Inhibition of cell cycle progression arrest cells cell cycle. Medical search. Frequent questions

In this study, we tested FGFR3 as a therapeutic target in WM and tested the effect of dovitinib on cell proliferation and apoptosis of WM cells in the context of BM microenvironment. (aacrjournals.org)
No appreciable levels of apoptosis or mitotic figures were observed in the BDO2-treated cells through 96 hr posttreatment. (nih.gov)
Mitochondria play a central role in these pathways not only through energetics and ATP production but also through metabolites generated in the tricarboxylic acid cycle, as well as mitochondria-nuclear signaling related to mitochondria morphology, biogenesis, fission/fusion, mitophagy, apoptosis, and epigenetic regulation. (nih.gov)
The UPS is the primary selective proteolytic system in mammalian cells, regulating numerous biological processes such as development, gene transcription, signal transduction, metabolism, apoptosis, cell cycle, DNA repair and inflammation (Chen et al. (springer.com)
It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. (cancerindex.org)
Furthermore, substituting Rapamycin in the modified multimodal RIST protocol with Torin-2 reduced cell viability and induced apoptosis despite a significant lower Torin-2 drug concentration applied. (medsci.org)
In addition, the apoptosis rate was increased in CD73 shRNA-transfected cells treated with EGFR-TKI. (e-crt.org)
The study demonstrated that inhibiting CD73 in EGFR-TKI-resistant cell lines resulted in increased apoptosis and cell cycle arrest, which overcame the acquired resistance to first-generation EGFR-TKIs. (e-crt.org)
It was found that vitexicarpin may block the cell cycle in Growth 2 Phase (G2)/Mitosis (M) phase by inhibiting the expression of Cyclin-Dependent Kinase 1 (CDK1), Cellular Myelocytomatosis Oncogene (c-myc) and survivin, thereby inhibiting the proliferation and promoting the apoptosis of human non-small cell lung cancer cell line (H322) [ 3 ]. (ijpsonline.com)
Vitexicarpin inhibits the growth of human prostate cancer cell line (PC-3) cells and promotes the apoptosis by blocking the cell cycle of prostate cancer PC-3 cells in G 2 /M phase [ 5 ]. (ijpsonline.com)
Iron withdrawal by DIBI is associated with S-phase cell cycle arrest and DNA damage resulting in cancer cell death by apoptosis. (cufsaa.com)
Evidence already exists that nutrients may alter prostate cancer risk and tumor cell behavior by influencing hormonal regulation, cell signaling, cell cycle control, apoptosis, differentiation, and carcinogen metabolism. (nih.gov)
The ensuing replication stress triggers the DNA damage response that includes cell cycle arrest, senescence or apoptosis. (nature.com)
During the early phase of epithelial tumorigenesis, TGFβ inhibits primary tumor development and growth by inducing cell cycle arrest and possibly apoptosis. (uthscsa.edu)
This inhibited SIRT1 expression and increased histone H3K9 acetylation, leading to decreased cell viability, cell cycle arrest, and apoptosis. (geneticsmr.com)
We analyzed cell viability, cell cycle phase distribution, and apoptosis after TSA and SAHA treatment, determined the level of H3K9 acetylation, and measured the transcription and translation of genes related to multipotency, proliferation, and apoptosis. (geneticsmr.com)
Induce apoptosis, cell cycle arrest and tumor growth inhibition. (standardofcare.com)
Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
Overexpression of ANK3 promotes cell apoptosis and suppresses epithelial-mesenchymal transition in papillary thyroid carcinoma cells [ 16 ]. (genominfo.org)

8. Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors. (nih.gov)
It also slowed formation of tumors and their progression in animals exposed to cancer-causing substances. (mskcc.org)
Moreover, apart from being cytotoxic, chemotherapeutics are mutagenic, which might accelerate tumor progression and induce secondary tumors (see Fig. 1 ). (nature.com)
Despite favorable responses to TKI inhibitors EGFR mutant tumors sustain progression by 1 year, mostly due to the development of resistant mutations. (standardofcare.com)
Long non-coding RNAs (lncRNAs) are a crucial class of RNA molecules and an increasing number of lncRNAs have been demonstrated to have important roles in the development and progression of tumors. (spandidos-publications.com)
Dysregulated lipid metabolism is a prominent metabolic alteration in cancer, and increased synthesis or uptake and storage of lipids occur in tumors, promoting rapid cancer cell growth and tumor formation ( 4 , 5 ). (spandidos-publications.com)

Pure apigenin is used primarily in research as a protein kinase inhibitor that may suppress tumor promotion and that has anti-proliferating effects on human breast cancer cells and inhibitory actions on MAP kinase. (nih.gov)
LY2835219 is a novel cell cycle inhibitor selective for CDK4/6, and preclinical models indicate this complex plays a critical role in breast cancer. (medscape.com)
20. Suppression of ARG kinase activity by STI571 induces cell cycle arrest through up-regulation of CDK inhibitor p18/INK4c. (nih.gov)
The mTOR inhibitor rapamycin has similar inhibitory effects on G1 cell cycle progression and expression of cyclin D1, CDK4, CDC25A, and Rb phosphorylation. (cdc.gov)
Individually, TGF-β1 and PEG10 siRNA increase AKT phosphorylation, whereas an AKT inhibitor, MK2206, mitigates the effect of PEG10 silencing on cell migration. (cancerindex.org)
Waetzig R, Matthes M, Leister J, Penkivech G, Heise T, Corbacioglu S, Sommer G. Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cells. (medsci.org)
Single treatment of both mTOR inhibitors induced a significant G 1 cell cycle arrest and combination treatment with Dasatinib reduced the expression of cell cycle regulator cyclin D1 or increased the expression of cell cycle inhibitor p21. (medsci.org)
The RBM4 high/LKB1 low expression confers increased sensitivity of ESCC cells to glutaminase inhibitor CB-839, providing a novel insight into mechanisms underlying the glutamine-dependency to improve the efficacy of glutamine inhibitors in ESCC therapeutics. (bvsalud.org)
ER beta from the prostate has a high affinity for genistein, a major soy isoflavone, which has several biological effects including a protein tyrosine kinase (PTK) inhibitor, an antioxidant, an inhibitor of angiogenesis, a blocker of topoisomerase II, an arrester of the cell cycle at the G2/M stage as well as acting as a phytoestrogen. (nih.gov)
Using a recently published methodology for synchronising T . hominis infection of mammalian cell lines, we demonstrated specific inhibition of T . hominis early meront growth and replication by an AOX inhibitor colletochlorin B. Treatment of T . hominis- infected host cells with the drug also inhibited re-infection by newly formed dispersive spores. (ncl.ac.uk)
Protein extraction and Westernblot evaluation Entire cell lysates selleck chem inhibitor had been ready from panobinostat taken care of cells, untreated controls and xenograft tissue samples as previously described. (pafr-signal.com)
We demonstrate that human leukemic cell lines carrying this translocation are highly sensitive to treatment with S3I-201, a specific STAT3 inhibitor, and, more interestingly, that primary human leukemic samples are also responsive to the drug in the same concentration range. (ashpublications.org)
In both Ba/F3 cells and major CML BCR ABLcells, therapy with AP24534 led to a marked decrease in phosphorylated reversible HDAC inhibitor CrkL, while imatinib, dasatinib, and nilotinib had no effect. (fakpathway.com)
Direct inhibition of PI3K with an inhibitor markedly reduced expression of 14 genes that were also affected by the antibody. (elsevierpure.com)

This inhibition of CDK4/6 prevents phosphorylation of Rb protein and thereby induces strong G1 arrest in cancer cells. (medscape.com)
Biochemical and physiological methods were used to determine contractility, Ca 2+ cycling parameters, and protein phosphorylation. (frontiersin.org)
The inhibition of PI3K activity also inhibited the phosphorylation of AKT and p70S6K, but not MAPK. (cdc.gov)
Interestingly, compared to Rapamycin, the combination treatment with Torin-2 resulted in a broader mTOR pathway inhibition as indicated by reduced phosphorylation of AKT (Thr308, Ser473), 4E-BP (Ser65), and S6K (Thr389). (medsci.org)
Further examination showed that KUD773 inhibited tubulin polymerization and induced an increase of mitotic phosphoproteins and polo-like kinase 1 (PLK1) phosphorylation, indicating a mitotic arrest of the cell cycle through an anti-tubulin action. (biomedcentral.com)
Treatment of breast cancer cells that overexpress HER2 with trastuzumab inhibited HER2-HER3 association, decreased PDK1 activity, reduced Thr-308 and Ser-473 phosphorylation of AKT, and reduced AKT enzymatic activity. (elsevierpure.com)

2. Oxidized LDL induces proliferation and hypertrophy in human umbilical vein endothelial cells via regulation of p27Kip1 expression: role of RhoA. (nih.gov)
We recently reported that genetic or pharmacological inhibition of insulin-like growth factor receptor (IGF-1R) slows DNA replication and induces replication stress by downregulating the regulatory subunit RRM2 of ribonucleotide reductase, perturbing deoxynucleotide triphosphate (dNTP) supply. (nature.com)
Mechanistically, in addition to transcriptional regulation, metformin induces a wide range of alternative splicing alteration, including genes involved in centrosome, cellular response to DNA damage stimulus, GTPase binding, histone modification, catalytic activity, regulation of cell cycle process and ATPase complex. (bvsalud.org)
It inhibits tubulin polymerization associated with an anti-Aurora A activity, leading to Cdk1 activation and mitotic arrest of the cell cycle that in turn induces Bcl-2 degradation and a subsequent caspase activation in HRPCs. (biomedcentral.com)

6. The histone demethylase RBP2 Is overexpressed in gastric cancer and its inhibition triggers senescence of cancer cells. (nih.gov)
However, the detailed mechanisms by which tumor cells evade premature senescence to malignant progression remain largely elusive. (bvsalud.org)
Here we reported that RBM4 adversely impacted cellular senescence to favor glutamine-dependent survival of esophageal squamous cell carcinoma (ESCC) cells by dictating the activity of LKB1, a critical governor of cancer metabolism. (bvsalud.org)
RBM4 contributed to overcome H-RAS- or doxorubicin-induced senescence, while its depletion caused P27-dependent senescence and proliferation arrest by activating LKB1-AMPK-mTOR cascade. (bvsalud.org)
Therefore, such molecular process leads to bypassing senescence and sustaining cell proliferation through the activation of glutamine metabolism. (bvsalud.org)
Cellular senescence serves as a powerful tumor suppressing mechanism that inhibits the proliferation of cancer cells bearing oncogenic mutations at the initial stage of cancer development. (bvsalud.org)
Depletion of RBM4 induced senescence in different types of cells, including multiple cancer cells. (bvsalud.org)
Specifically, knockdown of RBM4 significantly increased the level of SERPINE1, a known promoter of senescence, thereby inducing the senescence of lung cancer cells. (bvsalud.org)
Altogether, our study revealed a novel mechanism of RBM4 in the regulation of cancer progression through controlling senescence, providing a new avenue for targeting RBM4 in cancer therapeutics. (bvsalud.org)
Targeting TPX2 caused a rising impaired chromosomal instability resulting in multinuclearity, cell cycle progression arrest, apotosis, senescence and an increased polyploidy in cells. (thinkbeforeyouclickca.org)

Protein homeostasis, or proteostasis, is essential for cell function and viability. (springer.com)
Co-inhibition of IGF and CHK1 caused synergistic suppression of cell viability, cell survival and tumour growth in 2D cell culture, 3D spheroid cultures and in vivo. (nature.com)
By comparing the IC 50 values of Torin-1, Torin-2, AZD3147 and PP242 we established that only Torin-2 inhibited cell viability of all three MycN-amplified neuroblastoma cell lines tested at nanomolar concentration. (medsci.org)
CD73 inhibition synergistically inhibited cell viability with first-generation EGFR-TKI treatment compared with the negative control. (e-crt.org)
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. (lookformedical.com)

12. [Effects of extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway activation on proliferation and cell cycle associated genes in human colon cancer cells]. (nih.gov)
These results suggest that PI3K mediates G1 progression and cyclin expression through the activation of AKTI mTOR/p70S6K signaling pathway in the ovarian cancer cells. (cdc.gov)
However, in late stages of progression, as tumor cells evade the growth inhibition by TGFβ due to inactivation of its signaling pathway or aberrant regulation of cell cycle machinery, the role of TGFβ signaling is often switched from tumor suppression to promotion. (uthscsa.edu)
Since the function of miRNAs varies according to the tumor type, it is highly desirable to investigate whether miRNA inhibition or replacement therapy can effectively interfere with the signaling pathway associated with therapeutic resistance to enhance the efficacy of anticancer therapy [ 9 , 10 ]. (biomedcentral.com)

mus, have exhibited equipotent activity to inhibit ki- nase activity of mammalian target of rapamycin (mTOR), a key mediator of phosphoinositide 3-kinase signal transduction.7 Inhibition of mTOR leads to arrest of cells in the G1 phase of the cell cycle, which may in turn delay time to tumor progression or recurrence. (hormonessignaling.com)
In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. (lookformedical.com)
Signal transduction plays an important role in activating cellular functions, cell differentiation , and cell proliferation . (lookformedical.com)
Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. (lookformedical.com)
We propose that these activities are based on the inhibition of signal transduction mediated by HIF-1α. (go.jp)

CDK4/6 regulates G1 to S cell cycle progression by inactivating the retinoblastoma (Rb) tumor suppressor protein. (medscape.com)
Frog egg cell extracts have been used extensively in cell cycle research because they are relatively large, reaching a diameter of 1mm, and so contain large amounts of protein, making protein levels more easily measurable. (wikipedia.org)
p27Kip1 protein levels are elevated in arresting cells. (wikipedia.org)
4. Activation of protein kinase C promotes human cancer cell growth through downregulation of p18(INK4c). (nih.gov)
Thus, maintenance of protein homeostasis (proteostasis) is essential for cell function and survival (Fig. 1 ). (springer.com)
2015 ). With age, post-mitotic cells such as neurons lose extensive control of the proteostasis equilibrium, including deficits in protein degradation machineries (Vilchez et al. (springer.com)
Protein phosphatase 2A (PP2A) is an enzyme that specifically removes phosphates from serine and threonine residues and is essential for various signaling pathways involved in cell development and growth ( 1 , 2 ). (frontiersin.org)
Remarkably, it is generally accepted that the main in vivo anti-tumor target of CTD is protein phosphatases 2A (PP2A) [ 9 , 10 - 13 ] , suggesting that PP2A inhibition may be the underlying anti-tumor mechanism for CTD. (jcancer.org)
However, over-expressed EGFP-TPX2 protein enhanced the tumor spheroid formation and rescued the TPX2 depleted cell growth. (thinkbeforeyouclickca.org)
The regulation of Aurora A RNA, protein and kinase activity is dependent of cell cycle with peaking in the transition of G2 to mitotic phase [ 8 ]. (biomedcentral.com)
Here we show that BET inhibition also reduced c-Myc protein stability and suppressed progression of DNA replication forks in ALL cells. (birmingham.ac.uk)
Conclusions: Piperine could inhibit growth and migration of breast cancer cells by reducing Rac1 gene and protein expression. (bvsalud.org)
As a subunit of a ubiquitin ligase, Skp2 is implicated in facilitating cell cycle progression via degradation of various protein targets. (northwestern.edu)
We report here that Skp2 is rapidly degraded following cellular stimulation by the cytokine transforming growth factor β (TGF-β) and that this degradation stabilizes the cell cycle arrest protein p27. (northwestern.edu)
Total protein was extracted from cultured cells by including 2X sample buffer, twenty mM Tris HCl pH 7. (pafr-signal.com)
Echinoderm microtubule affiliated protein like 4 anaplastic lymphoma kinase has recently been recognized as a combination form driver oncogene in nonsmall cell lung cancer. (fakpathway.com)
We and others have shown, from basic biochemical studies and from molecular genetics studies in both mouse models and human genetic eye disease, that the RPE-restricted protein called RPE65, discovered in the early 1990s, is essential to the operation of the visual cycle. (nih.gov)
Acquisition of a point mutation in the propeller urgently monitored in the field because this pattern is not detected by current assays and represents a major threat to region of the K13 protein after 30 drug pressure cycles antimalarial drug policy. (cdc.gov)

3. Rho/ROCK signaling in regulation of corneal epithelial cell cycle progression. (nih.gov)
The following specific aims are proposed: I. Identify the mechanism(s) and vitamin D regulation of nuclear export of Cdk2 in prostate cancer cells. (nih.gov)
When CD73 inhibition and EGFR-TKI treatment were combined, G0/G1 cell cycle arrest was induced through the regulation of p21 and cyclin D1. (e-crt.org)
One critical aspect of intracellular signaling is regulation of key cell functions by lipid mediators, particularly phosphatidylinositol (PI). (nih.gov)
Transcriptional regulation by anti-HER2 antibody through PI3K-AKT pathway may potentiate the growth inhibitory activity of docetaxel by affecting cell cycle progression. (elsevierpure.com)
They have a critical role in regulation of cell proliferation and migration. (biomedcentral.com)
ANK3 is the most abundant ankyrin in kidney [ 6 ] and plays a crucial role in membrane assembly, epithelial cell polarization, and regulation of ion channels [ 7 - 9 ]. (genominfo.org)

The human epithelial cell line Caco-2 cells were divided into control group, low, middle and high dose groups of vitexicarpin, plasmid cloning DNA-circ_0000419 group, plasmid cloning DNA group, anti-microRNA-224 group, anti-microRNA-224-negative control group, vitexicarpin+small interfering-circ_0000419 group and vitexicarpin+microRNA-224 group. (ijpsonline.com)

Iron withdrawal from the tumor microenvironment with a selective and potent iron chelator such as DIBI may therefore prevent or inhibit tumor progression. (cufsaa.com)
Studies have shown that antagonizing TGFβ activity can inhibit tumor progression, especially metastasis, in certain tumor models. (uthscsa.edu)

Role of PI3K/AKT/mTOR signaling in G1 cell cycle progression in human ovarian cancer cells. (cdc.gov)

In cell culture, serum is the growth medium in which the cells are grown and contains vital nutrients. (wikipedia.org)
13. Growth inhibition of gastric cancer cells by all-trans retinoic acid through arresting cell cycle progression. (nih.gov)
17. Rb independent inhibition of cell growth by p15(INK4B). (nih.gov)
Human prostate cancer cell lines and primary prostate epithelial cells range from strongly growth inhibited (e.g. (nih.gov)
While the vitamin D receptor (VDR) is required for growth inhibition, VDR is not sufficient as exemplified by the human prostate cancer cell line, ALVA 31, which is minimally inhibited yet expresses relatively high levels of functional VDR. (nih.gov)
We speculate that vitamin D-mediated cytoplasmic mislocalization of Cdk2 is the critical event in prostate cancer growth inhibition by this nutrient. (nih.gov)
Determine the role of Cdk2 activation and cytoplasmic mislocalization on vitamin D-mediated growth inhibition. (nih.gov)
The pesticide DDT and the food colorant Red No. 3 were found to increase the growth of HTB 133 but not estrogen receptor (ER) negative human breast cells (HTB 125) or rat liver epithelial cells (RLE). (researchgate.net)
PEG10 counteracts signaling pathways of TGF-β and BMP to regulate growth, motility and invasion of SW1353 chondrosarcoma cells. (cancerindex.org)
Here, we report that PEG10 promotes SW1353 chondrosarcoma cell growth by preventing TGF-β1-mediated suppression. (cancerindex.org)
Specifically, while a cytostatic effect is the primary cause of growth inhibition of CTD, cytotoxic effect is the main contributing factor for the growth inhibition of NTCD. (jcancer.org)
MAIN METHODS: Cell proliferation and growth ability of CAL-27 and UM-SCC6 were analyzed by CCK8 and colony formation assays. (bvsalud.org)
Knockdown of TPX2 inhibited malignancy cell growth and downregulation of cyclin A, cyclin E and CDK2 proteins. (thinkbeforeyouclickca.org)
In patients with epidermal growth factor receptor ( EGFR )-mutant non-small cell lung cancer (NSCLC), EGFR tyrosine kinase inhibitors (TKIs) improve response rate and survival. (e-crt.org)
Since the rapid growth and metabolism of breast cancer cells results in an increased requirement for iron, withdrawal of bioavailable iron using highly selective iron chelators has been suggested to represent a new approach to cancer treatment. (cufsaa.com)
In comparison to other iron chelators, DIBI is superior to deferiprone and similar to or better than deferoxamine for inhibition of cancer cell growth. (cufsaa.com)
DIBI-treated cancer cells also showed increased sensitivity to growth inhibition by the chemotherapeutic drugs. (cufsaa.com)
This phytochemical has been shown to inhibit the growth of LNCaP human prostatic cancer cells in culture (IC50 = 50 ?M). It also has been shown to reduce one of the most fundamental biomarkers for prostate cancer, PSA, as well as modulate other proliferation and cell cycle related factors including PCNA, p21 (WAF1) and p27 (Kip1). (nih.gov)
In vitro cell proliferation and in vivo tumor growth were both inhibited by statins. (aacrjournals.org)
Results: Piperine inhibited the growth of MCF-7 and MDA-MB-231 cells and suppressed colony formation. (bvsalud.org)
Cancer is defined as a complex disease characterized by an uncontrolled growth of cells. (ijpsonline.com)
Of the 16 antibody-regulated genes, 64% had roles in cell growth/maintenance and 52% contributed to the cell cycle. (elsevierpure.com)
The antibody enhanced docetaxel-induced growth inhibition but did not increase the fraction of apoptotic cells induced with docetaxel alone. (elsevierpure.com)
In contrast, the antibody plus docetaxel markedly down-regulated two genes, HEC and DEEPEST, required for passage through G 2 -M. Thus, anti-HER2 antibody preferentially affects genes contributing to cell cycle progression and cell growth/maintenance, in part through the PI3K-AKT signaling. (elsevierpure.com)
Cells propagated in vitro in special media conducive to their growth. (lookformedical.com)
This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)

The present study aimed to investigate whether cell lines from human gastric and liver cancers respond differently toward cantharidin (CTD) and norcantharidin (NCTD) than other types of cancer cells. (jcancer.org)
We first established the half maximal inhibitory concentrations (IC50s) of CTD for a large panel of cancer cell lines representing the 12 major types of human cancers and the mode of cell death induced by the two compounds. (jcancer.org)
Neuroblastoma, derived from primitive nervous sympathetic cells, is the most common solid tumor of childhood and constitutes 7 % of all pediatric cancers [ 1 , 2 ]. (medsci.org)
Evidence suggests that vitamin D in our body may be negatively associated with the development and/or progression of several cancers including prostate cancer [10, 11].As discussed below, although experimental results from in vitro and preclinical models showed strong support of antiprostate cancer activities of this vitamin, epidemiological studies and clinical trials on human subjects hardly produce unanimous agreements for the potential of antiprostate cancer efficacy. (vitamindwiki.com)
Patients with EGFR-mutant lung cancers should be treated up front with EGFR inhibitors rather than chemotherapy as randomized trials show this improves progression free survival and quality of life. (standardofcare.com)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

The disease control rate was 80.6%, Dr. Patnaik pointed out, for women with HR-positive disease, and duration of progression-free survival was 9.1 months. (medscape.com)
Classical clonogenic survival assay was used to assess the anti-proliferative effect of CTD on selected cell lines of interest. (jcancer.org)
The available data indicate that IL-8, expressed by tumour cells and induced by chemotherapeutic treatment, is a key regulator of the survival and self-renewal of the population of CXCR1-expressing CSC. (oncotarget.com)
Recent advances in the understanding of oncogenic drivers and the development of targeted agents have improved the survival of patients with non-small cell lung cancer (NSCLC). (e-crt.org)
However, in these settings, the response rate to chemotherapy is only 20%-30%, and progression-free survival (PFS) is 3-6 months [ 6 , 7 ]. (e-crt.org)
Further innovations, including anti-T cell antibodies (both monoclonal and polyclonal preparations), as well as other maintenance immunosuppressants (eg, tacrolimus, mycophenolate, sirolimus), have made a significant impact on both patient and graft survival. (medscape.com)
More specifically, increased prostate cancer cell proliferation and prolongation of survival has been observed following linoleic and arachidonic acid treatment of cells in culture. (nih.gov)
In a type using Ba/F3 cells expressing native BCR ABL, AP24534 significantly extended survival at low doses of 2. (fakpathway.com)

Background: Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. (nih.gov)
PEG10 expression was suppressed by TGF-β signaling, and PEG10 interfered with the TGF-β and BMP-SMAD pathways in chondrosarcoma cells. (cancerindex.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
These pathways play important roles in cell energy supply, adhesion, and maintenance of the tumor microenvironment. (frontiersin.org)

AIMS: Oral squamous cell carcinoma (OSCC) is considered as the sixth most common cancer worldwide characterized by high invasiveness, high metastasis rate and high mortality. (bvsalud.org)
KEY FINDINGS: We demonstrated that metformin could significantly inhibit the proliferation and migration of oral squamous cell carcinoma cells. (bvsalud.org)
This chapter has covered a comprehensive state of the art literature review of the recent studies about the role of miRNAs in HNC including oral squamous cell carcinoma (OSCC) and human nasopharyngeal carcinoma. (intechopen.com)
An epidemiological study reported an inverse relationship between citrus peel consumption and squamous cell carcinoma, but such effects were not observed in early clinical trials. (mskcc.org)

16. Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. (nih.gov)
The toxicity of chemotherapy-induced DNA damage is counteracted by TLS, at the expense of mutations that might contribute to tumor progression (red star) or to secondary tumorigenesis (green star). (nature.com)
Therefore, there is an imperative need to generate innovative therapeutic strategies for cancer treatment, which act by modulating cell proliferation, lowering the risk of malignancy, promoting cytostatic effects and blocking or delaying the progression of tumorigenesis [ 4 ]. (ijpsonline.com)

Major tumour hepatocyte and cell culture The generation of single-cell suspensions was comprehensive dissociator from HCC specimens. (thinkbeforeyouclickca.org)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

Meanwhile, RBM4 ablation inhibited cancer cell progression both in vitro and in vivo. (bvsalud.org)
Final results Panobinostat inhibits DNMT exercise and expression in vitro Right after only 6 h of therapy, incubation of HepG2 and Hep3B cells led to a speedy and major lessen in total DNMT action by 46. (pafr-signal.com)
While fluctuating oxygen environments can be reproduced in vitro, the range of oxygen cycles that can be tested is limited. (ox.ac.uk)
Accordingly, in this paper we develop a mechanistic model of the cell-cycle that can be combined with in vitro experiments, to better understand the link between cyclic hypoxia and cell-cycle dysregulation. (ox.ac.uk)

1 However, since TLS polymerases inherently act in an error-prone fashion while replicating damaged nucleotides, they not only provide tolerance of nucleotide lesions but also generate mutations that are associated with tumor initiation and progression. (nature.com)

Accordingly, a novel approach that reduces toxic effect but reserves the activity to trigger mitotic arrest and cell death can be helpful in cancer chemotherapy. (biomedcentral.com)
However, drug resistance developed in cancer cells is always a key concern in cancer chemotherapy. (biomedcentral.com)
provides a proof of principle that cancer cells can be sensitized to DNA-damaging chemotherapy by the drug-induced inhibition of mutagenic DNA translesion synthesis, a process that endows tolerance of DNA damage. (nature.com)
Classical genotoxic chemotherapy of cancer is aimed at killing proliferating tumor cells by the introduction of DNA lesions that arrest the replication machinery. (nature.com)
Genotoxic chemotherapy exerts toxicity towards proliferating cells, including tumor cells and stem cells in tissues (left). (nature.com)
This results in sensitization of proliferating tumor cells (and, possibly, also of normal stem cells) to the toxic effects of chemotherapy, while avoiding the mutagenic consequences of TLS. (nature.com)
With this in mind, it has been hypothesized that the inhibition of mutagenic TLS might (i) increase the responses of cancer to genotoxic chemotherapeutics and (ii) reduce the mutagenicity and tumorigenicity of chemotherapy (see Fig. 1 ). (nature.com)
Cancer still remains the number one killer in the Western nations and most treatments for the disease rely on the use of chemotherapy that utilizes drugs that are also toxic against normal healthy cells. (sciepub.com)
Drinking grape juice 30 minutes before meals for a week following each cycle of chemotherapy doesn't seem to reduce nausea or vomiting caused by chemotherapy. (medlineplus.gov)

All patients received the drug orally every 12 hours for 28 days and remained on this schedule until disease progression or intolerable adverse events. (medscape.com)
Eleven patients had disease progression while receiving therapy. (medscape.com)

This natural process can be mimicked in a lab through the overexpression of p27Kip1, which results in induced cell cycle arrest in G1 phase. (wikipedia.org)
Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. (cancerindex.org)

Recent studies demonstrated that the gene encoding the p110a catalytic subunit of phosphoinositide 3-kinase (PI3K) is frequently amplified in ovarian cancer cells. (cdc.gov)
In this study, we demonstrate that the inhibition of PI3K activity by LY294002 inhibited ovarian cancer cell proliferation and induced the G1 cell cycle arrest. (cdc.gov)
Inhibition of signaling through the phosphatidylinositol 3-kinase (PI3K)-AKT pathway may be particularly important. (elsevierpure.com)

In human somatic cells, the cell cycle lasts about 18 hours, and the G1 phase makes up about 1/3 of that time. (wikipedia.org)
Mimosine is a plant amino acid that has been shown to reversibly inhibit progression beyond G1 phase in some human cells, including lymphoblastoid cells. (wikipedia.org)
The use of serum deprivation - partially or completely removing the serum and its nutrients - has been shown to arrest and synchronize cell cycle progression in G0 phase, for example in neonatal mammalian astrocytes and human foreskin fibroblasts. (wikipedia.org)
Acute exposure of human lung cells to 1,3-butadiene diepoxide results in G1 and G2 cell cycle arrest. (nih.gov)
This study examined the effect of the most active BD metabolite, butadiene diepoxide (BDO2), on cell cycle entry and progression in human lung fibroblasts (LU cells) with a normal diploid karyotype. (nih.gov)
We recently made the novel observation that 1,25-(OH)2D3 treatment of sensitive human prostate cancer cells results in the mislocalization of Cdk2 to the cytoplasm. (nih.gov)
In this study, we show that statins inhibited the histone deacetylase (HDAC) activity and increased the accumulation of acetylated histone-H3 and the expression of p21 WAF/CIP in human cancer cells. (aacrjournals.org)
Objective: To investigate the effect of piperine on human breast cancer cells. (bvsalud.org)
Methods: The effect of piperine on proliferation and migration of human breast cancer cells, MCF-7 and MDA-MB-231, was investigated using colony formation assays, wound healing assays, Matrigel migration assays, flow cytometry, RT-qPCR, and Western blotting assays. (bvsalud.org)
Indeed, experiments using Rev1 -knockout mouse embryonic fibroblasts (MEFs) or REV1-depleted human cells, provided genetic evidence that JH-RE-06 specifically inhibits a REV1-mediated highly mutagenic TLS pathway at severely helix-distorting nucleotide lesions such as those induced by chemotherapeutic drugs. (nature.com)
These biologically active compounds have positive impact on the progression of human pathology including non-communicable diseases, which indicating that administration of diet may have potential as therapeutic agents in modulating the risk of chronic diseases. (intechopen.com)
Results obtained demonstrated that A. cadamba bark methanol extract shown significant antiproliferative activity (IC 50 =319±4.98 μg/ml) against human cervical cancer cells as compared with standard cisplatin (IC 50 =5.6±0.52 μg/ml) drug. (ijpsonline.com)
lncRNAs are widely known for their key role in human cancer progression ( 11 ). (spandidos-publications.com)
In addition, MMS uses transgenic mouse models and RPE derived from human induced pluripotent stem cells (iPSCs) to generate and study interesting missense mutations for RPE65 -related retinal dystrophies (P25L, D477G, etc. (nih.gov)

3) CTD and NCTD caused distinctive cytotoxic effects on HepG2 cells. (jcancer.org)

3 Amplification of the MycN gene is found predominantly in advanced stage diseases and is associated with rapid tumor progression and poor prognosis [ 2 , 4 - 6 ]. (medsci.org)
IL-8, up-regulated in breast cancer, and associated with poor prognosis, increases CSC self-renewal in cell line models. (oncotarget.com)

Cellular processes like genome duplication and cell division stop. (wikipedia.org)
The BDO2-treated LU cells were evaluated for cell cycle progression, nuclear localization of arrest mediators, mitotic index, and cellular proliferation. (nih.gov)
Site-specific DNA binding by p53 in RLE, HTB 125, HTB 133, and MCF-7 cells was increased when they were treated with Red No. 3, which suggests that cellular DNA was damaged by this colorant. (researchgate.net)
The anticancer agents that act on different cellular targets may result in an arrest of the cell cycle at particular phase. (biomedcentral.com)
The recovery of physiological functionality, which is commonly seen in tissue mimetic three-dimensional (3D) cellular aggregates (organoids, spheroids, acini, etc.), has been observed in cells of many origins (primary tissues, embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and immortal cell lines). (mdpi.com)
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. (lookformedical.com)

The "pre-treatment" with Rapamycin and Dasatinib is anticipated to have an apoptotic, chemo-sensitizing and cell cycle synchronizing effect [ 9 ]. (medsci.org)

We therefore propose to investigate the mechanisms underlying Cdk2 nueleo-cytoplasmic transport in prostate cancer cells and to define how 1,25-(OH)2D3 regulates these processes. (nih.gov)
First, given evidence that IGFs regulate the response to IR, we also found evidence that IGF-1R depletion induced endogenous DNA lesions marked by γH2AX foci in prostate cancer cells [ 10 ]. (nature.com)
whereas, it showed less active in normal prostate cells. (biomedcentral.com)
Expanding these findings to several factors influencing other processes of prostate cancer cells will clarify if AR can serve as a molecular target or surrogate marker for nutrients. (nih.gov)
Prostate cells express ER beta abundantly, not ER alpha while uterine cells express ER alpha dominantly. (nih.gov)
Further studies are needed to determine which of these molecular targets is primarily responsible for genistein's antiproliferative effects on prostate cancer cells. (nih.gov)
Although laboratory studies including the use of animal models have shown that vitamin D has antiprostate cancer properties, whether it can effectively prevent the development and/or progression of prostate cancer in humans remains to be inconclusive and an intensively studied subject. (vitamindwiki.com)
It has been shown that ANK3 regulates cell cycle and inhibits cell invasion in prostate cancer cells [ 14 ]. (genominfo.org)

1. RhoA regulates G1-S progression of gastric cancer cells by modulation of multiple INK4 family tumor suppressors. (nih.gov)

Consistent with this, TLS across a site-specific DNA lesion, introduced by the chemotherapeutic drug cisplatin, was suppressed by treatment of the cells with JH-RE-06. (nature.com)
To date, the use of conventional synthetic chemotherapeutic drugs lack the properties to be considered as effective therapeutic agents, with most of those associated with severe side effects and toxicity of the normal host cells. (sciepub.com)

The IncuCyte ZOOM system was used as a semi-high throughput means to define IC50s and 90% inhibitory doses (IC90s) as a reference for the maximal tolerable doses (MTDs) for the two compounds in 72 cancer cell lines. (jcancer.org)
Addition of the drug during the later stages of the parasite life cycle, when our methods suggest that AOX is not actively produced and T . hominis mitosomes are mainly active in Fe/S cluster biosynthesis, had no inhibitory effects on the parasites. (ncl.ac.uk)

M: A mutant screen of budding yeasts with mitotic arrest identified CDC16, CDC23, and CDC27 as key genes that, when mutated, cause arrest in mitosis. (wikipedia.org)

RNA-binding proteins (RBPs) play important roles in cancer progression and treatment through distinct functions. (bvsalud.org)

Thus, STAT3 inhibition represents a promising possible therapeutic strategy for the treatment of TEL-AML1 leukemia. (ashpublications.org)

2). Among the individual cell lines of a given cancer types, the sensitivity trends for CTD and NCTD did not exhibit a good correlation. (jcancer.org)

Multidrug tolerance results from drug-induced parasites (ring-stage parasites) to arrest their cell cycle and quiescence, which enables parasites to survive exposure enter a quiescence state ( 9,10 ). (cdc.gov)

Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
TGFβ can apparently act in tumor stroma as well as tumor cells to inhibit host immune surveillance and stimulate invasion, angiogenesis, and metastasis. (uthscsa.edu)
For instance, lncRNA hypoxia-inducible factor 1α-antisense 2 (AS2) is an oncogenic KRAS-inducible lncRNA and its high expression may promote lung cancer cell proliferation and tumor metastasis ( 14 ). (spandidos-publications.com)
The tumor microenvironment is now recognized as a major factor that influences not only the response to conventional anti-cancer therapies but also helps define the potential for malignant progression and metastasis. (go.jp)

PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types. (lookformedical.com)

It results in a single layer of arrested cells of arrested cells, and is a process that is notably missing in cancer cells. (wikipedia.org)
Red No. 3, beta-estradiol, and DDT increase ER site-specific DNA binding to the estrogen response element in HTB 133 cells and increase cyclin-dependent kinase 2 activity in MCF-7 breast cancer cells. (researchgate.net)
Our findings reveal that concentrating on TPX2 result in suppress tumorigenicity in liver organ cancer cells, recommending that TPX2 is certainly a potential focus on for anticancer therapy in HCC. (thinkbeforeyouclickca.org)
To investigate the effect and molecular mechanism of vitexicarpin on the biological behavior of colorectal cancer cells is the objective of the study. (ijpsonline.com)
Cell reduction at the G 0 / G 1 phase and cell arrest at the G 2 /M phase were observed in breast cancer cells. (bvsalud.org)
Even though tumor wall was so crumbly that a significant part of the epi thelia flaked down, some part of the epithelia were replaced by cancer cells. (fakpathway.com)
Cancer cells use lipid metabolism for energy and then rapidly proliferate, invade and migrate. (spandidos-publications.com)

Childhood acute lymphoblastic leukemia (ALL) is a malignant disorder of lymphoid progenitor cells with a peak prevalence between the ages of 2 and 5 years, and is the most commonly occurring cancer in children. (ashpublications.org)

Similar phenotypes were induced by IGF:WEE1 co-inhibition, also via exacerbation of RRM2 downregulation. (nature.com)

Our results suggest that PP2A-PR72 plays an important role in regulating cardiac contractile function and Ca 2+ cycling, indicating that the upregulation of PR72 in heart failure is an attempt to compensate functionally. (frontiersin.org)

In addition to this method acting as a scientific control for when the cells resume the cell cycle, this can be used to investigate necessity and sufficiency. (wikipedia.org)
We use the calibrated model to investigate the response of cells to oxygen cycles not yet tested experimentally. (ox.ac.uk)

This study aimed to identify the role of CD73 in EGFR -mutant NSCLC and explore whether CD73 inhibition may serve as a therapeutic strategy in NSCLC patients with acquired resistance to EGFR-TKIs. (e-crt.org)

The proteome of a mammalian cell contains thousands of distinct proteins (Jayaraj et al. (springer.com)

The antiproliferative effects of 1,25-(OH)2D3 are mediated primarily by inhibition of G1 to S progression of the cell cycle due, in large part, to decreased cyelin dependent kinase 2 (Cdk2) activity and induction of cyclin dependent kinase inhibitors (CKIs), p21Cip1 and p27(ip1. (nih.gov)

11. Phospholipase C delta 1 regulates cell proliferation and cell-cycle progression from G1- to S-phase by control of cyclin E-CDK2 activity. (nih.gov)

Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
The main pathway by which cancer cell lipid metabolism influences cancer progression is increased fatty acid synthesis. (spandidos-publications.com)
RPE65 is the key isomerase in the visual cycle and is part of a family of carotenenoid oxygenase enzymes that specialize in carotenoid metabolism- including the enzyme b-carotene oxygenase (BCO1) that converts β-carotene into vitamin A. Mutations in RPE65 were shown to cause Leber congenital amaurosis type 2 (LCA2), a hereditary blinding disease resulting in severe loss of vision from birth or early childhood. (nih.gov)

Induced cell cycle arrest is the use of a chemical or genetic manipulation to artificially halt progression through the cell cycle. (wikipedia.org)
Given that some of the mechanisms below of inducing cell cycle arrest involve damaging the DNA, this allows investigation into how the cell responds to damage of its genetic material. (wikipedia.org)
Genetic engineering of cells with specific gene knockouts can also result in cells that arrest at different phases of the cell cycle. (wikipedia.org)
On the other hand, it has been reported that exposure to some xenoestrogens and to estrogenic metabolites promotes the production of free radicals through the hydrogen peroxide (H 2 O 2 ) reduction cycle, by means of the P 450 oxidase and reductase enzymes, giving origin to the production of oxygen reactive species which might damage the genetic material [33]. (researchgate.net)

Based on these considerations, we developed the antiangiogenic hypoxic cell radiosensitizers, TX-1877, TX-1898 and the hypoxic cytotoxin TX-402 that inhibits the HIF-1α pathway We will also discuss our research involved with the development of other drugs to exploit tumor hypoxia, including a hypoxia-targeting boron carrier for boron neutron capture therapy (BNCT) and a p53 inhibiting radiosensitizer. (go.jp)

Anatomy23

Organisms11

Diseases7

Chemicals and Drugs114

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes82

Disciplines and Occupations1

Information Science3

Health Care1

Apoptosis19

Tumors6

Inhibitor14

Phosphorylation6

Induces4

Senescence10

Viability5

Signaling pathway4

Signal transduction5

Protein18

Regulation7

Epithelial cell1

Inhibit tumor progression2

MTOR1

Growth26

Cancers6

Survival8

Pathways4

Squamous cell carc4

Tumorigenesis3

Tumour3

Vitro4

Associated with tumor1

Chemotherapy9

Disease progression2

Overexpression2

PI3K3

Human14

Cytotoxic1

Poor prognosis2

Cellular6

Apoptotic1

Prostate8

Gastric1

Chemotherapeutic2

Inhibitory2

Mitotic arrest1

Roles1

STAT31

Sensitivity1

Drug-induced1

Metastasis4

PCNA1

Cancer cells7

Malignant1

Downregulation1

PP2A1

Investigate2

Therapeutic strategy1

Mammalian cell1

Cyclin-depend1

Regulates cell1

Metabolism3

Genetic4

Inhibits1