Inhibitory effect. Medical search. Frequent questions

The potent inhibition of histamine release by TBX was observed equally in glucose-free as well as complete Tyrode's solution, whereas TBX reduced its inhibitory action in Ca2+-free or D2O-supplemented medium. (unboundmedicine.com)
In previous studies, we studied the effect of OS on α-amylase and α-glucosidase inhibition, however the effect of OS on pancreatic lipase inhibition and kinetics of α-amylase, α-glucosidase and pancreatic lipase inhibition were not studied. (iomcworld.com)
This study determined the in vitro inhibitory effects of OS against pancreatic lipase and characterized the kinetics of α-amylase, α-glucosidase and pancreatic lipase inhibition. (iomcworld.com)
These inhibitory effects may be associated with its dual‑receptor inhibition on P2Y12 and TP receptors. (spandidos-publications.com)
Recent investigation into immunoregulatory roles of both TIGIT and PD-1 T cell receptors reveals that their suppressive effects converge with the inhibition of another T cell receptor, CD226. (ku.edu)
The inhibition is thought to originate in the brain, and is thought to affect both wide dynamic range and nociception-specific neurons in the dorsal horn. (wikipedia.org)
Inhibition or inhibitory control is the ability to inhibit or control impulsive (or automatic) responses, and create responses by using attention and reasoning . (cognifit.com)
Inhibition or inhibitory control blocks behaviors and stops inappropriate automatic reactions, changing one response for a better, more thought-out response adapted to the situation. (cognifit.com)
It was concluded that the PUFA rather than their metabolites were responsible for the inhibition since: (a) antioxidants did not prevent the PUFA-induced migration inhibition and the hydroxylated intermediates were less active, and (b) inhibitors of the cyclooxygenase and lipoxygenase pathways were without effect. (jci.org)
The predominant effect of PTH at doses above 10 -10 M was an inhibition of replication and DNA synthesis. (nyu.edu)
Antagonistic effects of zinc and aluminum on lead inhibition of *-aminolevulinic acid dehydratase. (cdc.gov)
1976. The in vitro effect of zinc on the inhibition of human *-aminolevulinic acid dehydratase by lead. (cdc.gov)
The concentration of the substrate had no effect on the degree of inhibition. (cdc.gov)

The successive extracts obtained (62.5-1000 μg/ml) were subjected to in vitro pancreatic lipase inhibitory assay and the most active extract was selected for kinetic studies. (iomcworld.com)
Data from a radiolabeled ligand‑binding assay indicated that LGP exhibited apparent competing effects on thromboxane receptor (TP) and P2Y12 receptors. (spandidos-publications.com)

Tyrosinase inhibitors specifically interact with melanogenic cells and do not lead to side effects compared with other melanogenesis inhibitors [ 3 ]. (hindawi.com)
The melanogenesis inhibitory and antioxidant effects of N. satureioides on B16F10 cells may suggest this plant as a new pharmaceutical agent in reducing skin pigment and skin aging in cosmetic industry. (ac.ir)

Somatostatin-expressing inhibitory (SOM) neurons in the sensory cortex consist mostly of Martinotti cells, which project ascending axons to layer 1. (jneurosci.org)
By two-photon imaging guided cell-attached recordings, we characterized visual response and receptive field (RF) properties of SOM neurons and parvalbumin-expressing inhibitory (PV) neurons genetically labeled in the mouse primary visual cortex. (jneurosci.org)
The onset latency of the latter is consistent with that of inhibitory input to excitatory neurons. (jneurosci.org)
The respective contribution of each subtype of inhibitory neurons to cortical processing remains largely undetermined. (jneurosci.org)
Thus, the three chemically specified subtypes together can account for a majority of total inhibitory neurons. (jneurosci.org)
using two-photon imaging guided cell-attached recordings in GAD67 -GFP knock-in transgenic mice, we examined the receptive field (RF) properties of inhibitory neurons in layer 2/3 of the primary visual cortex (V1). (jneurosci.org)
Although the FS neurons were most likely PV cells ( Kawaguchi and Kubota, 1997 ), the RS inhibitory neurons were a mixture of other GABAergic subtypes. (jneurosci.org)
This balance is determined in part by the number and function of excitatory and inhibitory synapses, the excitability of input and output neurons and the ability of microcircuits to compensate for synaptic alterations, known as synaptic homeostasis. (sfari.org)
Many structures and processes are involved in the development of a seizure, including neurons, ion channels, receptors, glia, and inhibitory and excitatory synapses. (medscape.com)

However, there is no report about the effects of J147 on pigmentation in vitro and in vivo . (frontiersin.org)
Noni fruit juice has in vitro inhibitory effects on phosphodiesterase enzyme 3 (PDE-3), DPP-IV and aldose reductase enzymes. (noniresearch.org)
The present work reports for the first time the HPLC analysis and in vitro antioxidant evaluation of mango peel phenols (MPPs) and their cytotoxic effect on the A549 lung cancer cell line. (mdpi.com)
The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear (PMN) cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. (who.int)
The Committee also discussed procedures for assessing the effects of antimicrobial drug residues in food on the human intestinal microflora, including in vitro methods, such as determination of minimum inhibitory concentrations and continuous and semi-continuous culture systems, and in vivo methods, such as studies on conventional laboratory animals, human microflora associated with germ-free rodents, and volunteers. (who.int)
These methods differ in their relevance and practicality, and the Committee encouraged the development of better in vitro and in vivo methods that are relevant for determining the effects of low concentrations of antimicrobial agents on the human gastrointestinal microflora. (who.int)

Does the shift in the role of GABA from excitatory neurotransmission to inhibitory neurotransmission during early development play a role in autism? (sfari.org)
Dynamic target of seizure control in management of epilepsy is achieving balance between factors that influence excitatory postsynaptic potential (EPSP) and those that influence inhibitory postsynaptic potential (IPSP). (medscape.com)

B. fragilis D‐lactate dehydrogenase has been expressed, purified and inhibitory activities of 25 coumarin derivatives previously synthetize for their antioxidant activity were evaluated. (chemaxon.com)
The physiological characteristics of the fermented extracts, namely, tyrosinase inhibitory activity, antioxidant activity, antibacterial activity, and anti-skin-aging activity, were evaluated and compared with those of unfermented extracts. (hindawi.com)

In our previous study, several compounds extracted from this herb, including luteolin‑4'‑O‑β‑D‑glucopyranoside (LGP), were revealed to exert inhibitory effects on adenosine diphosphate (ADP)‑induced platelet aggregation. (spandidos-publications.com)

In conclusion, punicic acid, the main constituent of pomegranate seed (70-80%), exhibited potent growth inhibitory activities in androgen-dependent LNCaP cells, which appear to be mediated by both antiandrogenic and pro-apoptotic mechanisms. (nih.gov)
Of these compounds, luteolin showed the most potent inhibitory activity (IC(50)=1.5μg/mL). (greenmedinfo.com)

Their effect varied to some extent with the length of the incubation time and was inversely proportional to the cholinesterase activity of the areas involved. (erowid.org)
Of all the successive extracts studied, the ethanolic extract showed highest pancreatic lipase inhibitory activity. (iomcworld.com)
The aim of this study was to elucidate the effect of Myagropsis myagroides extract on tyrosinase activity. (ijpsonline.com)
Separation of the n-hexane fraction using silica gel column chromatography yielded the chloroform:methanol (50:1) fraction, which showed the highest tyrosinase inhibitory activity. (ijpsonline.com)
These 3 chromene compounds displayed strong tyrosinase inhibitory activity. (ijpsonline.com)
The inhibitory effect on synthesis of melanin, mushroom tyrosinase activity, cellular tyrosinase and oxidative stress were determined by the colorimetric and fluorometric methods. (ac.ir)
Tundis R, Nadjafi F, Menichini F. Angiotensin‐Converting enzyme inhibitory activity and antioxidant properties of Nepeta crassifolia Boiss & Buhse and Nepeta binaludensis Jamzad. (ac.ir)
The inhibitory effect diminished with increasing saturation and carbon chain length, and methylation abolished this activity. (jci.org)
The blueberry extract produced significant reductions in metabolic activity and acidogenicity only at the highest concentration tested, without significantly affecting bacterial/EPS biovolumes or biofilm architecture . (bvsalud.org)
Studies with nerve homogenates showed that the activity of GAPDH was lowered by 2,5-HD and that LDH was not affected. (cdc.gov)

LSM [lysergic acid morpholid] and 5-hydroxytryptamine, a well known LSD antagonist, up to 10-3M concentration had no inhibitory effect on cholinesterase in histochemical preparation. (erowid.org)
The sample consisted of six products (Plax®, Listerine®, Cepacol®, Oral B®, Sanifill® and Periogard ®) which were analyzed to measure their Minimum Inhibitory Concentration (MIC). (bvsalud.org)
The PUFA concentration required to inhibit migration was dependent on cell number, suggesting that the fatty acid effects on leukocyte migration in vivo may be governed by the stage of the inflammatory response. (jci.org)
CEC (critical environmental concentration) is the calculated concentration of a substance in surface water that is expected to have pharmacological effect in fish. (janusinfo.se)
EC 50 (effect concentration) refers to the test concentration of a substance at which 50 % of the animals are estimated to be immobile/dead. (janusinfo.se)
Can also be called LC 50 (lethal concentration) or IC 50 (inhibitory concentration). (janusinfo.se)

Furthermore, the results of viable counts and pH profile revealed that the combination of probiotic microorganisms exerts better inhibitory effect against enteropathogenic E. coli than a singIe probiotic dose. (scialert.net)
Today, a probiotic refers to any preparation "of live microorganisms which when applied to man or animal can beneficially affect the host by maintaining the intestinal microbial balance" ( Havenaar and Huis, 1992 ). (scialert.net)
Tannery effluent inhibited nitrification significantly (180 min EC 50 was 57 vol.%), but it did not affect heterotrophic microorganisms. (iwaponline.com)

Orthologous to human GIPR (gastric inhibitory polypeptide receptor). (nih.gov)

Scholars@Duke publication: The pore-domain of TRPA1 mediates the inhibitory effect of the antagonist 6-methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole. (duke.edu)

Rationale: Alcohol intoxication and alcohol cue exposure impair 'reactive' inhibitory control and increase motivation to drink. (ljmu.ac.uk)
In study 2, reactive control was significantly impaired following the alcohol and control primes, relative to the placebo, but there was no effect on proactive slowing or signal detection. (ljmu.ac.uk)

Nerve cells from the genetically engineered mice showed a significantly greater inhibitory action than their normal littermates, even though only about 10% of the normal amount of neuroligin-3 was present. (genengnews.com)

Serious' effects are those that evoke failure in a biological system and can lead to morbidity or mortality (e.g., acute respiratory distress or death). (cdc.gov)
As an example, acute inhalation MRLs may not be protective for health effects that are delayed in development or are acquired following repeated acute insults, such as hypersensitivity reactions, asthma, or chronic bronchitis. (cdc.gov)

The aim of this study was to evaluate the effect of methanol (MeOH), n -hexane and dichloromethane (CH 2 Cl 2 ) fractions of the extract on melanin synthesis and oxidative stress in B16F10 melanoma cell line. (ac.ir)

Additionally, TGF-beta1 has inhibitory effects on matrix degradation. (medscape.com)

However, the structures or domains of TRPA1 that mediate the inhibitory effect of Compound 31 are unknown. (duke.edu)

Performance decrements of inhibitory avoidance (IA) induced by lesions in either the dorsal or ventral hippocampus have been interpreted as a deficiency in acquisition. (karger.com)

All derivatives except for the methyl derivative (1b) exhibited effective inhibitory action at low micromolar concentrations on human isoforms, but only four derivatives (1e, 1f, 1h, 1i) inhibited the bovine enzyme. (ogu.edu.tr)
The effects were studied using both the crystalline enzyme and the endogenous enzyme present in nerve tissue. (cdc.gov)

The most common and devastating impairment of horizontal gaze results from pontine lesions that affect the horizontal gaze center and the 6th cranial nerve nucleus. (msdmanuals.com)

It was also found that LGP exhibited marked inhibitory effects on the activation of αIIbβ3 integrin, the secretion of serotonin from granules, and the synthesis of thromboxane A2. (spandidos-publications.com)

We demonstrated that NBPF1 exerts different tumor suppressive effects, depending on the cell line analyzed, and provide new clues into the molecular mechanism of the enigmatic NBPF proteins. (biomedcentral.com)

The results indicate that cranberry extract was the most effective extract in disrupting S. mutans virulence properties without significantly affecting bacterial viability . (bvsalud.org)

Therefore, exploring fermented herb extracts that have beneficial effects to prevent skin aging is important. (hindawi.com)
Cytotoxic and apoptotic effects of extracts of Artemisia ciniformis Krasch. (ac.ir)
Inhibitory effects of fruit berry extracts on Streptococcus mutans biofilms. (bvsalud.org)
Strawberry extracts had no significant effects on S. mutans biofilms . (bvsalud.org)

Here we highlight some of the discoveries from our lab in the field of cognitive development relying on two methodologies used for measuring inhibitory control: brain imaging and mental chronometry (i.e., the negative priming paradigm). (frontiersin.org)
According to this theoretical framework, the development of inhibitory control efficiency during childhood and adolescence contributes to the development of conceptual knowledge in various cognitive domains. (frontiersin.org)
1992. Auditory event-related potential (P300) in relation to peripheral nerve conduction in workers exposed to lead, zinc, and copper: Effects of lead on cognitive function and central nervous system. (cdc.gov)

These combined effects influenced the signal transduction in RBL-2H3 cells, thereby revealing the mechanisms of the anti-allergic effects of adlay. (greenmedinfo.com)
The aim of present study was to confirm these antiplatelet effects and elucidate the potential mechanisms. (spandidos-publications.com)
The inhibitory effects of Morinda citrifolia L. noni on phosphodiesterase enzymes: The possible mechanisms for increasing energy and improving diabetic conditions. (noniresearch.org)
In this study we evaluated whether the anti-osteoporotic agent strontium ranelate can prevent the deleterious effects of AGEs on bone cells, and possible mechanisms of action involved. (osteoporosis-studies.com)

This finding was a surprise, as other studies have indicated that a loss of inhibitory action might be involved in autism spectrum disorders, according to the investigators. (genengnews.com)

Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAELs) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)

Radiosensitizers are chemical agents that have the potential to increase the lethal effect of radicals induced during irradiation [1-6].The extent of radiation damage to cells is dependent on the amount of oxygen available to the cell [1,2,7,8]. (who.int)

Activation of GIPR Exerts Analgesic and Anxiolytic-Like Effects in the Anterior Cingulate Cortex of Mice. (nih.gov)
Inhibitory effect of Solanum nigrum on thioacetamide-induced liver fibrosis in mice. (bestayurveda.ca)
The purpose of this study was to investigate the effects of Solanum nigrum extract (SNE) on thioacetamide (TAA)-induced liver fibrosis in mice. (bestayurveda.ca)

Transcriptome Analysis Reveals Inhibitory Effects of Lentogenic Newcastle Disease Virus on Cell Survival and Immune Function in Spleen of Commercial Layer Chicks. (escholarship.org)
number of novel strategies such as ART intensification, treatment of co-infection, the use of anti-inflammatory drugs and brokers that reduce microbial translocation are currently being examined for their potential effects in reducing immune activation and SNAEs. (thetechnoant.info)
It is thought to have some effects on the immune system. (medlineplus.gov)
phenytoin has inhibitory effects on some immune functions (3). (cdc.gov)

Lightening effect on ultraviolet-induced pigmentation of guinea pig skin by oral administration of a proanthocyanidin-rich extract from grape seeds. (ac.ir)

To improve bacteriocin-like inhibitory substance (BLIS) production by Pediococcus pentosaceus ATCC 43200, the influence of pH as well as the addition of sugars-either prebiotic (inulin) or not (sucrose)-on its metabolism were investigated. (springer.com)
An MRL is defined as an estimate of daily human exposure to a substance that is likely to be without an appreciable risk of adverse effects (noncarcinogenic) over a specified duration of exposure. (cdc.gov)

Furthermore, the hypopigmentary effects of J147 were demonstrated in vivo in a zebrafish model and UVB-induced hyperpigmentation model in brown guinea pigs. (frontiersin.org)
This is the first report of diclofenac altering steroid metabolism in vivo, detrimentally affecting detection in urine, but not in hair which holds considerable advantages over urinalysis for anti-doping tests. (preprints.org)

The researchers' study also shows how the mutation affects nerve function. (genengnews.com)
Assessment of the effects of occupational and environmental factors on all faster and slower large myelinated nerve fibers: A study of the distribution of nerve conduction velocities. (cdc.gov)

A discussion relating other biological actions of 2-ATs or 2-AIs (e.g. alpha-adrenergic mediated antinociception) to the observed inhibitory neuroeffector responses is provided. (erowid.org)

Objectives: In two pre-registered studies, we investigated whether exposure to alcohol-related cues (study 1) and alcohol priming (study 2) impair each of these subprocesses of inhibitory control and increase motivation to drink. (ljmu.ac.uk)
Results: In study 1, alcohol cue exposure did not impair inhibitory control subprocesses. (ljmu.ac.uk)
Conclusions: Alcohol intoxication and cue exposure increase motivation to drink in the absence of impairments in subcomponents of inhibitory control. (ljmu.ac.uk)
1992. Symposium overview: An update on exposure and effects of lead. (cdc.gov)
The points in the figures showing no-observed-adverse-effect levels (NOAELs) or lowest- observed-adverse-effect levels (LOAELs) reflect the actual doses (levels of exposure) used in the studies. (cdc.gov)
3. HEALTH EFFECTS considered to be important because it helps the users of the profiles to identify levels of exposure at which major health effects start to appear. (cdc.gov)
MRLs are derived when reliable and sufficient data exist to identify the target organ(s) of effect or the most sensitive health effect(s) for a specific duration within a given route of exposure. (cdc.gov)
As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)

These results indicate that expectancy differentially effects monitoring and inhibitory control in PKU. (wustl.edu)

With regular monitoring of inhibitory impact biological treatment process upsets could be avoided and treatment optimised. (iwaponline.com)

In this study, we investigated the growth inhibitory, antiandrogenic, and pro-apoptotic effects of 13 pure compounds found in the pomegranate in androgen-dependent LNCaP human prostate cancer cells. (nih.gov)
The organic acids lower the pH and thereby indirectly affect growth of the pathogen. (scialert.net)
This study assessed the inhibitory effect of mouth rinses on the growth of Lactobacillus casei (ATCC 7469). (bvsalud.org)
The effects of the bone resorbing hormone, parathyroid hormone (PTH), on the growth of malignant osteoblastic cells have been examined. (nyu.edu)

Incentive effect on inhibitory control in adolescents with early-life stress: an antisaccade study," CHILD ABUSE & NEGLECT , vol. 36, no. 3, pp. 217-225, 2012. (ugent.be)
The present study used a personality-attitudes model to assess whether personality traits predicted aberrant self-reported driving behaviors (driving violations, lapses, and errors) both directly and indirectly, through the effects of attitudes towards traffic safety in a large sample of bus drivers. (who.int)

Taking it with other supplements that have the same effect might cause blood pressure to drop too much. (medlineplus.gov)
Taking it with other supplements with similar effects might lower blood sugar too much. (medlineplus.gov)
Taking it with other supplements with similar effects might increase the risk of bleeding in some people. (medlineplus.gov)

While some patients experience spontaneous regression or differentiation of the tumor, others are affected by rapid and fatal tumor progression despite increasingly intensive treatment strategies [ 9 ]. (biomedcentral.com)

The effect of probiotic organism on the micro ecology of the gut is to some extent dependent upon its ability to survive and preferably inhibit the proliferation of pathogens. (scialert.net)
Using the gal-3 inhibitor GB0139 (TD139) and gal-3C we found that the gal-3-induced inhibitory effect on ROS production was dependent on the carbohydrate recognition domain of the lectin. (lu.se)
Studies investigating gender differences in DNIC have shown mixed results with the effect dependent upon experimental methodology and measurement method. (wikipedia.org)
The inhibitory effect was in a dose-dependent pattern. (who.int)

The Effect of MS Scan Speed on UPLC Peek Separation and. (genengnews.com)

A newly developed eye movement measurement test sheds light on inhibitory control and brain aging. (neurosciencenews.com)

In our studies, we investigated the hypopigmentary effects of J147 treatment on melanocytes and explored the underlying mechanism. (frontiersin.org)
This view is consistent with a number of studies showing that the dramatic development of the inhibitory control efficiency between 3- and 5-years old (e.g. (frontiersin.org)

We found that the single-point mutation I624N in the N-terminus of TRPA1 specifically affects the sensitivity to mustard-oil, but not to cold temperatures. (duke.edu)

Erowid.org: Erowid Reference 1758 : Histochemical demonstration of the inhibitory effect of d-lysergic acid diethylamide (LSD) and its congeners on brain cholinesterases. (erowid.org)
The inhibitory effect of LSD and d-2-brom-lysergic acid diethylamide (BOL-148) on the hydrolysis of acetylthiocholine (AcThCh) in various areas of human and rabbit brain was investigated by Koelle's histochemical method. (erowid.org)

Neutrophil migration inhibitory properties of polyunsaturated fatty acids. (jci.org)

In summary, this is the first report of an inhibitory role of gal-3 in regulating phagocytosis-induced ROS production. (lu.se)
Masaki H. Role of antioxidants in the skin: anti-aging effects. (ac.ir)

Rescorla (1969) showed that a CS becomes inhibitory when the probability that the US will occur in the presence of the CS, p(US/CS), is smaller than the probability that the US will occur in the absence of the CS (p(US/noCS). (scholarpedia.org)
Inhibitory signals to opposing eye muscles occur simultaneously. (msdmanuals.com)

Using mouse MC3T3E1 osteoblastic cells in culture we evaluated the effects of 0.1mM strontium ranelate and/or 100 μg/ml AGEs-modified bovine serum albumin (AGEs-BSA) on cell proliferation, osteogenic differentiation and pro-inflammatory cytokine production. (osteoporosis-studies.com)

Anatomy27

Organisms16

Diseases1

Chemicals and Drugs147

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes47

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science3

Inhibition13

Assay2

Melanogenesis2

Neurons9

Vitro6

Excitatory2

Antioxidant activity2

Exert1

Potent2

Activity10

Concentration6

Microorganisms3

Gastric1

Antagonist1

Reactive2

Genetically1

Acute2

Melanin1

Additionally1

Compound1

Dorsal1

Enzyme2

Lesions1

Secretion1

Suppressive effects1

Bacterial1

Extracts4

Cognitive3

Mechanisms4

Involved in autism1

Humans1

Lethal1

Mice3

Immune4

Guinea-pig1

Substance2

Vivo2

Nerve2

Responses1

Exposure8

Results indicate1

Biological1

Growth4

STUDY2

Supplements3

Tumor1

Dependent4

Separation1

Measurement1

Studies2

Mutation1

Brain2

Properties1

Role2

Occur2

Proliferation1