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  • cyclin
  • We have previously found that the mechanism of the G 2 phase response to ionizing radiation comprises repression of the genes for Plk1 and cyclin B1, PLK and CCNB1 ( 10 ). (aacrjournals.org)
  • p21 in turn inhibits the activity of Cdk2- and Cdk4-cyclin complexes, thereby arresting the cells in a tetraploid G 1 state (reviewed in ref. 21 ). (pubmedcentralcanada.ca)
  • In addition to arresting cells in G 1 , p21 can inhibit Cdc2-cyclin B complexes ( 21 ) and proliferating cell nuclear antigen ( 22 - 24 ), preventing interaction of the latter with other components of the DNA polymerase complex. (pubmedcentralcanada.ca)
  • These findings indicate that exposure of 6-gingerol may induce intracellular ROS and upregulate p53, p27 Kip1 , and p21 Cip1 levels leading to consequent decrease of CDK1, cyclin A, and cyclin B1 as result of cell cycle arrest in LoVo cells. (hindawi.com)
  • Cell cycle is under sophisticated regulation through the interactions of different cyclins with their specific kinases, cyclin-dependent kinases (CDKs) [ 14 ]. (hindawi.com)
  • Expression of Cyclin D1 and pRb (Ser 795) indicate the cell cycle re-entry of neurons. (springer.com)
  • effector
  • The p53 effector genes involved in genomic instability are unknown, however. (beds.ac.uk)
  • Examples of known p53 effector genes that have distinct cellular effects. (beds.ac.uk)
  • We found that anti GD2 anti bodies did not cause substantial activation of caspase 3 the level of activity of this effector caspase was 3 4 folds lower for anti GD2 treated cells when compared to the EL 4 cells treated with staurosporine. (mek-inhibitors.com)
  • therapeutic
  • Among molecular cell cycle-targeted drugs currently in the pipeline for testing in early-phase clinical trials, HDAC inhibitors may have therapeutic potential as radiosensitizers. (aacrjournals.org)
  • So far, the results suggest that this compound may have a potential therapeutic effect against leukemia cells. (ijpsonline.com)
  • It is important to recognize these less appreciated functions of p38 MAPK when considering the potential use of pharmacological inhibitors of p38 MAPK in therapeutic treatments for disease. (ijbs.com)
  • The unusual gene activity has the potential to stimulate the immune system -- a previously unnoticed effect that may increase the effect of therapeutic agents. (medworm.com)
  • molecular
  • Additionally, in the group of intermediate-risk patients, molecular monitoring of the amount of residual leukemic cells during treatment [minimal residual disease (MRD)] allows the identification of a subgroup with high burden of persisting leukemic cells and significantly inferior prognosis ( 7 ). (aacrjournals.org)
  • Molecular and Cell Biology, 1988, 8: 1247-1252. (freepatentsonline.com)
  • adhesion molecule
  • The NF-kB dependent activation of cell adhesion molecules, such as vascular cell adhesion molecule (VCAM) and intercellular adhesion molecule (ICAM), which have been found to increase in various cancers, are involved in leukocyte adhesion and migration within the inflammatory tumor microenvironment. (oatext.com)
  • Cross reactivity of anti GD2 mAbs with cell adhesion molecule ALCAM and Inhibitors,Modulators,Libraries other gangliosides There is an evidence that 14G2a antibodies could cross react with highly glycosylated ALCAM adhesion molecule, which is expressed in different tissues, mainly on cells of the immune system, and this molecule does not exhibit tumor association. (mek-inhibitors.com)
  • regulators
  • in contrast, levels of the negative cell cycle regulators p27 Kip1 and p21 Cip1 were increased in response to 6-gingerol treatment. (hindawi.com)
  • thus
  • Thus, during this phase, the amount of DNA in the cell has effectively doubled, though the ploidy of the cell remains the same. (wikibooks.org)
  • Thus, we sug gested that the first event of anti GD2 mAb induced cell death was a hyperpolarization of mitochondrial membrane potential, and then AVD, cell membrane permeability and decrease in MMP were occurred. (mek-inhibitors.com)
  • defective
  • SCID cells defective in DNA-PKcs are hypersensitive to X-ray during G1 and early S phase ( 8 ). (spandidos-publications.com)
  • It also eliminated p53-defective, PTEN-deleted, highly-metastasized cancer cells grafted onto nude mice ( 5 ), for which the standard chemotherapies and some targeted therapies had not worked. (aacrjournals.org)
  • regulatory
  • Transcription of long noncoding RNAs (lncRNAs) within gene regulatory elements can modulate gene activity in response to external stimuli, but the scope and functions of such activity are not known. (nature.com)
  • cancers
  • Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), which are known collectively as nonmelanoma skin cancer, are two of the most common malignancies in the United States and are often caused by sun exposure, although several hereditary syndromes and genes are also associated with an increased risk of developing these cancers. (oncolink.org)
  • genome
  • By genome-wide assessment, we have identified target genes of STAT3. (pnas.org)
  • Here, we have performed a genome-wide transcriptome analysis by probing cDNA microarrays with fluorescent-labeled amplified RNA derived from laser capture microdissected cells procured from normal nasopharyngeal epithelium and areas of metaplasia-dysplasia and carcinoma from EBV-associated nasopharyngeal carcinomas. (aacrjournals.org)
  • 16 Although genome-wide linkage studies of nonsyndromic, familial IAs have shed light on susceptibility loci and genes, 17 - 19 such large kindreds are uncommon and preclude the extrapolation of results to the general population. (ahajournals.org)
  • Moreover, choosing just one oncogene in a complex cancer genome to inactivate and eliminate a heterogeneous population of cancer cells is very difficult and it may not be always possible. (aacrjournals.org)
  • PARP
  • We investigated the effect of the PARP-1 inhibitor INO1001 on aortic-occlusion-related porcine spinal cord injury. (springer.com)
  • The selective PARP-1 inhibitor INO1001 markedly reduced aortic occlusion-induced spinal cord injury. (springer.com)
  • HDAC
  • HDAC inhibitors sensitize cancer cells to DNA damaging therapies (e.g., irradiation and various chemotherapeutics) by altering chromatin structure and downregulating DNA repair. (aacrjournals.org)
  • A clear synergistic effect has been showed in vivo when combining HDAC inhibitors and anthracyclines ( 8 , 18 ). (aacrjournals.org)
  • 2017
  • Kwak TW, Park SB, Kim H-J, Jeong Y-I, Kang DH (2017) Anticancer activities of epigallocatechin-3-gallate against cholangiocarcinoma cells. (springer.com)
  • alterations
  • German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) Drugs that are used in cancer therapy to erase epigenetic alterations in cancer cells simultaneously promote the production of countless mysterious gene transcripts, scientists from the German Cancer Research Center now report in Nature Genetics. (medworm.com)
  • At the crux of newer agents in MCL lie alterations of the B cell receptor (BCR). (pubmedcentralcanada.ca)
  • activation
  • The effect was associated with the activation of cell cycle checkpoints. (spandidos-publications.com)
  • Because 2DG also sensitizes cancer cells to Bcl-2 antagonists such as ABT ( 5 ), addition of a Bcl-2 antagonist to 2DG-treated cells mechanically activates Bak, circumventing the usual signal transduction cascades required for Bak activation. (aacrjournals.org)
  • Next we investigated activation of caspase 3 in EL 4 cells treated for 24 h with anti GD2 antibody 14G2a using fluorescently labeled substrate for caspase 3 Z DEVD AFC. (mek-inhibitors.com)
  • Constitutive activation of signaling components downstream of the B cell receptor play an important role in the pathobiology of mantle cell lymphoma. (pubmedcentralcanada.ca)