• This Human Neuronal apoptosis inhibitory protein (NAIP) ELISA Kit employs a two-site sandwich ELISA to quantitate NAIP in samples. (abbkine.com)
  • Human Neuronal apoptosis inhibitory protein (NAIP) ELISA Kit has high sensitivity and excellent specificity for detection of Human NAIP. (abbkine.com)
  • Neuronal apoptosis inhibitory protein encoded by NAIP contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. (abbkine.com)
  • Here, we show for the first time that in the HCN2 channel cGMP can also exert an inhibitory effect on gating via cGMP-dependent protein kinase II (cGKII)-mediated phosphorylation. (cipsm.de)
  • The inhibitory cGMP effect can be either abolished by mutation of the phosphorylation site in HCN2 or by impairing the catalytic domain of cGKII. (cipsm.de)
  • Thus, the dephosphorylation of target proteins by PP4 is equally important in DDR as much as phosphorylation by kinases. (molcells.org)
  • Fig. 1: Serum mitogen-induced phosphorylation of PI3KC2-β induces complex formation with 14-3-3 proteins. (nature.com)
  • Fig. 5: mTORC2 signalling triggers PKN2 activation to control PI3KC2-β phosphorylation and sequestration with 14-3-3 proteins. (nature.com)
  • Stimulation of A1.Rs with 10 µM CPA increased the phosphorylation of protein kinase B at ser473, which was abolished by the PI3K inhibitor LY294002 (20 µM), thereby confirming that PI3K activity is upregulated in response to A1.R stimulation by CPA in ARVM. (kingston.ac.uk)
  • In mouse hepatocytes, p38γ induces proliferation after partial hepatectomy by promoting the phosphorylation of retinoblastoma tumour suppressor protein at known CDK target residues. (nature.com)
  • Nanoparticle inhalation enhances cardiac protein phosphorylation and neurotransmitter synthesis in the nodose ganglia of rats. (cdc.gov)
  • In this study, we assess on a large scale the possibility of deriving self-inhibitory peptides from protein domains with globular architectures. (huji.ac.il)
  • The aim of this study was to evaluate the role of mitogen-activated protein kinase (MAPK) family in serum-induced secretion of LIF and IL-6 by bone marrow stromal cells. (unboundmedicine.com)
  • 3: Both PD98059 (MAPK/ERK kinase inhibitor) and SB203580 (p38 MAPK inhibitor) attenuated FCS-induced LIF protein production and gene expression. (unboundmedicine.com)
  • TY - JOUR T1 - Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. (unboundmedicine.com)
  • We demonstrate that protein kinase N (PKN) facilitates mTORC1 signalling by repressing PI3KC2-β-mediated phosphatidylinositol-3,4-bisphosphate synthesis downstream of mTORC2. (nature.com)
  • Receptor-interacting protein kinase 1 (RIPK1) is a key component of the tumor necrosis factor (TNF) receptor signaling complex that regulates both pro- and anti-apoptotic signaling. (mdpi.com)
  • The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin protein complex 1 . (nature.com)
  • The protein interaction landscape of the human CMGC kinase group. (nature.com)
  • The NEMO protein is required for the activation of the kinase complex. (medscape.com)
  • The compound is an inhibitor of mammalian protein kinase and has been applied topically for the treatment of skin metastasis showing good local tolerability [5]. (who.int)
  • The toxicity data of protein kinase inhibitors in humans is also well established [5]. (who.int)
  • Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. (lu.se)
  • Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). (nih.gov)
  • A common genetic variation of melanoma inhibitory activity-2 labels a subtype of pancreatic adenocarcinoma with high endoplasmic reticulum stress levels. (nih.gov)
  • Protumoral roles of melanoma inhibitory activity 2 in oral squamous cell carcinoma. (nih.gov)
  • The X protein of hepatitis B virus activates hepatoma cell proliferation through repressing melanoma inhibitory activity 2 gene. (nih.gov)
  • Orthologous to human GIPR (gastric inhibitory polypeptide receptor). (nih.gov)
  • Because the activation of the retinoic acid receptor has an inhibitory action on Cushing's disease progression, we analyzed the putative interaction of these two pathways. (unisr.it)
  • Interestingly, U-46619, a G protein-coupled receptor agonist, caused a significant increase in the acidic spot, suggesting that it may represent a phosphorylated form of PHI-1. (uky.edu)
  • A1.R-induced PP2AC translocation to the particulate fraction was abrogated by adenoviral expression of the alpha subunit (Gαt1) coupled to the transducin G-protein coupled receptor. (kingston.ac.uk)
  • We have these molecules that try to block a protein from its receptor, prevent a protein from cleaving another protein, or increase the rate that a protein is broken down. (medscape.com)
  • That's one of the key features of siRNA - you don't have to find a chemical that binds strongly to some protein receptor, and worry about the off-target effects and all that nonsense. (medscape.com)
  • We here demonstrate for the first time that GDNF enhances GABAergic inhibitory drive onto mouse pyramidal neurons by modulating postsynaptic GABAA receptors, particularly in perisomatic inhibitory synapses, by GFRα1 mediated activation of the Ret receptor pathway. (lu.se)
  • The binding of SARS-CoV spike (S) protein to cellular angiotensin-converting enzyme 2 (ACE2) is the first step in SARS-CoV infection. (scienceopen.com)
  • SP-4 (residues 192-203), SP-8 (residues 483-494), and SP-10 (residues 668-679) significantly blocked the interaction between S protein and ACE2 by biotinylated enzyme-linked immunosorbent assay, with IC 50 values of 4.30 ± 2.18, 6.99 ± 0.71, and 1.88 ± 0.52 nmol, respectively. (scienceopen.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Virus Inhibitory Protein (Viperin) in tissue homogenates, cell lysates and other biological fluids. (orbitalbiosciences.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Virus Inhibitory Protein (Viperin) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (orbitalbiosciences.com)
  • Angiotensin-I converting enzyme (ACE) inhibitory peptides drew wide attention in the food industry because of their natural reliability, non-toxicity, and safety. (bioinfor.com)
  • Angiotensin-converting enzyme inhibitory (ACE-I) activity as affected by Lactobacillus helveticus strains (881315, 881188, 880474, and 880953), and supplementation with a proteolytic enzyme was studied. (uaeu.ac.ae)
  • According first data from re-striction enzyme digestion experiments and DNA sequence analysis a putative inhibitory protein DMIF2, homologous to DMIF1, is presumed. (tum.de)
  • The PDE6H gene provides instructions for making one part (called the inhibitory gamma subunit) of an enzyme called cone-specific phosphodiesterase. (medlineplus.gov)
  • Here, we used a genomics/proteomics approach (including immunoblot experiments from pigs infected with T. suis ) to prioritize putative immunogenic excretory/secretory (E/S) proteins conserved across and specific to several gastrointestinal (GI) parasitic nematode species. (frontiersin.org)
  • An antibody-protein array of putative immunogenic proteins was developed from a combined bioinformatic, experimental, and literature-based prioritization of homologous parasite proteins. (frontiersin.org)
  • 4: Expression of a dominant-negative mutant form of JNK1 that blocked FCS-induced JNK activity had no effect on protein production and gene expression of these cytokines. (unboundmedicine.com)
  • Melanoma-derived growth regulatory protein is a protein that in humans is encoded by the MIA gene. (wikipedia.org)
  • The T4 Gene 32 Protein is intended for molecular biology applications. (qiagen.com)
  • The native Gene 32 Protein from bacteriophage T4 (T4gp32) is a single-stranded DNA binding protein that is required for T4 DNA replication, recombination and repair. (qiagen.com)
  • The T4 Gene 32 Protein has exhibited an ability to enhance the performance of several DNA synthesis-related activities in secondary-structure rich regions, including PCR amplification and DNA sequencing. (qiagen.com)
  • The T4 Gene 32 Protein also stimulates the rate of synthesis of T4 DNA Polymerase on primed-single-stranded substrates showing a 5-10-fold increase in synthesis rate. (qiagen.com)
  • The T4 Gene 32 Protein is a single-stranded nucleic acid binding protein that has the function of stabilizing single-stranded regions of DNA. (qiagen.com)
  • The ability of T4 Gene 32 Protein to enhance the performance of several DNA synthesis-related activities is based on its essential function in the replication of bacteriophage T4. (qiagen.com)
  • Instructions for using T4 Gene 32 Protein are provided in the corresponding kit protocol in the resources below. (qiagen.com)
  • DNA binding of single stranded DNA by T4 Gene 32 Protein was measured using a gel shift assay with a single-stranded, fluorescently labeled oligonucleotide. (qiagen.com)
  • Protein concentration (OD 280 ) of T4 Gene 32 Protein was determined by OD 280 absorbance. (qiagen.com)
  • Tyrosine sulfation is an important post-translational modification that enhances the inhibitory activity of hirudin. (ccspublishing.org.cn)
  • Here, after research involving Sprague Dawley rats, we reported that spinal nerve ligation (SNL), in addition to causing allodynia, enhances the Rab3-interactive molecule-1α (RIM1α), a major active zone protein presumed to regulate neural plasticity, specifically in the synaptic plasma membranes (SPMs) of the ipsilateral dorsal horn. (jneurosci.org)
  • Thus, E2 acts on osteoblastic cells to increase availability of inhibitory IGFBP-4, by both increasing its production and decreasing its degradation, which may oppose the mitogenic effect of the IGFs on osteoblastic cells. (elsevierpure.com)
  • SIGNIFICANCE STATEMENT Ubiquitination is a well known process required for protein degradation. (jneurosci.org)
  • p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation. (nature.com)
  • Notably, IAIPPGIPYW exhibited the most potent DPP-IVi activity (half maximal inhibitory concentration ( IC50 ) 12.43 µM). (bvsalud.org)
  • Studies investigating pain pathology have demonstrated that ubiquitination contributes to chronic pain by regulating the turnover of synaptic proteins. (jneurosci.org)
  • An inhibitor of apoptosis protein that was initially identified during analysis of CHROMOSOME DELETIONS associated with SPINAL MUSCULAR ATROPHY. (bvsalud.org)
  • Reconstituted skim milk (12% RSM) or whey protein concentrate (4% WPC), with and without Flavourzyme® (0.14% w/w), were fermented with 4 different L. helveticus strains at 37 °C for 0, 4, 8, and 12 h. (uaeu.ac.ae)
  • Both strains produced inhibitory proteins of approximately 10 kD, possibly representing bacteriocins. (usda.gov)
  • Using pulse-chase experiments the present study shows that BFA (1 microgram/ml) inhibits basal and CCK-stimulated protein secretion in isolated pancreatic acinar cells by 65 ± 6% and 84 ± 5%, respectively. (mpg.de)
  • In isolated permeabilized cells higher concentrations of BFA (30 micrograms/ml) were necessary to obtain inhibition of protein secretion. (mpg.de)
  • In parallel experiments protein secretion was stimulated by GTP (1 mM). (mpg.de)
  • BFA had no inhibitory effect on protein secretion in the presence of GTP, indicating that BFA might act on a GTP-binding protein. (mpg.de)
  • BMP-4 treatment of AtT-20 mouse corticotrophinoma cells has an inhibitory effect on ACTH secretion and cell proliferation. (unisr.it)
  • In this study, chickpea protein hydrolysates (CPHs) obtained through Neutrase hydrolysis for 60 min (CPHs-Pro-60) exhibited the highest DPP-IVi activity. (bvsalud.org)
  • The ACE inhibitory peptides in the mulberry leaf protein hydrolysates were purified by ultrafiltration and gel filtration, aiming to obtain the highest active component. (bioinfor.com)
  • Based on the single-factor test, the Plackett-Burman test and response surface test were used to determine the key factors affecting the ACE inhibition rate in mulberry leaf protein hydrolysate and the optimum conditions of enzymatic hydrolysis. (bioinfor.com)
  • 0.70 mg/mL) demonstrated high ACE-inhibitory activity with competitive inhibition mode. (bioinfor.com)
  • The enzymatic activity of the type 2A protein phosphatase (PP2A) holoenzyme, a major serine/threonine phosphatase in the heart, is conferred by its catalytic subunit (PP2AC). (kingston.ac.uk)
  • The identified mutation replaces one protein building block (amino acid) near the beginning of the inhibitory gamma subunit with a signal to stop protein production. (medlineplus.gov)
  • This change prevents the production of any functional inhibitory gamma subunit, which interferes with the normal function of cone-specific phosphodiesterase. (medlineplus.gov)
  • Protein phosphatase 4 (PP4) is a crucial protein complex that plays an important role in DNA damage response (DDR), including DNA repair, cell cycle arrest and apoptosis. (molcells.org)
  • Phosphatase holoenzyme inhibitor (PHI)-1 is one of the newest members of the family of protein phosphatase inhibitor proteins. (uky.edu)
  • The current research emphasized on exploring the Protein-Tyrosine Phosphatase-1 B (PTP-1B) inhibitory potentials of hydroxylated chalcone derivatives against PDB ID: 4I8N (PTP-1B in complex with an inhibitor [(4-{(2s)-2-(1,3-benzoxazol-2-yl)-2-[(4-fluorophenyl)sulfamoyl]ethyl}phenyl)amino](oxo)acetic acid) by molecular docking approach using the iGEMDOCK (Genetic Evolutionary Method for Molecular Docking) software. (stmjournals.in)
  • Mahapatra DK, Bharti SK, Asati V. Recent perspectives of chalcone based molecules as protein tyrosine phosphatase 1B (PTP-1B) inhibitors. (stmjournals.in)
  • Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades. (stmjournals.in)
  • A cocktail of five recombinant proteins optimized for conserved GI nematode targets was used immunize pigs and test for active antibody responses in both the serum and intestinal ileal fluid of immunized pigs. (frontiersin.org)
  • The DMIF1 protein found in Dictyostelium is homologous to members of the F1F0-ATPase inhibitory protein family. (tum.de)
  • Screening the array with sera and ileal fluid samples from immunized pigs suggested cross-reactivity among homologous proteins and a general activation of immunity. (frontiersin.org)
  • The nucleocapsid (N) protein of SARS coronavirus (SARS-CoV) is a major structural component of virions, which appears to be a multifunctional protein involved in viral RNA replication and translation. (academicjournals.org)
  • Severe acute respiratory syndrome (SARS) coronavirus, nucleocapsid protein, macrophage migration inhibitory factor protein, yeast two-hybrid. (academicjournals.org)
  • After cleaning three times using the lysis buffer, destined proteins had been eluted by incubation with FLAG peptide (250 g/ml, for fSUR1 test) or HA peptide (10 g/ml, for HA-Kir6.2 sample) at space temperature for 30 min. (thetechnoant.info)
  • The precipitate was cleaned 3 x in the lysis buffer, as well as the proteins had been eluted with FLAG-peptide. (thetechnoant.info)
  • To identify cellular proteins that interact with the N protein and to elucidate the possible involvement of N protein in SARS-Cov replication and translation, a human lung cDNA library was screened using a yeast two-hybrid system assay. (academicjournals.org)
  • As resistance against drugs targeting viral proteins emerges rapidly, we assessed the antiviral activity of already approved drugs that target cellular proteins involved in the viral life cycle and were orally bioavailable. (frontiersin.org)
  • Carbon nanotube s induce apoptosis resistance through FLICE-inhibitory protein. (cdc.gov)
  • Such inhibitory peptides would inhibit interactions of their origin domain by mimicking its mode of binding to cognate partners, and could serve as promising leads for rational design of inhibitory drugs. (huji.ac.il)
  • These results indicated that the ACE-inhibiting peptides from mulberry leaf protein hydrolyzed (FHMP) had the potential activities to inhibit ACE and could be used as functional food or drugs to inhibit ACE. (bioinfor.com)
  • The results show that this population of commissural interneurons includes both excitatory and inhibitory cells that may excite or inhibit contralateral motoneurons directly. (nih.gov)
  • To the best of our knowledge, this is the first report that SARS-N protein interacts with the MIF within host cells, which enhance our understanding of the molecular mechanisms of SARS replication. (academicjournals.org)
  • This binding puts these ssDNA sequences into optimal conformations for interacting with DNA polymerases and other replication proteins. (qiagen.com)
  • Proteins that activated immunity are potential antigens for immunization and the multi-omics phylum-spanning prioritization database that was created is a valuable resource for identifying target proteins in a wide array of different parasitic nematodes. (frontiersin.org)
  • Some food protein -derived peptides are thought to have DPP-IV inhibitory (DPP-IVi) activity. (bvsalud.org)
  • Double-stranded exonuclease activity was determined in a 50 μL reaction containing a radiolabeled double-stranded DNA substrate and 10 μL of protein solution incubated for 4 hours at 37°C. (qiagen.com)
  • Double-stranded endonuclease activity was determined in a 50 μL reaction containing 0.5 μg of plasmid DNA and 10 μL of protein solution incubated for 4 hours at 37°C. (qiagen.com)
  • The chief inhibitory neurons of the mammalian brain, GABAergic neurons, are comprised of a myriad of diverse neuronal subtypes. (jneurosci.org)
  • To facilitate the study of these neurons, transgenic mice were generated that express enhanced green fluorescent protein (EGFP) in subpopulations of GABAergic neurons. (jneurosci.org)
  • GABAergic neurons, the chief inhibitory neurons of the mammalian brain, are comprised of diverse neuronal subtypes distinguishable on the bases of location in given brain regions, microanatomical features, including dendritic arborizations and axonal projections, expression of specific macromolecules, and neurophysiological properties. (jneurosci.org)
  • These data indicate that GDNF may exert its seizure-suppressant action by enhancing GABAergic inhibitory transmission in the hippocampal network, thus counteracting the increased excitability of the epileptic brain. (lu.se)
  • In this study, we expressed and characterized a new serine protease inhibitory protein (PI-QT) from the metagenome of sponge-associated microorganisms in Escherichia coli . (bmrat.org)
  • To improve bacteriocin-like inhibitory substance (BLIS) production by Pediococcus pentosaceus ATCC 43200, the influence of pH as well as the addition of sugars-either prebiotic (inulin) or not (sucrose)-on its metabolism were investigated. (springer.com)
  • For every major excitatory pathway of the brain, there appears to be associated inhibitory pathways ( Buzsáki and Chrobak, 1995 ). (jneurosci.org)
  • Brefeldin A (BFA) causes rapid redistribution of Golgi proteins into the endoplasmic reticulum (ER), leaving no definable Golgi-apparatus, and blocks transport of proteins from the ER to distal secretory compartments of the cell. (mpg.de)
  • The enhanced anti-cancer effect of the combined use of dipyridamole with aspirin was found to rely on the induction of an overwhelmed endoplasmic reticulum (ER) stress and subsequent pro-apoptotic unfolded protein response (UPR), which was different from the anti-platelet effect. (lu.se)
  • Nevertheless, the mechanism for ubiquitination-regulated turnover of presynaptic active zone proteins in the progression of spinal plasticity-associated neuropathic pain remains unclear. (jneurosci.org)
  • In this study, we found that RING finger protein 4 (RNF4), a RING finger E3 ubiquitin ligase, is required for the RIPK1 autophosphorylation and subsequent cell death. (mdpi.com)
  • Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins. (lu.se)
  • Longman, Michael R. , Ranieri, Antonella , Avkiran, Metin and Snabaitis, Andrew K. (2014) Regulation of PP2AC carboxylmethylation and cellular localisation by inhibitory Class G-Protein coupled receptors in cardiomyocytes. (kingston.ac.uk)
  • Bhavya M, Ramya M, Nagarjun N, Amresh N, Sathyamurthy B. Docking study of selected Vitis vinifera seeds constituents on dengue viral proteins: An in silico approach. (stmjournals.in)
  • Eluted protein had been separated by SDS-polyacrylamide gel electrophoresis (Web page) and used in nitrocellulose membrane. (thetechnoant.info)
  • Structure of a soluble, glycosylated form of the human complement regulatory protein CD59. (lu.se)
  • Lundberg, A. S. & Weinberg, R. A. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. (nature.com)
  • In conclusion, this is the first report of small peptides designed to disrupt the binding of SARS-CoV S protein to ACE2. (scienceopen.com)
  • A) ELISA against SARS-CoV-2 S1, RBD, and N proteins, and VN analysis with SARS-CoV-2 pseudotyped virus. (cdc.gov)
  • This sheds light upon the role of the Smad7 protein in this system. (lu.se)
  • However, how N protein interacts with host protein remains largely elusive. (academicjournals.org)
  • An inhibitory molecule of the IKB family interacts with NF-KB to sequester it in the cytoplasm. (medscape.com)
  • By contrast, the inhibitory effect is preserved in a HCN2 mutant carrying a CNBD deficient for cGMP binding. (cipsm.de)
  • Investigating the effect of BFA on small molecular weight GTP-binding proteins we observed that [alpha- 32 P]GTP binding to a 21 kDa protein in a subcellular fraction enriched in ER was increased in the presence of BFA. (mpg.de)
  • Inhibitory effect of soyabean protein versus casein on apparent absorption of magnesium in rats is due to greater excretion of endogenous magnesium. (wur.nl)
  • A similar inhibitory effect on A1.R-induced PP2AC translocation was also seen with LY294002 (20 µM). (kingston.ac.uk)
  • RESULTS: We found that dipyridamole combined with aspirin had a better inhibitory effect on CRC than either monotherapy alone. (lu.se)
  • For our large-scale analysis, we analyzed short linear segments that were cut out of protein interfaces in silico in complex structures of protein-protein docking Benchmark 3.0 and CAPRI targets from rounds 1-19. (huji.ac.il)
  • Altogether, we provide an elaborate framework for the in silico selection of candidate inhibitory molecules for protein-protein interactions. (huji.ac.il)
  • Sushmitha HS, Sathyamurthy B. In Silico drug designing studies on Dengue NS5 Protein. (stmjournals.in)
  • NEMO consists of 10 exons, and most mutations cause deletions of exons 4-10, resulting in a truncated protein. (medscape.com)
  • Hypomorphic mutations may impair but not abolish NEMO protein function. (medscape.com)
  • 1: In the haematopoietic microenvironment, bone marrow stromal cells play an important role in regulating haematopoiesis by expressing various cytokines, including leukaemia inhibitory factor (LIF) and interleukin-6 (IL-6). (unboundmedicine.com)
  • In this study, we report that bone morphogenetic protein-4 (BMP-4) is expressed in the corticotrophs of human normal adenohypophysis and its expression is reduced in corticotrophinomas obtained from Cushing's patients compared with the normal pituitary. (unisr.it)
  • Potential mechanism of estrogen-mediated decrease in bone formation: estrogen increases production of inhibitory insulin-like growth factor-binding protein-4. (elsevierpure.com)
  • Dive into the research topics of 'Potential mechanism of estrogen-mediated decrease in bone formation: estrogen increases production of inhibitory insulin-like growth factor-binding protein-4. (elsevierpure.com)
  • SP-10 blocked both binding of the S protein and infectivity of S protein-pseudotyped retrovirus to Vero E6 cells. (scienceopen.com)
  • Violin plots show distribution of expression levels for migration and invasion-inhibitory protein (SMED30011486) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
  • Expression of migration and invasion-inhibitory protein (SMED30011486) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
  • Violin plots show distribution of expression levels for migration and invasion-inhibitory protein (SMED30011486) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
  • We conclude that this 21 kDa and possibly also other GTP-binding proteins may be the molecular target of Brefeldin A in pancreatic acinar cells. (mpg.de)
  • AtT-20 cells stably transfected with a dominant-negative form of the BMP-4 signal cotransducer Smad-4 or the BMP-4 inhibitor noggin have increased tumorigenicity in nude mice, showing that BMP-4 has an inhibitory role on corticotroph tumorigenesis in vivo. (unisr.it)
  • The MeOH extract of Ganoderma lucidum has an inhibitory action on histamine release from rat mast cells. (researchgate.net)
  • Scientists have discovered that the absence of a specific protein in cells lining the esophagus may cause inflammation and tissue damage in people with eosinophilic esophagitis (EoE). (nih.gov)
  • 0.01) in a dose-dependent fashion but did not alter IGFBP-3 mRNA or protein. (elsevierpure.com)
  • About 20 base pairs long, siRNAs seek out a complementary target mRNA, attached to it, and call in a group of proteins to destroy it. (medscape.com)
  • With the target mRNA gone, no protein can be created. (medscape.com)