• Atherosclerotic disease, intimal calcification, is one cause of peripheral arterial disease (PAD) and is the most referenced. (aawconline.org)
  • Ultimately, increased arterial stiffness reduces the downstream blood flow and skeletal muscle microcirculation, even without intimal calcification or stenosis. (aawconline.org)
  • Importantly, mice deficient in both MGP and OPN had twice as much arterial calcification as MGP −/− OPN +/+ at 2 wk, and over 3 times as much at 4 wk, suggesting an inhibitory effect of OPN in vascular calcification. (silverchair.com)
  • Sanifit conducted a phase-IIb trial (CaLIPSO) in 274 patients to assess the effect of SNF472 on slowing arterial calcification, a major risk factor for cardiovascular disease in dialysis patients. (menafn.com)
  • abstract: BACKGROUND AND AIMS:Mutations in the 5'-nucleotidase ecto (NT5E) gene that encodes CD73, a nucleotidase that converts AMP to adenosine, are linked to arterial calcification. (shengsci.com)
  • As a symptom of their condition, CKD patients express intense arterial calcification, which makes them a strong group to examine the impact of K2 as MK-7. (nutritioninsight.com)
  • For the arterial calcification, vitamin D supplement provides adjunctive role in regressing proteinuria, reverse renal osteodystrophy, and restoring calcification inhibitors. (tmu.edu.tw)
  • Elsewhere in the body, vitamin D acts at its specific receptors to promote immune function, subdue inflammation, reduce arterial calcification, enhance cardiac function, improve brain and nerve tissue performance, and even prevent cancer by regulating the cell replication cycle. (lifeextensioneurope.com)
  • At least 13 mutations in the ABCC6 gene have been identified in individuals with generalized arterial calcification of infancy (GACI), a life-threatening disorder characterized by abnormal calcification in the blood vessels that carry blood from the heart to the rest of the body (the arteries). (medlineplus.gov)
  • Santos JMA, Laizé V, Gavaia PJ, Conceição N, M. Cancela L . Zebrafish Models to Study Ectopic Calcification and Calcium-Associated Pathologies . (ualg.pt)
  • Vascular calcification is a pathology characterized by the deposition of calcium-phosphate in cardiovascular structures, mainly in the form of hydroxyapatite crystals, resulting in ectopic calcification. (revistanefrologia.com)
  • Studies have shown that AlkP may have an important role in ectopic calcification and ossification of soft tissues. (medscape.com)
  • Wang XR, Zhang JJ, Xu XX and Wu YG: Prevalence of coronary artery calcification and its association with mortality, cardiovascular events in patients with chronic kidney disease: A systematic review and meta-analysis. (spandidos-publications.com)
  • We examined the association of inflammation and progression of coronary artery calcification (CAC)-a marker of subclinical atherosclerosis-in adults with and without type 1 diabetes. (silverchair.com)
  • A nested case-control study was performed within the prospective cohort of the Coronary Artery Calcification in Type 1 Diabetes (CACTI) study. (silverchair.com)
  • The aims of this thesis were to characterise the roles of OPG/RANKL/TRAIL in VC,and to measure how insulin and liraglutide affect coronary artery calcification (CAC) in T2DM. (rcsi.com)
  • [ 9 , 10 ] Chronic inflammatory conditions may predispose to calciphylaxis by reducing serum levels of fetuin-A, an important inhibitor of calcification produced in the liver. (medscape.com)
  • Vascular calcification occurs most extensively in individuals with chronic kidney disease, the investigators write, particularly in those on hemodialysis, which is considered lifesaving in patients whose kidneys have failed. (eurekalert.org)
  • Vascular calcification is commonly observed in chronic kidney disease. (spandidos-publications.com)
  • Ren SC, Mao N, Yi S, Ma X, Zou JQ, Tang X and Fan JM: Vascular calcification in chronic kidney disease: An update and perspective. (spandidos-publications.com)
  • Nelson AJ, Raggi P, Wolf M, Gold AM, Chertow GM and Roe MT: Targeting vascular calcification in chronic kidney disease. (spandidos-publications.com)
  • Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G and Jansen F: Vascular pathologies in chronic kidney disease: Pathophysiological mechanisms and novel therapeutic approaches. (spandidos-publications.com)
  • It is well established that patients with chronic kidney disease and diabetes have poor cardiovascular outcomes which is thought to be due to increased vascular calcification and atherosclerosis. (manchester.ac.uk)
  • Vascular calcification is a common pathological feature of atherosclerosis, chronic kidney disease, vascular injury, and aging. (omicsdi.org)
  • It should be interpreted as the clinical syndrome caused by critical ischaemia of calcified terminal skin (candelabra) arterioles, independently of whether the cause of chronic vascular calcification has been uraemia, chronic inflammation, ageing, pharmacological, genetic predisposition or all of them in combination. (renalandurologynews.com)
  • Published in Nephrology Dialysis Transplantation, the paper examined the link between early vascular aging in chronic kidney disease (CKD), with a focus on the role of NattoPharma's MenaQ7 vitamin K in counteracting oxidative stress and the aging process. (nutritioninsight.com)
  • Vascular calcification associated with high plasma phosphate (Pi) level is a frequent complication of hyperglycemia, diabetes mellitus, and chronic kidney disease. (unideb.hu)
  • Association Between Proton Pump Inhibitor Use and Risk of Progression of Chronic Kidney Disease. (janusinfo.se)
  • In addition, we are examining the effects of blocking BMP receptors, using small molecule inhibitors, on the anemia of inflammation and the development of atherosclerosis. (massgeneral.org)
  • In this study, we sought to investigate the effect of the recently developed TNAP inhibitor SBI-425 on atherosclerosis plaque calcification and progression. (nih.gov)
  • Systemic inhibition of TNAP protects from atherosclerosis, by ameliorating dyslipidemia, and preventing plaque calcification. (nih.gov)
  • Atherosclerosis is the main pathophysiological foundation of cardiovascular disease, which was caused by inflammation and lipid metabolism disorder, along with vascular calcification. (thno.org)
  • It has multiple pharmacological effects, but no research on aortic calcification during atherosclerosis was performed. (thno.org)
  • This study investigated the effects of GLSP on atherosclerosis and aortic calcification and revealed the underlying mechanism. (thno.org)
  • In vivo , 8-week-aged male LDLR -/- mice were fed a high-fat diet to induce atherosclerosis along with aortic calcification. (thno.org)
  • Subsequently, the mice tissues were collected to evaluate the effects of GLSP on atherosclerosis, and aortic calcification, and to reveal the underlying mechanism. (thno.org)
  • We observed GLSP attenuated plaque area and aortic calcification in the mice with early and advanced atherosclerosis. (thno.org)
  • This work allows us to link clinical and basic research into a working theoretical model to explain the pathway of development of vascular calcification in CKD. (scite.ai)
  • Inhibition of STAT1 expression in VSMCs using fludarabine or knockdown of STAT1 expression using small interfering RNA alleviated the calcification of VSMCs. (spandidos-publications.com)
  • Furthermore, lithium chloride (Wnt activator) reversed the protective effect of STAT1 inhibition on VSMC calcification, while Dickkopf‑1 (Wnt inhibitor) exerted the opposite effect, suggesting that activation of the Wnt/β‑catenin signaling pathway was involved in STAT1‑mediated VSMC calcification. (spandidos-publications.com)
  • TNAP activation preceded and predicted calcification in human and mouse plaques, and TNAP inhibition prevented calcification in human VSMCs and in ApoE-deficient mice. (nih.gov)
  • These acquisitions are a perfect fit for our expanding nephrology pipeline, which now includes vascular calcification inhibition treatments across various stages of non-dialysis CKD and even non-CKD patient populations. (menafn.com)
  • Vitamin D supplement for CKD patients provides a protective role in vascular calcification on the endothelium by (1) renin-angiotensin-aldosterone system inactivation, (2) alleviating insulin resistance, (3) reduction of cholesterol and inhibition of foam cell and cholesterol efflux in macrophages, and (4) modulating vascular regeneration. (tmu.edu.tw)
  • Inhibition ofautophagy by LIRA and/or the autophagy inhibitors attenuated VSMCphenotype conversion, proliferation, migration, and calcification andpromoted VSMC apoptosis in HG conditions. (balkanmedicaljournal.org)
  • 1953) described this form of medial artery calcification (MAC) as having no symptoms or signs of impaired circulation. (aawconline.org)
  • 5 One of the possible explanations is that patients with tibial artery calcification have microvascular disease that leads to altered skeletal muscle perfusion, and exercise vasodilation is compromised in the medial and small arterioles with reduced capacitance due to the rigid microvascular structures. (aawconline.org)
  • Next, CBF (1-8), a small fragment of CBF, was identified which is a more potent inhibitor of medial vascular calcification compared to CBF. (rwth-aachen.de)
  • The accelerated early vascular aging (EVA) process mediated by medial vascular calcification (VC) is a hallmark of senescence - the condition or process of deterioration with age - as well as a strong predictor of cardiovascular morbidity and mortality in the CKD population. (nutritioninsight.com)
  • Fetuin-A is therefore regarded as a potent inhibitor of systemic calcification. (wikipedia.org)
  • MGP is a potent inhibitor of vascular calcification. (naturalproductsinsider.com)
  • It is commonly considered the most potent inhibitor of vascular calcification, along with Bone Gala protein/osteocalcin. (aawconline.org)
  • Where cardiovascular health is concerned, Matrix Gla Protein (MGP) is the most potent inhibitor of vascular calcification, but it needs adequate Vitamin K2 to activate it. (menaq7.com)
  • The mechanism of how the calcification signal from endothelial cells is transmitted to vascular smooth muscle cells (VSMCs) remains unknown. (spandidos-publications.com)
  • Alizarin Red S staining and calcium (Ca) content analysis were carried out to detect calcification in VSMCs. (spandidos-publications.com)
  • Exosomes derived from HP‑HUVECs promoted the calcification of VSMCs, as assessed by Alizarin Red S staining, alkaline phosphatase activity assays, Ca content measurements and the increased expression of runt‑related transcription factor 2 and osteopontin. (spandidos-publications.com)
  • TNAP was inhibited in mice using SBI-425 administered from 10 to 25 weeks of age, and in human vascular smooth muscle cells (VSMCs) with MLS-0038949. (nih.gov)
  • The present study investigated the effects of PQS on the calcification of vascular smooth muscle cell (VSMCs). (biomedcentral.com)
  • The present study used calcification medium containing 3 mM inorganic phosphate (Pi) to induce rat VSMCs calcification. (biomedcentral.com)
  • We investigated the effects of PQS on VSMCs calcification using alizarin red staining and alkaline phosphatase (ALP) activity assays. (biomedcentral.com)
  • During VSMCs calcification, PQS inhibited the mRNA and protein expression of Runx2 and BMP2. (biomedcentral.com)
  • Taken together, these findings suggest that PQS could effectively inhibit VSMCs calcification by ameliorating oxidative stress and regulating osteogenic genes via the promotion of Nrf2 expression. (biomedcentral.com)
  • The production of reactive oxygen species (ROS) and the oxidative modification of various biomolecules induce the transformation of VSMCs from the contractile type to the osteogenic type, which is accompanied by calcification [ 7 ]. (biomedcentral.com)
  • Vascular calcification is an active, regulated process in which vascular smooth muscle cells (VSMCs) differentiate into osteoblast-like cells and deposit a mineralised matrix. (manchester.ac.uk)
  • Therefore, the initial aim of this study was to determine the effects of farnesyl transferase inhibitors (FTI-277 and manumycin A) on vascular calcification using a well validated in vitro model in which VSMCs are induced to deposit a mineralised matrix in the presence of β-glycerophosphate. (manchester.ac.uk)
  • Autophagy in the vascular smooth musclecells (VSMCs) facilitates AS. (balkanmedicaljournal.org)
  • Additionally, VSMC migration, calcification,proliferation, and apoptosis in HG conditions were observed.Results: Addition of LIRA alone or in combination with autophagyinhibitors significantly downregulated Beclin, increased the LC3-II/LC3-I ratio, and upregulated p62 in VSMCs in HG conditions.Furthermore, autophagolysosome formation was markedly curbedafter treatment with LIRA and/or autophagy inhibitors. (balkanmedicaljournal.org)
  • Yamada S and Giachelli CM: Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho. (spandidos-publications.com)
  • Vascular smooth muscle cells are sensitive to changes in inorganic phosphate (Pi) levels. (revistanefrologia.com)
  • The uremic milieu provides a perfect storm of risk factors for accelerated calcification, but elevated calcium and phosphate levels remain key to the initiation and progression of vascular smooth muscle cell calcification in CKD. (scite.ai)
  • Here, we discuss current understanding of the process of vascular calcification, focusing specifically on the discrete and synergistic effects of calcium and phosphate in mediating vascular smooth muscle cell apoptosis, osteochondrocytic differentiation, vesicle release, calcification inhibitor expression, senescence, and death. (scite.ai)
  • Using our model of intact human vessels, factors initiating vascular calcification in vivo and the role of calcium and phosphate in driving accelerated calcification ex vivo are described. (scite.ai)
  • It helps prevent calcification in the arteries and it may also help to reduce the risk of bone injuries and fractures. (naturalremedies.org)
  • It is widely recognized that DM patients demonstrate calcification of the arteries below the knee. (aawconline.org)
  • Around 72% of the arteries had MAC, and only 43% had intimal calcification. (aawconline.org)
  • Mice deficient in MGP alone (MGP −/− OPN +/+ ) showed calcification of their arteries as early as 2 weeks (wk) after birth (0.33 ± 0.01 mmol/g dry weight), and the expression of OPN in the calcified arteries was greatly up-regulated compared with MGP wild-types. (silverchair.com)
  • [ 2 ] constructed an experimental model and was able to precipitate systemic calcification, somewhat analogous to this syndrome, in nephrectomized rats. (medscape.com)
  • Matrix Gla Protein (MGP) is a strong vitamin K-dependent inhibitor of soft tissue calcification with high dp-ucMGP plasma levels (concentrations above 500 pmol/L) indicative of vitamin K insufficiency. (dsm.com)
  • Vifor Pharma has announced the acquisition of Sanifit Therapeutics, a Spanish clinical-stage cardio-renal biopharmaceutical company focused on treatments for end-stage kidney disease patients with progressive vascular calcification disorders, and Inositec AG, a Swiss company, developing first-in-class non-dialysis treatments for soft tissue and vascular calcification disorders. (menafn.com)
  • The major role of AlkP in soft tissue is to remove inhibitors of mineralization. (medscape.com)
  • Recognition of Vitamin K2's benefits as a strong and significant elucidated inhibitor of vascular and soft tissue calcification is one of the core reasons a separate RDI should be established. (nutritioninsight.com)
  • Liver kinase B1 inhibits smooth muscle calcification via high mobility group box 1. (omicsdi.org)
  • In addition, we show that this peptide inhibits calcification by hindering transdifferentiation of SMCs by interacting with PIT-1 to inhibit the activation of NF-κβ and its downstream BMP2/p-SMAD pathway, effectively reducing the expression of osteogenic genes and inhibiting apoptosis while promoting metabolism. (rwth-aachen.de)
  • Feeding a mineral-rich diet to fetuin-A-deficient mice resulted in widespread calcification (ectopic mineralization) of lung, heart, and kidneys in these mice. (wikipedia.org)
  • Pyrophosphate helps control deposition of calcium (calcification) and other minerals (mineralization) in the body. (medlineplus.gov)
  • Fetuin-A deficiency dramatically increased the calcification proneness of these mice in that all mice spontaneously calcified throughout their body even without a mineral-rich diet or surgical tissue trauma. (wikipedia.org)
  • mice showed intensified vascular calcification, which was alleviated by treatment with the HMGB1 inhibitor glycyrrhizic acid. (omicsdi.org)
  • Patients can experience PAD symptoms without intimal calcification or luminal stenosis. (aawconline.org)
  • 3,4,6,7,8 In the areas with intimal calcification, it was contiguous with MAC and precipitated along the elastic lamina within the vessels. (aawconline.org)
  • However, the role of purinergic receptor signaling in the pathology of intimal calcification is not well understood. (shengsci.com)
  • Active MGP appears to be the only natural inhibitor of vascular calcification and vitamin K the only known activator of MGP. (eurekalert.org)
  • She notes that like vitamin K levels, vascular calcification is difficult to measure directly, so they measured these two related indicators of cardiovascular health. (eurekalert.org)
  • There may be a relationship between vitamin K2-MK7-dependent regulation of endothelial function via the MGP to inhibit osteogenic properties in vascular endothelial cells. (aawconline.org)
  • Long-term depletion of vitamin K in patients on anticoagulation therapy have noted significant vascular calcifications. (aawconline.org)
  • Nevertheless, despite a significant reduction in the biomarker, MGP, two large studies failed to demonstrate any improvement in vascular calcification with supplemental vitamin K2-MK7. (aawconline.org)
  • A new study, which included 4,275 people from the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort, aimed to evaluate the prevalence of vitamin K deficiency using plasma desphospho-uncarboxylated MGP (dp-ucMGP) as a marker. (dsm.com)
  • After the year 2000, 23.8% patients had diabetes mellitus, 23.8% had a previous parathyroidectomy, and 42.9% were treated with vitamin K inhibitors. (renalandurologynews.com)
  • Not only is it helpful in making a case to manufacturers considering Vitamin K2 for their healthy aging support products, but it is an important piece of NattoPharma's RDI efforts," Leon Schurgers, Professor of Biochemistry of Vascular Calcification and senior author and leader of the INTRICARE project, tells NutritionInsight . (nutritioninsight.com)
  • Schurgers says that the study will highlight the accumulated research demonstrating that vitamin K2 consumption might serve as a potential therapy for patients who express intense calcification as a symptom of their condition. (nutritioninsight.com)
  • Vitamin D deficiency, another complication of CKD, is associated with vascular calcification in patients with CKD. (tmu.edu.tw)
  • In summary, vitamin D supplement may provide an ancillary role for ameliorating uremic vascular calcification. (tmu.edu.tw)
  • Increasing evidence indicates that senescent cells could be a promising new target for therapeutic intervention known as senotherapy, which includes depleting senescent cells, modulating SASP and restoration of senescence inhibitors. (frontiersin.org)
  • Current therapeutic approaches for diabetic nephropathy (DN) are focussing on blood pressure control with inhibitors of the renin-angiotensin-aldosterone system, on glycaemic and lipid control, and life-style changes. (scite.ai)
  • PQS suppressed the Pi-induced protein expression of Keap1, which is an endogenous inhibitor of Nrf2. (biomedcentral.com)
  • The kit is suitable for high throughput screening of apoptosis inducers and inhibitors. (eurogentec.com)
  • Osteoprotegerin (OPG) has been proposed as an inhibitor of VC, potentially via blockade of either receptor activator of nuclear factor kappa-beta ligand (RANKL) or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). (rcsi.com)
  • Plaque calcification was imaged in vivo with 18 F-NaF-PET/CT, ex vivo with osteosense, and in vitro with alizarin red. (nih.gov)
  • Vascular calcification is a pathology in the vascular system with various forms. (aawconline.org)
  • As calcification paradox is a complex process, subsequent investigation of the key factors affecting VC will help to identify specific pathology associated substances affecting bone density. (rwth-aachen.de)
  • In vitro , we determined the major components of GLSP triterpenes by HPLC, and subsequently assessed the protective effects of these main active components on lipid metabolism, inflammation, and calcification in RAW264.7 and HASMC cells. (thno.org)
  • We know that the lifespan of patients on hemodialysis is reduced, that cardiovascular disease accounts for about half their deaths and that vascular calcification is a key contributor," says Dr. Norman Pollock, bone biologist at MCG's Georgia Prevention Institute. (eurekalert.org)
  • The increased burden of cardiovascular disease is due, at least in part, to calcification of the vessel wall. (scite.ai)
  • The aim of the present study was to investigate whether exosomes from HUVECs (HUVEC‑Exos) could regulate VSMC calcification and its potential signaling pathway. (spandidos-publications.com)
  • In conclusion, the present results indicated that exosomal STAT1 derived from HP‑treated HUVECs could promote VSMC calcification, and activation of the Wnt/β‑catenin pathway may be a potential mechanism of the VSMC calcification promoted by exosomes. (spandidos-publications.com)
  • A VSMC injury model induced by high glucoseconcentrations was used to detect the regulatory effects of LIRAon VSMC autophagy, calcification, migration, proliferation andphenotype conversion. (balkanmedicaljournal.org)
  • Previous work from the host laboratory has shown that nitrogen-containing bisphosphonates attenuate vascular calcification by inhibiting farnesyl pyrophosphate synthase, depleting cells of farnesyl pyrophosphate and geranylgeranyl pyrophosphate which are essential for the prenylation and activation of small GTPases such as Ras and Rho. (manchester.ac.uk)
  • Key questions we want to answer include exactly how vascular calcification occurs in this very high-risk population of individuals and how we might better recognize, treat and ideally prevent these unhealthy changes to their blood vessels," says Pollock, the study's corresponding author. (eurekalert.org)
  • Calcium accumulation in atherosclerotic plaques predicts cardiovascular mortality, but the mechanisms responsible for plaque calcification and how calcification impacts plaque stability remain debated. (nih.gov)
  • Tissue-nonspecific alkaline phosphatase (TNAP) recently emerged as a promising therapeutic target to block cardiovascular calcification. (nih.gov)
  • instead, through its metabolic targets, p53 is able to modulate the ferroptosis response in the presence of ferroptosis inducers such as GPX4 inhibitors or high levels of ROS. (nature.com)
  • The P2Y2 nucleotide receptor is an inhibitor of vascular calcification. (shengsci.com)
  • Vascular calcification is a highly regulated process that involves a complex interplay between promoters and inhibitors of calcification and has many similarities to bone ossification. (scite.ai)
  • However, high mobility group box 1 (HMGB1) overexpression partially counteracted the promotion of vascular calcification induced by LKB1 overexpression. (omicsdi.org)
  • CBF (1-8) is derived from the protein chromogranin A and might be on of the missing link in our current knowledge about the calcification paradox. (rwth-aachen.de)
  • Investigation and clinical application to the prevention of estrogen receptor α and β prevent vascular disease. (nii.ac.jp)
  • Vascular calcification, common in patients with CKD, is a predictor of cardiovascular mortality. (tmu.edu.tw)