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  • senescence
  • We conclude that the level of ROS is crucial in initiating p53's transcription of p21 leading to senescence. (nih.gov)
  • Keywords: Croverin Diabetic nephropathy Iron P21 Proximal tubular cells Cellular senescence 1 Launch Iron plays Croverin a significant role in preserving physiological home-ostasis in the torso (for instance in enzymatic reactions and air transport). (angiogenesis-blog.com)
  • 1990 In today's study we as a result hypothesized that iron overload within the kidney induces cell senescence and irritation with a p21-reliant system. (angiogenesis-blog.com)
  • PCNA
  • p21 may also directly block DNA replication by inhibiting the proliferating cell nuclear antigen (PCNA), an essential DNA replication protein. (cshl.edu)
  • The ability of p21 to inhibit the role of PCNA in DNA replication but not in DNA repair rationalizes in vivo data showing that genetic damage leads to inactivation of chromosomal replication while allowing damage responsive repair. (cshl.edu)
  • The central region contains a highly acidic patch where it allows for interaction with cdc2, PCNA, and p21. (wikipedia.org)
  • differentiation
  • If the cell cycle is lengthened or arrested, for example, in G1 by overexpression of G1 cyclin-dependent kinase (CDK) inhibitors (e.g., p21, p27, p16), differentiation will generally result. (pnas.org)
  • In contrast, it was recently reported that olomoucine II, another CDK inhibitor, could induce mRNA up-regulation of differentiation markers in mouse ESCs and that CDK2 siRNA could induce morphology changes characteristic of differentiation ( 20 ). (pnas.org)
  • p21 anti-sense inhibited vesnarinone- and TGF-beta-induced differentiation. (nii.ac.jp)
  • Publications] Kazunori Yoneda: 'Induction of cyclin-dependent kioase inhibitor p21 in vesnarinone-induced differentiation of squamous cell carcinoma cells' Cancer Letters. (nii.ac.jp)
  • Kinases
  • PAK3 (p21-activated kinase 2, beta-PAK) is one of three members of Group I PAK family of evolutionary conserved serine/threonine kinases. (wikipedia.org)
  • selective
  • These observations gave rationale to treat human patients suffering from the familial form of the disease FAP with selective COX-2 inhibitors. (wikipedia.org)
  • orally
  • The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma. (nih.gov)
  • mice
  • Eight-week-old male p21-KO mice on the C57BL/6J background had been sourced from our mating colony (Nishioka et al. (angiogenesis-blog.com)
  • human
  • In human ESCs exposure to roscovitine and other CDK inhibitors sometimes led to a loss of pluripotency markers but other times did not ( 21 ⇓ ⇓ - 24 ). (pnas.org)