aaaaxxxInhibitor of apoptosis proteins. Medical search. FAQ
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  • tumour
  • Levels of this protein were also significantly higher in tumour tissue, compared to matched normal tissue in highly resistant tissue. (biomedcentral.com)
  • induction
  • Subsequently, these mutant clones were subjected to more physiologic three-dimensional (3D) colony forming assays, immunofluorescence staining of DNA double strand break markers γH2AX and 53BP1, analysis of cell cycle distribution, induction of apoptosis, caspase 3/7 activity and transmigration assays following irradiation with doses ranging from 1 to 6 Gy. (tu-darmstadt.de)
  • Inhibitor of apoptosis (IAP) proteins were identified in 1993 in a cDNA-based screen for baculovirus genes that prevent the induction of apoptosis in Spodoptera frugiperda SF-21 insect cells after viral infection (Crook et al. (springer.com)
  • It counteracts a default induction of apoptosis in G2/M phase. (aarkstore.com)
  • TAK1, a member of the MAP kinase kinase kinase family, and its activator, TAB1, participate in the bone morphogenetic protein (BMP) signaling pathway involved in mesoderm induction and patterning in early Xenopus embryos. (embopress.org)
  • We found that proteasome inhibitor treatment of SW620, HCT-116, and DLD-1 cells caused upregulation of Fem1b protein levels, associated with induction of apoptosis. (gla.ac.uk)
  • baculovirus
  • An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif. (springer.com)
  • Apoptosis-inducing genes that encode IAP-binding protein have been determined in (fall armyworm) can be a Lepidopteran sponsor from the GSK1059615 nuclearpolyhedrovirus (AcMNPV), an associate from the baculovirus family members. (biodigestor.net)
  • cpIAP
  • 293 cells (106) had been cotransfected through the use of Superfect (Qiagen) with 0.1 GSK1059615 g of green fluorescence proteins (GFP) marker plasmid pEGFP (CLONTECH), 0.25 g of either pcDNA3-Bax or pcDNA3-Fas, and 1.5 g of either pcDNA3 myc-SfIAP or pcDNA3 myc-CpIAP. (biodigestor.net)
  • homolog
  • Fem1b is a homolog of feminization-1 (FEM-1), a protein in Caenorhabditis elegans that is regulated by proteasomal degradation, but whether Fem1b is likewise regulated by proteasomal degradation is unknown. (gla.ac.uk)
  • We cloned a fresh inhibitor of apoptosis proteins (IAP) homolog, SfIAP, from Sf-21 cells, a bunch of insect baculoviruses. (biodigestor.net)
  • cancer
  • Owens TW, Gilmore AP, Streuli CH, Foster FM (2013) Inhibitor of Apoptosis Proteins: Promising Targets for Cancer Therapy. (omicsonline.org)
  • We also show that combination therapy of IAP antagonists with some pro-apoptotic agents (for example, TRAIL) enhances apoptosis of breast cancer cells. (biomedcentral.com)
  • Increasing Fem1b expression induces apoptosis of cancer cells, but effects on colon cancer cells have not been reported. (gla.ac.uk)
  • Herein, we found that Fem1b protein is expressed in primary human colon cancer specimens, and in malignant SW620, HCT-116, and DLD-1 colon cancer cells. (gla.ac.uk)
  • In conclusion, the proapoptotic protein Fem1b is downregulated by the proteasome in malignant colon cancer cells and mediates proteasome inhibitor-induced apoptosis of these cells. (gla.ac.uk)
  • correlates
  • This study revealed for the first time that ML-IAP protein expression correlates with GBM patient survival and that its antagonist GDC-0152 improves outcome in xenografted mouse. (univ-amu.fr)
  • Activator
  • The protein level of Apaf-1, an activator of procaspase-9, remained constant with the application of agents affecting the cleavage of procaspase-9. (aacrjournals.org)