Proteolytic degradation of the ECM components is a central event of invasion and angiogenesis processes. (aspetjournals.org)
In this report, we show that disulfiram inhibited invasion and angiogenesis in both tumor and endothelial cells at nontoxic concentrations. (aspetjournals.org)
The 3 H-labeled type IV collagen degradation assay suggested that disulfiram has type IV collagenase inhibitory activity, and this inhibition was responsible for blocking invasion and angiogenesis through cell-mediated and non-cell-mediated pathways. (aspetjournals.org)
These observations raise the possibility clinical therapeutic applications for disulfiram used as a potential inhibitor of metastatic cell invasion and angiogenesis. (aspetjournals.org)
inhibition of angiogenesis is a promising new approach in cancer therapy. (karger.com)
Finally, MCT4 inhibition mitigates the induction of angiogenesis, suggesting that MCT4 also plays a crucial role in tumor-related angiogenesis. (hindawi.com)
For this purpose, we designed an MCT4 overexpression and knockdown/inhibition model to explore the functional consequences of MCT4 expression on cancer cell metabolism, survival, proliferation, migration, invasion potential, and angiogenesis as well as on cell cycle profiles and cell death mechanisms. (hindawi.com)
Angiogenesis plays rate limiting roles in tumor growth and invasion. (benthamscience.com)
Angiogenesis inhibition has been proposed as a general strategy to fight against cancers. (benthamscience.com)
Metastasis8
This results in the invasion of surrounding tissues, their metastasis to nearby organs, and eventually tumorigenesis. (wikipedia.org)
Invasion and Metastasis (1998) 18 (4): 209-218. (karger.com)
In recent years, emerging studies have highlighted the critical role of these pathways and their regulation by microRNAs (miRNAs) in cancer invasion and metastasis. (intechopen.com)
However, the molecular changes driving lung cancer invasion and metastasis remain unclear. (aacrjournals.org)
In this study, we identified fibulin-5, a vascular ligand for integrin receptors, as a suppressor of lung cancer invasion and metastasis. (aacrjournals.org)
Collectively, these results suggest that epigenetic silencing of fibulin-5 promotes lung cancer invasion and metastasis by activating MMP-7 expression through the ERK pathway. (aacrjournals.org)
Tumor metastasis is characterized by cell detachment from primary tumors and invasion of recipient tissues ( 2 ). (aacrjournals.org)
Accumulating evidence suggests that the activation of MMPs and TIMPs through integrin signaling plays an important role in cancer invasion and metastasis ( 5, 6 ). (aacrjournals.org)
Cell proliferation and invasion were assayed using the kidney cell lines HEK293 with wild-type p53 and a ccRCC cell line MZ1257RC mutated for p53. (frontiersin.org)
MZ1257RC showed induction of ERV-K113 expression and significantly increased both proliferation and invasion in the presence or absence of Aza. (frontiersin.org)
In addition, ERV-K env significantly regulates proliferation and invasion depending on p53 status and Aza treatment. (frontiersin.org)
In addition, knockdown of miR‑320 in breast cancer cell lines promoted cell proliferation and invasion in vitro, whereas miR‑320 overexpression had the opposite effect. (spandidos-publications.com)
Downregulation of Herg1 suppresses osteosarcoma proliferation and invasion by targeting Hippo signaling pathway]. (cancerindex.org)
Function of Plasma Membrane V-ATPases in Breast Tumor Cell Invasion. (tufts.edu)
These studies suggest that human breast tumor cells employ particular a subunit isoforms to target V-ATPases to the plasma membrane, where they aid in tumor cell invasion. (tufts.edu)
Contact inhibition9
In cell biology, contact inhibition refers to two different but closely related phenomena: contact inhibition of locomotion (CIL) and contact inhibition of proliferation (CIP). (wikipedia.org)
Both types of contact inhibition are well-known properties of normal cells and contribute to the regulation of proper tissue growth, differentiation, and development. (wikipedia.org)
However, contact inhibition of locomotion and proliferation are both aberrantly absent in cancer cells, and the absence of this regulation contributes to tumorigenesis. (wikipedia.org)
Contact inhibition is a regulatory mechanism that functions to keep cells growing into a layer one cell thick (a monolayer). (wikipedia.org)
Thus, it may be reasonably concluded that cell-cell contact is an essential condition for contact inhibition of proliferation, but is by itself insufficient for mitotic inhibition. (wikipedia.org)
This property is known as contact inhibition of proliferation and is essential to proper embryonic development, as well as tissue repair, differentiation, and morphogenesis. (wikipedia.org)
Cells of naked mole rats, a species in which cancer has never observed, show hypersensitivity to contact inhibition. (wikipedia.org)
Furthermore, recent studies have further revealed some mechanisms of contact inhibition of proliferation and its potential implications in cancer therapy. (wikipedia.org)
Cr(VI)-transformed cells exhibited loss of contact inhibition, colony formation, and increased rates of cell invasion, migration, and proliferation, as compared with passage-matched control cells. (cdc.gov)
Overexpression2
KLF6 overexpression attenuated the migration and invasion of oral cancer SAS cells. (medsci.org)
Importantly, overexpression of the a3 isoform in the parental MCF10a cells significantly increased both the level of plasma membrane V-ATPases and in vitro invasion. (tufts.edu)
Migration9
These results showed apigenin might inhibit the invasion and migration abilities of Caski cells by reducing the MMP-9 expression through suppressing the p38 MAPK signaling pathway. (spandidos-publications.com)
Wound healing assay was used to determine Caov-3 cell migration while cell invasion was evaluated using Transwell assay. (ajol.info)
The results demonstrate that zerumbone inhibits cell proliferation, migration and invasion, but represses the EMT process via inactivation of Wnt/β-catenin signaling pathway. (ajol.info)
Inhibition of SCAMP1 suppresses cell migration and invasion in human pancreatic and gallbladder cancer cells. (nih.gov)
Furthermore, lactate production induced by PKM2 significantly promotes migration and invasion. (researchsquare.com)
High expression of wingless-type MMTV integration site family 5A (WNT5A) has been reported in melanoma and correlates with increased migration and invasion of melanoma cells. (lu.se)
Further analyses revealed that simultaneously targeting HuR, with MS-444, and WNT5A signaling, with Box5, reduces melanoma cell migration and invasion via two different and partially overlapping signaling pathways, which are PKC and PI3K-AKT. (lu.se)
Our results also show that acquired BRAF-inhibitor (BRAFi) resistance leads to increased expression of HuR and WNT5A in malignant melanoma cells, and simultaneous therapeutic inhibition of HuR function and WNT5A signaling could be an efficient treatment strategy to impair the invasive migration of BRAFi-resistant melanomas. (lu.se)
Taken together, our results extend our knowledge about WNT5A regulation in melanoma and highlight the importance of HuR and WNT5A in melanoma cell migration and invasion. (lu.se)
Apoptosis1
These effectors manipulate host cell processes to enable e. g. bacterial invasion, acquisition of nutrients, inhibition of apoptosis, or interference with immune signalling. (europa.eu)
Inhibitor2
Instead, inhibition of STAT3 activity using the JAK inhibitor ruxolitinib decreases breast cancer invasion in vivo. (nki.nl)
The effects of PIP5K1α and its inhibitor on growth and invasion of BC were confirmed by using in vitro assays including. (lu.se)
Vitro2
By coupling efficient chemical synthesis routes to multiple upfront in parallel phenotypic screens, we identify that KBU2046 inhibits cell motility and cell invasion in vitro. (nature.com)
We find that inhibition of V-ATPase activity by concanamycin reduced in vitro invasion of MCF10CA1a cells, but not the parental MCF10a cells. (tufts.edu)
Knockdown3
Knockdown of fibulin-5 was sufficient to stimulate cell invasion and MMP-7 expression. (aacrjournals.org)
Prior work from our laboratory comparing a subunit expression in human breast cancer cell lines has shown that both a3 and a4 are highly expressed in highly invasive MDA-MB231 cells compared to poorly invasive MCF7 cells and that knockdown of either isoform using isoform-specific siRNAs significantly inhibits invasion of MDA-MB231 cells. (tufts.edu)
MCF10CA1a cells expressed higher levels of the a3 isoform and higher levels of plasma membrane V-ATPases relative to MCF10a cells, and knockdown of a3 (but not other isoforms) using isoform-specific siRNAs inhibits invasion of MCF10CA1a cells. (tufts.edu)
Therapeutic1
Inhibition of EZH2 may prove therapeutic in diseases in which aberrant vascularization plays a role. (plos.org)
Invasiveness1
Addition of zinc could reverse the inhibition of invasiveness and collagenase inhibition through disulfiram treatment. (aspetjournals.org)
Cells5
To investigate the effects of zerumbone on cell invasion, epithelial-mesenchymal transition (EMT) and the potential signaling pathway involved in ovarian cancer cells. (ajol.info)
HEK293 cells demonstrated a restriction of ERV-K113 env expression and invasion with no changes in proliferation in the absence of Aza. (frontiersin.org)
It is therefore conceivable that the inhibition of the function of these genes may specifically affect the proliferation and survival of brain tumor cells. (cancerindex.org)
The quantification of parasite release without any contribution of parasite invasion is the prerequisite for studying parasite release from host cells, a largely unexplored aspect of parasite biology. (biomedcentral.com)
Inhibition of plasma membrane V-ATPases is shown to significantly reduce invasion of MDA-MB231 cells. (tufts.edu)
Reduces1
MLL1 inhibition reduces IgM levels in Waldenstrom macroglobulinemia. (mayo.edu)
Bacterial1
Any drug impairing crucial processes for bacterial life will inevitably lead to the development of drug-resistant strains, whereas the inhibition of biofilm formation might prevent the onset of bacterial resistance. (intechopen.com)
Inhibitory1
To determine whether expression of V-ATPases at the plasma membrane is important in breast cancer cell invasion, we have employed an inhibitory antibody that selectively blocks plasma membrane V-ATPase activity. (tufts.edu)
Onset1
This delay between cell-cell contact and onset of proliferation inhibition is shortened as the culture becomes more confluent. (wikipedia.org)
Promotes1
Our findings demonstrate that PKM2 promotes tumor progression and galectin-9-mediated immunosuppression via NF-κB signaling inhibition in HNSCC, which bridges metabolism and immunosuppression. (researchsquare.com)
Lung Cancer1
It inhibited lung cancer cell invasion and down-regulated matrix metalloproteinase-7 (MMP-7), which promoted lung cancer cell invasion. (aacrjournals.org)
Activity1
Exponential growth has been shown to occur between colonies in contact for numerous days, with the inhibition of mitotic activity occurring far later. (wikipedia.org)
Expression1
However, in the presence of Aza despite increased ERV-K113 env expression, an inhibition of HEK293 proliferation and a further restriction of invasion was found. (frontiersin.org)
Cancer cell1
Previous studies have implicated V-ATPases in human cancer cell invasion. (tufts.edu)
Effects1
In the first stage, prior to the psychological effects of cultural invasion taking a firm grasp, the invader establishes control of the territory to be invaded through military conquest. (counterpunch.org)
Stages1
This Collins argues is the end product of a cultural invasion that has proceeded through a number of stages. (counterpunch.org)
Matrix1
This is accompanied by increased, VAMP3-dependent secretion of MT1-MMP, enhanced degradation of extracellular matrix, and increased cell invasion. (nature.com)
Controls1
More importantly, the Hippo-YAP pathway uses upstream elements to act in response to cell-cell contact and controls density-dependent inhibition of proliferation. (wikipedia.org)
Cell lines1
PANX1 channel inhibition using probenecid (PBN) or carbenoxolone (CBX) reduced the proliferation of our panel of high-risk NB cell lines. (jcancer.org)