Inhibition of macrophage tumor necrosis factor. Medical search. Frequent questions

Once inhaled by the host, the fungus interacts with alveolar macrophages and dendritic cells present in the lungs, where it can form a pulmonary focus or spread through the blood and lymphatic vessels [ 6 ]. (hindawi.com)
In differentiated human THP-1 macrophages and human and mouse alveolar macrophages stimulated with lipopolysaccharide (LPS) and other Toll-like receptor ligands, hypercapnia inhibited expression of tumor necrosis factor and interleukin (IL)-6, nuclear factor (NF)-κB-dependent cytokines critical for antimicrobial host defense. (northwestern.edu)
Elevated P CO2 also decreased phagocytosis of opsonized polystyrene beads and heat-killed bacteria in THP-1 and human alveolar macrophages. (northwestern.edu)
Lipopolysaccharide (LPS)-stimulated monocyte derived macrophages (MDMs) and alveolar macrophages (AMs) were cultured with dexamethasone and/or SB706504. (ox.ac.uk)
however, we measured no change in T lymphocyte proliferation or in the percentage of alveolar macrophages expressing HLA-DP. (cdc.gov)
BAMBI was expressed ubiquitously on alveolar macrophages (AM) and to a lesser degree on alveolar epithelial cells (AEC). (nih.gov)
HealthDay News - Electronic cigarette (e-cigarette) vapor condensate (ECVC) is significantly more toxic to alveolar macrophages than e-cigarette liquid (ECL), according to a study published online Aug. 13 in Thorax . (pulmonologyadvisor.com)
Alveolar macrophages were treated with ECVC and nicotine-free ECVC (nfECVC). (pulmonologyadvisor.com)
There was an approximately 50-fold increase in reactive oxygen species production, and a significant inhibition of phagocytosis with exposure of alveolar macrophages to a sublethal 0.5 percent ECVC/nfECVC. (pulmonologyadvisor.com)
Most of those depositing in the gas-exchange region will be phagocytized by alveolar macrophages and cleared to and through the mucociliary escalator within a few weeks. (cdc.gov)

The activation of macrophages leads to the production of T helper 1 (Th1) inflammatory cytokines such as tumor necrosis factor- (TNF-) α , interleukin- (IL-) 1 β , IL-6, and IL-12, whereas limited activation develops into a Th2 response (IL-4 secretion) [ 11 - 13 ]. (hindawi.com)
Consistent with polarization to M1 macrophages, MWCNTs induced the production of the proinflammatory cytokines tumor necrosis factor-a and interleukin-1ß, and the proinflammatory lipid-mediators leukotriene B4 (LTB4) and prostaglandin E2 (PGE2). (cdc.gov)
Macrophages also secrete collagenases and elastases, which break down injured tissue and release cytokines. (medscape.com)
SB706504 caused transcriptional inhibition of a range of cytokines and chemokines in COPD MDMs. (ox.ac.uk)
Upon engagement, these receptors activate a series of signaling pathways resulting in upregulation of genes encoding pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNFα ), interleukin 1β (IL-1β ), and interleukin 6 (IL-6). (docksci.com)
Spironolactone inhibits production of proinflammatory cytokines, including tumour necrosis factor-alpha and interferon-gamma, and has potential in the treatment of arthritis. (ox.ac.uk)
Spironolactone, at in vivo attainable doses, markedly suppressed transcription of several proinflammatory cytokines and, accordingly, inhibited release of tumour necrosis factor, lymphotoxin, interferon-gamma, granulocyte-macrophage colony-stimulating factor and interleukin 6 (70-90% inhibition). (ox.ac.uk)
The combination of NTHI-mediated induction of proinflammatory cytokines and inhibition of TGF-beta expression may influence inflammation induced tissue remodeling. (nih.gov)

RSV also inhibited expression of interleukin- (IL-) 1 β , IL-6, tumor necrosis factor- α , and IL-18 in vivo . (hindawi.com)
Tumor necrosis factor-alpha (TNF-alpha) potently enhances in vitro macrophage production from primitive murine hematopoietic progenitor cells in combination with stem cell factor and interleukin-7: novel stimulatory role of p55 TNF receptors. (ox.ac.uk)
In the present study we show the reverse phenomenon in that TNF-alpha on the same progenitor cell population in combination with stem cell factor (SCF) and interleukin-7 (IL-7) through the p55 TNF receptor can recruit additional progenitors to proliferate. (ox.ac.uk)
Both silica and LPS increased mRNA expression in these cells for cyclooxygenase II, inducible nitric oxide synthase, tumor necrosis factor-α and interleukin-1α. (psu.edu)
Alpha-pinene showed anti-inflammatory properties in human peripheral blood mononuclear cells and mouse macrophages through inhibition of tumor necrosis factor-α, interleukin-1β, nitric oxide, and mitogen activated protein kinases. (richardcyoung.com)
PM 2.5 increased the mRNA and protein expression of M1 markers including interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and inducible nitric oxide synthase (iNOS) in RAW264.7 cells. (medsci.org)
Among the tested spices, cinnamon exhibited most strongly inhibited both the formation of AGEs and the AGEs-induced production of nitric oxide, interleukin-6 and tumor necrosis factor-α. (h2-therapy.com)
Following ECVC challenge, there was a significant increase in secretion of interleukin 6, tumor necrosis factor α, CXCL-8, monocyte chemoattractant protein 1, and matrix metalloproteinase 9. (pulmonologyadvisor.com)
Serum interleukin (IL)-1, IL-6, tumour necrosis factor (TNF) and quantitative urinary -2-microglobulin (-2-m) excretion were estimated. (who.int)

Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504). (ox.ac.uk)
Primary bone marrow-derived macrophages (BMDM) was isolated from p58IPK knockout (KO) and wildtype (WT) mice and treated with lipopolysaccharide (LPS) and ATP to activate TLR4 signaling and stimulate inflammasome activation. (docksci.com)
Notably, a higher inducibility of NLRP3 inflammasome activation in response to ATP and nigericin following challenge with lipopolysaccharide (LPS) was observed in BACH1-deficient macrophages compared to wild-type cells. (stanford.edu)
Administration of bacterial lipopolysaccharide (LPS) to laboratory animals and cultured macrophages induces tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine. (elsevierpure.com)
Wadsworth, TL, McDonald, TL & Koop, DR 2001, ' Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-α ', Biochemical Pharmacology , vol. 62, no. 7, pp. 963-974. (elsevierpure.com)

Genetic BACH1 deficiency alters mitochondrial function and increases NLRP3 inflammasome activation in mouse macrophages. (stanford.edu)
In the current study, we utilized a proteomics approach and demonstrate that genetic deletion of BACH1 in mouse macrophages is associated with decreased levels of various mitochondrial proteins, particularly mitochondrial complex I. Bioenergetic studies revealed alterations of mitochondrial energy metabolism in BACH1-/- macrophages with a shift towards increased glycolysis and decreased oxidative phosphorylation. (stanford.edu)
The cytotoxicity and the anti-inflammatory properties of luteolin and its glycosides were evaluated in LPS-stimulated mouse macrophages. (uc.pt)

Investigation of the reason why M. avium is able to sense the changes in the intracellular environment triggering a change to the invasive phenotype suggests a direct relationship with macrophage apoptosis. (oregonstate.edu)
In addition, we found H2 significantly improved HDL functionality assessed in four independent ways, namely, i) protection against LDL oxidation, ii) inhibition of tumor necrosis factor (TNF)-α-induced monocyte adhesion to endothelial cells, iii) stimulation of cholesterol efflux from macrophage foam cells, and iv) protection of endothelial cells from TNF-α-induced apoptosis. (molecularhydrogenstudies.com)
TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. (bdbiosciences.com)
Compared with ECL, ECVC was cytotoxic at lower concentrations, and resulted in increased apoptosis and necrosis. (pulmonologyadvisor.com)
We now show that during early apoptosis limited membrane permeabilization occurs in blebs and apoptotic bodies, which allows release of proteins that may affect the proximal microenvironment before the catastrophic loss of membrane integrity during secondary necrosis. (nature.com)
Therefore, the shift from apoptosis to secondary necrosis is more graded than a simple binary switch, with the membrane permeabilization of apoptotic bodies and consequent limited release of DAMPs contributing to the transition between these states. (nature.com)
BP act in the regulation of osteoclast function by decreasing bone resorption by different mechanisms, inhibiting the development of their precursor cells, increasing apoptosis rate, stimulating inhibitor factors and reducing its activity 28 . (bvsalud.org)

Notably, hypercapnia did not affect LPS-induced degradation of IκBα, nuclear translocation of RelA/p65, or activation of mitogen-activated protein kinases, but it did block IL-6 promoter-driven luciferase activity in mouse RAW 264.7 macrophages. (northwestern.edu)
To begin to understand the mechanism of this inhibition, we evaluated the in vitro effects of EGb 761 and its flavonoid component, quercetin, on LPS-treated RAW 264.7 macrophages. (elsevierpure.com)
This study evaluated the protective capacities against diabetic complications of several spices based on their inhibition of the formation of AGEs in an in vitro BSA/glucose system and on the AGEs-induced production of proinflammatory cytokine in RAW 264.7 macrophages. (h2-therapy.com)

Here we examined the molecular mechanism by which MWCNTs induce M1 polarization using in vitro assays and the murine macrophage cell line, J774A.1. (cdc.gov)

that genetic deletion and pharmacological inhibition of beta-amyloid cleaving enzyme (BACE1) markedly accelerate axonal regeneration in the injured peripheral nerves of mice. (hopkinsmedicine.org)
Mechanistically, pharmacological inhibition of mtROS markedly attenuated inflammasome activation. (stanford.edu)
Genetic ablation and pharmacological inhibition of NLRP3 inflammasome dampen inflammatory responses to particulates. (cdc.gov)

In addition, neonatal rat cardiomyocytes (NRCMs), cardiac fibroblasts (CFs), and macrophages were isolated for in vitro experiments. (hindawi.com)
Multi-walled carbon nanotube s stimulate arachidonate 5-lipoxygenase-dependent M1 polarization of macrophages to promote proinflammatory response in vitro. (cdc.gov)
Taken together, these findings demonstrate that MWCNTs induce the polarization of M1 macrophages in vitro and that induction of Alox5 is an important mechanism by which MWCNTs promote proinflammatory responses by boosting M1 polarization and production of proinflammatory lipid mediators. (cdc.gov)
This study aims to determine if pathologic mitochondrial fission mediated by Drp1/Fis1 interaction impacts extracellular mitochondrial content and macrophage function in sepsis-induced immunoparalysis.DESIGN: Laboratory investigation.SETTING: University laboratory.SUBJECTS: C57BL/6 and BALB/C mice.INTERVENTIONS: Using in vitro and murine models of endotoxin tolerance (ET), we evaluated changes in Drp1/Fis1-dependent pathologic fission and simultaneously measured the quantity and quality of extracellular mitochondria. (stanford.edu)

MWCNT-induced chemotaxis was blocked by inhibition of leukotriene A4 hydrolase or the LTB4 receptor, but not cyclooxygenase 2, revealing LTB4 as a major mediator of neutrophilic chemotaxis from MWCNT-polarized macrophages. (cdc.gov)
The two candidate substrates are the amyloid precursor protein (APP) in axons and tumor necrosis factor receptor 1 (TNFR1) on macrophages , which infiltrate injured nerves and clear the inhibitory myelin debris. (hopkinsmedicine.org)
TNF-alpha generally inhibits the growth of primitive murine hematopoietic progenitor cells (Lin-Scal+) in response to multiple cytokine combinations, and the p75 TNF receptor is essential in signaling such inhibition. (ox.ac.uk)
Growth within macrophages increases the efficiency of Mycobacterium avium in invading other macrophages by a complement receptor-independent pathway. (oregonstate.edu)
In contrast to EG, IG uptake into macrophages was significantly inhibited in the presence of anti-beta1-integrin and anti-transferrin receptor antibodies. (oregonstate.edu)
Inhibition of IL-1β signaling by IL-1 receptor antagonist IL-1RA or IL-1β antibody demonstrate encouraging therapeutic effect in type 2 diabetes6,7. (docksci.com)
LPS-stimulated TNF-α production could not be inhibited by an α7 nicotinic acetylcholine receptor agonist, whereas inhibition by the β(2) adrenergic agonist, salmeterol, was significantly less (-35%) than that obtained in HCR rats. (duke.edu)

Polarization of the macrophages regulates the acute inflammation and its resolution in a time-dependent manner. (cdc.gov)
Using a variety of techniques, including molecular and cellular biology, biochemistry, mouse models and more, we study the role of IL-4/IL-13 signaling in asthma and allergic disease, as well as the role of alternatively activated macrophages (AAM) in the pathogenesis of allergic inflammation. (hopkinsmedicine.org)
The meeting will also highlight recent work on macrophage inflammation in the context of SARS-CoV-2 infection and work from recently-funded NIMH, NIDA, and NINDS investigators. (nih.gov)
A panel will discuss research gaps and priorities related to human macrophage reservoirs and inflammation/comorbidities and treatment strategies for HIV remission and cure. (nih.gov)
Chronic low-grade inflammation is an important pathogenic factor in the development of type 2 diabetes and cardiovascular diseases ( 1 ). (diabetesjournals.org)
These cells interact with tumor cells, via common signaling, and induce inflammation and immunosuppression locally in the tumor, but also systemically. (lu.se)

Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)
Tumor necrosis factor-alpha (TNF-alpha) is a bifunctional regulator of hematopoiesis, and its cellular responses are mediated by two distinct cell surface receptors. (ox.ac.uk)
Entry into macrophages by alternate receptors was associated with resistance to tumor necrosis factor alpha (TNF-alpha) stimulation. (oregonstate.edu)

Tumor necrosis factor (TNF), the first pro-inflammatory cytokine to be released by an inflammatory response, suppresses the translation of the key enzyme of melatonin synthesis (arylalkylamine- N -acetyltransferase, Aanat ). (frontiersin.org)
matory response, IL-10 has been shown to inhibit macrophage and Chronic beryllium disease (CBD) provides a human disorder in T lymphocyte cytokine synthesis and MHC class II and B7 ex- which to study the delayed type hypersensitivity response to persistent pression. (cdc.gov)
Immune cell responses induced by DAMPs may include cytokine and chemokine release to activate inflammatory cells such as neutrophils and macrophages. (nature.com)

We have studied the effects of the p38 MAPK inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d]-pyrimidin-2-yl]amino}ethyl)guanidine (SB706504) and dexamethasone on COPD macrophage inflammatory gene expression and protein secretion. (ox.ac.uk)
We also found that DAEB significantly stimulated lymphocyte proliferation, especially Concanavalin A-induced lymphocyte proliferation in a dose-dependent manner, and augmented phagocytosis and secretion of NO and TNF-alpha in peritoneal macrophages. (google.com)
Pretreatment with specific PKR inhibitor or overexpression of p58IPK largely abolished the changes in inflammasome activation and IL-1β secretion in p58IPK null macrophages. (docksci.com)
Collectively, these results suggest a novel and crucial role of p58IPK in regulation of inflammasome activation and IL-1β secretion in macrophages. (docksci.com)
Macrophages are key inflammatory cells that provide an innate immune defense against foreign agents and also promote an adaptative immune response by the secretion of several inflammatory mediators, which expression is controlled by intracellular signaling pathways. (uc.pt)

RSV has also been found to regulate other molecular targets such as AMP-activated protein kinase, nuclear factor erythroid 2-related factor 2, nuclear factor- (NF-) κ B, and endothelial nitric oxide synthase and has also been considered to have powerful antioxidant and anti-inflammatory properties. (hindawi.com)
Recent mechanistic insights into the trophic activities of these cells point to ultimate regulation by nitric oxide, nuclear factor-kB, and indoleamine, among other signaling pathways. (biomedcentral.com)
In addition, it is shown that inducible nitric oxide synthase and cyclooxygenase-2, both of which are markedly induced by LPS in macrophages, are directly implicated in BACH1-dependent regulation of NLRP3 inflammasome activation. (stanford.edu)
The production of several pro-inflammatory mediators, namely nitric oxide (NO) and prostaglandin (PG) E2 in RAW 264.7 murine macrophages, as well as tumor necrosis factor (TNF)-α and chemokine (C-C motif) ligand (CCL) 5 in human macrophages were inhibited by Cy extract (1.115 mg/mL). (uc.pt)
Data revealed that PAF and TF were partially responsible by Cy anti-inflammatory properties through the inhibition of NF-kB activation, NO production, the expression of inducible nitric oxide synthase (iNOS) and TNF-α. (uc.pt)

RNA sequencing was performed in primary human macrophages (Mφ) and polymorphonuclear neutrophils (PMNs) infected with a clinical strain of Brucella spp. (frontiersin.org)

Multi-walled carbon nanotube s (MWCNTs) induce the polarization of M1 and M2 macrophages in mouse lungs. (cdc.gov)
Confronting PM 2.5 , macrophages are able to be activated and induce inflammatory responses. (medsci.org)
Despite the success in the treatment of various diseases, these drugs have the ability to induce an avascular necrosis of bone tissue, especially in the maxilla and mandible. (bvsalud.org)
Despite the success in the treatment of various diseases, this drug class has the ability to induce an avascular necrosis of bone tissue, especially in the maxilla and mandible, as initially presented by Marx 13 and Ruggiero et al. (bvsalud.org)

Activation of mitogen-activated protein kinases (MAPKs) and the redox-sensitive transcription factors, nuclear factor-κB (NF-κB) and activator protein 1 (AP-1), are key events in the signal transduction pathways mediating TNF-α induction. (elsevierpure.com)

To explore whether hypercapnia interferes with host defense, we studied the effects of elevated PCO2 on macrophage innate immune responses. (northwestern.edu)
BTB-and-CNC homologue 1 (BACH1), a heme-regulated transcription factor, mediates innate immune responses via its functional role in macrophages. (stanford.edu)

CXC chemokine ligand (CXCL)-8, tumor necrosis factor (TNF)-alpha and TGF-beta expression were evaluated in lung tissue and cell culture using ELISA. (nih.gov)
TRAIL (Apo2 ligand) and TWEAK (Apo3 ligand) mediate CD4+ T cell killing of antigen-presenting macrophages. (bdbiosciences.com)

While stimulation with TNF-alpha resulted in inhibition of the growth of EG, it was not associated with inhibition of intracellular growth of IG. (oregonstate.edu)

The molecular and cellular pathways leading to the macrophage polarization induced by MWCNTs are incompletely understood. (cdc.gov)
Therefore, compounds targeting signal transduction pathways and mediators produced by macrophages stimulated with an inflammatory stimulus can act as anti-inflammatory, and consequently, can be potential therapeutic agents. (uc.pt)
Its anti-inflammatory activity was correlated with the inhibition of p38 mitogen-activated protein kinase (MAPK) and c-jun NH2-terminal kinase (JNK) 1/2 signaling pathways. (uc.pt)
Tumor-induced glaucoma may be produced by obstruction of outflow pathways by pigment cells (pigment dispersion syndrome), melanin-laden macrophages (melanomalytic glaucoma), or tumor cells. (medscape.com)

Treatment of macrophages with MWCNTs (Mitsui-7), but not CB, increased the expression of arachidonate 5-lipoxygenase (Alox5) mRNA and protein in a concentration- and time-dependent manner. (cdc.gov)
We also show that the TNF signaling reduces the level of inhibitory nuclear factor kappa B protein subtype A (NFKBIA), leading to the nuclear translocation of two NFKB dimers, p50/p50, and p50/RelA. (frontiersin.org)
p38 mitogen-activated protein kinase (MAPK) signaling is known to be increased in chronic obstructive pulmonary disease (COPD) macrophages. (ox.ac.uk)
MDMs were used for gene array and protein studies, whereas tumor necrosis factor (TNF) alpha protein production was measured from AMs. (ox.ac.uk)
Mechanistically, we found that AMPK activation increased, whereas AMPK inhibition decreased, the levels of mitogen-activated protein kinase phosphatase-1 (MKP-1), an inducible nuclear phosphatase, by regulating proteasome-dependent degradation of MKP-1. (diabetesjournals.org)
Importantly, inhibition of miR-146a-3p upregulated SIRT1 protein and suppressed M1 polarization in PM 2.5 treated RAW264.7 cells. (medsci.org)

The cellular aspect of the inflammatory phase occurs within hours of injury, and it includes neutrophils, macrophages, and lymphocytes. (medscape.com)

By interfering with essential innate immune functions in the macrophage, hypercapnia may cause a previously unrecognized defect in resistance to pulmonary infection in patients with advanced lung disease. (northwestern.edu)
So this meeting will examine emerging data relating to macrophage interactions with the immune system during HIV infection, macrophage reservoirs and approaches to their elimination, and the involvement of CNS myeloid reservoirs and associated comorbidities. (nih.gov)
So on day one, Session 1 will focus on macrophages and the immune system during HIV and SARS-CoV-2 infection, Session 2 will focus on challenges to study HIV/SIV reservoirs, and Session 3 will really have the highlights from recent awardees of the NIMH/NINDS/NIDA Myeloid Reservoir RFA. (nih.gov)
Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by rapid hepatocellular necrosis due to various acute injuries induced by hepatotoxic drugs, immune-mediated attack, or viral infections. (springer.com)
As the first defense line, macrophage is one of the most important parts of innate immune system and is a cross-link between innate immunity and adaptive immunity. (medsci.org)
Most tumors, including brain tumors in children, contain not only tumor cells, but also various types of immune cells and other stromal cells. (lu.se)
Our research is focused on investigating how the immune system can be modulated from tumor-promoting conditions to a state where the immune system instead helps to reject tumors. (lu.se)

p58(IPK) suppresses NLRP3 inflammasome activation and IL-1β production via inhibition of PKR in macrophages. (docksci.com)

Moreover, it was verified, for the first time, that Cy extract inhibited the chymotrypsin-like activity of proteasome, with the consequent inhibition of the nuclear factor (NF)-kB, a transcription factor that regulates the expression of numerous inflammatory mediators. (uc.pt)
Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance. (lu.se)

Moreover, the cell-free media from MWCNT-polarized macrophages induced the migration of neutrophilic cells (differentiated from HL-60). (cdc.gov)
We are trying to identify virulence genes (genes that evolved in response to the host environment) by screening transposon mutants of C. glabrata for mutants that are specifically altered in adherence to epithelial cells, in survival in the presence of macrophages and PMNs. (hopkinsmedicine.org)
By this mechanism, factors and cells necessary for healing flow from the intravascular space and into the extravascular space. (medscape.com)
Vasodilation is an important means by which the wound can be exposed to increased blood flow, accompanied by the necessary inflammatory cells and factors that fight infection and débride the wound of devitalized tissue. (medscape.com)
Macrophages are essential to wound healing and perhaps are the most important cells in the early phase of wound healing. (medscape.com)
Although CD4 T cells are the main targets of HIV infection, macrophages also become infected and resist the cytopathic effects of infection, contributing potentially to HIV reservoir persistence. (nih.gov)
Compared to WT macrophages, p58IPK deficient cells demonstrated significantly stronger activation of PKR, NF-κB, and JNK and higher expression of pro-inflammatory genes TNF-α and IL-1β. (docksci.com)
In cultured human aortic smooth muscle cells, pharmacologic or genetic activation of AMPK inhibited the signal transducer and activator of transcription-1 (STAT1), while inhibition of AMPK had opposite effects. (diabetesjournals.org)
Separate cohorts were killed at POD3 to collect plasma for LXA4 and to isolate splenic mononuclear cells (MNCs) to analyze CAP signaling, regulatory T cells (Tregs) and M2 macrophages (M2 Mφ). (duke.edu)
Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
Its metastatic potential depends on the phenotype of the tumor cells, and it frequently disseminates before diagnosis. (medscape.com)
These models can be used to answer how tumors respond to new cancer treatments, how current treatment works in tune with new treatments, and provide detailed knowledge of specific interactions between the tumor and surrounding cells. (lu.se)

Acute liver failure is a life-threatening clinical syndrome characterized by rapid development of hepatocellular necrosis leading to high mortality and resource costs. (springer.com)
Few data are available regarding the influence of acute and persistent infection on tissue remodelling and repair factors such as transforming growth factor (TGF)-beta. (nih.gov)
These results indicate that limited membrane permeabilization occurs in blebs and apoptotic bodies before secondary necrosis, leading to acute and localized release of immunomodulatory proteins during the early phase of active apoptotic membrane blebbing. (nature.com)

We conclude that SB706504 targets a subset of inflammatory macrophage genes and when used with dexamethasone causes effective suppression of these genes. (ox.ac.uk)

Afterwards, whether Sirtuin1 (SIRT1) an important intermediate regulator in various physiological processes takes part in the macrophage polarization induced by PM 2.5 is unknown. (medsci.org)

By combining MRI, MRS and optical imaging, we are studying the tumor microenvironment to understand the role of hypoxia, tumor vascularization, macromolecular transport and tumor metabolism in tumor progression, metastasis and ascites formation in orthotopic models of cancer. (hopkinsmedicine.org)

We also are studying the role of tumor-associated macrophages in tumor progression. (hopkinsmedicine.org)
In addition, obesity is associated with progression (but not incidence) of tumour microenvironment through prostate cancer. (who.int)

Finally, whereas SCF plus IL-7 promoted primarily granulopoiesis, the addition of TNF-alpha switched the differentiation toward the production of almost exclusively macrophages. (ox.ac.uk)
0.01) in relative spleen and thymus weight, and production of tumor necrosis factor alpha (TNF-alpha) were observed in DAEB treated groups. (google.com)
In this report, we demonstrate that NF-κB, a ubiquitous transcription factor, plays an essential role in silica-induced inflammatory mediator production in the mouse macrophage cell line RAW 264.7. (psu.edu)

It is present as a cell surface bound or a secreted form, expressed on most tissues and non-lymphoid tumor cell lines, but weak or no expression on hematopoietic lineage lines. (bdbiosciences.com)

To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. (nature.com)

We investigated that antioxidant-related biological functionality of various honey mixed with propolis using the Raw264.7 macrophage. (bee.or.kr)

The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)

Welcome to the Macrophage Infection of HIV Implications for Pathogenesis and Cure meeting, jointly organized by the National Institute of Mental Health and the Ragon Institute of MGH, MIT, and Harvard. (nih.gov)
So we at the NIMH Division of AIDS Research are very happy to be co-sponsoring this conference with the Ragon Institute, recognizing the importance of macrophages in HIV pathogenesis and cure efforts. (nih.gov)

[ 1 ] Macrophages phagocytose debris and bacteria. (medscape.com)
These results suggest that intracellular growth is associated with novel mechanisms of M. avium uptake of macrophages and that those mechanisms appear to offer advantages to the bacteria in escaping the host defense. (oregonstate.edu)

Herein we investigate the role of p58IPK in TLR4 signaling and inflammasome activation in macrophages. (docksci.com)

Brucella infects macrophages and evades clearance mechanisms, thus resulting in chronic parasitism. (frontiersin.org)
Whether PM 2.5 exposure affects macrophage polarization and associated mechanisms remains to be further explored. (medsci.org)

After inhibition of sirtuin 1 (Sirt1) by EX27, RSV failed to inhibit p53 acetylation and expression. (hindawi.com)
In addition, while an anti-CR3 antibody was able to inhibit approximately 60% of EG uptake by macrophages, it failed to inhibit the entry of IG. (oregonstate.edu)

Inhibition of IL-6 expression by hypercapnia was concentration dependent, rapid, reversible, and independent of extracellular and intracellular acidosis. (northwestern.edu)
These MSC influences can range from relatively rare activities that require cell contact, such as mitochondrial transfer and cell fusion, to relatively common paracrine MSC actions through extracellular microvesicles or secreted factors. (biomedcentral.com)
Drp1/Fis1-Dependent Pathologic Fission and Associated Damaged Extracellular Mitochondria Contribute to Macrophage Dysfunction in Endotoxin Tolerance. (stanford.edu)

More recently, histiocytic diseases have been reclassified into five groups: (1) Langerhans-related, (2) cutaneous and mucocutaneous, (3) malignant histiocytosis, (4) Rosai-Dorfman disease, and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. (medscape.com)
See The Case of the Middle-Aged Woman with Sudden Unilateral Vision Loss , a Critical Images slideshow, to help identify and treat malignant intraocular tumors. (medscape.com)
Ciliary body melanoma is a subtype of uveal melanoma, the most common primary malignant tumor of the eye. (medscape.com)

Anatomy36

Organisms14

Diseases22

Chemicals and Drugs122

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes38

Disciplines and Occupations1

Information Science3

Health Care2

Alveolar macrophages10

Cytokines8

Interleukin9

Lipopolysaccharide5

Mouse macrophages3

Apoptosis7

264.7 macrophages3

Murine macrophage cell line1

Pharmacological inhibition3

Vitro4

Receptor7

Inflammation6

Receptors3

Cytokine3

Secretion5

Nitric oxide5

Human macrophages1

Induce4

Mitogen-Activat1

Innate immune responses2

Ligand2

Stimulation1

Pathways4

Protein6

Neutrophils1

Immune7

NLRP31

Regulates2

Cells12

Acute3

Targets1

Polarization induced1

Metastasis1

Progression2

Production3

Hematopoietic1

Metabolism1

Raw264.71

Dendritic1

Pathogenesis2

Bacteria2

Inflammasome activation1

Mechanisms2

Failed to inhibit2

Extracellular3

Malignant3