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  • kinase
  • The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1. (semanticscholar.org)
  • In this study, we have identified apoptosis signal-regulating kinase 1 (ASK1) as a CDC25A-interacting protein by yeast two-hybrid screening. (semanticscholar.org)
  • Calcium/calmodulin-dependent protein kinase type IV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons. (semanticscholar.org)
  • Further exploration of the mechanism revealed that Sirt1 protects hypoxic cardiomyocytes from apoptosis, at least in part, through inositol requiring kinase enzyme 1α (IRE1α). (spandidos-publications.com)
  • Although studies have shown that 4-HNE-mediated apoptotic cell death involves intracellular calcium uptake and 4-HNE directly interacts and activates c-Jun amino-terminal kinase (JNKs) [ 15 ], the mechanism of 4-HNE-induced apoptosis has not been clearly delineated. (hindawi.com)
  • PI3K
  • TNF-α-induced activations of PI3K and Akt were inhibited by DMS. (jimmunol.org)
  • Toxic concentrations of cadmium induce astrocytic apoptosis by depleting intracellular glutathione levels, elevating intracellular calcium levels, altering mitochondria membrane potentials, and activating JNK and PI3K/Akt signaling pathways. (bioportfolio.com)
  • stimuli
  • When added in combination, dexamethasone did not increase survival with LPS, but did augment the effect of GM-CSF, suggesting diversity in the mechanisms by which these stimuli regulate apoptosis. (jimmunol.org)
  • 9 10 In addition, CSA has been shown to stabilize the mitochondrial transmembrane potential and thereby inhibit apoptosis induced by different stimuli. (ahajournals.org)
  • extracellular
  • When switched from depolarizing culture conditions HK (extracellular K+ 30 mM) to LK (K+ 5 mM), these neurons rapidly undergo nuclear fragmentation, a typical feature of apoptosis. (semanticscholar.org)
  • protein
  • Czabotar PE, Lessene G, Strasser A, Adams JM (2014) Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. (springer.com)
  • effect
  • To demonstrate that the antiapoptotic effect of CSA was not restricted to oxLDL-mediated apoptosis, we additionally evaluated its effects on apoptosis induced by the inflammatory cytokine tumor necrosis factor-α (TNF-α) and the proatherosclerotic factor angiotensin II (Ang II). (ahajournals.org)