Inhibitor caspase 12. Medical search. Frequent questions

For the death pathway, the caspase-8 zymogen is cleaved into subunits that assemble to form the mature, highly active caspase heterotetramer whereas for the activation pathway, the zymogen appears to remain intact perhaps to limit its proteolytic function but enhance its capability as an adapter protein. (wikipedia.org)
Radiation induces caspase activation fundamentally via the mitochondrial pathway. (spandidos-publications.com)
Radiation and other agents induce caspase activation fundamentally via the mitochondrial pathway, which includes mitochondrial integration of apoptotic signals and the subsequent release of cytochrome c into the cytosol ( 5 , 9 , 10 ). (spandidos-publications.com)
This study describes an integrated pathway in beta cells that links beta cell dysfunction induced by pro-inflammatory cytokines with 12-lipoxygenase and NADPH oxidase (NOX-1) activation. (nih.gov)
Inhibitors of this pathway may provide a new therapeutic strategy to preserve beta cell mass in diabetes. (nih.gov)
Recent studies have demonstrated that pharmacological inhibition of the Notch pathway with γ-secretase inhibitor (GSI) induces apoptosis of multiple myeloma (MM) cells via upregulation of the proapoptotic protein Noxa. (aacrjournals.org)
Though inducing more significantly pyroptosis by activating Caspase-1/GSDMD pathway, OP-B relieved DDP resistance of A549 cells. (researchsquare.com)
The activation of classical and non-classical pathway is separately dependent on Caspase-1 or Caspase-4/5/11 (6, 7). (researchsquare.com)
combined BI2536 (an inhibitor of PLK1) with cisplatin (DDP) to treat ESCC cells and found the combination of two drugs had a synergistic effect on tumor inhibition and resulted in pyroptotic death of cancer cells by Caspase-3/GSDME pathway. (researchsquare.com)
Our data provide novel evidence that a Akt/GSK-3β/tau-dependent, but not caspase-3 signaling pathway plays a pivotal role in GT1b-mediated neurotoxic actions on mesencephalic DA neurons. (biomedcentral.com)
Nuclear factor-kappa B (NF- κ B) inhibits cell death through suppression of the caspase cascade, the c-Jun N-terminal kinase (JNK) pathway, and reactive oxygen species (ROS) accumulation. (nature.com)
After polymers produced by 2-5OAS activate RNase L, RNase L begins to fragment mRNA and upregulates an apoptotic pathway involving caspases. (phoenixrising.me)
There was also no translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus in apoptotic keratinocytes, indicating Tan IIA-induced apoptosis occurs mainly through the caspase pathway. (hindawi.com)
Protein and gene expression of apoptotic signaling pathway-related proteins such as caspase-3, cytochrome c, and PARP were determined to provide evidence for the mechanisms of action of Tan IIA in the treatment of psoriasis. (hindawi.com)

Contemplating that only a modest raise in VEGF protein results in efficacious new vessel formation inside a range of animal models and that angiogenesis is regulated by a balance of angiogenesis inducers and inhibitors, achievable explanations for an insufficient angiogenesis in SSc incorporate a blockade in the biologic effects of VEGF by one particular or a lot more angiostatic things [25,29]. (scdinhibitor.com)
Caspase-8 is a caspase protein, encoded by the CASP8 gene. (wikipedia.org)
Caspase-activated DNase (CAD) or DNA fragmentation factor subunit beta is a protein that in humans is encoded by the DFFB gene. (wikipedia.org)
it acts as a CAD inhibitor and also as a chaperone for CAD synthesis assisting the correct assembly of the protein. (wikipedia.org)
Caspase 3 is responsible for cellular differentiation, although it is unclear how this kind of protein can promote the cell apoptosis. (wikipedia.org)
The present study performed immunohistochemistry, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and western blot analysis and identified no significant changes in the expression of the X-linked inhibitor of apoptosis protein (XIAP) following radiation (P>0.05). (spandidos-publications.com)
Recognition of the inflammatory ligand results in the formation of inflammasomes ( 3 , 6 ), which are multi-protein signaling hubs that initiate immune responses by recruiting and activating proteases, such as caspase-1 (Casp-1) ( 4 - 7 ). (frontiersin.org)
Wnt3a protein rescued both caspase-blocked regeneration and branchial sac growth. (biologists.com)
We showed that LPS/zVAD- and poly I:C/zVAD-induced cell death in bone marrow-derived macrophages (BMDMs) was inhibited by receptor-interacting protein kinase 1 (RIP1) inhibitor necrostatin-1 and autophagy inhibitor 3-methyladenine. (molcells.org)
We have recently shown that tumor necrosis factor (TNF) α induces caspase-dependent and -independent JNK activation and ROS accumulation in cellular FLICE-inhibitory protein (c-Flip) −/− murine embryonic fibroblasts (MEFs). (nature.com)
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors. (nature.com)
The actual [Ca(2+)]i and also the protein appearance of caspase-3, -8, -9 as well as -12 ended up examined in most new organizations. (methylation-inhibitors.com)
The apoptosis induced by 35 was characterized by the regulation of markers, including an increase in Bax, cleaved- caspase 3, and cleaved-PARP proteins, and a decrease in Bcl-2 protein. (atpasesignal.com)
It has been proposed that adjuvanticity of some particulate adjuvants (such as alum) is dependent upon the activation of a protein complicated called the Nlrp3 inflammasome that processes specific pro-inflammatory cytokines like pro-IL1 via Caspase 1 (12, 16). (itkinhibitor.com)
Free shipping on inhibitor and protein orders over $500. (adooq.com)

The most important enzymes involved in apoptosis are caspases, which hydrolyze important structural and functional proteins of the cell, ultimately leading to apoptosis. (spandidos-publications.com)
Once activated by their respective upstream signals, caspase-8 and -9 may cleave and activate downstream executioner caspases -3 and -7, which, in turn, cleave a plethora of target proteins, resulting in apoptotic death ( 6 - 8 ). (spandidos-publications.com)
The inhibitor of apoptosis proteins (IAPs) inhibit apoptosis by interacting with and then regulating the functions of caspase-8 or caspase-9, -3 and -7 ( 9 , 11 , 12 ). (spandidos-publications.com)
It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains. (thermofisher.com)
Activated caspase-3 cleaves proteins essential for cell survival, including bcl-x L . To explore the potential of caspase-3 as a cytotoxic and immunostimulatory molecule in the treatment of malignancy, an RU486-inducible caspase-3 retrovirus was constructed, validated, and used to transduce first 3T3 and subsequently murine myeloma B9BM1 cells (creating the cell line B9BM-C3). (elsevierpure.com)
Activated caspase-3 cleaves proteins essential for cell survival, including bcl-xL. (elsevierpure.com)

CAD release from ICAD inhibition is achieved by cleavage of ICAD at these Asp residues by the caspase-3. (wikipedia.org)
Upon caspase-3/7 cleavage, Ac-DEVD-AFC generates the AFC fluorophore which has bright blue fluorescence and can be detected at Ex/Em=380 nm/500 nm. (eurogentec.com)
Cell Signaling Technology, Inc.) to recognize FL-caspase-3 (350 kDa) and caspase-3 fragment (170 kDa) resulting from cleavage at asparate position 175. (flapinhibitor.com)
Treatment with tea polyphenols caused rapid induction of caspase-3, but not caspase-1, activity and stimulated proteolytic cleavage of poly(ADP-ribose) polymerase (PARP). (tmu.edu.tw)

Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. (wikipedia.org)
Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. (wikipedia.org)
The defect in lymphocyte activation and protective immunity suggested that caspase-8 had additional signaling roles in lymphocytes. (wikipedia.org)
Caspase-3 activation is a cell requirement during early stages of the skeletal myoblast differentiation. (wikipedia.org)
Caspase signals resulting from the activation of nuclease CAD indicate that the cell differentiation is due to a CAD modification in chromatin structure. (wikipedia.org)
We demonstrated that UVB irradiation induces IL-1β upregulation and IL-1β-dependent inflammation via caspase-1 activation in these Nlrp1b KI mice. (frontiersin.org)
The caspase activation and recruitment domain (CARD) of caspase-4 recognises the lipid A moiety of LPS. (guidetopharmacology.org)
Activation of caspase-4 results in pyroptosis, and induction of NLRP3 inflammasome activation which promotes IL-1β and IL-18 maturation and secretion. (guidetopharmacology.org)
In this study, we used circulating lymphocytes isolated from human blood and found that rotenone (50-250microM, 12-18h) caused apoptosis (phosphatidylserine externalization, caspase 3/7 activation), reactive oxygen species production (superoxide, H2O2), mitochondrial dysfunction (inactivation of complex I, decrease of mitochondria membrane potential, depletion of ATP) and activation of peroxidase activity of mitochondria. (cdc.gov)
Previously we reported that UVB irradiation induces apoptosis accompanied by sequential activation of caspase 8, 3 and 1 in keratinocytes, and that the process is inhibited by various caspase inhibitors. (bioone.org)
These cytokines induce caspase-3 activation as an effector caspase that activates hepatic stellate cells (HSCs) and cause fibrogenesis [ 11 ]. (bsmiab.org)
Consistent with the results using c-Flip −/− MEFs, we found that TNF α stimulation induced caspase-dependent prolonged JNK activation and ROS accumulation, followed by apoptotic and necrotic cell death in various tumor cells. (nature.com)
It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. (thermofisher.com)
Mitochondrial regulation of apoptosis further downstream was investigated, showing changes in the mitochondrial membrane potential, cytochrome c release into the cytoplasm, and enhanced activation of cleaved caspase-3 and Poly ADP-ribose polymerase (PARP). (hindawi.com)
Activation of caspase-3 was evident in induced cells and cell death could be inhibited by the addition of a caspase-3-specific inhibitor. (elsevierpure.com)
The molecular mechanisms of tea polyphenol-induced apoptosis as determined by annexin V apoptosis assay, DNA fragmentation, and caspase activation were further investigated. (tmu.edu.tw)

2001) Potent and selective nonpeptide inhibitors of caspases 3 and 7. (guidetopharmacology.org)
2007) (S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18. (guidetopharmacology.org)
A commonly used pesticide , rotenone, is a mitochondrial respiratory complex I inhibitor capable of selective oxidation of mitochondrial phospholipid, cardiolipin (CL). (cdc.gov)
Given that ROS accumulation and necrotic cell death enhance inflammation followed by compensatory proliferation of tumor cells, selective suppression of caspase-dependent ROS accumulation will be an alternative strategy to protect cells from ROS-dependent DNA damage and compensatory tumor progression. (nature.com)

Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unknown. (thermofisher.com)

As a specificity control, the inhibitor LEHD-FMK for caspase-9 was added to the reactions along with relevant substrate (d). (cdc.gov)
DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. (wikipedia.org)
Both caspase-3 and caspase-7 have substrate selectivity for the amino acid sequence Asp-Glu-Val-Asp (DEVD). (eurogentec.com)
Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9. (adooq.com)

The kit is suitable for high throughput screening of apoptosis inducers and inhibitors. (eurogentec.com)

Moreover, the biochemical form of caspase-8 differed in the two pathways. (wikipedia.org)
Anticancer effects of the HDAC inhibitor, 3β,6β‑dihydroxyurs‑12‑en‑27‑oic acid, in MCF‑7 breast cancer cells via the inhibition of Akt/mTOR pathways. (iasp-pain.org)
When caspase activity was impaired, genes known to be involved in metamorphosis were downregulated along with other implicated in cell migration and survival molecular pathways. (biomedcentral.com)

2005) Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. (guidetopharmacology.org)
We compared the HCV anti- viral effect of the most potent SKI-1/S1P small molecule inhibitor (PF-429242) with a set of two statins on different steps of the viral life cycle, and showed that SKI-1/S1P inhibitor blocked HCVcc (strain JFH-1) RNA replication (EC50 = 5.8 lM) more efficiently than statins. (cp-673451inhibitor.com)
Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1. (adooq.com)
Pretreatment with a potent caspase-3 inhibitor, Z-Asp-Glu-Val-Asp-fluoromethyl ketone, inhibited theasinensin A induced DNA fragmentation. (tmu.edu.tw)

Our data further support the involvement of autocrine IFNs action in reactive oxygen species (ROS)-dependent necroptosis, LPS/zVAD-elicited ROS production was inhibited by necrostatin-1, neutralizing antibody of IFN receptor (IFNR) and JAK inhibitor AZD1480. (molcells.org)

Accessed on 09/12/2023. (guidetopharmacology.org)

VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18. (adooq.com)

z-VAD-fmk ( N -benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone) is a powerful, irreversible and cell permeable inhibitor of caspases, and has been demonstrated to directly block the activity of caspases ( 13 ). (spandidos-publications.com)
Z-VDVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-2. (adooq.com)
Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor. (adooq.com)

Cytochrome c in turn activated caspases cascade resulting in the induction of apoptosis. (afpm.org.my)
Furthermore, it was found that theasinensin A induced loss of mitochondrial transmembrane potential, elevation of ROS production, release of mitochondrial cytochrome c into the cytosol, and subsequent induction of caspase-9 activity. (tmu.edu.tw)

Nted by the caspase-inhibitor zVAD (Supple mentary Figure S3b). (caspaseinhibitor.com)
In macrophages, necroptosis can be induced by co-treatment with Toll-like receptor (TLR) ligands (lipopolysaccharide [LPS] for TLR4 and polyinosinic-polycytidylic acid [poly I:C] for TLR3) and a cell-permeable pan-caspase inhibitor zVAD. (molcells.org)

Biochemically, caspase-8 was found to enter the complex of the inhibitor of NF-κB kinase (IKK) with the upstream Bcl10-MALT1 (mucosa-associated lymphatic tissue) adapter complex which were crucial for the induction of nuclear translocation of NF-κB. (wikipedia.org)
Pharmacological inhibition of Trx by 1-methyl-2-imidazolyl-disulfide (PX-12) reduced viability of three GBM cell lines, induced expression of active caspase-3, and reduced phosphorylation of AKT-kinase and expression of -catenin. (uni-koeln.de)

Cell morphological feature, mitochondrial membrane potential, LDH release rate, production of IL-1β and expression of Caspase-1/GSDMD all showed that pyroptosis happened more significantly in A549/DDP cells than that in A549 cells after OP-B treatment. (researchsquare.com)
Moreover, silencing of S100A11 stimulated mitochondrial superoxide production, which was decreased by AACOCF 3 , as well as N -acetyl- L -cysteine, which also mimicked the effect of PLA 2 inhibitor on NSCLC chemosensitization upon S100A11 silencing. (oncotarget.com)

ABCG2 inhibitor verapamil, downregulate ABCG2, induce ER stress markers and induces apoptosis. (pka-signal.com)

Caspase-3 is activated in the apoptotic cell. (wikipedia.org)
In conclusion, addition of HuMSC-S to UDCA lowered caspase-3 levels and apoptotic cell count in rats with hepatic cholestasis after choledochal duct ligation. (bsmiab.org)
Annexin V staining demonstrated 43, 76, and 98% apoptotic cell death at 12, 18, and 24 h postinduction. (elsevierpure.com)

The CASP8 gene encodes a member of the cysteine-aspartic acid protease (caspase) family. (wikipedia.org)
Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. (wikipedia.org)
The clinical phenotype of CEDS patients represented a paradox since caspase-8 was considered to be chiefly a proapoptotic protease, that was mainly involved in signal transduction from Tumor necrosis factor receptor family death receptors such as Fas. (wikipedia.org)
AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β [2] . (medchemexpress.com)

Further work revealed that caspase-8 was essential for the induction of the transcription factor "nuclear factor κB" (NF-κB) after stimulation through antigen receptors, Fc receptors, or Toll-like receptor 4 in T, B, and natural killer cells. (wikipedia.org)
A colorimetric caspase activity assay was performed with pcWNV-Cp-DJY- or pcDNA3.1-transfected cells for caspase-3 (c) or caspase-9 (d) activity. (cdc.gov)
It remains inactive in growing cells while it is associated with its inhibitor (ICAD, DNA fragmentation factor 45 kDa subunit, DFFA or DFF45) resulting into a complex ICAD-CAD. (wikipedia.org)
Per usual in non-apoptotic growing cells caspase activated dnase is held in check inactivated in the cytoplasm thanks to the association with its inhibitor, inhibitor of caspase-activated DNase (ICAD) also known as DNA fragmentation factor 45 kDa (DFF45). (wikipedia.org)
The antimyeloma effect of ABT-737 on MM cell lines or primary cells was substantially increased by the addition of Notch inhibitor. (aacrjournals.org)
Following UVB irradiation caspase 8, 3 and 9 activities were stimulated in NMK cells, whereas in bcl-2-transfected cells only caspase 8, but not caspase 3 or 9, activity was stimulated. (bioone.org)
A significant increase in the G1 phase cell population was observed in MCF‑7 cells and ACT‑3 induced apoptosis by reducing the ratio of B‑cell lymphoma‑2 (Bcl‑2)/Bcl‑2‑associated X (Bax) and releasing cleaved caspase 9. (iasp-pain.org)
Resistance of GBM cell lines and primary cells to drugs and signaling inhibitors was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. (uni-koeln.de)
In addition, PX-12 also sensitized primary human GBM cells to temozolomide. (uni-koeln.de)
Western blotting analysis of the expression level of pATF6, CHOP, Cleaved Caspase12 and Bax in shRNA-Cs1429 and shRNA-Cs1429+AEBSF cells. (medchemexpress.com)
Statins (HMG-CoAR inhibitors) have been shown to exert an antiviral effect in vitro, principally on repli- con harboring cells, but the effect of their use alone in vivo remains controversial. (cp-673451inhibitor.com)
Thus, this study aims to determine the effect of Human mesenchymal stem cell secretome (HuMSC-S) administration on caspase 3 levels and apoptotic hepatic cells in a rat model with cholestasis after choledochal duct ligation receiving urso deoxy cholic acid (UDCA). (bsmiab.org)
Suppression of caspase-3 is known to have protective and anti-apoptotic effects on liver cells and reduces collagen deposition, ultimately leads to inhibition of fibrogenesis [ 12 ]. (bsmiab.org)
OXA-R LoVo cells exposed to NF-κB inhibitor QNZ effectively reduced the ABCG2 and p-NF-κB expression and increased ER stress marker expression. (pka-signal.com)
10 TRPV1 agonist, capsaicin, is capable of inducing apoptosis 11 , 12 and inhibiting cancer cell growth by cell cycle arrest in many different types of cancer, for example, osteosarcoma, colon, and pancreatic cancer cells, while normal cells remained unharmed. (dovepress.com)
These results indicate that therapeutic attempts to induce caspase-3 in malignant cells may prove useful in the treatment of bcl-x L -expressing tumors. (elsevierpure.com)
We performed differential transcriptomic analysis between control metamorphosing larvae and larvae treated with the pan-caspase inhibitor Z-VAD-fmk in order to explore the transcriptional control of apoptotic cells on neighbouring cells that survive and migrate. (biomedcentral.com)
Accumulating evidence in many metazoans suggest that apoptotic cells can emit caspase-dependent signals to their neighbours, modulating their fate (survival/death, differentiation or proliferation) or behaviour (migration) [ 12 , 13 ]. (biomedcentral.com)
Apoptotic-induced proliferation was reported in several organisms, such as in the cnidarian Hydra , where apoptosis promotes proliferation of adjacent cells through emission of Wnt3 signalling in a caspase-dependant manner during head regeneration [ 14 ]. (biomedcentral.com)
While caspase-dependent signals emitted by apoptotic cells start to be characterised, almost no target genes are identified in receptor cells. (biomedcentral.com)
Evaluating the capacity of caspases to affect gene expression and influence fate and/or behaviour of cells adjacent to apoptosis is the first fundamental step to better characterise this new function in animals. (biomedcentral.com)
All patients can evolve into trisomy 8+ MDS [12], cells, since acquiring adequate samples diagnosed with MDS have a reduced in which 8+ appears to confer a favour- for flow cytometric analysis renders the life expectancy compared with age- able prognosis [13]. (who.int)

In addition to inducing apoptosis, caspase inhibition contributes to necroptosis and/or autophagy depending on the cell type and cellular context. (molcells.org)
This can be induced by caspase inhibition under certain circumstances. (molcells.org)
AACOCF 3 , a phospholipase A 2 (PLA 2 ) inhibitor, strongly abrogated chemosensitization upon silencing of S100A11 suggesting that PLA 2 inhibition by S100A11 governs the chemoresistance of NSCLC. (oncotarget.com)

The SensoLyte® Homogeneous AFC Capase-3/7 Assay Kit uses Ac-DEVD-AFC as the fluorogenic indicator for assaying caspase-3/7 activities. (eurogentec.com)

Sensitivity to cisplatin could be restored by both PX-12 and recombinant expression of the upstream Trx inhibitor TXNIP, respectively. (uni-koeln.de)

12 Sequential NIK/IKK/NF-κB and TRADD/ FADD/caspase-8/10/caspase-3 are the central signaling chains for cell growth, proliferation and apoptosis. (xiahepublishing.com)

NLRP1 consists of a NACHT domain, a function-to-find domain (FIIND) ( 7 , 8 ), and two effector-recruitment domains: an N-terminal pyrin domain (PYD) and a C-terminal caspase-activating and recruitment domain (CARD) ( Figure 1A ) ( 7 ). (frontiersin.org)

Theasinensin A, TF-1, and TF-2 displayed strong growth inhibitory effects against human histolytic lymphoma U937, with estimated IC50 values of 12 μM, but were less effective against human acute T cell leukemia Jurkat, whereas TF-3 and (-)-epigallocatechin-3-gallate (EGCG) had lower activities. (tmu.edu.tw)

Thus, this kit can measure caspase-3/7 activity in cell culture directly in a 96-well or 384-well plate without a time-consuming cell extraction step. (eurogentec.com)
Caspases are synthesized in the cell as inactive zymogens and require to be activated to be functional. (spandidos-publications.com)
Activated Caspase-1/4/5/11 catalyze GSDMD to cleave into GSDMD-N and GSDMD-C fragments, and GSDMD-N can bind and form pores at cell membrane, so as to lead pyroptosis and release IL-1β and IL-18 to extracellular environment (8, 9). (researchsquare.com)
Moreover, a GSK-3β specific inhibitor, L803-mt, attenuated tau phosphorylation and rescued DA neurons from cell death in mesencephalic cultures. (biomedcentral.com)
Because of this, we aimed to study the effect of human mesenchymal stem cell secretome (HuMSC-S) administration on caspase 3 levels and apoptosis of hepatocytes in a rat model with cholestasis after choledochal duct ligation receiving standard UDCA therapy. (bsmiab.org)
Apoptosis is a caspase regulated cell death present in all metazoans defined by a conserved set of morphological features. (biomedcentral.com)
In contrast to the apoptotic function of cell elimination, this new role of apoptosis is not well understood but seems caspase-dependent. (biomedcentral.com)

Statins, HMG-CoA reductase inhibitors that are widely used in human to lower cholesterol levels (Carroll et al. (cp-673451inhibitor.com)
Another found that HMG-CoA reductase inhibitor (rotuvastatin) treatment could be used as an alternative therapy to decrease oxidative stress parameters and liver enzyme activities [ 7 - 10 ]. (bsmiab.org)

Their further research revealed that BI2536 can reverse DDP resistance of ESCC by inhibiting DNA damage repair and inducing pyroptosis (12). (researchsquare.com)

As a result, the present study aimed to investigate changes in the expression of X-linked IAP (XIAP) induced by radiation injury, the activity and expression of caspase members following radiation and the effect of caspase blockade. (spandidos-publications.com)
This invention relates to a compound of formula I and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases. (justia.com)
Caspase-9 activity, but not caspase-3 or -8 activity, was significantly reduced in LPS-treated neutrophils after incubation for 12 hours (neutrophils from blood samples of 17 horses). (avma.org)
The anticancer activity of 3β,6β‑dihydroxyurs‑12‑en‑27‑oic acid (ACT‑3), a major component isolated from , has not yet been investigated in detail. (iasp-pain.org)
Interestingly, while GT1b enhanced caspase-3 activity, DEVD, a caspase-3 inhibitor, failed to rescue DA neuronal death. (biomedcentral.com)

J Med Chem , 44 (12): 2015-26. (guidetopharmacology.org)

Chavanas et al[19] studied steady-state levels of the mRNA encoding LEKTI (lymphoepithelial Kazal-type related inhibitor), the gene product of the SPINK5 gene, in cultured epidermal keratinocytes from a healthy control and 5 Netherton syndrome patients. (medscape.com)

It is also known as caspase activated nuclease (CPAN), dna fragmentation factor 40 (DFF-40), DFF2 and DFFB. (wikipedia.org)
These results indicate that theasinensin A allows caspase-activated deoxyribonuclease to enter the nucleus and degrade chromosomal DNA and induces DFF-45 (DNA fragmentation factor) degradation. (tmu.edu.tw)

reported that NLRP1A generates a functional caspase-1-containing inflammasome in vivo to drive IL-1β-dependent inflammatory disease ( 12 ). (frontiersin.org)

Interestingly, caspase-3 level was significantly lower in the UDCA and HuMSC-S-treated groups compared to the UDCA or HuMSC-S alone. (bsmiab.org)

Our data further confirm that caspase-3 is not a major effector of DA neuronal death in GT1b neurotoxicity. (biomedcentral.com)

The caspase-3 His-237 stabilizes the target Aspartate causing the break of the association of ICAD and CAD leaving the endonuclease CAD active allowing it to degrade chromosomal DNA. (wikipedia.org)

Two independent research have demonstrated that MF59induced adjuvant effects are independent of Nlrp3 and Caspase 1 (19, 28). (itkinhibitor.com)

DFFA is encoded by an alternatively encrypted mRNAs originating two distinct forms: short (ICAD-S) and long (ICAD-L), which act like a specific chaperone ensuring the correct CAD's folding Besides, it contains two aspartic acid residues (Asp117 and Asp224) where CAD is identified and, consequently, it stays bounded until Caspase-3 splits this union. (wikipedia.org)

Mitochondria transmembrane potential and caspase activities measurement. (cdc.gov)

Overexpression of the myeloma-associated oncogene FGFR3, which upregulates bcl-x L , delayed but did not prevent caspase-3-mediated killing. (elsevierpure.com)

Neutrophil apoptosis was assessed by use of cytologic examination, annexin V and propidium iodide staining quantified with flow cytometry, coincubation with inducers of intrinsic and extrinsic apoptosis or a toll-like receptor (TLR) 4 inhibitor, and measurement of caspase-3, -8, and -9 activities. (avma.org)
Treatment with a TLR4 inhibitor or intrinsic and extrinsic inducers of apoptosis prevented LPS-delayed apoptosis. (avma.org)

Once the inhibitor is released and in order to properly function, two CAD monomers need to come together to form a functional dimer that has vertical symmetry. (wikipedia.org)

11] The multidomain proteinase inhibitor LEKTI consists of 15 potential serine proteinase inhibitory domains. (medscape.com)

It has previously been reported that pro-inflammatory cytokine stimulation induces 12-lipoxygenase (12-LO) expression in human islets. (nih.gov)

Anatomy24

Organisms5

Diseases3

Chemicals and Drugs119

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes46

Disciplines and Occupations1

Information Science2

Health Care1

Pathway14

Protein15

Proteins6

Cleavage4

Activation16

Selective4

Proteolytic1

Substrate4

Inducers and inhibitors1

Pathways3

Potent4

Reactive Oxygen1

20231

Cytokines1

Irreversible3

Cytochrome2

ZVAD2

Kinase2

Mitochondrial2

Induces apoptosis1

Apoptotic cell3

Protease4

Cells22

Inhibition3

Assay1

Upstream1

FADD1

Recruitment domain1

IC501

Cell7

Reductase2

Pyroptosis1

Activity5

Chem1

Gene1

Fragmentation2

Inflammatory disease1

Significantly1

Effector1

Degrade chromosomal1

NLRP31

Residues1

Mitochondria1

Upregulates1

Intrinsic2

Functional1

Serine1

Stimulation1