs prefrontal function via cAMP intracellular signaling, leading to disconnection of prefrontal networks, while excessive norepinephrine stimulation of alpha1 receptors impairs prefrontal function via phosphatidylinositol-protein kinase C intracellular signaling. (bvsalud.org)
and c) Gi alpha subunit-Giβγ) complexes which releases Gi that then simulates phospholipase C to cleave phosphatidylinositol triphosphate into inositol triphosphate that raises intracellular CaCa2 levels thereby regulating Calcium signaling pathways and diacylglycerol that activates certain protein kinase C enzymes )that phosphorylate and thereby regulate target proteins involved in cell signaling (see Protein kinase C#Function). (wikipedia.org)
ROS may induce intracellular calcium increase and subsequent contraction of PASMCs via direct or indirect interactions with protein kinases, phospholipases, sarcoplasmic calcium channels, transient receptor potential channels, voltage-dependent potassium channels and L-type calcium channels, whose relevance may vary under different experimental conditions. (ersjournals.com)
Ubiquitin-like protein containing PHD and RING finger domains 1 (UHRF1) is a major regulator of epigenetic mechanisms and is overexpressed in various human malignancies. (biomedcentral.com)
two like one, which anchors protein kinase C to your cytoskeleton, EPHA7, the receptor for that A1 to 5 members on the ephrin A household of ligands, and neuronal nitric oxide synthase, the enzyme that synthesizes nitric oxide, a fuel using a wide range of signaling functions. (mek-inhibitors.com)
Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)
SnRK1: a versatile plant protein kinase that limits geminivirus infection. (ncsu.edu)
Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. (lookformedical.com)
An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. (lookformedical.com)
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. (lookformedical.com)
The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters. (lookformedical.com)
Mammalian aurora-A belongs to a multigenic family of mitotic serine/threonine kinases comprising two other members: aurora-B and aurora-C. In this review we will focus on aurora-A that starts to localize to centrosomes only in S phase as soon as centrioles have been duplicated, the protein is then degraded in early G1. (lookformedical.com)
More particularly, the present invention relates to a regulator for the activity of inositol-1,4,5-triphosphate (IP 3 ) receptor (IP 3 R) comprising carbonic anhydrase-related protein (CARP), a control agent for intracellular calcium release comprising carbonic anhydrase-related protein (CARP), and a method of control therewith. (justia.com)
A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury. (musc.edu)
This pathway leads to the Ca 2+ intracellular mobilization from internal stores and activation of protein kinase C (PKC) [ 1 ] . (encyclopedia.pub)
G protein-independent mechanisms mainly lie on β-arrestin binding, favored by the receptor phosphorylation by G-protein-coupled receptor kinases (GRKs). (encyclopedia.pub)
Scheme of the principal mGluR1 and mGluR5 signaling pathways, showing that G q/11 -dependent activation of phospholipase C β (PLCβ) mediates phosphatidylinositol hydrolysis with the generation of diacylglycerol (DAG) (that activates protein kinase C, PKC) and inositol-1,4,5-trisphosphate (IP 3 ) (that fosters Ca 2+ intracellular release from internal stores by acting on IP 3 R receptors on the endoplasmic reticulum). (encyclopedia.pub)
Additional G protein-independent mechanisms involve the recruitment of β-arrestin or other scaffolding/adaptor proteins such as Homer long isoforms, that provide mGluRI coupling with other effectors, thus fostering activation of signaling pathways, such as the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K-Akt-mTOR) kinase pathway, or MEK1/2-ERK 1/2 pathway, both involved in mechanisms promoting protein synthesis. (encyclopedia.pub)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
The main biological activity of staurosporine is the inhibition of protein kinases through the prevention of ATP binding to the kinase. (ncats.io)
It is a potent, cell permeable protein kinase C inhibitor with an IC50 of 0.7 nM. (ncats.io)
The main process of this pathway: the growth factor activates the receptor by binding to the tyrosine kinase receptor, and the activated tyrosine kinase receptor activates the Ras protein, then the Ras protein phosphorylates the Raf, and the activated Raf phosphorylates the downstream MEK. (cusabio.com)
The c-Jun N-terminal kinase (JNK), also known as stress-activated protein kinase (SAPK), is another subclass of MAPK in mammals. (cusabio.com)
Inhibition of the p38 MARK pathway down-regulates the activity of protein kinase C ( PKC ), which plays an important role in osteogenic differentiation of cells. (cusabio.com)

AICA-Riboside, CAS 2627-69-2, is a cell-permeable nucleoside compound whose phosphorylated metabolite activates AMPK and acts as a regulator of de novo purine synthesis. (emdmillipore.com)
DAG also activates C kinase. (justia.com)

Signaling A crucial intracellular signaling pathway would be the inositol tri phosphate/diacylglycerol pathway. (mek-inhibitors.com)
Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. (musc.edu)

regulators of the rat and human 5-HT1A receptor genes using luciferase reporter fusion constructs transfected in cell lines. (vdocuments.net)

To address the possibility that activation of phosphatidylinositol-3-kinase (PI3K) and the mammalian target of rapamycin (mTOR/FRAP), represents one of these pathways, we have examined the effect of simultaneous inhibition of the Ras-MAPK and PI3K-mTOR pathways on transformation of CEF by v-Src. (embl.de)
Inhibition of the Ras-MAPK pathway by expression of the dominant-negative Ras mutant HRasN17 or by addition of the MAPK kinase (MEK) inhibitor PD98059 reduced several of these parameters but failed to block transformation. (embl.de)
Currently, there are 4 known MAPK signaling pathways, including the extracellular signal-regulated kinase ( ERK ), c- Jun N-terminal kinase (JNK, also known as SAPK), p38 and ERK5 pathways. (cusabio.com)

The synthesis, chemical derivatization, and investigation of the inhibitory properties of novel cyclitol derivatives on the phosphatidylinositol 4-kinase enzymes PI4K55 and PI4K230 involved in the phosphatidylinositol cycle are reported. (embl.de)
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPEPLD) and sn-1-specific diacylglycerol lipase-α and β (DAGLA and DAGLB) are the main enzymes involved in the biosynthesis of NAEs and 2-AcGs, respectively [ 17 , 19 ]. (biomedcentral.com)

We report here that Sac1p has a specific role in secretion and acts as an antagonist of the phosphatidylinositol 4-kinase Pik1p in Golgi trafficking. (embl.de)
Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230. (embl.de)
Phosphatidylinositol (PI) is a substance that inositol is bound as a phosphate ester to a remaining hydroxyl group of diacylglycerol. (justia.com)

Also, a reduction of Myc action trailed the reduction of NFB and STAT3 action right after PI3K was inhibited in iMycEu 1 cells. (mek-inhibitors.com)

OBJECTIVE: Dual leucine zipper kinase (DLK), which regulates the c-Jun N-terminal kinase pathway involved in axon degeneration and apoptosis following neuronal injury, is a potential therapeutic target in amyotrophic lateral sclerosis (ALS). (bvsalud.org)
The first reaction of the Kennedy pathway involves the cytosol-localized enzyme choline/ethanolamine kinase catalyzing the conversion of choline into phosphocholine. (smpdb.ca)

A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. (lookformedical.com)
A family of serine/threonine kinase Aurora constitutes a key regulator in the orchestration of mitotic events. (lookformedical.com)

Another important role of the PI(4,5)P 2 is that it is hydrolyzed by phospholipase C (PLC) into inositol-1,4,5-triphosphate (IP 3 ) and diacylglycerol (DAG) which are then released as second messengers. (justia.com)

In certain cells, activation of IP also stimulates G12/G13-Gβγ G proteins to activate the Rho family of GTPases signaling proteins and Gi-Gβγ G proteins to activateRaf/MEK/mitogen-activated kinase pathways. (wikipedia.org)
Staurosporine induces apoptosis by multiple pathways and that the inhibition of more than one kinase is responsible for its potent activity. (ncats.io)

At higher concentration (1-20 nM), staurosporine also inhibits other kinases such as PKA, PKG, CAMKII and Myosin light chain kinase (MLCK). (ncats.io)

By contrast, ITSN2, which might regulate the formation kinase inhibitor Dabrafenib of clathrin coated vesicles, was upregulated on all dpa. (mek-inhibitors.com)
Staurosporine is a prototypical ATP-competitive kinase inhibitor in that it binds to many kinases with high affinity, though with little selectivity. (ncats.io)

Extracellular-regulated kinase 3 (ERK3) is overexpressed in a variety of cancers, including lung cancer. (wright.edu)

Accumulation of neutral lipids, such as triglycerides, in key insulin target tissues, has been postulated to inhibit metabolic functions, however, they are less likely to be deleterious. (frontiersin.org)
The hallmarks of impaired insulin sensitivity in these three tissues are decreased insulin-stimulated glucose uptake into skeletal muscle, impaired insulin-mediated inhibition of hepatic glucose production in liver, and a reduced ability of insulin to inhibit lipolysis in adipose tissue. (jci.org)
Insulin also inhibits lipolysis via a central mechanism that involves the sympathetic nervous system. (imingo.net)
Pancreatic delta cells produce somatostatin which functions to inhibit glucagon, insulin, and itself. (smpdb.ca)

DGKζ is an isoform in the DGK family, all the members of which phosphorylate the lipid diacylglycerol (DAG) to generate phosphatidic acid (PA). (wright.edu)
Lipid mass spectrometry analysis revealed that knockdown of ERK3 reduced phosphatidic acid levels but promoted diacylglycerol and triacylglycerol levels. (wright.edu)
Together, this study has identified DGKζ as a new binding partner and negative regulator of ERK3 in controlling lung cancer cell migration and found important insights into a role for ERK3 in the regulation of lipid metabolism. (wright.edu)

The PX domain of Vam7p selectively binds PtdIns-3-P, while the PX domain of the CPK PI-3 kinase selectively binds PtdIns-4,5-P(2). (embl.de)
The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene. (lookformedical.com)

We assessed the expression and activation of these proteins in MPNST cells and inhibited them to determine the effect this had on proliferation, migration, invasion, survival and the phosphoproteome. (biomedcentral.com)
Consistent with classical Ras inhibition, DN R-Ras and R-Ras2 knockdown inhibited proliferation. (biomedcentral.com)
Inhibition of R-Ras action inhibited proliferation, migration and invasion but not survival. (biomedcentral.com)

MEK can phosphorylate and activate ERK, which is transferred into the nucleus and regulates gene expression by activating other kinases or transcription factors. (cusabio.com)

GDI2, which regulates the exchange reaction of most Rab proteins by inhibiting the dissociation of guanidine dihydrogen phosphate from them, was downregulated at one dpa, then returned to control value at four and 7 dpa. (mek-inhibitors.com)

The key regulator of this process, hypoxia inducible factor 1 (HIF-1), can initiate apoptosis by inducing high concentrations of proapoptotic proteins, such as BNIP3, and can cause stabilisation of p53. (bmj.com)
Ceramide: an endogenous regulator of apoptosis and growth suppression. (musc.edu)

However, aldosterone is a major regulator of the reabsorption of these ions as well, as it changes the permeability of the distal convoluted tubule to these ions. (smpdb.ca)

Mutations of the NF1 gene potentially results in the activation of multiple Ras proteins, which are key regulators of many biologic effects. (biomedcentral.com)

The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. (lookformedical.com)

In Escherichia coli, the genes coding for glycerol-3-phosphate acyltransferase and diacylglycerol kinase (plsB and dgkA) are found next to each other in divergent orientations, suggesting a co-ordinated regulation. (hal.science)

IP activation of animal and human platelets inhibits their aggregation response and as one consequence of this inhibition of platelet-dependent blood clotting. (wikipedia.org)

The PGI2-IP axis along with the production of nitric oxide, acting together additively and potentially synergistically, are powerful and physiological negative regulators of platelet function and thereby blood clotting in humans. (wikipedia.org)

Finally, dgkA is activated by the two-component regulator BasR, linking dgkA function of phospholipid recycling to LPS modifications. (hal.science)

Works in various organisms have revealed that the kinase is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability. (lookformedical.com)

Sphingosine inhibits monocyte tissue factor-initiated coagulation by altering factor VII binding. (musc.edu)

A Fatty Diet Induces a Jejunal Ketogenesis Which Inhibits Local SGLT1-Based Glucose Transport via an Acetylation Mechanism-Results from a Randomized Cross-Over Study between Iso-Caloric High-Fat versus High-Carbohydrate Diets in Healthy Volunteers. (gu.se)

Those transformed cells form tumours when implanted in immunodeficient mice, indicating that the kinase is an oncogene. (lookformedical.com)
while p38 kinase inhibited cell develop into ectodermal cells and eventually differentiate into neural cells. (cusabio.com)

Several synthetic compounds bind to, but do not activate, IP and thereby inhibit its activation by the activating ligands just described. (wikipedia.org)

Aurora kinases are found in all organisms in which their function has been conserved throughout evolution, namely the control of chromosome segregation. (lookformedical.com)

Knowledge about how growth factors and hormones function is pivotal in order to rationally try to stimulate or inhibit their effects for therapeutical purposes. (beauty104.com.tw)

A second proximal promoter for plsB expression is responsible for basal plsB expression and is inhibited during stringent response. (hal.science)

Ectopic kinase overexpression in any culture cell line leads to polyploidy and centrosome amplification. (lookformedical.com)

Anatomy5

Organisms1

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes16

Information Science3

Mitogen-activa4

Protein24

Activates2

Intracellular2

Receptor1

MAPK3

Enzymes2

Phosphatidylinositol3

PI3K1

Pathway2

Serine2

Phospholipase1

Pathways2

Myosin1

Inhibitor2

Extracellular1

Insulin4

Lipid3

Binds2

Proliferation3

Phosphorylate1

Regulates1

Apoptosis2

Major regulator1

Proteins1

Calcium1

Phosphate1

Inhibition1

Physiological1

Phospholipid1

Stability1

Tissue1

Mechanism1

Cells2

Activation1

Found1

Function1

Response1

Leads1