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  • CETP
  • Abstract -Cholesteryl ester transfer protein (CETP) catalyzes the net transfer of cholesteryl ester (CE) between lipoproteins in exchange for triglyceride (heteroexchange). (ahajournals.org)
  • Cholesteryl ester transfer protein (CETP) is a plasma protein that mediates the exchange and net transfer of cholesteryl ester (CE) and triglyceride (TG) molecules between lipoprotein particles during their circulatory lifetime. (ahajournals.org)
  • 1 2 The ability of CETP to facilitate the remodeling of lipoprotein composition endows an important role to this protein in the intravascular metabolism of lipoproteins. (ahajournals.org)
  • We and others have suggested that the function of CETP, that is, its capacity to affect changes in the composition of individual lipoprotein fractions, is modulated by a second plasma protein, lipid transfer inhibitor protein (LTIP). (ahajournals.org)
  • 19 20 21 22 23 24 LTIP is a LDL-associated protein of ∼30 kd that preferentially reduces the action of CETP on LDL, probably through its capacity to prevent CETP binding to lipoproteins. (ahajournals.org)
  • A series of novel quinoline-3-carboxamide derivatives 10 - 17 and 23 - 27 were designed and synthesized as cholesteryl ester transfer protein (CETP) inhibitors. (mdpi.com)
  • encodes
  • Here, we isolated and functionally characterized the pepper (Capsicum annuum L.) gene CaPMEI1, which encodes a pectin methylesterase inhibitor protein (PMEI), in pepper leaves infected by Xanthomonas campestris pv. (deepdyve.com)
  • chemotherapy
  • Knowing the levels of these two proteins can help women and their doctors decide whether chemotherapy or other treatments are needed after surgery. (breastcancer.org)
  • PD 407824 and SB 218078 were the two small molecule inhibitors to CHEK1, that were found to sensitize pancreatic cancer cells to the chemotherapy drug gemcitabine, according to a paper published by the same group last year in the Journal of Translational Medicine. (healthcanal.com)
  • Pathways
  • Santa Cruz Biotechnology offers an extensive range of biochemicals with protein-interacting properties which are useful for the studying protein function, cell signaling pathways and other biological processes. (scbt.com)
  • tissue
  • Testing for these two proteins is done on breast cancer tissue removed during biopsy or surgery. (breastcancer.org)
  • In this study, we aimed to evaluate whether the expression patterns of these proteins change and it may be related to the global primordial follicle loss after autotransplantation of the frozen-thawed ovarian tissue. (springermedizin.de)
  • The purpose of this study was to examine the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in drusen, and in the surrounding cells and tissues. (arvojournals.org)
  • cellular
  • Speaking with Australia's The Advertiser , Samuel said that by inhibiting or removing the protein, the body is able to increase production of scaffolds , or stiff cellular constructs that serve as the building blocks of new skin. (advancedtissue.com)
  • ovarian
  • Ovarian tissues were evaluated for the dynamic expressions of the Pten, Tsc1, p27, and Amh proteins using immunohistochemistry, and H-score analyses were done. (springermedizin.de)
  • A scientific paper that will be published in the September issue of the journal Gynecologic Oncology describes how the inhibition of a protein, CHEK1, may be an effective element to incorporate into therapies for women with ovarian cancer. (healthcanal.com)
  • The importance of the paper is that it provides evidence that combinations of cisplatin and CHEK1 inhibitors may be worthwhile pursuing in patients with ovarian cancer," said Dr. Tibes. (healthcanal.com)
  • According to the paper, one of those small molecule inhibitors, PD 407824, was especially effective in sensitizing ovarian cancer cells, SKOV3 and OVCAR3, to the growth inhibiting effects of cisplatin. (healthcanal.com)
  • enzymes
  • In the current study, the researchers at Karolinska Institutet have tested the effects of small drug-like molecules - inhibitors - on PARP1 and other enzymes of the same class. (redorbit.com)
  • The chemical interaction map was complemented with high-resolution structural information, showing at atomic detail how inhibitors bind to these PARP enzymes. (redorbit.com)
  • patients
  • Prognostic value of protein inhibitor of activated STAT3 in breast cancer patients receiving hormone therapy. (nih.gov)
  • In early analysis from a Phase II clinical trial, the JAK1 inhibitor INCB039110 appears to improve symptoms in patients with myelofibrosis. (cancerconnect.com)
  • Levels of hemoglobin (a protein in red blood cells that carries oxygen) were increased for patients in the 200- and 600-mg groups who did not require transfusions: by 5.6% and 8.6%, respectively. (cancerconnect.com)
  • According to these findings, treatment with the JAK1 inhibitor INCB039110 can improve symptoms in patients with myelofibrosis, as well as moderately decrease spleen size. (cancerconnect.com)
  • Primary Analysis Results from an Open-Label Phase II Study of INCB039110, a Selective JAK1 Inhibitor, in Patients with Myelofibrosis. (cancerconnect.com)
  • The TGen team proved their method in the research laboratory, which is very encouraging, considering that the use of protein inhibitors in combination with cisplatin, is also proving to be effective in clinical trials with cancer patients. (healthcanal.com)
  • sequence
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • Zha, X.-F. P-element Somatic Inhibitor Protein Binding a Target Sequence in dsx Pre-mRNA Conserved in Bombyx mori and Spodoptera litura . (mdpi.com)
  • The majority of these proteins are encoded in the nucleus and synthesized in the cytoplasm as higher molecular weight precursors carrying an NH 2 -terminal domain called a transit sequence. (springer.com)
  • The import process starts with binding of precursor proteins to the envelope membrane via the interaction of the transit sequence with proteinaceous receptors at the surface of the outer membrane. (springer.com)
  • bind
  • Compared with BmPSI, the mutant SlPSI proteins of I116 and IGGI lost their ability to bind to CE1. (mdpi.com)
  • concentration
  • how to use S35 Met and tritiated uracil to determine if the concentration of the inhibitors and the timing of the treatments were appropriate. (bio.net)
  • Protein concentration is above or equal to 0.05 mg/ml. (abcam.com)
  • therapies
  • Sekijima and team believe that their study's findings are indicative of the promise that docking simulation holds for the identification of potential drug-like inhibitors of the target protein and therapies for Chagas disease. (eurekalert.org)
  • activity
  • However, in plasma deficient in lipid transfer inhibitor protein (LTIP) activity, HDL and LDL are equivalent donors of CE to VLDL ( Arterioscler Thromb Vasc Biol . (ahajournals.org)
  • If the protein is required for survival of a species, inhibiting that protein could be a potential mechanism of action for a drug with activity against the parasite that causes Chagas disease. (eurekalert.org)
  • To further test potential activity and binding, they employed X-ray crystallography to confirm these four compounds in complex with the protein structure. (eurekalert.org)
  • Pepper pectin methylesterase inhibitor protein CaPMEI1 is required for antifungal activity, basal. (deepdyve.com)
  • specific
  • Through virtual screening by TSUBAME at Tokyo Tech, one of the world's top, large-scale supercomputers, they selected their target protein, T. cruzi spermidine synthase, based on specific structural features and properties indicating its importance for survival in another Trypanosoma species. (eurekalert.org)
  • researchers
  • A team of researchers at Karolinska Institutet has generated a map over the effects of small drug-like molecules on PARP1 and other similar proteins in the body. (redorbit.com)
  • In a study funded by the National Institutes of Health and published online in advance of print in The FASEB Journal, the researchers report on the development of a protein-based inhibitor that could provide a topical treatment for HPV. (infectioncontroltoday.com)
  • In a new study published in Developmental Cell , researchers uncovered a protein that can help speed up wound healing rates . (advancedtissue.com)
  • suppression
  • JAK1/JAK2 inhibitors can, however, result in too much suppression of the bone marrow's production of blood cells, or myelosuppression-a condition that can negatively impact patient health and quality of life. (cancerconnect.com)
  • compounds
  • Following selection, potential drug candidate inhibitors were identified through a screening search known as docking simulation--a structure-based drug design approach using 3D simulations to computationally match drug compounds to SpdSyn. (eurekalert.org)
  • treatment
  • We have developed a protein inhibitor that blocks HPV protein expression in cell culture, a first step toward a topically-applied treatment for this cancer-causing virus," said senior author James Baleja, PhD, associate professor of biochemistry at Tufts University School of Medicine (TUSM) and member of the biochemistry program faculty at the Sackler School of Graduate Biomedical Sciences at Tufts. (infectioncontroltoday.com)
  • The resulting proteins are not neurotoxins, but a new class of biopharmaceuticals, Targeted Secretion Inhibitors (TSI), suitable for the treatment of a wide range of diseases where secretion plays a major role. (mdpi.com)
  • Literature
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • structural
  • The PDBFlex database explores the intrinsic flexibility of protein structures by analyzing structural variations of the same protein across the archive. (rcsb.org)
  • This allows for the easy identification of regions and types of structural flexibility present in a protein of interest. (rcsb.org)
  • amino
  • This inhibitor, designated PIN, appears to be one of the most conserved proteins in nature, showing 92 percent amino acid identity with the nematode and rat homologs. (sciencemag.org)
  • found
  • The urokinase plasminogen activator and its inhibitor are proteins found on the outside of breast cancer tumor cells that help the cancer grow and spread. (breastcancer.org)
  • We found that when a particular protein called 14-3-3 zeta was not present wounds healed a lot quicker in our models of wound healing ," Samuel told ABC News Australia. (advancedtissue.com)
  • regulation
  • PIAS3 is involved in cytoplasmic regulation, such as functional interaction of PIAS3 with metabotropic glutamate receptor-8, voltage-gated potassium channel Kv1.5 and pyruvate kinase subtype M2 , but the majority of so far reported interactions of the PIAS3 protein occurred with transcription factors or other proteins linked to nuclear regulation. (atlasgeneticsoncology.org)
  • Different
  • Chloroplasts are double membraned organelles which require a lot of proteins to maintain their structure and to perform different functions. (springer.com)
  • play
  • Proteins known as JAK1 and JAK2 may play a role in the development of MPNs, including myelofibrosis, by causing the body to make the wrong number of blood cells. (cancerconnect.com)
  • Pten, Tsc1, p27, and Amh are the inhibitor proteins that play crucial roles in suppressing the transition from the primordial follicle to primary state, maintaining the primordial follicle reserve. (springermedizin.de)
  • toward
  • In the coming years, the Aussie team will reate a protein specifically geared toward humans which could be on the market in the next decade or so. (advancedtissue.com)