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  • peptide
  • It was attempted to achieve this goal by simple modifications of the molecular structure of the known inhibitors, with the focus on modifications of the peptide backbone. (uni-regensburg.de)
  • A peptide sequence containing only AA 28-79 retains substantial Kip1 cyclin A/CDK2 inhibitory activity. (rcsb.org)
  • In this paper, we report lectin pathway-specific short peptide inhibitors developed by phage display against mannose-binding lectin-associated serine proteases (MASPs), MASP-1 and MASP-2. (jimmunol.org)
  • On the basis of the selected peptide sequences, two 14-mer peptides, designated as sunflower MASP inhibitor (SFMI)-1 and SFMI-2, were produced and characterized. (jimmunol.org)
  • Properties of signal peptide-specific systems are highlighted for the development of new therapeutic and antimicrobial applications, as compounds can target signal peptides from either host cells or pathogens and thereby selectively prevent translocation of those specific proteins. (springer.com)
  • Here we show the crystal structures of the prefusion MeV-F alone and in complex with the small compound AS-48 or a fusion inhibitor peptide. (pnas.org)
  • membrane
  • The antiangiogenic properties and neurotrophic activities of the protein are due to peptides derived from the N-terminal region of this protein, while the C-terminal peptides interact with its membrane receptor [ 7 ]. (hindawi.com)
  • It consists of ∼30 proteins (circulating in the serum or membrane bound) forming a sophisticated molecular network capable of recognizing, tagging, and eliminating invading pathogen microorganisms and altered host cells (e.g., apoptotic and necrotic cells) via Ab-independent mechanisms ( 1 ). (jimmunol.org)
  • In general, translocation from the cytosol requires three key steps: (1) substrate recognition and targeting to the destination membrane, while maintaining the substrate in a translocation-competent state (2) translocation across or integration into that membrane, which usually requires energy expenditure in the form of GTP, ATP or proton motive force and (3) release, folding and maturation of the protein substrate. (springer.com)
  • Farnesyltransferase inhibitors (FTIs) were developed to prevent Ras farnesylation and cell membrane association and therefore block aberrant Ras function in cancer. (aspetjournals.org)
  • Since then, p97 has been shown to play a critical role in the degradation of misfolded membrane and secretory proteins ( 4 ) and has also been linked to a broad array of cellular processes, including Golgi membrane reassembly ( 5 ), membrane transport ( 6 ), regulation of myofibril assembly ( 7 ), cell division ( 8 ), formation of protein aggregates ( 9 ), and autophagosome maturation ( 10 , 11 ). (pnas.org)
  • ANV-KPI fusion proteins represent a new class of anticoagulants that specifically target the anionic membrane-associated coagulation enzyme complexes present at sites of thrombogenesis and are potentially useful as antithrombotic agents. (bloodjournal.org)
  • novel
  • In this study, we proposed a novel automated counting method of mammosphere using the National Institute of Standards and Technology (NIST)'s Integrated Colony Enumerator (NICE) with a screening of protein kinase library. (biomedcentral.com)
  • In an effort to identify novel therapeutic targets for autoimmunity and transplant rejection, we developed and performed a large-scale retroviral-based functional screen to select for proteins that inhibit antigen receptor-mediated activation of lymphocytes. (rupress.org)
  • In addition to known regulators of antigen receptor signaling, we identified a novel adaptor protein, SLAP-2 which shares 36% sequence similarity with the known Src-like adaptor protein, SLAP. (rupress.org)
  • A series of novel quinoline-3-carboxamide derivatives 10 - 17 and 23 - 27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. (mdpi.com)
  • responses
  • These TNF-α-mediated responses were abrogated by the inhibitors of NADPH oxidase [apocynin (APO) and diphenyleneiodonium chloride (DPI)], ROS [N-acetyl cysteine, (NAC)], NF-κB (Bay11-7082) and transfection with siRNA of ASK1, p47 phox , TRAF2, NIK, IKKα, IKKβ, or p65. (frontiersin.org)
  • Protein farnesyltransferase inhibitors (FTIs) have shown clinical responses in hematologic malignancies, but the mechanisms are unclear. (aspetjournals.org)
  • IaIp are endogenous proteins that control excessive inflammatory responses to toxins, infectious organisms, and tissue and organ damage. (medindia.net)
  • biological
  • The underlying frameworks of natural products represent the evolutionarily selected fractions of chemical space explored by nature so far and meet the criteria of relevance to nature and biological prevalidation most crucial to inhibitor development. (pnas.org)
  • structural
  • The underlying frameworks of natural products (NPs) provide evolutionarily selected chemical structures encoding the properties required for binding to proteins, and their structural scaffolds represent the biologically relevant and prevalidated fractions of chemical space explored by nature so far ( 7 - 9 ). (pnas.org)
  • complexes
  • The broad range of cellular functions for p97 is thought to derive from its ability to unfold proteins or disassemble protein complexes, but the detailed mechanism of how p97 works and is linked to specific cellular processes remains largely unknown. (pnas.org)