AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
ApoptosisApoptosis Regulatory ProteinsCaspasesCaspase 3Inhibitor of Apoptosis ProteinsProto-Oncogene Proteins c-bcl-2DNA FragmentationIn Situ Nick-End Labelingbcl-2-Associated X ProteinX-Linked Inhibitor of Apoptosis ProteinCell Line, TumorApoptosis Inducing FactorCell SurvivalCASP8 and FADD-Like Apoptosis Regulating ProteinCaspase 9Caspase InhibitorsSignal TransductionCaspase 8MitochondriaFas Ligand ProteinTumor Suppressor Protein p53Enzyme ActivationCytochromes cTumor Cells, CulturedCells, Culturedbcl-X ProteinAnnexin A5Cell ProliferationBlotting, WesternAmino Acid Chloromethyl KetonesCysteine Proteinase InhibitorsCell LineProto-Oncogene ProteinsFlow CytometryCell CycleAntineoplastic AgentsPoly(ADP-ribose) PolymerasesEnzyme InhibitorsTNF-Related Apoptosis-Inducing LigandReactive Oxygen SpeciesJurkat CellsTransfectionCell DivisionRNA, Small InterferingCaspase 7HL-60 CellsDown-RegulationMembrane Potential, MitochondrialCell DeathDose-Response Relationship, DrugTumor Necrosis Factor-alphaGenes, bcl-2Phosphorylationbcl-2 Homologous Antagonist-Killer ProteinMembrane GlycoproteinsNecrosisCytochrome c GroupUp-RegulationMyeloid Cell Leukemia Sequence 1 ProteinRNA, MessengerBH3 Interacting Domain Death Agonist ProteinNF-kappa BDNA DamageProto-Oncogene Proteins c-aktTime FactorsStaurosporineReverse Transcriptase Polymerase Chain ReactionMice, Inbred C57BLbcl-Associated Death ProteinGene Expression Regulation, NeoplasticAntineoplastic Agents, PhytogenicCeramidesReceptors, TNF-Related Apoptosis-Inducing LigandProtein-Serine-Threonine KinasesCarrier ProteinsMice, KnockoutCaspase 2HeLa CellsOxidative StressDrug SynergismImmunohistochemistryFas-Associated Death Domain ProteinNeoplasm ProteinsGene Expression RegulationCysteine EndopeptidasesRNA InterferenceApoptotic Protease-Activating Factor 1Mitogen-Activated Protein KinasesMembrane ProteinsEpithelial CellsGene ExpressionDNA-Binding ProteinsReceptors, Tumor Necrosis FactorMice, NudeCaspase 1Cell NucleusU937 CellsIntracellular Signaling Peptides and ProteinsModels, BiologicalDrug Resistance, Neoplasm
Proliferation and induces apoptosisViabilityInduceProteinCaspaseInhibitionPromotesMitochondrial membrane potentialFlow cytometryNecrosisProteinsAssayInductionColorectal cancer cellsKnockdownPancreatic cancerArrest and apoptosisVitroInvasionInduces cellInhibitor of apoptoProstaglandin biosynthesisPhosphorylationVivoGrowthMarkedly inhibitedAbstractTumorigenesisDose-dependentInflammatorySynthesisReactiveCytotoxicityMigrationWestern blotPathwaysBone resorptionAntitumor effectsCytochromeHypothesized that statinsMTORMetastasisCervical cancerAntiproliferative effect
Proliferation and induces apoptosis1
Viability7
  • AVM induced the release of cleaved PARP and cleaved caspase‑3 caused apoptosis and inhibited the viability of these cells. (spandidos-publications.com)
  • In previous research, the authors demonstrated that the methanol extract of A. vulgaris (AVM) has the ability to inhibit the viability of CML cells ( 10 ). (spandidos-publications.com)
  • Cell viability and apoptosis were detected by MTT assay and TdT-mediated dUTP nick end labeling (TUNEL) staining, respectively. (ijbs.com)
  • Apoptosis in both hypoxic and H 2 O 2 -treated cardiomyocytes were markedly reduced and cell viability was increased by miR-195 inhibitor. (ijbs.com)
  • Effects of regorafenib on cell viability, apoptosis pathways, metastatic potential, and expression of metastatic and anti-apoptotic proteins were evaluated with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay, flow cytometry, cell migration and invasion assay, and western blotting. (tmu.edu.tw)
  • Our results established that fucoxanthin stimulates apoptosis as confirmed through reduced cell viability, improved production of ROS, and altered MMP in A2780 cells. (phcog.com)
  • Results of the present study revealed that luteolin decreased viability of JAR and JEG-3 cells, which are valuable placental models, in a dose-dependent manner, and it induced apoptosis and loss of mitochondrial membrane potential in JAR and JEG-3 cells. (ewha.ac.kr)
Induce6
  • TUNEL and western blot assay showed that KTC could induce apoptosis of endometriotic tissues, accompanied with the increased protein expression of caspases 8 and 9, activated caspase-3, and cytochrome c in a dose-dependent manner. (hindawi.com)
  • On the other hand, Triphala failed to induce apoptosis or activate ERK or p53 in normal human pancreatic ductal epithelial (HPDE-6) cells. (biomedcentral.com)
  • CONCLUSIONS: Statins inhibit proliferation and induce apoptosis in EAC cells via inhibition of Ras farnesylation and inhibition of the ERK and Akt signaling pathways. (uea.ac.uk)
  • The results show that downregulation of Rab21 can significantly inhibit cell growth and remarkably induce cell apoptosis in T98G and U87 cell lines. (biomedcentral.com)
  • We inferred that Rab21 silencing can induce apoptosis and inhibit proliferation in human glioma cells, indicating that Rab21 might act as an oncogene and serve as a novel target for glioma therapy. (biomedcentral.com)
  • This plant had shown to induce antiproliferative effect as well as apoptosis in cancer cells. (upm.edu.my)
Protein16
  • Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. (hindawi.com)
  • In the present study, we reported that celastrol potentiated tumor necrosis factor-α (TNF-α)-induced apoptosis, affected activation of caspase-8, caspase-3 and PARP cleavage, and inhibited the expression of anti-apoptotic proteins such as cellular inhibitor of apoptosis protein 1 and 2 (cIAP1 and cIAP2), cellular FLICE-inhibitory protein (FLIP), and B-cell lymphoma 2 (Bcl-2). (spandidos-publications.com)
  • DcR3 protein in our experimental results showed significant expression among the pancreatic cancer cell lines and their decreased expression by lentivirus-mediated shRNA resulted in the inhibition of cell proliferation and augmentation of apoptosis. (academicjournals.org)
  • BS effectively inhibited the growth of PC cell lines by inhibiting proliferation, inducing G0/G1 phase arrest and apoptosis, suppressed the NF- kB activity, and increased expression of the protein Bax but decreased expression of the protein Bcl-2. (nih.gov)
  • The pro-apoptotic function of bcl-XL is realized by binding to anti-apoptotic protein Bcl-XL and inhibiting its anti-apoptotic activity. (researchsquare.com)
  • As an important anti-apoptotic protein, dissociated Bcl-XL mainly binds to BAK or Bax and inhibits the pore-promoting activity of BAK or Bax [ 10 ] to achieve its anti-apoptotic function. (researchsquare.com)
  • Thus the inhibitory effects of SLTM on gene expression appear to result from generalized down-regulation of mRNA synthesis and initiation of apoptosis consequent upon overexpressing the protein. (bris.ac.uk)
  • Aurintricarboxylic acid (ATA) is a chemical compound that readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. (wikipedia.org)
  • It is used to inhibit protein biosynthesis in its initial stages. (wikipedia.org)
  • Simvastatin inhibited activation of extracellular signal-regulated kinase (ERK) and protein kinase B (Akt) but not c-Jun NH2-terminal kinase or p38 mitogen-activated protein (MAP) kinase. (uea.ac.uk)
  • Blebbing, apoptotic body formation and protein release during early apoptosis are dependent on ROCK and myosin ATPase activity to drive actomyosin contraction. (nature.com)
  • 2 , 3 A key feature of apoptosis has been defined as the maintenance of an intact cellular membrane (detectable as exclusion of impermeable dyes such as propidium iodide, PI) throughout the apoptotic program to prevent intracellular protein release and subsequent immunological activation. (nature.com)
  • Fibrinogen-like protein 2 (Fgl2) is involved in apoptosis, angiogenesis and inflammatory response. (silverchair.com)
  • We found that Fgl2 gene silencing inhibits apoptosis and improves heart function of streptozotocin (STZ)-induced diabetes rats, the possible mechanism maybe that Fgl2 gene silencing reduces the tumour necrosis factor (TNF)±levels, decreases the expression of B-cell lymphoma-2 (bcl2), bcl-2-associated X (bax), toll-like receptors 4 (TLR4) and p38 mitogen-activated protein kinase (MAPK). (silverchair.com)
  • Shiga toxins (Stx) are potent AB 5 cytotoxins that inhibit eukaryotic protein synthesis, eventually leading to host cell death ( 1 ). (cdc.gov)
  • Effect of cadmium on P53 and mitogen-activated protein kinases in a murine macrophage cell line: relation to apoptosis. (cdc.gov)
Caspase14
  • Loss of mitochondrial membrane potential, upregulation of proapoptotic proteins, activation of MCL-1, PARP-1 and Caspase 9 suggest that MESF treatment leads to activation of mitochondrial pathway of apoptosis. (nature.com)
  • Apoptosis was partially blocked by the caspase-3 inhibitor Ac-DEVD-CHO. (hindawi.com)
  • Mitochondrial regulation of apoptosis further downstream was investigated, showing changes in the mitochondrial membrane potential, cytochrome c release into the cytoplasm, and enhanced activation of cleaved caspase-3 and Poly ADP-ribose polymerase (PARP). (hindawi.com)
  • There was also no translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus in apoptotic keratinocytes, indicating Tan IIA-induced apoptosis occurs mainly through the caspase pathway. (hindawi.com)
  • Co-localization of P2Y12-Cleaved caspase-3 in apoptosis models was detected by dual-standard immunofluorescence staining. (researchsquare.com)
  • Caspase-3 is one of the most critical effector proteases in cell apoptosis. (researchsquare.com)
  • In response to cell death stimulation, mitochondrial survivin is rapidly discharged in the cytosol, where it prevents caspase activation and inhibits apoptosis. (umassmed.edu)
  • In addition, miR-139-5p induced apoptosis, as indicated by up-regulation of key apoptosis gene cleaved caspase-3, and down-regulation of anti-apoptosis gene Bcl2. (oncotarget.com)
  • Apoptosis was determined using assays for intracellular nucleosomes and caspase-3 activity. (uea.ac.uk)
  • Broad-spectrum caspase inhibitor Z-VAD-FMK treatment indicated that surfactin induces caspase -independent apoptosis in F. graminearum. (bvsalud.org)
  • High dietary taurine inhibits myocardial apoptosis during an atherogenic diet: association with increased myocardial HSP70 and HSF-1 but not caspase 3. (austin.org.au)
  • This study investigated whether taurine affects atherogenic diet-induced myocardial apoptosis, and whether HSP70, HSF-1 and caspase 3 are involved.New Zealand white rabbits were divided into 3 groups for 4 weeks according to their diet. (austin.org.au)
  • Results CD inhibited both 786-O and A-498 cell proliferation and induced a series apoptotic characteristics expressions, ROS accumulation, caspase-3 activation as well as poly-(ADP-ribose) polymerase cleavage in both ccRCC cells. (ncku.edu.tw)
  • SK228-induced apoptosis was confirmed by terminal deoxynucleotidyl transferase dUTP nick end labeling assay and immunohistochemistry of cleaved caspase-3 in tumors from treated mice. (ntnu.edu.tw)
Inhibition5
  • Therefore, mitochondrial survivin orchestrates a novel pathway of apoptosis inhibition, which contributes to tumor progression. (umassmed.edu)
  • Moreover, miR-139-5p inhibited cellular metastasis through inhibition of matrix metalloproteinases (MMP)-7 and MMP-9. (oncotarget.com)
  • Accumulated intracellular ROS, decreased mitochondrial membrane potential ( MMP ), activated metacaspase activity and condensed chromatin , were induced by surfactin in F. graminearum hyphae , suggesting that growth inhibition of fungus is mainly caused by apoptosis -like cell death . (bvsalud.org)
  • NF-κB is a transcription factor and if activated, it induces apoptosis inhibition. (chemoprev.org)
  • Inhibition of ERK suppressed DNA synthesis and had an additive effect with Cd-inhibited proliferation suggesting that Cd-induced ERK activity is not responsible for the G2/M arrest and subsequent inhibition of cell proliferation. (cdc.gov)
Promotes2
Mitochondrial membrane potential3
Flow cytometry5
Necrosis5
  • Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
  • Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via upregulation of heme oxygenase-1 expression. (stembook.org)
  • Tumor necrosis factor-α (TNF-α) secreted from LPS-stimulated macrophages is an important mediator of apoptosis in this model. (elsevierpure.com)
  • We now show that during early apoptosis limited membrane permeabilization occurs in blebs and apoptotic bodies, which allows release of proteins that may affect the proximal microenvironment before the catastrophic loss of membrane integrity during secondary necrosis. (nature.com)
  • Therefore, the shift from apoptosis to secondary necrosis is more graded than a simple binary switch, with the membrane permeabilization of apoptotic bodies and consequent limited release of DAMPs contributing to the transition between these states. (nature.com)
Proteins7
  • The cell death program can be stalled at several points and we were interested in identifying new proteins inhibiting cell death downstream of Cyt c release. (uni-frankfurt.de)
  • 1997). The screen resulted in the identification of six proteins displaying cell death-inhibiting activity in S. pombe as well as anti-apoptotic potential in mammalian cells. (uni-frankfurt.de)
  • Silencing Rab21 resulted in significantly increased expression of apoptosis-related proteins (caspase7, Bim and Bax) in glioma cells. (biomedcentral.com)
  • Proapoptotic, anti-apoptotic proteins and intracellular signaling molecules involved in CD-induced apoptosis were examined by Western blot analysis. (ncku.edu.tw)
  • These mechanisms include the ability of lead to inhibit or mimic the action of calcium and to interact with proteins. (cdc.gov)
  • Thus, statins may inhibit the synthesis of isoprenoids and thereby suppress the activation of small G proteins (7). (cdc.gov)
  • A large group of proteins that control APOPTOSIS. (bvsalud.org)
Assay3
Induction6
  • Therefore, based on clinical experience as well as cytotoxic activity against multiple human cancer cells, we hypothesized that induction of apoptosis is the underlying mechanism for the treatment of psoriasis. (hindawi.com)
  • These findings indicate that sesamin inhibits cervical cancer cell proliferation, and its mechanism may be attributed to the induction of p53/PTEN-mediated apoptosis. (medsci.org)
  • Triphala-mediated reduced cell survival correlated with induction of apoptosis, which was associated with reactive oxygen species (ROS) generation. (biomedcentral.com)
  • Researchers discovered that excessive induction of Fgl2 under certain medical conditions (e.g., pathogen invasion) could trigger complement activation, inflammatory response, cellular apoptosis and immune dysfunctions. (silverchair.com)
  • Mechanically, we address that CD suppressed cell proliferation and induced apoptosis via induction of FOXO3a as well as decreased phosphorylation of Akt, mTOR, MEK/ERK and their downstream molecules, cMyc and hypoxia inducible factor 2α expression in a concentration- and time-dependent trend. (ncku.edu.tw)
  • More than 15 years ago, cholesterol decrement was first shown to inhibit tumor cell growth, metastasis of tumor cells, and induction of apoptosis (7). (cdc.gov)
Colorectal cancer cells2
  • An arabinogalactan (PTPS-1-2) was isolated and characterized from Pollen Typhae, and its potential antitumor effects on activating macrophages to produce immunomodulatory factors and promoting apoptosis in colorectal cancer cells were investigated. (yiacupuncture.com)
  • This manuscript demonstrated that DAPG and DPPG inhibited lung and colorectal cancer cells by inducing apoptosis. (harvard.edu)
Knockdown4
  • Overexpression of miR-128-3p or knockdown of TGFBR2 ameliorated LPS-induced inflammation and apoptosis. (degruyter.com)
  • Of note, the effects of Ang II in facilitating cell apoptosis, increasing matrix metalloproteinase (MMP)-2 and MMP-9, reducing tissue inhibitor of MMP (TIMP)-1, and promoting switching from the contractile to synthetic phenotype in cultured VSMCs were enhanced by overexpression of PVT1 but attenuated by knockdown of PVT1 . (molcells.org)
  • Furthermore, knockdown of PVT1 reversed Ang II-induced AAA-associated alterations in mice, as evidenced by attenuation of aortic diameter dilation, marked adventitial thickening, loss of elastin in the aorta, enhanced aortic cell apoptosis, elevated MMP-2 and MMP-9, reduced TIMP-1, and increased pro-inflammatory cytokines. (molcells.org)
  • In conclusion, our findings demonstrate that knockdown of lncRNA PVT1 suppresses VSMC apoptosis, ECM disruption, and serum pro-inflammatory cytokines in a murine Ang II-induced AAA model. (molcells.org)
Pancreatic cancer3
  • Similarly, Triphala induced apoptosis in another pancreatic cancer cell line BxPC-3 by activating ERK. (biomedcentral.com)
  • Our preclinical studies demonstrate that Triphala is effective in inhibiting the growth of human pancreatic cancer cells in both cellular and in vivo model. (biomedcentral.com)
  • In the present study, we demonstrate that Triphala significantly inhibit the proliferation of Capan-2 and BxPC-3 human pancreatic cancer cells. (biomedcentral.com)
Arrest and apoptosis2
  • The aim of the present investigation was to elucidate the cellular mechanisms whereby Tanshinone IIA (Tan IIA) leads to cell cycle arrest and apoptosis in vitro in keratinocytes, the target cells in psoriasis. (hindawi.com)
  • Results suggested that p53 is not involved in Cd-induced cell cycle arrest and apoptosis in J774A.1 cells. (cdc.gov)
Vitro4
  • The aim of the present study was to verify the effects of regorafenib on apoptosis and metastatic potential in TSGH 8301 human bladder carcinoma cells in vitro. (tmu.edu.tw)
  • These results show that regorafenib not only induces apoptosis, but also inhibits metastatic potential in bladder cancer TSGH 8301 cells in vitro. (tmu.edu.tw)
  • These results strongly suggest that EETs exert protective functions during the growth and apoptosis of CSMCs, via the JNK/c-Jun and mTOR signaling pathways in vitro. (molcells.org)
  • It was found that the growth of leukemia cells in vitro was inhibited by the various extracts of TF. (upm.edu.my)
Invasion8
  • Park SK, Hwang YS, Park KK, Park HJ, Seo JY and Chung WY: Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells. (spandidos-publications.com)
  • Kim Y, Kang H, Jang SW and Ko J: Celastrol inhibits breast cancer cell invasion via suppression of NF-κB-mediated matrix metalloproteinase-9 expression. (spandidos-publications.com)
  • Zhang S, Li Z, Wu X, Huang Q, Shen HM and Ong CN: Methyl-3-indolylacetate inhibits cancer cell invasion by targeting the MEK1/2-ERK1/2 signaling pathway. (spandidos-publications.com)
  • The role of hPOT1 in the cell proliferation, apoptosis and invasion of gastric cancer 7901 cells was determined by means of the RNA interference (RNAi) of hPOT1 mRNA. (bmj.com)
  • Transfection of hPOT1 siRNA into SGC-7901 cells led to a decrease in cell proliferation, colony formation and invasion, and also an increase of apoptosis. (bmj.com)
  • hPOT1 RNAi inhibits proliferation and invasion, and induces apoptosis of gastric cancer cells. (bmj.com)
  • In addition, SK228 inhibits cancer cell invasion via FAK/Paxillin disruption at noncytotoxic doses. (ntnu.edu.tw)
  • In addition, we uncovered upstream signaling cascade (Akt/mTOR) induced by incubation A2780 cell lines with fucoxanthin that mediated cell apoptosis, migration, and invasion process. (phcog.com)
Induces cell1
  • We found that a significant increase occurred in Rab21 expression in T98G and U87 glioma cell lines and that downregulation of Rab21 using specific-siRNA transfected with two glioma cell lines (T98G and U87) significantly inhibits cell growth and remarkably induces cell apoptosis. (biomedcentral.com)
Inhibitor of apopto1
  • Here we show that survivin, a member of the inhibitor of apoptosis gene family that is overexpressed in cancer, exists in a novel mitochondrial pool in tumor cells. (umassmed.edu)
Prostaglandin biosynthesis2
  • Flurbiprofen may inhibit cyclooxygenase, thereby inhibiting prostaglandin biosynthesis. (medscape.com)
  • However, the physiologic significance of prostaglandin production did not unfold until 1971, when Vane, Smith, and Willis discovered that aspirin and indomethacin inhibited prostaglandin biosynthesis. (medscape.com)
Phosphorylation3
Vivo3
  • Tan IIA administration inhibited CAL27-deprived xenograft tumor growth and increased PUMA expression in vivo. (jcancer.org)
  • Selective targeting of survivin to mitochondria enhances colony formation in soft agar, accelerates tumor growth in immunocompromised animals, and abolishes tumor cell apoptosis in vivo. (umassmed.edu)
  • It is immunotoxic in vivo and induces apoptosis in many cultured cells. (cdc.gov)
Growth11
  • Our findings suggest that KTC could inhibit the growth of ectopic endometrial tissue through upregulating the level of TNF- α and its downstream signaling, including caspases and cytochrome c. (hindawi.com)
  • Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)
  • Reduced tumor-growth in Triphala fed mice was due to increased apoptosis in the tumors cells, which was associated with increased activation of p53 and ERK. (biomedcentral.com)
  • Apoptosis is a fundamental homeostatic mechanism essential for the normal growth, development and maintenance of every tissue and organ. (nature.com)
  • In this article, the role of EET in the growth and apoptosis of CSMCs and the underlying mechanisms under oxygen glucose deprivation (OGD) conditions were addressed. (molcells.org)
  • SK228 significantly inhibited growth of different lung and esophageal cancer cell lines at sub-micromolar range, but not normal lung cells. (ntnu.edu.tw)
  • Growth of an A549 tumor cell xenograft was markedly inhibited without significant side effects. (ntnu.edu.tw)
  • DPPG and DAPG inhibited 83 and 59% of human colorectal cancer HCT116 cell growth at 40.0 µg/ml, and 74 and 57% of human lung cancer A549 cell growth at 10.0 µg/ml concentrations respectively. (harvard.edu)
  • DAPG and DPPG inhibited A549 and HCT116 cells growth by inducing apoptosis. (harvard.edu)
  • Studies have suggested that statins may inhibit tumor cell growth and possibly prevent carcinogenesis. (cdc.gov)
  • May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. (lu.se)
Markedly inhibited1
  • In addition, PTPS-1- 2-containing CM markedly inhibited the proliferation of RKO cells in a time- and dose-dependent manner. (yiacupuncture.com)
Abstract1
  • abstract = "We assessed the effect of acteoside, a naturally occurring antioxidative phenylethanoid, on hepatic apoptosis and the subsequent liver failure induced by D-Galactosamine (D-GalN) and lipopolysaccharide (LPS). (elsevierpure.com)
Tumorigenesis2
  • Apoptosis alteration is responsible for tumorigenesis and tumor resistance to therapies. (jcancer.org)
  • Experiments using tumors obtained from Apc min/+ mice and cells from human colon cancers showed that this Ino80 defect induced stalled replication forks, the concomitant activation of ATR-Chk1 signaling and an increase in apoptosis, suggesting that Ino80 haploinsufficiency inhibited colon cancer tumorigenesis by activating replication stress-induced ATR-Chk1 signaling to increase apoptosis. (ewha.ac.kr)
Dose-dependent3
  • Sesamin (75 and 150 μM) clearly inhibited SiHa and HeLa cell proliferation in a dose-dependent fashion, but did not affect the proliferation of Hs68 cells. (medsci.org)
  • RESULTS: All three statins reduced viable cell number and inhibited proliferation in a similar dose-dependent manner. (uea.ac.uk)
  • Cd inhibited cell proliferation via cell cycle arrest and induced apoptosis in a dose-dependent manner. (cdc.gov)
Inflammatory4
  • During the progression of FJOA, these pro-inflammatory cytokines are considered to be key factors in promoting chondrocyte apoptosis. (researchsquare.com)
  • It inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis. (medscape.com)
  • It inhibits inflammatory reactions and pain by decreasing the activity of cyclooxygenase, which is responsible for prostaglandin synthesis. (medscape.com)
  • Neutrophil apoptosis may be inhibited, enhancing the release of inflammatory mediators. (msdmanuals.com)
Synthesis2
  • This agent inhibits prostaglandin synthesis. (medscape.com)
  • Further investigations by Smith concluded that aspirin and indomethacin inhibited synthesis by specifically blocking oxygenation of arachidonic acid. (medscape.com)
Reactive2
Cytotoxicity3
  • It is thus concluded that AVM inhibits the activity of BCR/ABL and their subsequent molecular signals, including AKT and MAPK, resulting in cytotoxicity via apoptosis. (spandidos-publications.com)
  • Xanthoxyletin significantly inhibited the proliferation of oral cancer cells (IC₅₀, 10-30 µM) with lower cytotoxicity for normal cells. (medscimonit.com)
  • Our study provides the first evidence that SK228 exhibits cancer cell-specific cytotoxicity by inducing mitochondria-mediated apoptosis. (ntnu.edu.tw)
Migration1
  • Jin ML, Park SY, Kim YH, Park G and Lee SJ: Halofuginone induces the apoptosis of breast cancer cells and inhibits migration via downregulation of matrix metalloproteinase-9. (spandidos-publications.com)
Western blot1
  • Immunohistochemistry and Western blot were used to observe the expression of P2Y12, MMP13, COL2 and other cartilage degeneration and apoptosis related indexes. (researchsquare.com)
Pathways1
Bone resorption6
  • Calcitonin analogues directly inhibit osteoclastic bone resorption and have a significant analgesic effect on bone. (medscape.com)
  • Alendronate is a potent third-generation bisphosphonate that principally acts by inhibiting osteoclastic bone resorption. (medscape.com)
  • Risedronate is a potent aminobisphosphonate that principally acts by inhibiting osteoclastic bone resorption. (medscape.com)
  • Zoledronate inhibits bone resorption. (medscape.com)
  • This agent is a peptide hormone that binds to calcitonin receptors on osteoclasts and rapidly inhibits bone resorption. (medscape.com)
  • BP act in the regulation of osteoclast function by decreasing bone resorption by different mechanisms, inhibiting the development of their precursor cells, increasing apoptosis rate, stimulating inhibitor factors and reducing its activity 28 . (bvsalud.org)
Antitumor effects2
  • Overall, our results revealed that Tan IIA exerted potent antitumor effects via promoting PUMA-mediated apoptosis in OSCC cells. (jcancer.org)
  • PTPS-1-2 exerted marked antitumor effects by inhibiting RKO cell proliferation and suppressing cell colony formation. (yiacupuncture.com)
Cytochrome1
  • In addition, analysis of cell-cycle parameters, chromatin condensation and cytochrome c release showed that SLTM induced apoptosis in a range of cultured cell lines. (bris.ac.uk)
Hypothesized that statins1
MTOR1
  • Collectively, these results showed that luteolin plays an important role in the treatment of human choriocarcinoma cells by inhibiting the PI3K/AKT/mTOR/SREBP cascade and expression of lipogenic genes. (ewha.ac.kr)
Metastasis1
  • Taken together, our results demonstrated that miR-139-5p plays a pivotal role in lung cancer through inhibiting cell proliferation, metastasis, and promoting apoptosis by targeting oncogenic c-Met. (oncotarget.com)
Cervical cancer1
  • Here, we explored whether sesamin activates p53, which is widely inhibited in cervical cancer cells, thereby inducing p53-mediated apoptosis. (medsci.org)
Antiproliferative effect1
  • Statins induced apoptosis and enhanced the antiproliferative effect of NS-398, a selective cyclooxygenase (COX)-2 inhibitor. (uea.ac.uk)