PLN interacts with sarco/endoplasmic reticulum Ca 2+ -ATPase (SERCA) and regulates calcium uptake, which is modulated by the protein kinase A (PKA)-dependent phosphorylation of PLN during the fight-or-flight response. (elifesciences.org)
Computational studies were enrolled to predict the interaction of the synthesized compound with sarco-endoplasmic reticulum (SR) Ca 2+ transport ATPase (SERCA), a target of relevance for developing new therapeutics against arthritis. (mdpi.com)
This pathway, known as 'store-operated Ca 2+ entry' (SOCE), was activated by depleting endoplasmic reticulum Ca 2+ stores using inhibitors of sarco/endoplasmic reticulum ATPases (SERCA). (open.ac.uk)
Investigations of the function of the sarcoplasmic-endoplasmic reticulum calcium ATP-ase (SERCA) reveal that protein kinase C (PKC)-modulated SERCA activity controls branch formation across tissues and species. (caltech.edu)
Artemisinin released calcium from intracellular stores in a similar way to thapsigargin, a known inhibitor of the Sarco/Endoplasmic Reticulum Calcium ATPase pump (SERCA), but unlike thapsigargin, artemisinin blocks only the SERCA3 isoform. (kcl.ac.uk)
We describe a strategy to selectively inhibit, within tumor sites, the function of a critical intracellular protein, the sarcoplasmic/endoplasmic reticulum calcium adenosine triphosphatase (SERCA) pump, whose proper function is required by all cell types for viability. (johnshopkins.edu)
Enhanced phosphorylation of phospholamban and downregulation of sarco/endoplasmic reticulum Ca2+ ATPase type 2 (SERCA 2) in cardiac sarcoplasmic reticulum from rabbits with heart failure. (badrilla.com)
It was initially described as a tumor promoting agent that induces rapid Ca 2+ release from intracellular stores 3 by the inhibition of the sarcoplasmic endoplasmic reticulm Ca 2+ -dependent ATPase pump without inositol phosphate formation 4 . (alomone.com)
In the first instance, a dominant mutant for the sarco-endoplasmic reticular Ca 2+ -ATPase (SERCA) pump was introduced into itpr mutant backgrounds. (jneurosci.org)
SERCA is responsible for pumping cytosolic Ca 2+ into the endoplasmic reticulum (ER) store and thus maintaining the intracellular concentrations of Ca 2+ both in the cytosol and in the ER store. (jneurosci.org)
Inhibitor5
Removal of inhibitor partially rescues these defects, while simultaneous treatment with both SERCA inhibitor and PKC activator remarkably rescues tracheal and neural development. (caltech.edu)
0.05), whereas 1 M thapsigargin [SERCA inhibitor (15)] decreased uptake even further ( (brinda.info)
We generated a prodrug, G202, consisting of a PSMA-specific peptide coupled to an analog of the potent SERCA pump inhibitor thapsigargin. (johnshopkins.edu)
The analog not only inhibits stimulation of housefly fluid secretion by the native kinin Musdo-K, but also by thapsigargin, a SERCA inhibitor, and by ionomycin, a calcium ionophore. (bbk.ac.uk)
2008. Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload. (badrilla.com)
Thapsigargin1
SERCA inhibition by thapsigargin was used as a control for inhibited reuptake. (brinda.info)
ATPase2
Since PfATP6 is the only SERCA-type Ca2⫹-ATPase in the malaria ARTs contain an endoperoxide bridge that is essential for the parasite's genome, it was evaluated as the target of ARTs. (2medicalcare.com)
Istaroxime is a clinical-phase IIb compound with a double mechanism of action, Na+/K+ ATPase inhibition and SERCA2a stimulation. (unimib.it)
Calcium1
As part of the "flight or fight" response, protein kinase A phosphorylates phospholamban (PLN), thereby relieving a tonic inhibition of the endo/sarco-plasmic reticulum calcium pump, which results in an increased force of cardiac contraction. (elifesciences.org)
Growth inhibition2
The EGF like motifs of G3 domain did not seem to get one of several major participants within the TGF B induced growth inhibition of MC3T3E1 cells. (micrornalibrary.com)
Based on growth inhibition and ring survival assays, no cross-resistance was observed between artemisinins and SC83288, using parasite lines that were resistant to either one of these drugs. (biomedcentral.com)
CaMKII4
induced by ACh or bradykinin (in zero extracellular Ca2+), suggesting a role for CaMKII-mediated SERCA regulation. (brinda.info)
These data indicate that in human ASM, SERCA is regulated by mechanisms such as CaMKII and that airway inflammation maintains [Ca2+]i levels by decreasing SERCA expression and slowing Ca2+ reuptake. (brinda.info)
Effect of calmodulin kinase II (CaMKII) inhibition on decay of ACh and bradykinin-induced [Ca2+]i transients in human ASM cells. (brinda.info)
2011. SR-targeted CaMKII inhibition improves SR Ca2+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKII delta(C). Journal of Molecular and Cellular Cardiology. (badrilla.com)
Pharmacological2
Using pharmacological inhibition of various Ca 2+ -sensitive kinases, it was found that at least part of the autophagy that occurred during SOCE was due to activation of Ca 2+ /calmodulin-dependent kinase kinase-β (CaMKK-β, also known as CaMKK-2). (open.ac.uk)
Pharmacological inhibition, genetic silencing or knockout of Plk1 attenuated obstructive nephropathy due to suppressed fibroblast activation mediated by reduced autophagic flux. (nature.com)
Jako1
Funkcja serca jako narządu endokrynnego była przedmiotem badań już w latach 50-tych ubiegłego wieku (1). (redmed.com.pl)
Regulates1
Together, these finding reveal that SERCA regulates cell migration, and this serves as a conserved mechanism that governs branch formation in various cell types and species during development. (caltech.edu)
PfATP61
In vitro resistance to SC83288 develops slowly and might involve mutational changes in the Ca 2+ transporting PfATP6, the P. falciparum SERCA orthologue. (biomedcentral.com)
Stimulation4
Furthermore, we found that both the basal Ca 2+ level and the Ca 2+ rise during sinusoidal stimulation were significantly increased by inhibition of PMCA, MCU, or SERCA. (jneurosci.org)
A C-terminal aldehyde insect kinin analog, Fmoc-RFFPWG-H (R-LK-CHO), demonstrates stimulation of Malpighian tubule fluid secretion in crickets, but shows inhibition of both in vitro and in vivo diuresis in the housefly. (bbk.ac.uk)
A small number of process-based leaf isoprene emission models can reproduce this CO2 stimulation and inhibition. (lu.se)
We show here for five model test sites that the suggested CO2-inhibition of leaf-isoprene metabolism can be large enough to offset increases in emissions due to CO2-stimulation of vegetation productivity and leaf area growth. (lu.se)
Protein2
I show that the complexes that sAnk1 forms with SLN or PLN and SERCA1 are distinct, suggesting unique roles for each protein in SERCA regulation. (umaryland.edu)
Studying the multi-protein complex of SERCA, sAnk1, SLN, and/or PLN can help us better understand physiological SERCA regulation. (umaryland.edu)
Uptake2
Under control conditions when ATP and oxalate were present, steady SERCA activity was detected, resulting in increasing nanomoles of 45Ca uptake over a 45-min period (Fig. 5). (brinda.info)
This is mediated by a reduction in SR content via reduced SERCA, which itself is caused by reduced SR uptake and decreased sarcolemmal Ca entry via ICa-L and background influx. (manchester.ac.uk)
Phosphorylation2
We found Plk1 plays a critical role in maintaining intralysosomal pH by regulating ATP6V1A phosphorylation, and inhibition of Plk1 impaired lysosomal function leading to blockade of autophagic flux. (nature.com)
This inhibition is relieved upon PLN phosphorylation at Ser-16 or Thr-17 sites, Ca2+-transport into the SR is accelerated and the contraction cycle quickens and generates more force. (badrilla.com)
Blockade1
SERCA blockade results in breaks in the tracheal structure and displaced axons. (caltech.edu)
Lysosomal1
Gyp-L-induced cell death was associated with lysosomal swelling and autophagic flux inhibition. (oncotarget.com)
Peptide1
In addition, we demonstrate that another more ubiquitous SERCA-regulatory peptide, called another-regulin (ALN), shares a similar mechanism mediated by PKA in regulating SERCA activity. (elifesciences.org)
Tissues2
Similarly, during Drosophila embryonic development, SERCA activity is required for the proper formation of both the central nervous system axon tracts and the network of tracheal tubules that deliver oxygen to tissues. (caltech.edu)
I also examined sAnk1 and SERCA in several CNS tissues, and found that sAnk1 is not expressed in neurons, but that it is expressed in astrocytes, where it has the potential to bind and regulate SERCA2B. (umaryland.edu)
Interacts1
Like SLN and PLN, sAnk1 also interacts with SERCA at least in part through its transmembrane domain (Asahi et al. (umaryland.edu)
Calmodulin1
Release of Ca 2+ was elicited by arachidonic acid or the calmodulin antagonist W7, the latter due to inhibition of the pump. (biomedcentral.com)
Artemisinin1
Inhibition of SERCA3 by artemisinin was irreversible and was inhibited by iron chelation, suggesting iron-catalysed alkylation of a specific cysteine residue in SERCA3 as the mechanism by which artemisinin inhibits neutrophil motility. (kcl.ac.uk)
Cardiac1
SERCA is inhibited by sarcolipin (SLN) in fast twitch skeletal muscle and atrial cardiac muscle and by phospholamban (PLN) in slow twitch muscle and ventricular cardiac muscle. (umaryland.edu)
Reduces1
Collectively, exercise with adipose tissue lipolytic inhibition reduces postprandial blood glucose and insulin excursions and, as such, further improves glycemic control in male type 2 diabetes patients. (edu.au)
Cells5
Consistently, phase-locking of synaptic vesicle releases from hair cells was also significantly reduced by blocking PMCA, MCU, or SERCA, but not NCX. (jneurosci.org)
Targeted neural ablation, but not inhibition of acetylcholine receptors, halts lung branching and causes a reduction in endothelial cells and epithelial and mesenchymal proliferation. (caltech.edu)
SERCA expression was decreased by cytokine exposure, and the rate Coluracetam of fall of [Ca2+]i transients was slowed in cells exposed to TNF and IL-13. (brinda.info)
To achieve targeted inhibition, we took advantage of the unique expression of the carboxypeptidase prostate-specific membrane antigen (PSMA) by tumor endothelial cells within the microenvironment of solid tumors. (johnshopkins.edu)
We uncovered that G3EGF expressing MC3T3 E1 cells didn't display enhanced cell development inhibition induced by TGF B1 when in comparison with the G3 transfected cell group. (micrornalibrary.com)
Resistance1
Dissemination of the novel plasmid-mediated beta-lactamase CTX-1, which confers resistance to broad-spectrum cephalosporins, and its inhibition by beta-lactamase overwatch 2 wallhack free the most appropriate way pubg battlegrounds undetected multihack load Mapbox Studio tiles in Leaflet? (divinasdeuzas.com.br)
Activity2
Vessel sprouting recovers upon removal of inhibition and restoration of pump activity. (caltech.edu)
2015). The interaction of SERCA with SLN and PLN has been studied individually and together, but the effects of sAnk1 and its regulatory activity have only recently started to be addressed (Desmond et al. (umaryland.edu)
Vivo1
These findings highlight novel antiarrhythmic properties of PDE5 inhibition and translate to suppression of triggered arrhythmias in vivo. (manchester.ac.uk)
Cell3
METHODS: An initial screen was completed using HCoV-OC43 to identify compounds that inhibit virus-induced cytopathic effect (CPE) and cell death inhibition. (bvsalud.org)
On the other hand the EGF repeats have been demonstrated to play a vital role in TGF B induced inhibition of cell dif ferentiation. (micrornalibrary.com)
In summary, dependency on EGF like motifs in versican G3 was observed in G3s ability to increase inhibition of MC3T3 E1 cell differentiation induced by TGF B and cell apoptosis induced by TNF. (micrornalibrary.com)
Results1
The results supported that inhibition of Plk1 ameliorated kidney fibrosis by suppressing fibroblast activation and partial EMT. (nature.com)
Rate2
SERCA controls the rate of intersomitic blood vessel sprouting and branching in zebrafish embryos in a dose-dependent manner. (caltech.edu)
Underlying this effect, sildenafil reduced rate constant of SERCA, transiently increased sarcolemmal efflux via NCX tail current, and reduced sarcolemmal entry by decreasing both ICa-L and background influx. (manchester.ac.uk)
Type2
Exercise combined with adipose tissue lipolytic inhibition augments intramuscular lipid and glycogen use in type 2 diabetes patients. (edu.au)
The present study investigates the impact of adipose tissue lipolytic inhibition during exercise on subsequent postprandial glycemic control in type 2 diabetes patients. (edu.au)
Release1
This was achieved by expressing an enzyme that prevented Ca 2+ release from inositol 1,4,5-trisphosphate receptors, inhibition of mitochondrial respiration, and knockdown of the mitochondrial Ca 2+ uniporter. (open.ac.uk)
Complex2
sAnk1 forms a three-way complex with SLN and SERCA1 that ablates SLN inhibition (Desmond et al. (umaryland.edu)
2017). sAnk1 can also form a three-way complex with PLN and SERCA1 that abolishes all inhibition. (umaryland.edu)
Found1
It was found that sustained cellular Ca 2+ signals arising via chronic inhibition of SERCA were pro-autophagic. (open.ac.uk)