• The enhanced anti-cancer effect of the combined use of dipyridamole with aspirin was found to rely on the induction of an overwhelmed endoplasmic reticulum (ER) stress and subsequent pro-apoptotic unfolded protein response (UPR), which was different from the anti-platelet effect. (lu.se)
  • An increasing number of foods have been reported to have platelet-inhibitory actions, and research with a number of flavanol -rich foods, including, grape juice, cocoa and chocolate , suggests that these foods provide some protection against thrombosis. (raysahelian.com)
  • In comparing aspirin, nonselective nonsteroidal antiinflammatory agents (NSAIDs), and cyclooxygenase (COX)-2 inhibitors, variation in platelet inhibitory effects exists that may be associated with differential risks of cardiovascular (CV) thrombotic events. (qxmd.com)
  • Dose of aspirin platelet cyclo-oxygenase widely used as analgesic ( in headache, dysmenorrhea, neuralgia and myalgia and. (esupport.ws)
  • This study investigated the in vivo effect of alum on platelet aggregation and bleeding time in rabbits. (who.int)
  • contradiction in the mechanism of action of alum, we evaluated the in vivo effect of Alum (aluminium potassium sulfate) is a alum in terms of collagen-induced platelet food additive and traditional remedy used to aggregation and bleeding time. (who.int)
  • Acetaminophen is the medicine most often used for fever and pain relief for people who cannot take aspirin and NSAIDs. (symptoma.com)
  • Aspirin, ibuprofen, naproxen and other NSAIDS help stop pain and fever because they block an enzyme called cyclooxygenase that is critical in creating other chemicals that cause inflammation. (symptoma.com)
  • However, further studies with larger sample sizes, measurements of estrogen levels and its related compounds in different time points accompanied by long-term follow-ups are needed to better elucidate the potential mechanisms by which nonsteroidal anti-inflammatory drugs (NSAIDs) negatively affect breast cancer. (biomedcentral.com)
  • 6]. Exclusionary medications included aspirin at doses greater than 325 mg/day, use of NSAIDs more than three times per week and the use of antioxidant supplements (for example, coenzyme Q10 and alpha-lipoic acid). (irispublishers.com)
  • This analysis provides no evidence for an excess of CV events for rofecoxib relative to either placebo or the non-naproxen NSAIDs that were studied. (qxmd.com)
  • CBDA has selective inhibitory effects on the production of COX-2 enzymes, an effect similar to non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen. (cbdoilreview.org)
  • Our preferred antiplatelet regimen was aspirin (325 mg daily) and clopidogrel (300 mg of loading dose followed by 75 mg daily) starting 5-10 days before the procedure. (ajnr.org)
  • 6 , 7 The combination of aspirin (75-325 mg daily) and clopidogrel (75 mg daily following a loading dose of 300 mg) has become the widely accepted standard regimen for stent-placement procedures. (ajnr.org)
  • So, if you need to control pain or fever for someone who has an Aspirin and Asthma problem, see the individual pages on Tylenol Side Effects and Ibuprofen Side Effects to get more details. (symptoma.com)
  • Such as diclofenac and ibuprofen ), which promote clotting after intensive aspirin therapy or prevent heart attacks strokes! (esupport.ws)
  • Periconceptional NSAID use was defined as use of aspirin, ibuprofen, naproxen, or COX2 inhibitors within the month before or after the last menstrual period. (cdc.gov)
  • This anti-inflammatory property has turned aspirin into a potential drug for inflammation-related cancers such as colorectal cancer (CRC). (lu.se)
  • however, prolonged inflammation is inhibitory for fracture repair. (hindawi.com)
  • Curcumin inhibits lipoxygenase and cyclooxygenase-2 that synthesize pro- inflammatory leukotrienes, prostaglandins, and thromboxane, blocks cytokine- mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity and suppresses inducible nitric oxide synthase in activated macrophages, processes that promote inflammation [5]. (irispublishers.com)
  • In a meta-analysis of the literature on the effects of early life stress on inflammation, early (mostly pre-pubertal) exposure to physical and sexual violence, or severe social deprivation increased inflammation in young adults-especially (but not only) if depressed. (psychiatrictimes.com)
  • Aspirin-induced asthma is a specific syndrome affecting asthmatic patients, consisting of chronic rhinosinusitis , nasal polyps , and asthma attacks caused by aspirin and other non-steroidal anti-inflammatory cyclooxygenase enzyme inhibiting drugs. (symptoma.com)
  • Although paracetamol (acetaminophen) is a generally safe substitute for pain relief, it does have weak cyclooxygenase inhibitory properties. (symptoma.com)
  • Digalloyl-resveratrol (di-GA) is a synthetic compound aimed to combine the biological effects of the plant polyhydroxy phenols gallic acid and resveratrol, which are both radical scavengers and cyclooxygenase inhibitors exhibiting anticancer activity. (nature.com)
  • Aspirin therapy its irreversible inactivation of cyclooxygenase inhibits production of prostaglandins and. (esupport.ws)
  • Since low doses of aspirin may decrease estradiol levels, it could be considered a promising adjunctive therapeutic candidate in postmenopausal women to decrease BC incidence. (biomedcentral.com)
  • "Healing was only observed when CBD was given within a very limited dose range, whereas no beneficial effect was achieved at either lower or higher doses," This characteristic of single-molecule CBD is a serious obstacle that limits its usefulness in a clinical context. (7liquidgold.com)
  • Aspirin (acetylsalicylic acid) is a novel organic compound that does not occur in nature, and was first successfully synthesised in 1899. (wikipedia.org)
  • By 1899, Bayer created acetylsalicylic acid and named the drug 'Aspirin', going on to sell it around the world. (wikipedia.org)
  • After many years, it was synthesised as acetylsalicylic acid, now known as aspirin. (wikipedia.org)
  • An impressive body of evidence supports the concept that dietary factors are key modulators of colorectal cancer. (aacrjournals.org)
  • Rothwell and his team had previously observed that aspirin treatment for longer than five years appeared to significantly reduce risk for colorectal cancer, one of the most common malignancies in older adults. (lifeextension.com)
  • 1990. The effect of mild stress on DMH-induced colorectal cancer. (cdc.gov)
  • The present study aimed to evaluate the effect of aspirin on estrogen levels in postmenopausal women. (biomedcentral.com)
  • METHODS: Population-based clinical data analysis was conducted to assess a possible therapeutic effect of combined dipyridamole and aspirin treatment in inhibiting CRC compared with either monotherapy. (lu.se)
  • RESULTS: We found that dipyridamole combined with aspirin had a better inhibitory effect on CRC than either monotherapy alone. (lu.se)
  • 1 - 5 Dual antiplatelet therapy, consisting of aspirin and a thienopyridine, has been used for more than a decade because aspirin monotherapy turned out to be insufficient. (ajnr.org)
  • The in vitro effects of the drugs on CRC cells were tested using CCK8 and flow cytometry assays. (lu.se)
  • While this effect on in vitro systems is promising, Lunasin 's efficacy in an in vivo system is yet to be assessed. (weeksmd.com)
  • Hanus and two colleagues from the Hebrew University of Jerusalem surveyed the scientific literature and found that during the past fifteen years several preclinical studies had focused on the anti-inflammatory effects of pure, single-molecule CBD using in vitro and in vivo animal models of various diseases including rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and diabetes. (7liquidgold.com)
  • 247-257 Aspirin sales revived considerably in the last decades of the twentieth century, and remain strong in the twenty-first with widespread use as a preventive treatment for heart attacks and strokes. (wikipedia.org)
  • PURPOSE: Available evidence indicates that dipyridamole enhances the anti-thrombotic effects of aspirin for the prevention of secondary strokes. (lu.se)
  • INTRODUCTION: The evidence about the optimal revascularization strategy in patients with left-main coronary artery (LMCA) disease and impaired renal function is limited. (bvsalud.org)
  • 43 Individuals with chronic kidney disease may experience an increased risk of end stage renal disease with aspirin usage. (lifeextension.com)
  • T affect renal function in short, aspirin buffers and transports the protons, acting as a to. (esupport.ws)
  • These results suggest that the use of alum as an oral antiplatelet drug could be explored further, taking into account possible side-effects especially in renal compromised patients. (who.int)
  • However, flavonoid supplements may affect the action of anticoagulants and increase the toxicity of a wide range of drugs when taken concurrently. (oregonstate.edu)
  • Indeed, evidence obtained with isotopically labeled 20-carbon fatty acids incubated with sheep vesicular glands, an abundant source of PGs, confirmed this assumption. (jci.org)
  • 42 Long-term use of more than one type of analgesic such as aspirin may cause analgesic nephropathy. (lifeextension.com)
  • Since it is illegal to promote aspirin as a cancer preventive, and the FDA dilutes what can be said about its heart attack-reducing effects, most Americans will not find out what Life Extension members did in the early 1980s, which is to take 81 milligrams of aspirin every day. (lifeextension.com)
  • Despite promising results in animal studies, only a limited number of observational studies have reported potential cancer preventive effects of flavonoids in humans. (oregonstate.edu)
  • Moreover, early IgG immune complexinduced C5a and its interaction with C5aR led to induction of activating FcRIII and suppression of inhibitory FcRII on alveolar macrophages, which appears important for cytokine production and neutrophil recruitment inside the IgG immune complex-injured lung (26). (estrogen-receptor.com)
  • In the 1960s and 1970s, John Vane and others discovered the basic mechanism of aspirin's effects,: 226-231 while clinical trials and other studies from the 1960s to the 1980s established aspirin's efficacy as an anti-clotting agent that reduces the risk of clotting diseases. (wikipedia.org)
  • Although the exact mechanism through which aspirin exerts protective effects on BC is not fully understood, the primary mechanism could be explained by inhibiting cyclooxygenases (COXs), especially COX-2, followed by lower prostaglandin E-2 (PGE-2) synthesis. (biomedcentral.com)
  • The underlying mechanism responsible for the effects of lunasin on NK cells is likely due to epigenetic modulation on target gene loci. (weeksmd.com)
  • Allergic or pseudo allergic reactions include skin rashes, urticaria, pruritus, angioedema aspirin mechanism of action thrombocytopenic purpura and anaphylactoid. (esupport.ws)
  • Isolated adverse effects will increase the use has been conducted. (myjuicecup.com)
  • Abdominal pain, nausea, and diarrhea are all common adverse effects. (myonlinemedshop.com)
  • Of central and north southwark health, tools use of Liprace to guide whether these might be at tributable to the adverse effects. (hybridnutrition.co.za)
  • Cranberry, as well as many other fruits and vegetables, contains significant amounts of salicylic acid , which is an important ingredient in aspirin . (rxlist.com)
  • Salicylic acid can reduce swelling, prevent blood clots , and can have antitumor effects. (rxlist.com)
  • Besides causing symptoms of asthma, aspirin can cause nasal congestion and abdominal pains in susceptible individuals. (symptoma.com)
  • CONCLUSIONS: Our data indicate that the anti-cancer effect of aspirin against CRC may be enhanced by combined administration with dipyridamole. (lu.se)
  • Cialis Ingredients, and herbal supplements, weak inhibitory effects toward other isoforms CYP2C8. (confidentlovers.com)
  • Even mild, intermittent asthma patients may have acute episodes induced by aspirin consumption and up to one-quarter of patients that need to be admitted to the hospital due to a crisis have ingested non-steroidal anti-inflammatories during the last 3 hours [5]. (symptoma.com)
  • Accumulating evidence from randomized controlled trials suggests that consumption of flavan-3-ols and anthocyanidins can be beneficial for metabolic and cardiovascular health. (oregonstate.edu)
  • Evidence suggesting that some flavonoids or flavonoid-rich foods may enhance cognitive function is currently limited, and it is not yet known whether their consumption could lower the risk of cognitive impairments and dementia in humans. (oregonstate.edu)
  • Aloe may also interfere with certain medications and excessive or prolonged internal use may affect potassium levels. (earthtokathy.com)
  • 4 Medications and evidence-based behavioral therapies can be used to treat heroin addiction. (drugabuse.com)
  • Growing evidence of the relationship between poor antiplatelet response and occurrence of clinical events elicited the need of monitoring the response which has not been part of our daily practice. (ajnr.org)
  • 10 , 11 Growing evidence of the relationship between poor response to antiplatelet therapy and the occurrence of clinical events, such as the recurrence of ischemic events and stent-related thrombosis or thromboembolic complications during neurointerventional procedures, elicited the need for monitoring the response to antiplatelet agents. (ajnr.org)
  • Accumetrics, San Diego, Calif) enabled us to perform assays to determine the effect of antiplatelet agents. (ajnr.org)
  • Differences observed between rofecoxib and naproxen are likely the result of the antiplatelet effects of the latter agent. (qxmd.com)
  • 10 Anticancer effects of this agent in lung, 11 colon and small intestine 12 have been proved. (j-epilepsy.org)
  • Soy contains many bioactive molecules known to elicit anticancer effects. (weeksmd.com)
  • The prolonged continuous effect of Extended-Release permits a reduction in dosage frequency. (nih.gov)
  • The prolonged continuous effect of acetazolamide permits a reduction in dosage frequency. (nih.gov)
  • The protective effects of anti-C5a appeared to become associated to its ability to suppress lung alveolar macrophage production of TNF- (25). (estrogen-receptor.com)
  • Unlike some vision products that provide nutrients and herbs for long term healthy eyesight support, and prevention of visual impairment, but don't seem to have much of an immediate effect on visual acuity, Eyesight Rx was formulated to provide a quick and noticeable eyesight improvement within days of use. (raysahelian.com)
  • Thus, in the present study we investigate possible effects of licofelone on prevention and termination of SE. (j-epilepsy.org)
  • This early study suggests that adjunctive treatment with a standardized extract of Withania somnifera provides significant benefits, with minimal side effects, for negative, general, and total symptoms and stress in patients with recent exacerbation of schizophrenia. (psychiatrist.com)
  • 5 Licofelone was developed in order to find compounds with anti-inflammatory activity to obviate the gastrointestinal side-effects related to non-steroidal anti-inflammatory drugs and its safety profile compared to these agents has been authenticated in healthy individuals. (j-epilepsy.org)
  • Possible Side Effects, die Sie einnehmen wollen, so you donapos. (confidentlovers.com)
  • Seven people dropped out while on curcumin of which four were due to gastrointestinal side effects. (irispublishers.com)
  • Side effects can include stomach irritation, sweating, and runny nose. (medlineplus.gov)
  • Side effects can include skin irritation and itching. (medlineplus.gov)
  • The reasons cited for such use include improving health, reducing the risk of recurrence, and reducing the side effects of cancer treatments. (cancernetwork.com)
  • You will also learn what you can do to optimize aspirin's chemopreventive capabilities, naturally minimize its potential side effects-and possibly save your life. (lifeextension.com)
  • This therapeutic effect was further verified in. (lu.se)
  • This therapeutic effect was further verified in different CRC mouse models, i.e. an orthotopic xenograft mouse model, an AOM/DSS mouse model, an Apc min/+ mouse model and a patient derived xenograft (PDX) mouse model. (lu.se)
  • One strategy for securing better healthcare can be using medicinal plants if sufficient evidence on their safety and therapeutic benefits can be ascertained. (thieme-connect.de)
  • TCM has vast and untapped potential for evidence-based therapy [ 7 ] and modern therapeutic agents, with the CP [ 5 ] being a resource well worth exploring in more detail. (thieme-connect.de)
  • This meant that when the dose of CBD exceeded a certain point its therapeutic effects went away. (7liquidgold.com)
  • Like the research investigating the therapeutic potential of CBD, THC, and other cannabinoids found naturally in hemp, most of the evidence supporting the therapeutic potential of cannabidiolic acid (CBDA) is based on preclinical, non-human trials. (cbdoilreview.org)
  • 38-40 The first evidence that salicylates might have medical uses came in 1876, when the Scottish physician Thomas MacLagan experimented with salicin as a treatment for acute rheumatism, with considerable success, as he reported in The Lancet. (wikipedia.org)
  • Aspirin has been linked with acute kidney injury. (lifeextension.com)
  • Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate. (medlineplus.gov)
  • Insufficient Evidence to Rate Effectiveness for. (rxlist.com)
  • Basal serum and cerebrospinal fluid levels were 10-13 mg/L after intravenous administration and 6 mg/L after oral administration (isolate 90% inhibitory concentration 64 mg/L). Both patients were exposed to infected horses, 1 during the late incubation period in a horse. (cdc.gov)
  • Adjunctive modafinil can affect concentration of the expiry date. (myjuicecup.com)
  • People using those who have undesirable effects, rasagiline, linezolid, or any of postpartum psychosis is an antidepressant medication. (myjuicecup.com)
  • And herbal supplements, effecting up to 40 of men by the age. (confidentlovers.com)
  • Our predictive approach may contribute to developing a more evidence-based use of herbal medicines. (thieme-connect.de)
  • Individual species, especially those already available as herbal medicinal products, continue to be developed, often with a vision for a more evidence-based practice [ 4 ]. (thieme-connect.de)
  • After analyzing data drawn from over 25,000 human subjects, a team of researchers at Oxford University has conclusively demonstrated that long-term, low-dose aspirin therapy (75 mg per day) effectively combats multiple forms of cancer-and prevents cancer death. (lifeextension.com)
  • Having specialized primarily in cardiovascular medical research, he and his colleagues had at their disposal a trove of information compiled from eight massive studies examining the effect of aspirin therapy on cardiovascular health. (lifeextension.com)
  • Individuals with certain heart, kidney, and other medical conditions may not be suitable candidates for low-dose aspirin therapy. (lifeextension.com)
  • Effect that occurs when an individual takes an overdose of Salicylates secretion and increases plasma urate level therapy even low. (esupport.ws)
  • For suspected liver injury, promptly discontinue PTU therapy and evaluate for evidence of liver injury and provide supportive care. (medscape.com)
  • Increasing evidence suggests an involvement of COX and LOX enzymes in epileptic disorders. (j-epilepsy.org)
  • Researchers believe CBDA affects different enzymes and non-ECS receptors than its decarboxylated cousin cannabidiol. (cbdoilreview.org)
  • 1978. Effects of short-term administration of maleic hydrazide or hydrazine on rat hepatic microsomal enzymes. (cdc.gov)
  • You will discover the precise mechanisms of action by which aspirin impedes cancer cell development. (lifeextension.com)
  • Curcumin is a natural product with anti-inflammatory properties for which there is preliminary evidence of efficacy in the treatment of arthritis. (irispublishers.com)
  • This observation provides evidence for the efficacy of curcumin for the treatment of joint pain in the elderly. (irispublishers.com)
  • Here we report evidence for efficacy of Curcumin in the treatment of joint pain observed serendipitously in a randomized placebo-controlled trial for Alzheimer's disease (AD). (irispublishers.com)
  • Evidence seems to indicate that Acetazolamide has utility as an adjuvant in treatment of certain dysfunctions of the central nervous system (e.g., epilepsy). (nih.gov)
  • We recently reviewed the effects of immune gene variants on depression's severity and response to antidepressant treatment. (psychiatrictimes.com)
  • Adding lunasin to IL-12- or IL-2-stimulated NK cells demonstrated synergistic effects in the induction of IFNG and GZMB involved in cytotoxicity. (weeksmd.com)
  • Food does not affect bioavailability of Acetazolamide Extended-Release. (nih.gov)
  • Moreover, a number of studies have shown that the effects of some SNPs may only become evident in the presence of life stressors, through a "gene-environment" interaction. (psychiatrictimes.com)
  • http://www.who.int/cardiovascular_diseases/resources/atlas/en/index.html. (southampton.ac.uk)
  • This review updates the recent evidence of classification, diagnostic strategies, and management of skin NSAID hypersensitivity reactions. (intechopen.com)
  • Many of the biological effects of flavonoids appear to be related to their ability to modulate a number of cell-signaling cascades. (oregonstate.edu)
  • The antioxidant activity of gallic acid and the inhibitory activity of cinnamic acid against Helicobacter pylori found in ginger rhizomes contributed to its gastroprotective ability. (earthtokathy.com)
  • It was defined as "the effect of herbs, other plants, or plant extracts on the activity, metabolism, or toxicity of drugs. (cancernetwork.com)
  • We have utilized lithium-pilocarpine model of SE in adult Wistar rats to assess the potential effect of licofelone on seizure susceptibility. (j-epilepsy.org)
  • Ginger had a gastroprotective and anti-ulcerogenic effect in rats. (earthtokathy.com)
  • Ginger had a protective effect in rats induced with gastric ulcers, likely related to gingerol and shogaol constituents. (earthtokathy.com)
  • Study of ethanolic extract of Trianthema portulacastrum showed a significant dose-dependent protective effect against paracetamol and thiocetamide-induced hepatotoxicity in albino rats. (stuartxchange.org)
  • 3H-dialkylhydrazines in the neuroendocrine system and their antigonadotropic effect in rats. (cdc.gov)
  • The diuretic effect of Acetazolamide is due to its action in the kidney on the reversible reaction involving hydration of carbon dioxide and dehydration of carbonic acid. (nih.gov)
  • There is inconsistent evidence on the use of cranberry to lower the risk of kidney stones. (rxlist.com)
  • Some early evidence suggests that drinking cranberry juice might lower the risk of kidney stones forming. (rxlist.com)
  • However, other early evidence suggests that drinking cranberry juice or taking cranberry extracts might actually increase the risk of kidney stones. (rxlist.com)
  • It is important that people with aspirin sensitivity read labels of all over-the-counter drugs used to treat pain, colds and flu, and fever . (symptoma.com)
  • Early evidence suggests that drinking cranberry juice daily for 4 weeks does not improve blood flow in people with clogged arteries. (rxlist.com)
  • With increasing focus on some of the many lesser-known cannabinoids found in industrial hemp, many people have been curious about the effects of CBDA and the potential natural benefits. (cbdoilreview.org)
  • Some people should consult a physician before taking daily low-dose aspirin. (lifeextension.com)
  • Browser for the aggregation of platelets that form blood clots of cyclo-oxygenase via acetylation an aspirin overdose is arrest! (esupport.ws)
  • Aspirin's popularity grew over the first half of the twentieth century, leading to fierce competition with the proliferation of aspirin brands and products. (wikipedia.org)
  • Many other compounds, including natural products, have anti-inflammatory properties and objective and controlled evidence for their efficacy in various forms of arthritis is growing. (irispublishers.com)
  • Gastroprotective effect of ginger rhizome (Zingiber officinale) extract: role of gallic acid and cinnamic acid in H. Evidence-Based Complementary and Alternative Medicine, 2011. (earthtokathy.com)
  • 6 Recent experimental studies have shown that licofelone exerts anti-inflammatory properties, 7 anti-asthmatic 8 and neuroprotective effects in the central nervous system. (j-epilepsy.org)
  • Celecoxib is used to treat osteoarthritis, the type of arthritis caused by a breakdown of the joint lining, rheumatoid arthritis (arthritis caused by swelling of the joint lining), and ankylosing spondylitis, which causes pain, soreness, swelling, and stiffness (arthritis that mainly affects the spine). (myonlinemedshop.com)
  • Radiographic evidence of knee osteoarthritis increases from 27% in persons under 70 to 44% of persons 80 years of age and above [1]. (irispublishers.com)
  • Levitra 20 mg did not potentiate the hypotensive effects of alcohol during the 4hour observation period in healthy volunteers when administered with alcohol. (confidentlovers.com)
  • Allergic to aspirin was discovered in bark of willow tree by Red Edmund Stone blood and involved. (esupport.ws)
  • We reviewed our neurovascular prospectively collected data base for consecutive patients pretreated with aspirin and/or clopidogrel for planned or expected stent-placement procedures by the nature of the patient's vascular lesion. (ajnr.org)
  • If patients are atopic, chronic rhinitis and asthma occur earlier in life, unlike aspirin intolerance and nasal polyps [3]. (symptoma.com)
  • Cumulatively, these studies provided solid and detailed medical data on nearly 26,000 patients who either took aspirin daily, or took no aspirin, for 5 years or longer. (lifeextension.com)
  • Destroy epithelial cells group by esterification by some drugs aspirin-modified COX-2 produces lipoxins, most of which are anti-inflammatory patients. (esupport.ws)
  • Ces résultats semblent indiquer que l'utilisation de l'alun en tant qu'antiplaquettaire oral pourrait faire l'objet d'études complémentaires, en tenant compte des effets secondaires éventuels notamment chez les patients dont la fonction rénale est altérée. (who.int)
  • There have been continuous efforts to develop strategies for a more stringent and evidence-based preselection, based, for example, on specific chemical parameters and rules (in the case of natural product screening or the frequency of use in ethnopharmacology). (thieme-connect.de)