Inhibitory receptor expression. Medical search. Frequent questions

Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. (wikipedia.org)
Les IgIV intéragissent avec de nombreux composants du système immunitaire comme les récepteurs Fc, le complément, les cytokines, les lymphocytes T et B, les cellules dendritiques, les granulocytes et les cellules NK, ce qui explique en partie leurs effets anti-inflammatoires. (academie-medecine.fr)
2 The interaction of IVIG with a large number of components of the immune system including Fc receptors, complement molecules, cytokines, B and T lymphocytes, neutrophils and NK cells, may explain at least in part their anti-inflammatory effects. (academie-medecine.fr)
LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. (jci.org)
Consistently, T cells from patients are characterized by features of exhaustion, expressing inhibitory receptors and showing low expression of effector cytokines. (curie.fr)
As we previously reported, receptor activator of nuclear factor kappa-B (RANK) ligand (RANKL)/RANK signaling on M2 macrophages promotes the production of chemokines and proinflammatory cytokines to maintain the immunosuppressive tumor environment of extramammary Paget's disease (EMPD). (iiarjournals.org)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)

Here, we show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-4 or IL-13. (uni-muenchen.de)
CD300f signalling induces inhibitory human monocytes/macrophages. (nih.gov)
In this review, we have discussed the status and roles of various immune effector cells ( e.g ., dendritic cells, natural killer cells, macrophages, and T cells), their cytokine profile, and the chemokine-receptor axis in promoting or impeding HCC. (wjgnet.com)
The preclinical study demonstrated that the histamine receptor H1 (HRH1) acts in tumor-associated macrophages (TAMs) to suppress T cell activation in the tumor microenvironment. (newswise.com)
To understand how HRH1 in TAMs influences T cell activity, the researchers looked at additional regulatory receptors on the macrophages. (newswise.com)
Further, blocking HRH1 caused broad changes in gene expression, resulting in a shift from M2-like features to a more pro-inflammatory state consistent with M1-like macrophages. (newswise.com)
In contrast, PD-L2 expression is more restricted and can be induced on hematopoietic cells such as DCs, B cells, and monocytes/macrophages. (frontiersin.org)
However, the cellular origin for this gene expression is controversial as it is also known to be expressed in intestinal macrophages. (stanford.edu)

Cancer cells, suggesting how the growth inhibitory effects exerted by mibolerone. (showyou.com)
We also determined that TGF-β1 induction is required for the AhR-dependent growth inhibitory effects of flutamide. (oregonstate.edu)

Classical macrophage activation is inhibited by the CD200 receptor (CD200R). (uni-muenchen.de)
Blockade of macrophage Fc receptors is considered the primary mechanism of action of immune globulin in persons with ITP and other autoantibody-mediated cytopenias. (medscape.com)

Fig. 5: Co-expression of CD80 on sEVs disrupted PD-L1-positive sEV-mediated PD-1 binding and T cell inhibition. (nature.com)
Together with James P. Allison, who worked on another co-inhibitory receptor called cytotoxic T-lymphocyte-associated Protein 4 (CTLA-4), Tasuku Honjo was awarded the Nobel Prize in Physiology or Medicine 2018 for the discovery of cancer therapy by inhibition of negative immune regulation ( Wolchok, 2018 ). (frontiersin.org)
In addition, the lack of inhibition of the NMDA receptors may lead to seizures and delirium. (medscape.com)
These inhibitory effects may be associated with its dual‑receptor inhibition on P2Y12 and TP receptors. (spandidos-publications.com)
Oct-4 expression was also downregulated by withaferin A inhibition. (bvsalud.org)

Receptor tyrosine kinase-mediated resistance to mitogen-activated protein kinase targeted therapies and activation of the inflammatory signaling associated with immune therapy involves transitions along this differentiation trajectory, which lead to increased sensitivity to ferroptosis. (bvsalud.org)

During withdrawal from alcohol, the loss of GABA-A receptor stimulation causes a reduction in chloride flux and is associated with tremors, diaphoresis, tachycardia, anxiety, and seizures. (medscape.com)
Ethanol interacts with GABA receptors, enhancing activity. (medscape.com)
GABA receptors are a family of chloride ion channels that mediate inhibitory neurotransmission. (medscape.com)
MG also demonstrated sedative effects at high doses, a hallmark of drugs that activate inhibitory GABA receptors on neurons. (sciencedaily.com)
In collaboration with Leigh Plant, now at Brandeis University, the researchers demonstrated that MG activated GABA-A receptors on neurons, a previously unknown inhibitory mechanism. (sciencedaily.com)
These changes occur without any increase in intrinsic neuronal excitability and are unaffected by blockade of inhibitory GABA currents. (jneurosci.org)

It is proposed that rapid in vivo modulation of lymphocyte Fcγ-receptors occurs following oral antigen (cows' milk) challenge probably mediated by soluble food antigen-antibody complexes. (karger.com)
Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
The most active T cell endogenous inhibitory pathway is the immunoglobulin superfamily such as CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4): B7-1/B7-2 receptor/ligand grouping, which plays a central role in coordinating immune responses [ 7 , 8 ]. (hindawi.com)

Blockade of inhibitory receptor programmed cell death protein 1 (PD-1) in vivo increased mTOR activity in virus-specific CTLs, and its therapeutic effects were abrogated by the mTOR inhibitor rapamycin. (nih.gov)

To understand the molecular-genetic basis of functional specialization and identify potential drug targets specific to each neuron subtype, we performed a genome wide assessment of both gene expression and splicing across EXC, PV, SST and VIP neurons from male and female mouse brains. (jneurosci.org)
We provide a searchable web resource for exploring differential mRNA expression and splice form usage between excitatory, PV, SST, and VIP neurons ( http://research-pub.gene.com/NeuronSubtypeTranscriptomes ). (jneurosci.org)
We sorted excitatory neurons and key inhibitory neuron subtypes from mouse brains and assessed differential mRNA expression. (jneurosci.org)

CONCLUSIONS- Collectively, these data suggest that high glucose induces TLR2 and -4 expression via PKC-α and PKC-δ, respectively, by stimulating NADPH oxidase in human monocytes. (diabetesjournals.org)

These receptors classify as G-protein coupled receptors with either inhibitory or excitatory effects and different binding affinities to norepinephrine. (meltingpointathens.com)

Our findings establish a method to potentiate PD-1 function and propose the removal of restraining mechanisms as an efficient strategy to potentiate the function of inhibitory molecules. (nature.com)
Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules. (lu.se)

Briefly, following receptor stimulation, activated Gs leads to stimulation of adenylyl cyclase and the generation of intracellular cAMP which induces further downstream signaling responsible for the physiological actions of beta1 receptor activation. (meltingpointathens.com)
These data are consistent with the hypothesis that AGE-RAGE interaction induces expression of VCAM-1 which can prime diabetic vasculature for enhanced interaction with circulating monocytes. (jci.org)

We previously showed that peroxisome proliferator-activated receptor (PPAR)-γ in β-cells regulates pdx-1 transcription through a functional PPAR response element (PPRE). (diabetesjournals.org)
Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)

Very happy with instant never come off androgen receptor gene and maleness. (showyou.com)
The androgen receptor better, prevents aromatic compounds from forming tT, E2, LH, and FSH after systemically administered corticosteroids to raise blood glucose levels is well known. (showyou.com)
Flutamide is an androgen receptor (AR) antagonist approved by the United States Food and Drug Administration for the treatment of prostate cancer. (oregonstate.edu)

These results reveal numerous examples where neuron subtype-specific gene expression, as well as splice-isoform usage, can explain functional differences between neuron subtypes, including in presynaptic plasticity, postsynaptic receptor function, and synaptic connectivity specification. (jneurosci.org)

This was associated with DIM‐enhanced phosphorylation of the signaling intermediates Akt, insulin receptor substrate‐1, and insulin receptor early in differentiation. (researchgate.net)

It's a completely different system that is tying neuronal inhibitory tone into metabolic activity," Palmer said. (sciencedaily.com)

We investigated TIGIT gene expression in T cells of the patient from our study (Co45), a 43-year-old man, and compared it with 2 other sex- and age-matched patients who had severe COVID-19 (Co6 and Co84) ( Appendix ). (cdc.gov)
This resource, combining a unique new dataset and novel application of analysis methods to multiple relevant datasets, identifies numerous potential drug targets for manipulating circuit function, reveals neuron subtype-specific roles for disease-linked genes, and is useful for understanding gene expression changes observed in human patient brains. (jneurosci.org)
We used a genome-wide analysis which not only examined differential gene expression levels but could also detect differences in splice isoform usage. (jneurosci.org)
Her research group (funded by the BBSRC, The Wellcome Trust and the British Heart Foundation) is investigating the molecular mechanisms important for regulating pro- and anti-inflammatory gene expression and downstream cellular functions in response to a range of external stimuli, including ligands for G protein-coupled receptors and growth factor receptors, and exogenous lipoproteins. (rvc.ac.uk)
The group uses in vitro, ex vivo and in vivo cell and molecular approaches to delineate the signalling pathways controlling gene expression and functional responses of human and murine large vessel and microvascular endothelial cells.Caroline was an associate editor of the Biochemical Journal for over 10 years and is a founder member of the European Vascular Biology Organisation and of the London Vascular Biology Forum. (rvc.ac.uk)
It's not changing gene expression, and it's not having long-term downstream effects," Distler said. (sciencedaily.com)
To enhance vaccine potency and improve thus responses to ICI, we analyzed the gene expression profile of an immunosuppressive dendritic cell (DC) population induced during vaccination, with the goal of identifying druggable inhibitory mechanisms. (unav.edu)
Our gene expression analysis of human melanoma cell lines and patient tumors revealed that melanoma follows a two-dimensional differentiation trajectory that can be subclassified into four progressive subtypes. (bvsalud.org)

Sharpe, A. H. & Pauken, K. E. The diverse functions of the PD1 inhibitory pathway. (nature.com)
Also disruption of this signaling pathway may account for the lowered β-cell GIP-R expression and resulting GIP resistance in type 2 diabetes. (diabetesjournals.org)
Passage control and SWCNT-transformed human lung epithelial cells were treated with known inducers of apoptosis via the intrinsic (antimycin A and CDDP) or extrinsic (FasL and TNF-a) pathway and analyzed for apoptosis by DNA fragmentation, annexin-V expression, and caspase activation assays. (cdc.gov)
The SWCNT-transformed cells exhibited defective death receptor pathway in association with cellular FLICE-inhibitory protein (c-FLIP) overexpression. (cdc.gov)
This study is the first to demonstrate carbon nanotube -induced defective death receptor pathway and the role of c-FLIP in the process. (cdc.gov)

The subsequent recovery of these receptors in vivo and in vitro may be due to the binding of 'fluid-phase' Fcγ-receptors found in normal human serum. (karger.com)
It was verified that co-expression of CD80 disrupted the binding of sEV PD-L1 to its receptor PD-1 on T cells and attenuated the immunosuppression mediated by sEV PD-L1 both in vitro and in vivo. (nature.com)

Toll-like receptors (TLRs) play a key role in innate immune responses and inflammation. (diabetesjournals.org)

In the present experiments, we quantified receptor autoradiographic binding data for GABAA and GABAB, AMPA, and NMDA receptors in the primary somatosensory cortices of adult squirrel monkeys at four postnerve injury survival durations: immediately (1-3 hours), 3 days, 1 month, and 2 months. (nih.gov)
GABAB receptor binding is decreased in layer IV by 1 month after nerve injury, while binding for AMPA receptors is increased in layer IV by this time. (nih.gov)

A prominent mechanism of acquired resistance to BRAF inhibitors in BRAF (V600) -mutant melanoma is associated with the upregulation of receptor tyrosine kinases. (bvsalud.org)

The 5-HT 1B and 5-HT 1D receptor antagonist, GR127935, could reverse the inhibitory effect of Lasmiditan (a selective 5-HT 1F receptor agonist) on CGRP release in the soma-rich TG but not in soma-poor TG or dura mater. (lu.se)

A dysregulated immune system (including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. (wjgnet.com)

These studies demonstrate that beta(1)-adrenergic receptors play a dominant role in the murine vascular system to mediate vasodilation. (meltingpointathens.com)
In view of the accelerated vascular disease observed in patients with diabetes, and the enhanced expression of VCAM-1 in diabetic rabbits, we examined whether irreversible advanced glycation endproducts (AGEs), could mediate VCAM-1 expression by interacting with their endothelial cell receptor (receptor for AGE, RAGE). (jci.org)

There are many classes of G α subunits: G sα (G stimulatory), G iα (G inhibitory), G oα (G other), G q/11α, and G 12/13α are some examples. (meltingpointathens.com)
At least 2 weeks or 5 half-lives, whichever is shorter, must have elapsed since any prior systemic therapy at the time the subject is planned for leukapheresis, except for systemic inhibitory/stimulatory immune checkpoint therapy, which requires 5 half-lives. (who.int)

Background: 5-Hydroxytryptamine (5-HT) receptors 1B, 1D and 1F have key roles in migraine pharmacotherapy. (lu.se)
Natural killer (NK) cells, with inhibitory and activating receptors, play unique roles in AXR by promoting graft rejection or tolerance. (iupui.edu)
Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma. (nih.gov)

High glucose increased TLR expression, myeloid differentiation factor 88, interleukin-1 receptor-associated kinase-1, and nuclear factor-κB (NF-κB) p65-dependent activation in THP-1 cells. (diabetesjournals.org)
The present study examined the ability of the tumor cell surface receptor, interleukin (IL)‑13 receptor α2 (IL13Rα2)‑ and epidermal growth factor receptor (EGFR)‑targeted pseudomonas exotoxin (PE) to sensitize TRAIL‑resistant GBM cells and assessed the dual effects of interleukin 13‑PE (IL13‑PE) or EGFR nanobody‑PE (ENb‑PE) and TRAIL for the treatment of a broad range of brain tumors with a distinct TRAIL therapeutic response. (spandidos-publications.com)
Absence of interleukin-1 receptor 1 increases excitatory and inhibitory scaffolding protein expression and microglial activation in the adult mouse hippocampus. (lu.se)

Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid incretin hormone that binds to a seven-transmembrane G-protein-coupled receptor (GIP-R) that is expressed in numerous tissues including islet β-cells and α-cells ( 1 , 2 ). (diabetesjournals.org)
Epinephrine binds both α and β adrenergic receptors to cause vasoconstriction and vasodilation. (meltingpointathens.com)

Data from a radiolabeled ligand‑binding assay indicated that LGP exhibited apparent competing effects on thromboxane receptor (TP) and P2Y12 receptors. (spandidos-publications.com)
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and a member of the basic helix-loop-helix PER/ARNT/SIM family of chemosensors and developmental regulators. (oregonstate.edu)
In contrast, the potent AhR agonist 2,3,7,8-Tetrachlorodibenzo-p-dioxin had no effect on TGF-β1 expression, indicating the ligand specificity of AhR activation. (oregonstate.edu)
For example, Paget's cells release soluble receptor activator of nuclear factor kappa-B ligand (sRANKL) into the tumor microenvironment, stimulating RANK + TAMs to produce CCL17, which recruits Tregs into the lesional skin of patients with extramammary Paget's disease (EMPD) ( 11 , 17 ). (iiarjournals.org)

Fig. 6: Co-expression of CD80 suppressed PD-L1-positive sEV-induced immunosuppression and tumor progression in melanoma model. (nature.com)
Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). (nih.gov)
A common genetic variation of melanoma inhibitory activity-2 labels a subtype of pancreatic adenocarcinoma with high endoplasmic reticulum stress levels. (nih.gov)
The X protein of hepatitis B virus activates hepatoma cell proliferation through repressing melanoma inhibitory activity 2 gene. (nih.gov)

Here, we investigated the biological mechanisms that regulate neutrophil CXCR2 expression after CDI, and the influence of host genetics on this process. (frontiersin.org)
Through various cellular signaling mechanisms, hormones and medications activate the beta-1 receptor. (meltingpointathens.com)
This finding is consistent with the idea that the earliest reorganizational changes are due to a relaxation in tonic inhibitory mechanisms permitting the expression of formerly subthreshold receptive fields. (nih.gov)

Looking closer at this relationship, we discovered that histamine, through its receptor HRH1, can promote cancer cell immune evasion and resistance to immunotherapy. (newswise.com)
Using The Cancer Genome Atlas and other publicly available patient cancer data, the team also discovered that high expression of HRH1 in tumors was correlated with markers of T cell dysfunction, poor responses to checkpoint inhibitors and poorer survival outcomes. (newswise.com)
Blocking HRH1 activity reduced the membrane localization of VISTA, an inhibitory receptor known to suppress T cell activation. (newswise.com)
In vivo verification was shown by a 70% reduction in GIP-R protein expression in islets from PANC PPARγ −/− mice and a twofold increase in islets of 14-day post-60% Px Sprague-Dawley rats that hyperexpress β-cell PPARγ. (diabetesjournals.org)
Receptor-activated G proteins are bound to the inner surface of the cell membrane. (meltingpointathens.com)
Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-β1. (oregonstate.edu)
We found that flutamide inhibited the growth of several cancer cell lines independent of AR status, and that suppression of AhR expression reversed the anti-proliferative effects of flutamide. (oregonstate.edu)
In addition to cell surface receptors, intracellular drug targets such as the phosphodiesterases (PDEs) are known to impact signaling pathways that affect long-term memory formation and working memory. (sri.com)
Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. (jci.org)
The proportion of NK T cells expressing Ly-49C/I is higher (2-5 fold) in thymus than in liver (immature and mature NK T cells, respectively), and there is evidence that the down-regulation of Ly-49 receptor expression is necessary for normal NK T-cell development. (bdbiosciences.com)
The Ly-49 family of NK-cell receptors are disulfide-linked type-II transmembrane protein homodimers with extracellular carbohydrate-recognition domains (CRD) that bind to MHC class I alloantigens. (bdbiosciences.com)
The Ly-49 family members are expressed independently, such that an individual NK or T cell may display more than one class of Ly-49 receptor homodimers. (bdbiosciences.com)
Characterization of human NK cells using the NK cell inhibitory receptor panel. (bdbiosciences.com)
Mainz/Martinsried/Munich, Germany, 21 February 2022 - BioNTech SE (Nasdaq: BNTX, "BioNTech") and Medigene AG (FSE: MDG1, Prime Standard, "Medigene"), a clinical-stage immuno-oncology company focusing on the development of T cell immunotherapies, today announced that they have entered a multi-target research collaboration to develop T cell receptor (TCR) based immunotherapies against cancer. (pressetext.com)
NK cell degranulation was accessed by the percentage of CD107a expression in the CD3-CD56+population. (iupui.edu)
Conclusion and Impacts: Co-expression of HLA-E and HLA-G in 5GKO pECs significantly reduced human NK cell degranulation, compared to 5GKO.HLA-E, 5GKO.HLA-G, and 5GKO pECs. (iupui.edu)

LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. (wikipedia.org)
LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, glycoprotein 130 (IL6ST, gp130). (wikipedia.org)
The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase. (nih.gov)

The mechanistic data demonstrated that HRH1 acts in TAMs to drive cells toward an immune-suppressive M2-like state and to increase membrane expression of the inhibitory checkpoint VISTA, ultimately leading to dysfunctional T cells and a suppressed anti-tumor response. (newswise.com)

Thus, in the present study, we examined TLR2 and TLR4 mRNA and protein expression and mechanism of their induction in monocytic cells under high-glucose conditions. (diabetesjournals.org)

Carbon nanotube s induce apoptosis resistance of human lung epithelial cells through FLICE-inhibitory protein. (cdc.gov)

The leukemia inhibitory factor (LIF) is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. (wikipedia.org)
A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. (cdc.gov)
However, PD-L1-positive sEVs derived from immune cells did not exert immunosuppressive functions due to the co-expression of CD80. (nature.com)
Our studies have shown physiologic and pharmacologic regulation of GIP-R expression in β-cells by PPARγ signaling. (diabetesjournals.org)
We have recently found abundant and selective expression of Adamdec1 in colonic mucosal PDGFRalpha+ cells. (stanford.edu)
We show that mouse intratumor T cells exhibit increased expression of inhibitory receptors at the protein level. (curie.fr)
Small inhibitory RNA to p47Phox in THP-1 cells abrogated high-glucose-induced TLR2 and TLR4 expression. (diabetesjournals.org)
Exposure of cultured human ECs to AGEs induced expression of VCAM-1, increased adhesivity of the monolayer for Molt-4 cells, and was associated with increased levels of VCAM-1 transcripts. (jci.org)
Two-color analysis of the expression of Ly-49C/I on splenic NK cells. (bdbiosciences.com)
LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells. (bvsalud.org)
[ 5 ] The Fc region of IgG facilitates interaction with and signaling through Fc receptors on phagocytes, B cells, and other cells and with Fc-binding plasma proteins (eg, components of the complement system). (medscape.com)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)

Selective agonists targeting these receptors, such as triptans and ditans, are effective in aborting acute migraine attacks and inhibit the in vivo release of calcitonin gene-related peptide (CGRP) in human and animal models. (lu.se)
The functional role of these receptors was examined ex vivo with a capsaicin/potassium induced 5-HT and CGRP release. (lu.se)

The inhibitory effect of anti-RAGE IgG, a truncated form of the receptor (soluble RAGE) or N-acetylcysteine on VCAM-1 expression indicated that AGE-RAGE-induced oxidant stress was central to VCAM-1 induction. (jci.org)

Cardiac malondialdehyde, H2O2 generation in heart tissues, mRNA expression and omega-6 PUFA are both required steroids in a given cycle. (showyou.com)

In our previous study, several compounds extracted from this herb, including luteolin‑4'‑O‑β‑D‑glucopyranoside (LGP), were revealed to exert inhibitory effects on adenosine diphosphate (ADP)‑induced platelet aggregation. (spandidos-publications.com)

The study aimed to examine the localization, genetic expression and functional aspects of 5- HT 1B/1D/1F receptors in the trigeminal system in order to further understand the molecular sites of action of triptans (5-HT 1B/1D ) and ditans (5-HT 1F ). (lu.se)

Targeted activation of the beta-1 receptor increases heart rate, renin release, and lipolysis. (meltingpointathens.com)
Alpha1 adrenergic receptors are a type of adrenergic receptors that play a central role in the sympathetic nervous system-the part of the nervous system that increases heart rate, blood pressure, breathing rate, and eye pupil size. (meltingpointathens.com)
MeCP2 is a transcriptional regulatory protein, and in its absence, large numbers of genes exhibit abnormal increases or decreases in expression. (jneurosci.org)

Co-expression of CD80 on PD-L1-positive sEVs was examined to evaluate the immunosuppressive and tumor-promotive effects. (nature.com)

Methods: Utilizing immunohistochemistry, the localization of 5-HT and of 5-HT 1B/1D/1F receptors was examined in rat. (lu.se)
Methods: Utilizing immunohistochemistry, the localization of 5-HT and of 5-HT 1B/1D/1F receptors was examined in rat trigeminal ganglion (TG) and combined with quantitative polymerase chain reaction to quantify the level of expression for 5-HT 1B/1D/1F receptors in the TG. (lu.se)

Background: The beta-adrenergic receptors of the myocardium play an important role in the regulation of heart function. (meltingpointathens.com)

It was also found that LGP exhibited marked inhibitory effects on the activation of αIIbβ3 integrin, the secretion of serotonin from granules, and the synthesis of thromboxane A2. (spandidos-publications.com)

Excessive nervous system excitability during periods of abstinence from alcohol is related to the effect of alcohol on the number and function of brain receptors. (medscape.com)
The beta 1 receptor is vital for the normal physiological function of the sympathetic nervous system. (meltingpointathens.com)

What is the mechanism of action of the beta1 receptor? (meltingpointathens.com)

Anatomy31

Organisms9

Diseases7

Chemicals and Drugs136

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes48

Disciplines and Occupations1

Information Science3

Cytokines7

Macrophages8

Growth inhibitory effects2

Macrophage2

Inhibition5

Mitogen-activa1

GABA6

Antigen3

Blockade1

Neurons3

Human monocytes1

Excitatory effects1

Molecules2

Induces2

Peroxisome2

Androgen receptor3

Postsynaptic1

Phosphorylation1

Neuronal1

Gene expression8

Pathway5

Vitro2

Immune responses1

AMPA2

Tyrosine1

Antagonist1

Ligands1

Mediate2

Stimulatory2

Roles3

Interleukin3

Binds2

Ligand4

Melanoma4

Mechanisms3

Cell16

Subunit3

Checkpoint1

Protein expression1

Induce1

Cells12

Vivo2

Soluble1

MRNA expression1

Exert1

Functional1

Increases3

Tumor1

Localization2

Regulation1

Activation1

Function2

Mechanism of act1