• Peroxisome proliferator-activated receptors (PPAR) and the mitochondrial aldehyde dehydrogenase (ALDH2) promoter in vitro and in vivo. (adicciones.es)
  • The pl 7.1 protein was the most prominent, and protein sequencing identified it as mitochondrial aldehyde dehydrogenase (ALDH), a protein which oxidizes aldehydes to acids using NAD. (uconn.edu)
  • Effect of mitochondrial aldehyde dehydrogenase-2 genotype on cardioprotection in patients with congenital heart disease. (cdc.gov)
  • All investigated CSC populations contained a fraction highly positive for aldehyde dehydrogenase (ALDH) function and displayed robust expressions of programmed cell death 1 (PD-1) ligands. (uni-bielefeld.de)
  • N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes. (proquest.com)
  • Additionally, it investigates the underlying mechanism behind ß-blockers' anticancer effect by influencing a potential novel target named aldehyde dehydrogenase (ALDH). (bvsalud.org)
  • Aldehyde dehydrogenase (ALDH) enzymes are involved in the growth and development of several tissues, including cancer cells. (bvsalud.org)
  • These enzymes were identified as members of the aldehyde dehydrogenase (ALDH) family of proteins. (silverchair.com)
  • Use of an ALDH inhibitor, cyanamide, did not support a major role for aldehyde dehydrogenase in the APAP-induced NAD/NADH changes. (uconn.edu)
  • Accumulation of fatty aldehydes, which are highly reactive molecules, can form covalent Schiff-base derivatives with phosphatidylethanolamine, which may influence myelin membrane properties and alter the function of membrane-bound proteins. (medscape.com)
  • [ 16 ] Schiff-base aldehyde adducts with other amino-containing molecules, including key membrane enzymes and proteins, may also be detrimental to their function. (medscape.com)
  • Aldehyde dehydrogenase 1 (ALDH1), a human stem-cell marker, is an enzyme responsible for converting retinaldehydes to retinoic acids (RAs) to modulate cell differentiation. (bepress.com)
  • Isolated human fetal islet-epithelial cell clusters were treated with ALDH1 inhibitors, retinoic acid receptor (RAR) agonists and ALDH1A1 small interfering (si)RNA.In the developing human pancreatic cells, high ALDH1 activity frequently co-localised with key stem-cell markers as well as endocrine transcription factors. (bepress.com)
  • The significance of the expression of aldehyde dehydrogenase 1 (ALDH1), a cancer stem cell marker, for predicting the recurrence of estrogen receptor (ER)-positive/human epidermal growth factor receptor type 2 (HER2)-negative breast cancer is still poorly understood. (biomedcentral.com)
  • Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors. (proquest.com)
  • To study the correlation between the putative cancer stem cell (CSC) markers aldehyde dehydrogenase 1 (ALDH1), cluster of differentiation 44 (CD44), sex-determining region Y-box 2 (SOX2), and octamer-binding protein 4 (OCT4) and human papilloma virus (HPV) infection using p16, the surrogate marker of HPV in oral epithelial dysplasia (OED) and normal mucosa. (rmmj.org.il)
  • Tras consumir etanol, el disulfiram incrementa los niveles de acetaldehído en sangre y genera una reacción aversiva que desalienta el consumo de alcohol. (adicciones.es)
  • Disulfiram, an inhibitor of aldehyde dehydrogenase, also blocks the 20‐carboxy‐LXB 4 formation. (elsevierpure.com)
  • This medicine contains the active ingredient disulfiram, which is a type of medicine called an aldehyde dehydrogenase inhibitor. (dissectpodcast.com)
  • Disulfiram is an aldehyde dehydrogenase inhibitor licensed for specialist use as an adjunct in the treatment of alcohol dependence. (uktis.org)
  • Disulfiram is an irreversible inhibitor of aldehyde dehy-drogenase, the enzyme that catalyzes the conversion of alcohol to acetic acid. (brainkart.com)
  • 2. Using small molecules (identified in a high throughput screens and synthetic chemistry) as activators and inhibitors of aldehyde dehydrogenases, a family of detoxifying enzymes, and glucose-6-phoshate dehydrogenase, in normal cells and in models of human diseases. (stanford.edu)
  • in their interesting paper [ 1 ] focus their attention mainly on retinaldehyde dehydrogenases (RALDHs), which are enzymes converting retinal into retinoic acid (RA). (silverchair.com)
  • This process is catalyzed by one of three retinaldehyde dehydrogenase enzymes (RALDH1, RALDH2, RALDH3). (silverchair.com)
  • 673 A is an aldehyde dehydrogenase (ALDH1A) inhibitor (IC 50 values are 230, 246 and 348 nM for ALDH1A2, ALDH1A1 and ALDH1A3, respectively). (tocris.com)
  • In the embryo , RA production by RALDH2 (ALDH1A2), the main retinaldehyde dehydrogenase expressed at that stage, is inhibited by ethanol exposure. (xenbase.org)
  • Aldehyde dehydrogenases 1A2 (ALDH1A2) was thought to be one of potential candidates. (ijbs.com)
  • This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. (wikipedia.org)
  • The reaction is inhibited by pyrazole and 4‐methylpyrazole, inhibitors of alcohol dehydrogenase, and by substrates of the enzyme such as ethanol and 20‐hydroxy‐leukotriene B 4 . (elsevierpure.com)
  • The membrane-bound aldehyde dehydrogenase from ' Acetobacter rancens ' CCM 1774, solubilized from the membrane fraction by treatment with surfactants and subsequently purified to homogeneity, was characterized with respect to the M r of the dimeric enzyme (145000), pH optimum (5·1), pI value (5·3), substrate specificity towards straight-chain aldehydes, substrate inhibition and the effects of various inhibitors and ions. (microbiologyresearch.org)
  • Methanol extracts of the membrane fraction and of the purified enzyme showed properties identical with pyrroloquinoline quinone as revealed by spectrophotometric methods and reactivity with apoquinoprotein glucose dehydrogenase. (microbiologyresearch.org)
  • The solubilized, purified quinoprotein aldehyde dehydrogenase and the membrane-bound enzyme differed in substrate binding, substrate inhibition, pH optimum and linkage to a c -type cytochrome which acts as electron acceptor in membrane fractions. (microbiologyresearch.org)
  • [ 3 ] Subsequent studies identified a defect in fatty aldehyde dehydrogenase (FALDH), a component of the fatty alcohol:NAD oxidoreductase enzyme complex. (medscape.com)
  • [ 8 ] FALDH is a component of the fatty alcohol:NAD oxidoreductase enzyme complex that catalyzes the sequential oxidation of fatty alcohol to aldehyde and fatty acid. (medscape.com)
  • Centro de Investigación para el Estudio de la Conducta del Consumo de Alcohol en Adolescentes, Universidad Autónoma de Chile, Santiago, Chile. (adicciones.es)
  • Los resultados muestran que el tratamiento con fenofibrato no solo aumenta la actividad de catalasa en el hígado de ratas bebedoras de alcohol, sino que también incrementa los niveles y la actividad de ADH1, sin alterar ALDH2. (adicciones.es)
  • Esto contribuye a explicar el notable efecto del fenofibrato en aumentar los niveles de acetaldehído en sangre en animales bebedores de alcohol, en los que se registra una marcada reducción en la ingesta de etanol. (adicciones.es)
  • Cyclic expression of class I alcohol dehydrogenase in male rats treated with ethanol. (adicciones.es)
  • GS 455534 is a highly selective reversible aldehyde dehydrogenase 2 inhibitor that has been shown to reduce alcohol and cocaine intake in rats. (researchwithrutgers.com)
  • These observations suggest that both alcohol dehydrogenase and aldehyde dehydrogenase participate in the oxidation of 20‐hydroxy‐LXB 4 to 20‐carboxy‐LXB 4 . (elsevierpure.com)
  • Pharmacological inhibition of the embryonic alcohol dehydrogenase activity, prevents the oxidation of ethanol to acetaldehyde that in turn functions as a RALDH2 inhibitor. (xenbase.org)
  • Ethanol-dependent retinoic acid inhibition requires middle-chain alcohol dehydrogenases. (xenbase.org)
  • The enzymatic requirements for EtOH to inhibit RA biosynthesis were studied using inhibitors of the middle-chain alcohol dehydrogenases (ADH), 4-methylpyrazole (4MP), or the short-chain dehydrogenase/reductases, carbenoxolone (CBX) and chloral hydrate (CH). Late blastula stage embryos were treated with EtOH alone or in combination with 4MP (a,b), CH (c,d) or CBX (e,f). (xenbase.org)
  • Inhibiting aldehyde dehydrogenase alters the body's response to alcohol, leading to an accumulation of acetaldehyde. (brainkart.com)
  • Compounds which inhibit aldehyde-dehydrogenase (allowing buildup of acetaldehyde in the body) produce toxic effects including tachycardia, decreased diastolic blood pressure, hypertension, increased breathing rate, and symptoms of alcohol induced intoxication. (cdc.gov)
  • melting point = 240°C), also known as 4',5-dihydroxy-7- methoxyisoflavone and 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-1- benzopyran-4-one, inhibits alcohol dehydrogenase, aldehyde dehydrogenase, 3',5'-cyclic-nucleotide phosphodiesterase, phosphodiesterase 4, and protein-tyrosine kinase. (chemicalbook.com)
  • Therefore, patients with Sjögren-Larsson syndrome have deficient activity of FALDH and fatty alcohol:NAD oxidoreductase, which results in defective metabolism of both fatty aldehyde and fatty alcohol. (medscape.com)
  • Fatty alcohol and aldehyde may likewise alter the normal integrity of myelin membranes in the brain, leading to white-matter disease and spasticity. (medscape.com)
  • Sleeping Elegance is far more susceptible to more than expression inhibition than piggyBac and Tol2, the cargo capacity of Sleeping Attractiveness is constrained, and contrary to Tol2 and piggyBac that Inhibitors,Modulators,Libraries are lively in all mamma lian cell kinds tested, Sleeping Elegance display cell form dependent exercise. (p450inhibitors.com)
  • Other substances that interact with ethanol through aldehyde-dehydrogenase inhibition are also discussed: dimethylformamide (68122), cyanamide (420042), calcium-cyanamide (156627), and N-butyraldoxime (110690). (cdc.gov)
  • 1987 ) Isolated tumoral pyruvate dehydrogenase can synthesize acetoin which inhibits pyruvate oxidation as well as other aldehydes. (academictree.org)
  • Potent and cell permeable mitosis inhibitor. (abcam.com)
  • Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1. (proquest.com)
  • The genetic defect in Sjögren-Larsson syndrome results in deficient activity of FALDH, which catalyzes the oxidation of fatty aldehyde to fatty acid. (medscape.com)
  • [ 8 ] FALDH is involved in the oxidation of fatty aldehydes produced by catabolism of ether glycerolipids (plasmalogens), which are prominent phospholipids in myelin. (medscape.com)
  • The main objective of the study was to investigate retinaldehyde dehydrogenases (RALDHs), of which retinal is the main substrate and ALDH2, the mitochondrial isoform, having acetaldehyde as the main substrate. (silverchair.com)
  • Using rationally-designed peptide inhibitors to study protein-protein interactions in cell signaling. (stanford.edu)
  • Enrichment of chemical libraries docked to protein conformational ensembles and application to aldehyde dehydrogenase 2. (proquest.com)
  • The Inhibitor of DNA binding 3 ( ID3 ) is a member of the ID protein family, consisting of four members ( ID1 to ID4 ). (nature.com)
  • Results showed that the combination treatment experiments of the selective ALDH1A3 inhibitors (compounds 15 and 16) at variable concentrations with DOX resulted in significant increases in the cytotoxic effect on the MCF7 cell line for compound 15, and to a lesser extent for compound 16 on the PC-3 cell line, compared to DOX alone. (bvsalud.org)
  • BioAssay Systems' Hyaluronidase Inhibitor Screening Assay Kit uses a two-step turbidimetric reaction to measure hyaluronidase activity by the amount of hyaluronic acid that is hydrolyzed. (bioassaysys.com)
  • Strong P-glycoprotein inhibitors (e.g., cyclosporine): Co-administration may increase plasma silodosin concentration. (nih.gov)
  • Cyclosporine is a calcineurin inhibitor. (medscape.com)
  • 1986 ) Inhibitors of the mitochondrial cytochrome b-c1 complex inhibit the cyanide-insensitive respiration of Trypanosoma brucei. (academictree.org)
  • Incidence of drug interaction when using proton pump inhibitor and warfarin according to cytochrome P450 2C19 (CYP2C19) genotype in Japanese. (cdc.gov)
  • Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy. (cdc.gov)
  • It is commonly known that aldehyde dehydrogenases (ALDHs) are a promising therapeutic target in many diseases. (silverchair.com)
  • This relatively unexplored therapeutic potential and the putative advantages of allosteric drugs over classical active-site inhibitors fuel the attention allosteric-drug research is receiving at present. (biomedcentral.com)
  • The translational products of the two other open reading frames exhibited strong similarities to putative heterodimeric molybdenum hydroxylases (OxiAB) representing some isochinoline oxidoreductases and aldehyde dehydrogenases. (president2010.info)
  • An important factor fueling interest in allosteric drugs consists in their characteristic advantages compared to traditional active-site inhibitors. (biomedcentral.com)
  • Liang H, Wu C, Deng Y, Zhu L, Zhang J, Gan W, Tang C, Xu R. Aldehyde Dehydrogenases 1A2 Expression and Distribution are Potentially Associated with Neuron Death in Spinal Cord of Tg(SOD1*G93A)1Gur Mice. (ijbs.com)
  • Pimecrolimus is a calcineurin inhibitor that has an anti-inflammatory effect through decreasing cytokine production. (medscape.com)