Inhibitor combination of therapies. Medical search. Frequent questions

The BET and GSK3 inhibitor combination shows remarkable efficacy but also no increase in toxicity because the GSK3 and BET inhibitors synergize, but on its own, the GSK3 inhibitor doesn't seem to have an effect. (medicalxpress.com)
This hypothesis was confirmed in preclinical studies, conducted under a strategic research collaboration between Merck and Telix announced in 2019, [1] and provided evidence that the combined effect of Merck's investigational DNA-PK inhibitor peposertib with Telix's targeted radiation candidate has potential to significantly improve efficacy and reduce the required radiation dose for tumour reduction and remission, compared to targeted radiation alone. (aap.com.au)
Methods: The syngeneic CT26 colon cancer model was used to evaluate therapeutic efficacy of combination treatment with actinium 225-radiolabelled IGF-1R antibody (mAb), FPI-1792, and checkpoint inhibitors. (aacrjournals.org)
Jeremy R. Graff, Ph.D., Chief Scientific Officer and Senior Vice President, Research at Biothera Pharmaceuticals, will present data showing that Imprime PGG acts therapeutically as an immunological "ignition switch" to coordinate robust innate and adaptive immune responses that enhance the efficacy of immune checkpoint inhibitors. (econotimes.com)
Biothera Pharmaceuticals is a privately held biotechnology company developing Imprime PGG, a mid-clinical stage cancer immunotherapy that enhances the efficacy of anti-cancer immune response in combination with immune checkpoint inhibitor, tumor-targeting and anti-angiogenesis antibodies. (econotimes.com)
A 12-month, phase 2 trial, completed by Richeldi and colleagues, assessed the efficacy and safety of four different oral doses of the tyrosine kinase inhibitor nintedanib (formerly BIBF 1120) compared with placebo in patients with idiopathic pulmonary fibrosis. (medscape.com)
This study evaluated the safety and efficacy of switching HIV-infected patients with stable viral suppression on nonnucleoside reverse transcriptase inhibitor/nucleoside reverse transcriptase inhibitor (NNRTI/NRTI) therapy to lopinavir/ritonavir (LPV/r) monotherapy. (researchgate.net)
To compare the efficacy of methylene blue with combination therapy with hydroxocobalamin in patients experiencing vasoplegic syndrome after cardiac surgery. (nih.gov)
Tadalafil tablets are not recommended in combination with alpha-blockers for the treatment of BPH because efficacy of the combination has not been adequately studied and because of the risk of blood pressure lowering. (nih.gov)
Cognitive-behavioral therapy (CBT) and serotonin reuptake inhibitors (SRIs) are recommended treatments for pediatric obsessive-compulsive disorder (OCD), but their relative efficacy and acceptability have not been comprehensively examined. (lu.se)
In the combination study in parallel cohorts, efficacy was compared for low dose of each single agent and the same doses in combination. (vivoryon.com)
Accordingly, they illuminated new uses for IDO1 inhibitors to enhance the antitumor efficacy of hypoxia/metabolic stress-inducing drugs in cancer and other diseases. (mainlinehealth.org)
IDO inhibitors offer broad interest for cancer treatment, with preclinical and emerging clinical evidence that they can safely enhance the efficacy of chemotherapy, radiotherapy, radio-chemotherapy and immunotherapy. (mainlinehealth.org)
Combination drug studies using IDO inhibitors to safely enhance the efficacy of cancer cell-targeted therapeutics, including RAS/RAF pathway inhibitors, PI3K/mTOR pathway inhibitors and hypoxia-inducing agents. (mainlinehealth.org)
Proliferation signal inhibitors (PSI) have demonstrated efficacy in prevention and treatment in an animal model of lupus nephritis (LN) but there are no data regarding the use of PSI in human LN. We report here our experience of using PSI treatment in seven patients with severe proliferative lupus nephritis. (nih.gov)
He serves as Associate Director for Liver Tumor, Kidney Tumor, Germ Cell, and Neuroblastoma Targeted Therapies, and is currently the Sponsor and Study Principal Investigator the CaboMain trial, a Phase 2 study evaluating the efficacy of the oral anticancer agent cabozantinib as a maintenance therapy for ultra-high-risk solid tumors. (spotify.com)
Neoadjuvant endocrine therapy is an alternative to chemotherapy, but it has not shown high levels of efficacy for high-risk breast cancer, explained Gavilá. (aacr.org)
We already knew that the combination of endocrine therapy with CDK4/6 inhibitors was efficacious in advanced breast cancers, so we were interested in investigating the efficacy of this combination for high-risk, early-stage breast cancer," explained Gavilá. (aacr.org)
In this study, the authors examined the efficacy of the CDK4/6 inhibitor ribociclib in combination with the in patients with high-risk, luminal B, stage I to III operable breast cancer. (aacr.org)

STENDRA (avanafil) is a selective inhibitor of cGMP-specific PDE5. (rxlist.com)

Therefore, we have hypothesized that combination of TAT with immunotherapy will lead to a robust therapeutic effect resulting in a synergistic response as compared to monotherapy alone. (aacrjournals.org)
It is indicated as monotherapy, in combination with dexamethasone, or in combination with lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma in patients who have received at least 1 prior line of therapy. (medscape.com)
Despite marked activity in myeloid malignancy, monotherapy with DNMT inhibitors is limited by low complete and partial response rates (7-20%) and median response durations of 15 months. (johnshopkins.edu)
Overall, 28 doses were administered in 14 patients in the monotherapy group and 17 doses (10 methylene blue, 7 hydroxocobalamin) were administered in 6 patients in the combination therapy group. (nih.gov)
There were no differences in ability to maintain MAP at 1hour, with 71% of the monotherapy and 82% of combination therapy patients meeting MAP goals (p = 0.49). (nih.gov)
This is the first study to compare methylene blue monotherapy with combination therapy, which suggests there may be an advantage to combination therapy. (nih.gov)
Subjects in this analysis were adult outpatients (18-65 years) enrolled from 2 acute, double-blind, placebo-controlled trials comparing adjunctive l -methylfolate and placebo for DSM-IV major depressive disorder (MDD) with an inadequate response to monotherapy selective serotonin reuptake inhibitor (SSRI). (psychiatrist.com)
2 , 3 , 4 In the Sequenced Treatment Alternatives to Relieve Depression (STAR * D) trial, 5 among those who remitted with selective serotonin reuptake inhibitor (SSRI) monotherapy, 40.1% had a relapse or recurrence over the subsequent 12 months. (psychiatrist.com)

Results: While only transient tumor growth suppression was detected in animals treated with either checkpoint inhibitors or FPI-1792 alone, complete tumor regression was observed in 13 out of 15 mice treated with combination therapies, indicating development of potent synergy in the combination groups. (aacrjournals.org)
Conclusions: The combination of targeted alpha therapy with checkpoint inhibitors led to tumor regression in a CT26 syngeneic model. (aacrjournals.org)
Oral presentation to be delivered during the Cancer Immunotherapy session, Emerging Approaches for Checkpoint Inhibitor Combination Immunotherapy, at 11:45am Pacific Time, Wednesday, February 22. (econotimes.com)
The Novel Phase 2 Immunotherapeutic, Imprime PGG, Repolarizes the Tumor Immune Microenvironment and Activates Antigen Presentation to Drive an Integrated Anti-Cancer Immune Response with Checkpoint Inhibitors. (econotimes.com)
The clinical rationale for combining targeted and immunotherapy is to utilize the rapid onset of response and high response rate of BRAF/MEK inhibitors and the longer duration of benefit seen in patients responding to checkpoint inhibitors (CPI). (springermedizin.at)
Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)

NCT05663710 ) and STARLITE-2 ( NCT05239533 ) studies in combination with immunotherapy. (aap.com.au)
Objective: In the last decade, immunotherapy has revolutionized cancer care and became a mainstream therapy along with surgery, chemotherapy and radiation. (aacrjournals.org)
The rationale for the combination of TAT and immunotherapy stems from known immune stimulating properties of radiation, leading to release of tumor-associated antigens, maturation of antigen-presenting cells (APCs) and in turn activation and proliferation of CD8+ T cells. (aacrjournals.org)
Combination strategies, involving cytostatic drugs, harbor the potential to overcome refractoriness to immunotherapy. (cell-stress.com)
Especially since Trilogy had only a bit more than 30% of patients with elevated LDH and thus a rather positively skewed population, this raises the question whether it would be really an advantage to use both the immunotherapy and the targeted therapy option in first-line rather than saving targeted therapy as an ideal second-line treatment in the case of CPI failure. (springermedizin.at)
The claims of the new patent build on the protection provided by the two previously granted patents, and are directed to methods of treating cancer by administering Immutep's lead active immunotherapy candidate eftilagimod alpha ("efti") and a PD-1 pathway inhibitor, specifically BMS-936559, durvalumab, atezolizumab or avelumab. (itbusinessnet.com)
Its favourable safety profile enables various combinations, including with anti-PD-[L]1 immunotherapy and/or chemotherapy. (itbusinessnet.com)
Surgery, chemotherapy, radiation therapy, and immunotherapy are just some of the treatments doctors use for uterine cancer, depending on the type and stage of the cancer. (healthline.com)
Finding the right balance is a key consideration in cancer immunotherapy approaches such as combination therapies and precision medicine. (genengnews.com)

Patients with invasive breast cancer that is ER+ or progesterone receptor positive (PR+) should be considered for adjuvant endocrine therapy with tamoxifen or aromatase inhibitors (AIs). (medscape.com)
SAN ANTONIO - Neoadjuvant treatment with the CDK4/6 inhibitor ribociclib (Kisqali) and the aromatase inhibitor letrozole (Femara) produced response rates similar to multi-agent chemotherapy in patients with high-risk luminal B breast cancer, according to results from the SOLTI-1402/CORALLEEN trial presented at the San Antonio Breast Cancer Symposium , held Dec. 10-14. (aacr.org)

METHODS: Samples of semen and blood were obtained from a cohort of 12 nucleoside reverse transcriptase inhibitor experienced men before and during 25-68 weeks of combination therapy, which included the protease inhibitor indinavir. (bmj.com)
Protease inhibitor combination therapies and perceptions of gay men regarding AIDS severity and the need to maintain safer sex. (bvsalud.org)

Poor reduction of HIV-1 RNA titres in nucleoside reverse transcriptase inhibitor experienced patients treated with indinavir combination therapy. (bmj.com)
CONCLUSIONS: These data show that stable reduction of blood and seminal fluid viral titres is not achievable in a significant proportion of nucleoside reverse transcriptase inhibitor experienced men. (bmj.com)
Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/432835/all/Tenofovir_or_zidovudine_in_three_drug_combination_therapy_with_one_nucleoside_reverse_transcriptase_inhibitor_and_one_non_nucleoside_reverse_transcriptase_inhibitor_for_initial_treatment_of_HIV_infection_in_antiretroviral_na��ve_individuals:_Cochrane_systematic_review. (unboundmedicine.com)

Preclinical proof of concept for this drug class in combination with RAS/RAF, PI3K/mTOR and hypoxia-inducing targeted therapeutics. (mainlinehealth.org)

Patients at high risk for recurrence should be evaluated for adjuvant treatment with CDK4/6 inhibitors. (medscape.com)
Previous studies showed that combining endocrine therapy with CDK4/6 inhibitors, drugs designed to prevent cancer cells from dividing, resulted in similar response rates to chemotherapy for metastatic breast cancers. (aacr.org)

Bortezomib is the first drug approved in the group of anticancer agents known as proteasome inhibitors. (medscape.com)
ZnPP works in combination with anticancer drugs to increase cytotoxicity. (wikipedia.org)
This article reviews current anticancer small-molecule inhibitors targeting epigenetic modified enzymes and displays their performances in different stages of clinical trials. (frontiersin.org)

The clinical hypothesis is that the combination of TLX250 and a DNA-PK inhibitor provides an enhancement in potency through their synergistic action on cancer cells. (aap.com.au)
As with classical cytotoxic therapy, the targeting of biologic pathways and mechanisms may best be accomplished using a combination of agents offering complementary mechanisms and synergistic pharmacodynamic interactions. (johnshopkins.edu)
Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza. (ox.ac.uk)
Overall, this review highlights the possibilities of synergistic therapy by building on existing research. (nature.com)

The combination of Cytotoxic T-Lymphozyte Antigen-4 (CTLA‑4) and Programmed death-1 (PD‑1) antibodies and the combination of BRAF and MEK inhibitors are the current clinical standards for combination immune and targeted therapy for melanoma, respectively. (springermedizin.at)
Currently several alternative immune check points like Tim‑3, Tigit, Vista LAG‑3 and others are tested, mostly in combination with PD1 inhibitors in clinical trials. (springermedizin.at)
The current trend in cancer therapy is the addition of immunomodulators that leverage immune attacks in the context of traditional standards of care. (mainlinehealth.org)
King Cancer's favorite counterstrikes include disabling the immune system and stirring up resistance to once-potent therapies. (genengnews.com)
In addition, a deeper understanding of the complex interplay of cells in the tumor microenvironment will lead to therapies directed at the specific mechanism of immune suppression in a specific patient. (genengnews.com)

Shaela Wright et al, Interrogating bromodomain inhibitor resistance in KMT2A-rearranged leukemia through combinatorial CRISPR screens, Proceedings of the National Academy of Sciences (2023). (medicalxpress.com)

The choice of chemotherapy depends on several factors, including the patient's performance status, age, renal function, desire for inpatient or outpatient therapy, and likelihood of receiving future autologous stem cell transplantation. (medscape.com)
Treatment options include chemotherapy, surgery, and other targeted therapies. (medicalnewstoday.com)
For chemotherapy-naive patients, TAXOTERE was evaluated in combination with cisplatin. (drugs.com)
The study enrolled 106 patients, who were randomly assigned 1:1 to receive either the ribociclib and letrozole combination or multi-agent chemotherapy as neoadjuvant treatment. (aacr.org)
Our results indicate that neoadjuvant treatment with a combination of ribociclib and letrozole has similar clinical benefits as standard multi-agent chemotherapy, and with less toxicity," said Gavilá. (aacr.org)
We believe that this combination is worth exploring as an alternative to chemotherapy for patients with high-risk luminal B breast cancer. (aacr.org)
Chemotherapy is a systemic therapy, so it can attack cancer cells anywhere in the body. (healthline.com)
Chemotherapy usually involves a combination of two or more drugs. (healthline.com)

We are pleased to support the commencement of this study with Telix to help determine if there is a potential future clinical benefit regarding the combination of molecular targeted radiation and DNA-PK inhibitors. (aap.com.au)
The Company has announced plans for Phase 2 clinical studies to evaluate Imprime PGG in combination with Merck's KEYTRUDA ® (pembrolizumab) in advanced melanoma, triple negative breast cancer, head and neck cancer, and non-small cell lung cancer. (econotimes.com)
furthermore, a double-blinded clinical trial in 2005 by Demets et al (IFIGENIA Study) on 182 patients with the diagnosis of idiopathic pulmonary fibrosis concluded that a therapy with acetylcysteine at a dose of 600 mg three times daily, added to prednisone and azathioprine, preserves vital capacity and diffusion capacity of carbon monoxide (DL CO ) in patients with idiopathic pulmonary fibrosis. (medscape.com)
The evidence to date suggests that adherence to therapy and clinical outcomes in developing world programmes are at least the equal of those observed in developed countries. (lww.com)
Therefore, the funding bodies responsible for the roll-out of antiretroviral access across the globe must mandate, incorporate and fund clinical research as an intrinsic aspect of combination ART roll-out programmes. (lww.com)
Gore, SD 2005, ' Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies ', Nature Clinical Practice Oncology , vol. 2, no. (johnshopkins.edu)
Thus, the aim is to provide an overview of the most important combination strategies in late stage clinical development and an outlook on drug combinations in early development that might enter larger clinical trials within the next few years. (springermedizin.at)
Several new combinations that aim to further improve these numbers are currently undergoing late-stage clinical development. (springermedizin.at)
Laurence Albiges joins Pedro Barata to discuss the CaboPoint study, a clinical trial designed to examine the question of activity and safety of cabozantinib single agent in patients who failed first-line combination therapy for advanced renal cell carcinoma (aRCC). (urotoday.com)
Epigenetic drugs show significant effects on both preclinical and clinical studies in which the target development and research offer a promising direction for cancer therapy. (frontiersin.org)
In this review, we summarize the basic principles manipulating the abovementioned epigenetic pathways and highlight the evidence of the promising clinical and preclinical results using small-molecule inhibitors against chromatin regulators for cancer treatment. (frontiersin.org)
Sandesh Seth , Actinium's Chairman and CEO, said, "We are excited to present data from our Ac-225 clinical programs and AWE platform at the preeminent conference focused on targeted alpha-particle therapies. (prnewswire.com)
In gen- or providing alternative therapeutic regimens for high-risk eral, triple therapy regimens usually entail two of the fol- populations may be important for future clinical practice. (cdc.gov)

Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy. (cell-stress.com)

C1 inhibitor concentrate is preferred for acute treatment. (lu.se)

In our study, we show that combination treatment of targeted inhibition of mitogen-activated protein kinase (MAPK) kinase (MEK) and agonist immunostimulatory anti-CD40 antibody (Ab) is particularly suitable in counteracting aforementioned ICB resistance mechanisms (Fig. 1). (cell-stress.com)
The combination of vemurafenib and cobimetinib with the PD-L1 blocking antibody atezolizumab (NCT02908672, Trilogy) as well as the combination of dabrafenib and trametinib with the PD‑1 blocking antibody spartalizumab (NCT02967692, Combi-I) are currently being tested in phase III trials in patients with BRAF mutations and in comparison to the respective BRAF/MEK inhibitor combination. (springermedizin.at)

An expert shares her take on emerging strategies for combination treatment for NAFLD and NASH with GLP-1 receptor agonists plus SGLT2 inhibitors. (clinicaloptions.com)
Telix Chief Medical Officer, Dr. Colin Hayward stated, "Preclinical data has shown excellent combination response, which has potential to translate to additional response or more tolerable treatment regimens in patients. (aap.com.au)
DNA methyltransferase (DNMT) inhibitors - azacitidine and decitabine - have significant activity in the treatment of MDS. (johnshopkins.edu)
SGLT2 inhibitors are a new class of oral drugs for the treatment of type 2 diabetes mellitus currently in phase III studies. (bjcardio.co.uk)
Treatment with traditional glucose-lowering therapies, including metformin, sulphonylureas and insulin, is commonly limited by gastrointestinal side effects, weight gain and hypoglycaemia. (bjcardio.co.uk)
Phlorizin, a bitter white glycoside isolated from apple tree bark by French chemists in 1835, is a naturally occurring inhibitor of both SGLT1 and SGLT2 and was used for the treatment of diabetes in the pre-insulin era. (bjcardio.co.uk)
Cytokine -induced killer (CIK) cell therapy is considered as a potential treatment for cancer treatment . (bvsalud.org)
Our in vitro study indicated that knockdown of FAK in TNBC cells or treat with the FAK inhibitor followed by co-culture with CIK cells induced more cell death than CIK cells treatment only. (bvsalud.org)
The combination of FAK inhibitor and CIK cells significantly suppressed tumor growth than the treatment of FAK inhibitor or CIK cells alone in vivo. (bvsalud.org)
Our findings provide new insights into the cytotoxic effect of CIK cell therapy in TNBC treatment and indicate that the combination of CIK cell therapy with FAK inhibitors may be an alternative therapeutic strategy for patients with TNBC. (bvsalud.org)
Methods: We conducted a cohort study of 349,476 patients who received treatment with a DPP-4 inhibitor, sulfonylurea, or pioglitazone plus metformin for type 2 diabetes using the Korean national health insurance claims database. (ewha.ac.kr)
Conclusions: Compared with a DPP-4 inhibitor plus metformin, treatment with a sulfonylurea drug plus metformin was associated with increased risks of total CVD, MI, and IS, whereas the use of pioglitazone plus metformin was associated with decreased total CVD and IS risks. (ewha.ac.kr)
While there was a modest reduction in pGlu-Abeta and total Abeta following low dose treatment with each single agent, there was a significant reduction in pGlu-Abeta and total Abeta in the combination-treated mice. (vivoryon.com)
The combination prevented the 10-fold increase of pGlu-Abeta observed in control animals during the treatment period. (vivoryon.com)
It is important to emphasize that specific targeting of pGlu-Abeta by combination treatment also reduced total Abeta. (vivoryon.com)
As such, it offers a mechanism to broaden uses and markets for companies developing IDO/TDO inhibitors for cancer treatment. (mainlinehealth.org)
The mainstay of treatment includes first-line cholinesterase inhibitors (ChEI) and the addition of memantine in moderate to severe disease. (arcadia.edu)
In the other three patients combined steroid and PSI treatment as induction therapy led to improvements in serology, renal function and proteinuria. (nih.gov)
Proliferation signal inhibitors warrants further investigation as an alternative immunosuppressive treatment in lupus nephritis. (nih.gov)
Drugs of this class, which are used in the treatment of type II diabetes, include Galvus (vildagliptin), Januvia (sitagliptin), Onglyza (saxagliptin), Trajenta (linagliptin), and the combination tablets Eucreas (metformin + vildagliptin), Janumet (metformin + sitagliptin) and Jentadueto (metformin + linagliptin). (mims.co.uk)
The overall segmentation of the sinusitis treatment drugs market, especially therapy type is thoroughly studied. (medgadget.com)
Purpose ACE inhibitors (ACEi) and spironolactone are both used in the treatment of adult heart failure, due to their propensity to cause hyperkalemia and renal impairment in this ageing population, the concurrent administration is advised with caution by the Medicines and Healthcare products Regulatory Agency (MHRA). (bmj.com)
In all cases urea and electrolytes were measured pre-treatment and at intervals during the therapy. (bmj.com)
Stendra (avanafil) is a phosphodiesterase 5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction . (rxlist.com)
This article discusses different therapies for uterine cancer, when they're used, and what you can expect from treatment. (healthline.com)

In 10-20% of cases, this may reveal invasive cancer or DCIS that requires additional local or systemic therapy. (medscape.com)
analyzing the velocity (i.e., the change over time) of the markers, malignancy we could stipulate for each patient the risk of developing metas- tasis after the end of adjuvant systemic therapy. (lu.se)
This heterogeneity affects response to surgery and/or systemic therapy, and also facilitates inherent and acquired drug resistance. (cdc.gov)

Consider risk-reduction therapy with tamoxifen 20 mg PO qDay (in pre- and postmenopausal women) or raloxifene 60 mg PO qDay (in postmenopausal women) for 5 years in patients with estrogen receptor (ER)-positive DCIS. (medscape.com)

The main issue with these triplet trials is on the one hand that the comparator arm of BRAF/MEK inhibition is not the recommended first-line therapy for unresectable metastatic melanoma in major guidelines. (springermedizin.at)
MOHAPATRA P, PRASAD CP and ANDERSSON T. Combination therapy targeting the elevated interleukin-6 level reduces invasive migration of BRAF inhibitor-resistant melanoma cells. (lu.se)

Study first author Shaela Fields (Wright), from the lab of Chunliang, Li, PhD, St. Jude Department of Tumor Cell Biology, led research to understand BET inhibitor resistance. (medicalxpress.com)
However, the mechanisms governing response and resistance to this class of therapies are poorly understood. (medicalxpress.com)
The researchers found that loss of the SPOP gene causes significant BET inhibitor resistance, which they confirmed in cell lines and xenograft mouse models. (medicalxpress.com)
Our findings led us to a combination regimen that can reverse resistance to BET inhibition. (medicalxpress.com)
Existing pharmacological therapies, which have been previously described in this series, are focused on reducing insulin resistance, increasing insulin secretion, slowing carbohydrate digestion, restraining glucagon production, and supplying exogenous insulin. (bjcardio.co.uk)
The combination of these two therapies is highly effective in treating cancer in experiments thus far, and is a possible new method for overcoming drug resistance. (wikipedia.org)
Thus, site-directed drug combinations show potential to rejuvenate M2 as an antiviral target whilst reducing the risk of drug resistance. (ox.ac.uk)

Recent data from pivotal studies have demonstrated that roughly up to 35% (for BRAF/MEK inhibitors) and 50% (for Ipi/Nivo) of first-line patients treated with these combinations are still alive after 5 years. (springermedizin.at)
Methods A single centre retrospective study of paediatric heart failure patients treated with a combination of Captopril and Spironolactone. (bmj.com)

This study sought to determine whether a differential risk of cardiovascular disease (CVD) exists for the combination of a dipeptidyl peptidase-4 (DPP-4) inhibitor plus metformin versus a sulfonylurea derivative plus metformin or pioglitazone plus metformin. (ewha.ac.kr)
The dipeptidyl peptidase 4 (DPP4) inhibitors linagliptin. (mims.co.uk)

In elderly patients or patients in whom autologous transplantation is not possible in the future, melphalan and prednisone (MP) therapy is preferred because of its ease of administration and low toxicity. (medscape.com)

As the cost of "potent but expensive" injectable therapies has limited their uptake, he noted, "there remains a high unmet need for new effective, safe therapies. (medscape.com)
We are committed to bringing important therapies to patients with high unmet needs and feel that Ac-225 has the potential to be an optimal warhead when applied in a targeted manner as we do. (prnewswire.com)

More recently, it has been shown that PARP-1 inhibition increases the speed of fork elongation and does not cause fork stalling, which is in contrast to the accepted model in which inhibitors of PARP induce fork stalling and collapse 15 . (nature.com)

He emphasized that cost limits the use of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors and small-interfering (si)RNA drugs, "so there is a huge unmet need globally in order to get patients to goal. (medscape.com)
After that," Catapano said, there will be combination therapy, starting with bempedoic acid and ezetimibe, followed by PCSK9 inhibitors, siRNA drugs, and CETP inhibitors, all competing for the same space. (medscape.com)
The main dilemma in finding combinations of cytostatic and immunostimulatory drugs that act synergistically is as follows. (cell-stress.com)
It was also fueled by the fact that a lot of those early drugs, especially in the 1990s and early 2000s, were quite toxic - drugs like zidovudine (AZT) , stavudine (d4T), didanosine (ddI) , and the early protease inhibitors . (medscape.com)
Thus, there is a need for drug adjuvants to leverage the immunomodulatory effects of targeted drugs where IDO inhibitors are well-positioned. (mainlinehealth.org)

If licenced, this combination of treatments will offer an additional therapy option for those who have already had hormonal therapy but their cancer has relapsed. (nihr.ac.uk)

7 The increasing prevalence of type 2 diabetes, in combination with limitations of current therapies, has led to the search for newer alternatives. (bjcardio.co.uk)

Accordingly, the administration of proton pump inhibitors (PPI) is recommended to prevent UGIB. (yakhak.org)
이런 부작용의 예방목적으로 프로톤 펌프 억제제(proton pump inhibitors, PPI) 병용이 고려되고 있다. (yakhak.org)

Combination of FAK inhibitor and cytokine-induced killer cell therapy: An alternative therapeutic strategy for patients with triple-negative breast cancer. (bvsalud.org)

Access to second-line ART regimens in developing countries is problematic, mainly because of the expense of HIV protease inhibitors (PIs). (lww.com)
This review article touches on some of the more promising combination regimens in various phases of investigation. (johnshopkins.edu)
Combination therapies with DNMT inhibitors using optimal dosing regimens to focus on methylation reversal with lower doses over longer periods of time, rather than direct cytotoxic effects, are beginning to suggest promising results in MDS and AML. (johnshopkins.edu)
Quadruple regimens are used as a salvage therapy when triple therapy regimens have failed (4). (cdc.gov)

The year 2006 marked 25 years since the first description of AIDS and 10 years since the advent of the potent, combination antiretroviral therapy (ART) that has had such a dramatic success in reducing AIDS and prolonging the duration and quality of life of those living with HIV infection [1-4] . (lww.com)
Ac-225 is a potent alpha-particle emitting isotope being utilized in Actinium's ARC programs for targeted conditioning in the planned pivotal Actimab-MDS trial as well as therapeutic and combination trials such as its Actimab-A Venetoclax combination trials and Actimab-MRD therapeutic trial. (prnewswire.com)

Fusion utilizes targeted alpha therapy (TAT) which enables delivery of alpha particle emitting isotopes (actinium 225) to the targeted tumor cells. (aacrjournals.org)
TAT is a bi-annual global conference which brings together thought leaders in alpha-particle therapy innovation. (prnewswire.com)

OBJECTIVES: The long term effectiveness of combination therapy at reducing viral loads in seminal fluid and blood plasma obtained from HIV-1 infected men who had undergone previous antiretroviral therapy was assessed. (bmj.com)
Second-line combination antiretroviral therapy in resource-l. (lww.com)
Combination antiretroviral therapy (ART) has dramatically altered the prognosis of individuals infected with HIV. (lww.com)
What's New in the Field of Antiretroviral Therapy Guidelines for HIV? (medscape.com)
Today we're going to discuss antiretroviral therapy (ART) guidelines. (medscape.com)
These guidelines were developed by the Working Group on Antiretroviral Therapy and Medical Management of HIV-Infected Children convened by the National Pediatric and Family HIV Resource Center (NPHRC), the Health Resources and Services Administration (HRSA), and the National Institutes of Health (NIH). (cdc.gov)

MILAN - Adding the cholesteryl ester transfer protein (CETP) inhibitor obicetrapib to high-intensity statins significantly lowers cholesterol levels and substantially increases the number of patients achieving cholesterol targets, suggest data from the ROSE trial. (medscape.com)
Ray began his presentation by explaining that any update to risk-based goals for LDL cholesterol "inevitably means" the greater use of combination therapies in addition to high-intensity statins. (medscape.com)

Emerging results suggest that many molecular targeted therapies developed as precision medicines for cancer indirectly exert immunostimulatory effects. (mainlinehealth.org)

The target population is patients with CAIX-expressing solid tumours that are relapsed or refractory to standard therapies. (aap.com.au)
Patients who received methylene blue with or without hydroxocobalamin for refractory vasoplegic syndrome rescue therapy. (nih.gov)

In patients with renal failure or highly aggressive disease, therapy with vincristine, Adriamycin (doxorubicin), and dexamethasone (VAD) may be preferred. (medscape.com)

Targeted radiation effectively induces DNA damage in targeted cancer cells and the DNA-PK inhibitor may act to prevent the cell from repairing this damage, resulting in higher potency at lower doses. (aap.com.au)
Merck and Telix are continuing the initial scientific collaboration to further explore and optimise the combination of TLX250 or other next-generation targeted radiation therapy candidates with Merck's DDRi compounds in preclinical studies. (aap.com.au)
ZnPP and radiation combination therapy shows more apoptosis than the same amount of radiation displaying that ZnPP puts stress on cancerous tissue. (wikipedia.org)
Over half of cancer patients undergo radiation therapy (RT). (nature.com)
You may need radiation therapy when cancer has spread beyond the uterus. (healthline.com)
Internal radiation therapy involves putting radioactive materials inside the body. (healthline.com)
With external beam radiation therapy, a machine sends beams of radiation to a specific area of your body. (healthline.com)

The latest results are something of a reversal for the CETP inhibitor, after a series of disappointments led to many writing them off, and the original developer of obicetrapib, Amgen, discontinuing development in 2017. (medscape.com)

As such, the technology could enable companies to expand markets for their IDO inhibitors with other owned modalities. (mainlinehealth.org)

If taken in combination with an intramuscular injection of fulvestrant, which stops the effect of hormones altering the breast cells, taselisib has the potential to prolong survival. (nihr.ac.uk)

Noting that obicetrapib has previously demonstrated LDL-cholesterol reductions of 45% against low or no statin therapy, Ray said the ROSE study set out to examine the drug in addition to high-intensity statin therapy. (medscape.com)
ZnPP is finding a new use as a drug in combined cancer therapies. (wikipedia.org)
New uses of IDO inhibitors in combination drug therapy: PCT patent application. (mainlinehealth.org)

Organisms3

Diseases6

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes1

Disciplines and Occupations1

Information Science4

Efficacy19

Selective Inhibitor1

Monotherapy8

Checkpoint6

Immunotherapy9

Aromatase2

Protease inhibitor2

Nucleoside3

MTOR1

CDK42

Anticancer3

Synergistic4

Immune5

20231

Chemotherapy8

Clinical13

Antibodies1

Acute1

Antibody2

Treatment25

Systemic therapy3

Tamoxifen1

Melanoma2

Resistance7

Patients treated2

Dipeptidyl2

Toxicity1

High unmet2

Induce1

Drugs5

Treatments1

Type 2 diabet1

Proton2

Breast cancer1

Regimens4

Potent2

Alpha particle2

Antiretroviral6

Statins2

Molecular targeted1

Refractory2

Renal1

Radiation7

Reversal1

Modalities1

Fulvestrant1

Drug3