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  • Humans
  • Downregulation of miR-181 family contributes to aggressive leukemia phenotype through mechanisms related to the activation pathways of innate immunity mediated by toll-like receptors TLR2, TLR4, TLR7 and TLR8 and interleukin-1β IL1B (humans on chromose 2). (wikipedia.org)
  • Neuroblastoma
  • mir-181 a and b are over-expressed and act as bad prognosis maker of aggressive neuroblastoma (Stage 4) as compare to low grade stage (Stage 1;2;3 and 4S) whereas mir-181 c and d isoforms are not. (wikipedia.org)
  • inhibition
  • Constitutive Id2 expression accelerates final maturation of both eosinophils and neutrophils, whereas inhibition of Id2 expression blocks differentiation of both lineages. (ox.ac.uk)
  • Both of these effects implicate the catalytic activity of EGFR and ErbB-2 in the development and maintenance of the neoplastic phenotype, suggesting that inhibition of this activity could provide a therapeutic opportunity in patients with tumors expressing either or both of these receptors. (aacrjournals.org)
  • Signal Transduction
  • Our identification of the negative regulator SLAP-2 demonstrates that a retroviral-based screening strategy may be an efficient way to identify and characterize the function of key components of many signal transduction systems. (rupress.org)
  • EGFR
  • In addition, the tested compounds caused a reduction of ErbB-2 and EGFR autophosphorylation in tumor fragments from these xenograft models. (aacrjournals.org)
  • These data indicate that these compounds have potential use as therapy in the broad population of cancer patients overexpressing ErbB-2 and/or EGFR. (aacrjournals.org)
  • The family includes the EGFR, 2 ErbB-2, ErbB-3, and ErbB-4. (aacrjournals.org)
  • Antibodies or small molecule inhibitors targeted to ErbB-2 or EGFR are either approved for therapy or are showing encouraging safety and efficacy profiles in clinical trials. (aacrjournals.org)
  • complex
  • Adaptation to respiration at birth depends upon the synthesis of pulmonary surfactant, a lipid-protein complex that reduces surface tension at the air-liquid interface in the alveoli and prevents lung collapse during the ventilatory cycle. (jci.org)
  • Gissot, Mathieu 2017-06-30 00:00:00 Toxoplasma gondii has a complex life cycle characterized by multiple differentiation steps that are essential for its survival in both human and definitive feline host. (deepdyve.com)
  • Mice
  • Mice were vaccinated with plasmid DNA, RNA, peptide, protein, particles, and bacteria as well as adjuvants, and strong improvement of immune responses against all type of vaccines was observed. (jove.com)
  • receptors
  • Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. (medchemexpress.com)
  • TLRs are evolutionarily conserved receptors are homologues of the Drosophila Toll protein, discovered to be important for defense against microbial infection. (medchemexpress.com)
  • Through the expression of costimulating receptors and the production of cytokines, this specialized cell type constitutes the main help for B cell differentiation and humoral responses against T-dependent antigens ( 3 ). (frontiersin.org)
  • The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). (scbt.com)
  • interaction
  • We show that TgI2 encompasses conserved motifs involved in the interaction and modulation of the phosphatase activity of T. gondii protein phosphatase 1, named TgPP1. (deepdyve.com)
  • actin
  • Depletion of JunB by small interfering ribonucleic acid abrogates TGF-β-induced disruption of cell-cell junctions, formation of actin fibers, focal adhesions, and expression of fibrotic proteins. (biomedsearch.com)
  • inhibitory activity
  • Mutation of the putative myristoylation site of SLAP-2 compromised its inhibitory activity and impaired its localization to the membrane compartment. (rupress.org)
  • lung
  • Here, we investigate the role of MD-2 in Escherichia coli LPS-induced lung inflammation and E. coli-induced pneumonia. (semanticscholar.org)
  • role
  • Recent work on the bride of sevenless ( boss ) gene has demonstrated an inductive role for photoreceptor R8 in the differentiation of photoreceptor R7. (sdbonline.org)
  • ErbB-2 also plays an important role in the development and progression of many types of cancer. (aacrjournals.org)
  • biochemical
  • Biochemicals that inhibit EDG-2 have many applications in biochemical and physiological research. (scbt.com)
  • function
  • Deletion of the COOH terminus of SLAP-2 blocked function and abrogated its association with Cbl. (rupress.org)
  • Biological
  • That is, biological engineering technique has been employed for regeneration of periodontal tissues [ 2 , 3 ]. (medsci.org)
  • p>This section provides any useful information about the protein, mostly biological knowledge. (uniprot.org)
  • effects
  • The consequences of diabetes are devastating due to side effects that occur in the cardiovascular system [ 1 , 2 ]. (hindawi.com)
  • annotation
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. (uniprot.org)