• In addition, MEPY inhibited the contraction induced by extracellular Ca 2+ in endothelium-denuded rat thoracic aorta rings pre-contracted by PE (1 μM) or KCl (60 mM) in Ca 2+ -free solution. (biomedcentral.com)
  • Most of the drugs that stimulate or inhibit smooth muscle contraction do so by regulating the concentration of intracellular calcium , which is involved in initiating the process of contraction. (britannica.com)
  • The cytotoxic effect of 4-Aminopyridine (4-AP) at different doses in the cell model of glioblastoma was measured by MTT assay. (ac.ir)
  • Results: The 3-(4, 5-dimethylthiazol-2-yl)2, 5-diphenyltetrazolium bromide (MTT) viability assay was used to evaluate the cytotoxic effect of newly synthesized cantharidinimides against the previously mentioned carcinoma cell lines. (tmu.edu.tw)
  • Compounds 6 and 8 were bromine-containing aromatic cantharidinimide that produced significant cytotoxic effects on HONE-I and NUGC in high concentrations, but only compound 6 inhibited the growth of 59T and SCM-1 cell lines. (tmu.edu.tw)
  • Inhibits the cytotoxic action of quartz and is reported to have delayed the development of experimental silicosis in rats. (bvsalud.org)
  • In the present work, valence stabilization of divalent iron during gamma irradiation was studied in presence of some organic additives, belonging to some other classes of organic compounds such as Phenol (aromatic alcohol), Acetone (aliphatic ketone), 4-Aminopyridine (heterocyclic amino compound) and Hydrazine hydrate (aliphatic amino compound) to complement our previous studies. (scirp.org)
  • In the present work, the protective effect occurring due to the presence of additives belonging to different classes of organic compounds namely, Phenol (aromatic alcohol), Acetone (aliphatic ketone), 4-Aminopyridine (aromatic heterocyclic nitrogen compound) and Hydrazine hydrate (aliphatic amine) on divalent iron ions during extended gamma irradiation, has been studied. (scirp.org)
  • 2023. Volatile anesthetics inhibit presynaptic cGMP signaling to depress presynaptic excitability in rat hippocampal neurons. . (cornell.edu)
  • The compound 10H-indolo-2-Amino pyridine [3,2-b] quinoxalines inhibits Herpes simplex virus-1 and vaccinia virus at a concentration of 12 μg/ml, and the cytotoxicy was found to be 100 μg/ml. 4-Aminobenzene sulfonamide-10H-indolo [3,2-b] quinoxalines inhibit vaccinia virus at a concentration of 12 μg/ml and cytotoxicy was found to be 100 μg/ml. (ijpsonline.com)
  • evidence that neomycin inhibits binding of herpes simplex virus type 1 to the cellular receptor. (liverpool.ac.uk)
  • 2014. Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties. . (cornell.edu)
  • Idebenone Inhibits lipid peroxidation. (inopha.net)
  • 20mol/L), a-tocopherol (100rtmol/L) and glutathione (50tzmol/L). It can effectively inhibit the formation of lipid peroxides. (inopha.net)
  • Epilepsy is caused by abnormal coordinated firing of neuronal cells mainly due to disparity among excitatory and inhibitory neurotransmission [ 4 ] . (encyclopedia.pub)
  • These results suggest that isoflurane acts through multiple distinct mechanisms to inhibit neurotransmission within the NTS, which would underlie suppression of homeostatic reflexes. (silverchair.com)
  • 4 General anesthetic agents primarily target γ-aminobutyric acid type A (GABA A ) receptors and enhance inhibitory neurotransmission. (silverchair.com)
  • Midazolam (10, 100micrometer) tested significantly inhibited outward K+ currents in a dose-dependent manner and half-blocking concentration (IC50) was 15.94micrometer at 60 mV. (koreamed.org)
  • Midazolam inhibit outward K+ currents of rabbit cerebral arterial smooth muscle cells. (koreamed.org)
  • Nitroprusside inhibited L-type calcium currents, transient outward currents and transient inward current, but increased delayed rectified potassium currents. (biomedcentral.com)
  • Methods: We synthesized more than 34 cantharidinimide derivatives from heating the cantharidin (compound 1) to ca. 200°Cin toluene and triethylamine along with primary amine, aniline derivatives, and aminopyridines, respectively. (tmu.edu.tw)
  • Additionally, it was observed that the effects of E2 were unaltered by removing the urothelium, inhibiting nitric oxide and prostaglandin production or preventing neuronal conduction. (edu.au)
  • MMP9 activity significantly inhibits with increased 4-AP dose, compared to non-treated cells. (ac.ir)
  • It is reported that 0.5~mol/L of idebenone can significantly reduce the degree of apoptosis induced by diethyl maleate and hydrogen peroxide, thereby inhibiting the occurrence of inflammation and improving tissue repairing ability. (inopha.net)
  • Acidification of the external solution or externally applied BaCl 2 or quinidine strongly inhibited I ss,PE . (aspetjournals.org)
  • METHODS: Inward rectifier K(+) current (I(K1)), rapid delayed rectifier K(+) current (I(Kr)), and transient outward K(+) current (I(to)) were dissected under action potential clamp conditions using BaCl(2), E-4031, and 4-aminopyridine, respectively. (unideb.hu)
  • It could be concluded that L-type calcium channels and intracellular Ca2+ release is inhibited by wogonin. (niscpr.res.in)
  • 4 Inhibition induced by DHPG was independent of phospholipase C (PLC)/protein kinase C pathways, and did not require intact intracellular Ca2+ stores. (elsevierpure.com)
  • 2006. Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: 4-aminopyridine-evoked release. . (cornell.edu)
  • 4. Anatomical or functional disconnection from related cortical areas resulted in a membrane potential hyperpolarization of about 9 mV and in the occurrence of spontaneous slow oscillations in virtually all recorded neurones. (researchgate.net)
  • In the presence of a potassium channel blocker, 4-aminopyridine (10μM), the effects of E2 on frequency were prevented. (edu.au)
  • We inhibited the vascular response to the sympathetic vasomotor activity with a peripheral alpha-blocker (urapidil) and maintained mean blood pressure at control levels with angiotensin II. (researchgate.net)
  • Discovery of pyrrolo[1,2-a]quinoxalin-4(5H)-one Derivatives as Novel Non-covalent Bruton's Tyrosine Kinase (BTK) inhibitors. (ecust.edu.cn)
  • This was strongly reduced by the broad-spectrum antagonist (+)alpha-methyl-4-carboxyphenylglycine (MCPG, 1 mM, similar to95% reduction), by the mGluR1 antagonist LY367385 (100 muM, similar to 80% reduction) but not by the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP, 1 - 100 muM). (elsevierpure.com)
  • Inhibits IFNγ production in vivo in mice. (tocris.com)
  • Each dose lasts about 4 hours, and maximum effect of a given dosage may not be observed for 2-3 days. (medscape.com)
  • Paired-pulse depression was strongly reduced by DHPG, an effect that was also prevented by 4-AP. (elsevierpure.com)
  • receptor antagonist 6,7,8,9-tetrahydro-5[H]benzocyclohepte-5-ol-4-ylidene acetic acid (NCS-382), pointing to a specific effect of this drug. (123dok.org)
  • They act by inhibiting the breakdown of ACh, which is intended to help compensate for the relative lack of ACh quanta release in LEMS. (medscape.com)
  • Idebenone inhibits melanin production. (inopha.net)
  • Інфекційний мононуклеоз Infectious mononucleosis is caused by Epstein-Barr virus (EBV, human herpesvirus type 4) and is characterized by fatigue, fever, pharyngitis, and lymphadenopathy. (msdmanuals.com)
  • The anti-HIV activities of the new compounds were also screened for in vitro antiviral activity against replication of HIV-1 (IIIB) and HIV-2 (ROD) in MT-4 cells using zidovudine (AZT) as standard. (ijpsonline.com)
  • Pthalimide derivative inhibited the replication of HIV-2 (EC 50 =11.60 μg/ml and CC 50 =61.63 μg/ml) in MT-4 cells. (ijpsonline.com)
  • using [4-14c]edu as the radiolabeled analogue of edu, it was ascertained that, at antivirally active doses, edu is phosphorylated to a much greater extent by hsv-infected vero cells than by mock-infected cells. (liverpool.ac.uk)
  • 2. A slow (0.5-4 Hz) membrane potential oscillation was observed in thalamocortical cells recorded in motor, sensory, associational and intralaminar thalamic nuclei. (researchgate.net)
  • Increased incidence of seizures has been observed at 20 mg twice daily in controlled clinical studies of 9-14 weeks duration with dalfampridine in patients with MS. In open label extension trials in MS patients, the incidence of seizures during treatment with dalfampridine 15 mg twice daily (1.7/100PY) was over 4 times higher than the incidence during treatment with 10 mg twice daily (0.4/100PY). (wikidoc.org)
  • 4. In control conditions, spectral analysis yielded typical results. (researchgate.net)
  • 8. These results demonstrate that the majority of thalamocortical neurones are endowed with electrophysiological properties allowing them to oscillate at 0.5-4 Hz, if they have a membrane potential more negative than -65 mV and a high input resistance. (researchgate.net)
  • The reduction of cell viability, IL-6 secretion, and MMP-9 activity in an in vitro model of glioblastoma might be assumed 4-AP as an agent for chemoprevention of cancer. (ac.ir)
  • Cytotoxicity analysis data indicated that cell viability reduced by increasing 4-AP level and cell growth decreased gradually by removing 4-AP from the cell medium. (ac.ir)
  • Journal of Experimental and Clinical Medicine , 4 (5), 280-283. (tmu.edu.tw)
  • For example, crud formation (Fe 3 O 4 ) on stainless steel or carbon steel used in boiling water reactors [5] could be suppressed if the valence of the released Fe(II) is protected against oxidation to the trivalent state that leads to crud formation. (scirp.org)
  • Studies show that low-concentration idebenone still effectively inhibiting the formation of melanin and prohibit hyperpigmentation caused by ultraviolet radiation. (inopha.net)
  • The ELISA technique and gelatin zymography were used to assess cytokine levels and MMP-9 after 4-AP treatment. (ac.ir)
  • The 2-aminopyridine MMV048 was the first drug candidate inhibiting Plasmodium phosphatidylinositol 4-kinase (PI4K), a novel drug target for malaria, to enter clinical development. (zhihuiya.com)