X-Linked Inhibitor of Apoptosis ProteinInhibitor of Apoptosis ProteinsApoptosisCaspasesCaspase 3Apoptosis Regulatory ProteinsCaspase InhibitorsProto-Oncogene Proteins c-bcl-2Cell Line, TumorCaspase 9DNA Fragmentationbcl-2-Associated X ProteinIn Situ Nick-End LabelingCell SurvivalCaspase 7Signal TransductionMicrotubule-Associated ProteinsCaspase 8CASP8 and FADD-Like Apoptosis Regulating ProteinEnzyme ActivationCytochromes cNeoplasm ProteinsMitochondriaApoptosis Inducing Factorbcl-X ProteinFas Ligand ProteinTumor Cells, CulturedProteinsCells, CulturedTumor Suppressor Protein p53TNF-Related Apoptosis-Inducing LigandMitochondrial ProteinsCell ProliferationApoptotic Protease-Activating Factor 1Blotting, WesternAntineoplastic AgentsCysteine Proteinase InhibitorsCell LineDown-RegulationRNA, Small InterferingNeuronal Apoptosis-Inhibitory ProteinFlow CytometryCell CycleNF-kappa BTransfectionIntracellular Signaling Peptides and ProteinsPoly(ADP-ribose) PolymerasesProto-Oncogene ProteinsAnnexin A5Tumor Necrosis Factor-alphaEnzyme InhibitorsCarrier ProteinsJurkat CellsAmino Acid Chloromethyl KetonesCell DeathUp-RegulationCell DivisionReverse Transcriptase Polymerase Chain ReactionGene Expression Regulation, NeoplasticProto-Oncogene Proteins c-aktMembrane Potential, MitochondrialRNA, MessengerDose-Response Relationship, DrugHeLa CellsBH3 Interacting Domain Death Agonist ProteinDrug Resistance, NeoplasmPhosphorylationRNA InterferenceMembrane GlycoproteinsCytochrome c GroupReactive Oxygen SpeciesImmunohistochemistrybcl-Associated Death ProteinTime FactorsDrug SynergismAntineoplastic Agents, PhytogenicMice, Inbred C57BLHL-60 CellsApoptosomesReceptors, TNF-Related Apoptosis-Inducing LigandModels, BiologicalGenes, bcl-2Mice, KnockoutGene Expression RegulationMolecular Sequence DataImmunoblottingbcl-2 Homologous Antagonist-Killer ProteinNecrosisReceptors, Tumor Necrosis FactorAdaptor Proteins, Signal TransducingProtein BindingProtein-Serine-Threonine KinasesXenograft Model Antitumor AssaysMitochondrial MembranesOligopeptidesMyeloid Cell Leukemia Sequence 1 ProteinDNA DamageGene ExpressionAmino Acid SequenceMice, Nude