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  • aureus
  • As a first step toward determining whether this limitation is therapeutically relevant, we carried out in vitro studies comparing the relative susceptibility of an S. aureus clinical isolate (UAMS-1) and its isogenic sarA mutant (UAMS-929) in the specific context of a catheter-associated biofilm. (semanticscholar.org)
  • This study suggests that protease treatment could be a feasible tool to reduce and eradicate S. aureus biofilms. (kribb.re.kr)
  • significantly
  • Sinefungin is bacteriostatic to pneumococci and significantly decreased biofilm growth and inhibited proliferation and structure of actively growing biofilms but did not alter growth or the matrix structure of established biofilms. (hindawi.com)
  • P. aeruginosa cell surface hydrophobicity and biofilm integrity were significantly altered due to the cleavage of nucleic acids by prodigiosin or the prodigiosin/copper(II) complex. (frontiersin.org)
  • microbial
  • The oral cavity contains many different microbial species growing in a biofilm. (otago.ac.nz)
  • The work, Costa says, is relevant to anyone interested in manipulating microbial biofilms, which are common in natural, clinical, and industrial settings. (caltech.edu)
  • colonization
  • This study shows that sinefungin inhibits pneumococcal biofilm growth in vitro and colonization in vivo , decreases AI-2 production, and downregulates luxS , pfs , and speE gene expressions. (hindawi.com)
  • Candida albicans biofilm was formed on polystyrene flat-bottomed 96-well plates, and the inhibitory effects on the initial colonization and maturation phases were determined using the XTT reduction assay. (springer.com)
  • growth
  • The composition of EPS can be distinct among biofilms according to the type of microorganisms and growth conditions. (frontiersin.org)
  • This occurred at the very low and physiologically meaningful concentration of 0.5 μg/ml, far below that required to kill or inhibit growth (MIC = 64 μg/ml). (asm.org)
  • inhibitors
  • The current study suggests that plant secondary metabolites are important resource of biofilm inhibitors, as well as other bioactive compounds. (omicsdi.org)
  • reduction assay
  • In addition, these extracts and fractions were assessed against Candida albicans and C. glabrata biofilms via the XTT reduction assay, and their antioxidant potential was evaluated. (begellhouse.com)
  • coli
  • Global transcriptome analyses revealed that indole-3-acetaldehyde most repressed two curli operons, csgBAC and csgDEFG, and induced tryptophanase (tnaAB) in E. coli O157:H7 biofilm cells. (omicsdi.org)
  • Therefore
  • Therefore in the present study, the effect of limiting iron levels by addition of divalent Co[II] ions in combination with a bacteriophage was used for preventing/disrupting Klebsiella pneumoniae biofilms. (biomedcentral.com)
  • Therefore, treating biofilms with combinations of chemically distinct antimicrobials might be an effective strategy to kill some of these different cell types. (biomedcentral.com)
  • extracellular
  • Biofilms are formed through the production of extracellular matrix composed of water, exopolysaccharides (EPS), nucleic acids, proteins, and lipids ( Flemming and Wingender, 2010 ). (frontiersin.org)