• This study was taken up to evaluate the antigenotoxic potential of ginger in human peripheral blood lymphocytes. (scialert.net)
  • In vitro treatment of peripheral blood lymphocytes with TSO induced significant number of micronuclei in all samples. (scialert.net)
  • CVP did not affect the growth of normal human peripheral blood lymphocytes (PBL), whereas TET elicited concentration-dependent cytotoxic effects. (mushroomstudies.co)
  • Furthermore, MP increased WBC and HGB counts and reduced the ratio of G0/G1 phase obviously, increased the proportion of S phase and G2/M phase in peripheral blood lymphocytes, increased the counts of CD4+ T cells and the ratio of CD4+/CD8+, and reduced the inhibition rate of splenic lymphocytes. (hindawi.com)
  • Human peripheral blood lymphocytes (PBLs) were from mice infected with a SAg-producing S. pyogenes purified from blood of a healthy donor by using strain (29). (cdc.gov)
  • The disturbance of the function of Kv1.3-channels, for example due to inhibition of these channels, will lower the cytokines production and lymphocyte proliferation in vitro. (wikipedia.org)
  • While in vitro administration of glucocorticoids may inhibit concanavalin A (Con A)- and phytohemagglutinin (PHA)-induced T-cell proliferation, pokeweed mitogen (PWM)-driven B-cell mitogenesis is relatively resistant to glucocorticoids. (karger.com)
  • There was a significant decrease in PWM-induced B-cell mitogenesis and a more pronounced effect of DEX administered in vitro on spontaneous lymphocyte proliferation after MET treatment when compared with the DEX plus MET pretreated condition in vivo. (karger.com)
  • These data suggest that the inhibition of spontaneous lymphocyte proliferation by glucocorticoids in vitro is related to glucocorticoid receptor function. (karger.com)
  • The in vitro effects of MSC-Exo on immune cell migration and responder T cell proliferation were examined by chemotactic assays and lymphocyte proliferation assays, respectively. (nature.com)
  • In vitro studies were conducted to assess the antiproliferative effect of LAP using isolated lymphocytes. (biomedcentral.com)
  • We found that LAP is a potent DHODH inhibitor which had a remarkable ability to inhibit both human and murine lymphocyte proliferation in vitro. (biomedcentral.com)
  • Moreover, it was reported that LAP can reduce proliferation of the human keratinocytes in vitro, suggesting that it has potential antipsoriatic effects [ 17 ]. (biomedcentral.com)
  • These cells inhibited T cell proliferation in a standard in vitro mixed lymphocyte assay and, moreover, attenuated the development of vasculopathy mediated by autologous peripheral blood mononuclear cells in a functionally relevant humanized mouse transplant model. (lu.se)
  • In vitro inhibition of proliferation of HL-60 cells by tetrandrine and coriolus versicolor peptide derived from Chinese medicinal herbs. (mushroomstudies.co)
  • In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
  • The immune enhancing actions of vitamin D include induction of monocyte differentiation, inhibition of lymphocyte proliferation, stimulation of phagocytosis dependent and antibody-dependent macrophages, and modulation of T and B lymphocytes that produce cytokines and antibodies [ 5 - 8 ]. (hindawi.com)
  • Les IgIV intéragissent avec de nombreux composants du système immunitaire comme les récepteurs Fc, le complément, les cytokines, les lymphocytes T et B, les cellules dendritiques, les granulocytes et les cellules NK, ce qui explique en partie leurs effets anti-inflammatoires. (academie-medecine.fr)
  • 2 The interaction of IVIG with a large number of components of the immune system including Fc receptors, complement molecules, cytokines, B and T lymphocytes, neutrophils and NK cells, may explain at least in part their anti-inflammatory effects. (academie-medecine.fr)
  • Cytotoxic effect on lymphocytes of Tat from human immunodeficiency virus (HIV-1). (microbiologyresearch.org)
  • Binding of PD-L1 to its receptors suppresses T-cell migration, proliferation and secretion of cytotoxic mediators, and restricts tumour cell killing. (nih.gov)
  • Notch1 expression in B16 melanoma cells inhibited the infiltration of CD8+ cytotoxic T lymphocytes and NK cells and reduced IFN-γ release in tumor tissue. (biomedcentral.com)
  • These findings indicate that TET and BER, but not CVP, inhibited the proliferation of HL-60 cells via induction of apoptosis. (mushroomstudies.co)
  • Indeed, extended cell culture over 7 days resulted in profound growth inhibition, and induction of apoptosis in some initially resistant cell lines. (springernature.com)
  • The mechanism was perhaps related to inhibiting lymphocyte apoptosis and promoting the balance of Th1/Th2 cell subsets. (hindawi.com)
  • As a consequence, any modulations of the target transcript expression, miRNAs can affect various signalling pathways and cellular process such as apoptosis, proliferation or differentiation. (ukessays.com)
  • Margatoxin irreversibly inhibits the proliferation of human T-cells in a concentration of 20 μM. (wikipedia.org)
  • In the presence of accessory cells, IL-10 inhibits mitogen- or anti-CD3 induced proliferation of T lymphocytes. (bdbiosciences.com)
  • The inhibition of chemotactic factors and factors that increase capillary permeability inhibits recruitment of inflammatory cells into affected areas. (medscape.com)
  • Suppresses lymphocyte proliferation through direct cytolysis and inhibits mitosis. (medscape.com)
  • Azathioprine inhibits DNA synthesis and, as a purine antimetabolite, exerts its effect on activated lymphocytes, which requires purines during their proliferative phase. (illnesshacker.com)
  • We also investigated the 6 cell lines that showed no response to pharmacological CTPS1 inhibition in the 72 hour viability assays. (springernature.com)
  • matory response, IL-10 has been shown to inhibit macrophage and Chronic beryllium disease (CBD) provides a human disorder in T lymphocyte cytokine synthesis and MHC class II and B7 ex- which to study the delayed type hypersensitivity response to persistent pression. (cdc.gov)
  • Pharmacological inhibition of Potassium channels can be useful in the treatment of immune diseases. (wikipedia.org)
  • Here we demonstrate that stimulation of mouse CD4(+) T cells by immature allogeneic dendritic cells combined with pharmacological inhibition of phosphodiesterase 3 (PDE) resulted in a functional enrichment of Foxp3(+) T cells. (lu.se)
  • Inflammatory processes (edema, fibrin deposition, capillary dilatation, migration of leukocytes and phagocytosis) and the later stages of wound healing (capillary proliferation, deposition of collagen, cicatrization) are inhibited. (drugs.com)
  • LEF blocks lymphocyte proliferation and hence the clonal expansion of autoreactive T cells in RA patients by inhibiting dihydroorotate dehydrogenase (DHODH), the mitochondrial rate-limiting enzyme in the de novo synthesis of pyrimidine ribonucleotides [ 4 , 5 ]. (biomedcentral.com)
  • Consid- (for biopsy taking), pathologist (for bi- clonal proliferations of lymphocytes. (who.int)
  • The decrease in PWM-generated B-cell proliferation following cortisol depletion by MET may be seen in connection with impaired glucocorticoid-mediated induction of interleukin-1 receptor synthesis. (karger.com)
  • This new study represents the closing chapter on a story that started twenty years ago when Flamand et al reported on the capacity of HHV-6A to inhibit interleukin-2 (IL-2) synthesis in CD4+ lymphocytes (the primary cellular targets for HHV-6). (hhv-6foundation.org)
  • Mycophenolate mofetil acts by inhibiting inosine monophosphate dehydrogenase, which results in selective inhibition of the de novo pathway for purine synthesis. (ectrx.org)
  • HMGCR inhibition has a rate-limiting effect in the cholesterol synthesis pathway through conversion of 3-hydroxy-3-methyl glutaryl-CoA (HMG-CoA) to mevalonate. (archivesofmedicalscience.com)
  • This leads to inhibition of DNA, RNA, and protein synthesis. (illnesshacker.com)
  • Azathioprine acts to inhibit purine synthesis necessary for the proliferation of cells, especially leukocytes and lymphocytes. (illnesshacker.com)
  • Heterogeneity of inhibition of cytolytic T lymphocyte clones by monoclonal anti-Lyt-2/3 antibodies: parallel effects on cytolysis, proliferation and lymphokine secretion. (ox.ac.uk)
  • The aggressive T-cell/histiocyte-rich large B-cell lymphoma and the indolent nodular lymphocyte-predominant Hodgkin's lymphoma are both characterized by a paucity of tumor cells embedded in an overwhelming background. (haematologica.org)
  • Subsequent assessment of the CTPS1 inhibitor in a xenograft model confirmed the ability of selective CTPS1 inhibition to block tumor growth. (springernature.com)
  • Mice were treated with three doses of DAEB for 10 consecutive days by oral administration, the tumor inhibition was 61.17%, 67.65% and 70.59% at doses of 100, 200 and 400 mg/kg, respectively. (google.com)
  • Therefore, administration of MMF results in selective inhibition of lymphocyte proliferation. (ectrx.org)
  • For these experiments, we used a novel and highly-selective inhibitor of CTPS1 which demonstrated more than a 1,300 fold selectivity for inhibition of CTPS1 over CTPS2. (springernature.com)
  • However, WBCs, lymphocytes, and NEUs were significantly reduced, indicating that WBCs, NEUs, or lymphocytes may rapidly migrate into extra-vascular tissues or organs after dengue virus invasion. (shinyfastandloud.com)
  • Our data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte pro- liferation. (cdc.gov)
  • To further explore the link between the HPA and the immune system in relation to glucocorticoid receptor function, dose-response curves were obtained for Con A-and PHA-induced T-cell mitogenesis, PWM-generated B-cell mitogenesis and spontaneous lymphocyte proliferation in 13 healthy controls. (karger.com)
  • However, no inhibitory effect of MSC-Exo on IRBP-specific T cell proliferation was observed. (nature.com)
  • Design and Methods We collected 33 cases of T-cell/histiocyte-rich large B-cell lymphoma and 56 cases of nodular lymphocyte-predominant Hodgkin's lymphoma and performed microarray gene expression profiling on ten cases of each lymphoma, to obtain a better understanding of the lymphoma host response. (haematologica.org)
  • By quantitative reverse transcriptase polymerase chain reaction we verified that these 20 selected cases were representative of the entire population of T-cell/histiocyte-rich large B-cell and nodular lymphocyte-predominant Hodgkin's lymphomas. (haematologica.org)
  • Results We observed that the microenvironment in nodular lymphocyte-predominant Hodgkin's lymphoma is molecularly very similar to a lymph node characterized by follicular hyperplasia, while the microenvironment in T-cell/histiocyte-rich large B-cell lymphoma is clearly different. (haematologica.org)
  • Conclusions The gene expression profile of T-cell/histiocyte-rich large B-cell lymphoma, in comparison with that of nodular lymphocyte-predominant Hodgkin's lymphoma, shows features suggestive of a distinct tolerogenic host immune response that may play a key role in the aggressive behavior of this lymphoma, and that may serve as a potential target for future therapy. (haematologica.org)
  • 1 Initial studies demonstrated that a particular subgroup of T-cell-rich B-cell lymphomas mirror nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) and are characterized by a T-cell and histiocyte-rich stroma. (haematologica.org)
  • Without further manipulation or selection, the resultant population delayed skin allograft rejection mediated by polyclonal CD4(+) effectors or donor-reactive CD8(+) T cell receptor transgenic T cells and inhibited both effector cell proliferation and T cell priming for interferon-γ production. (lu.se)
  • Effects of sinusoidal magnetic field observed on cell proliferation, ion concentration, and osmolarity in two human cancer cell lines med. (emf-portal.org)
  • MiR-188 and miR-152 are apparently associated with the inhibition of cell proliferation and invasion [40, 41]. (shinyfastandloud.com)
  • MiR-21 and miR-590 may promote cell proliferation, whereas miR-188 and miR-152 inhibit cell proliferation. (shinyfastandloud.com)
  • To understand the underlying molecular consequences of CTPS1 inhibition, we focused on cell cycle regulation and the DNA damage response (DDR) pathway, both known to be impacted by nucleotide deficiency. (springernature.com)
  • Despite this initial apparent lack of effect, CTPS1 inhibition in these cell lines exhibited molecular consequences similar to sensitive lines, including S phase arrest, decreased histone 3 phosphorylation, DDR pathway activation and DNA damage. (springernature.com)
  • We observed that cell lines with shorter doubling times are more sensitive to CTPS1 inhibition, prompting investigation into whether the duration of the experiments impacted the outcomes. (springernature.com)
  • MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)
  • 1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
  • It could also enhance B16 cell-mediated inhibition of T cell proliferation and activation, and upregulate PD-1 expression on CD4 + and CD8 + T cells. (biomedcentral.com)
  • As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. (illnesshacker.com)
  • Although T-cell functions are the primary targets for this drug, inhibition of /(natural killer cells)/ NK function and macrophage activities have also been reported. (illnesshacker.com)
  • We hypothesized that, in CBD, failure of IL-10 to modulate the beryllium-specific, cell-mediated immune response would result in persistent, maximal cytokine production and T lymphocyte proliferation, thus contributing to the development of granulomatous lung disease. (cdc.gov)
  • We of both mitogen- and Ag-induced accessory cell-dependent T lym- phocyte proliferation. (cdc.gov)
  • Indeed, our analyses revealed that CTPS1 inhibition resulted in S phase arrest, reduced histone 3 phosphorylation (indicating reduced entry into mitosis), activation of key DDR pathway intermediaries (CHEK1, CHEK2) and induction of DNA damage. (springernature.com)
  • To activate an immune response a T-lymphocyte has to come into contact with a macrophage. (wikipedia.org)
  • this inhibition is maximal when the treatment course coincides with the proliferative expansion phase of the response. (illnesshacker.com)
  • Multiple myeloma (MM) is characterized by proliferation of malignant antibody-producing B cells known as plasma cells. (springernature.com)
  • This leads to an inhibition of the growth of malignant B cells that overexpress BTK. (latestsharenews.com)
  • The binding of miRNA- protein complexes to mRNA causes translation inhibition or destabilisation of target transcripts. (ukessays.com)
  • also called B7-H1 or CD274), which is expressed on many cancer and immune cells, plays an important part in blocking the 'cancer immunity cycle' by binding programmed death-1 (PD-1) and B7.1 (CD80), both of which are negative regulators of T-lymphocyte activation. (nih.gov)
  • Notably, PDE inhibition also enhanced the enrichment of human Foxp3(+) CD4(+) T cells driven by allogeneic APCs. (lu.se)
  • These data establish a method for the ex vivo generation of graft-reactive, functional mouse and human T(regs) that uses a clinically approved agent, making pharmacological PDE inhibition a potential strategy for T(reg)-based therapies. (lu.se)
  • Coriolus versicolor polysaccharide peptide (CVP) and the bis-benzylisoquinoline alkaloids, tetrandrine (TET) and berbamine (BER), the active ingredients isolated from Chinese medicinal herbs known to possess antitumor activities, concentration-dependently inhibited the proliferation of human leukemic HL-60 cells. (mushroomstudies.co)
  • bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)
  • Systemic expression of HIV-1 tat gene in transgenic mice induces endothelial proliferation and tumors of different histotypes. (microbiologyresearch.org)
  • exogenous rhIL-10 has a limited effect on cytokine production and no effect on T lymphocyte proliferation or HLA expression. (cdc.gov)
  • IL-2 is a key immune growth factor, essential for adequate T lymphocyte proliferation and expansion. (hhv-6foundation.org)
  • Dr. Louis Flamand's laboratory in Quebec, Canada, has published an article with evidence that points toward a detailed mechanism for inhibition of IL-2 gene expression by HHV-6. (hhv-6foundation.org)
  • However, lymphocytes are unique in that they almost exclusively use the de novo pathway. (ectrx.org)
  • it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival. (latestsharenews.com)
  • After the co-culture of B16 cells and CD8 + T cells, the effects of Notch1 on the proliferation and activation of T cells were assessed by CCK8 assay, CFSE dilution and Chromium-release test. (biomedcentral.com)
  • The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has been proven to be an effective strategy for rheumatoid arthritis (RA) treatment. (biomedcentral.com)
  • This study was designed to evaluate the safety, activity and biomarkers of PD-L1 inhibition using the engineered humanized antibody MPDL3280A. (nih.gov)