ApoptosisTumorPharmacological inhibitionVivoAngiogenesisVitroProgressionEndothelial cellsTranscriptionalDifferentiationMetabolismCaspase-dependentSuppressiveSynthesisEndogenousSelectiveMechanismsActivityEnzymeCellsPathways involvedMechanismDrug interactionsGeneticInflammationPlaysIntracellularPeripheralRegulationContributesCellular processesFunctionsImmuneMoleculesViralIncludeMiceSubstanceProcessExpressionResponsePatientsActiveBiologicalMultiple
Apoptosis10
- It plays a critical role in the inhibition of apoptosis and induces chemoresistance. (wikipedia.org)
- An increased expression of Bcl-2 was observed and induction of apoptosis confirmed in presence of AHCC. (researchgate.net)
- Together, these results show a strong preventive efficacy of silibinin against photocarcinogenesis, which involves the inhibition of DNA synthesis, cell proliferation, and cell cycle progression and an induction of apoptosis. (nih.gov)
- 1 - 4 Multiple mechanisms may be involved in its potent antitumor effect, including induction of apoptosis, cell cycle arrest, telomerase inhibition, antiangiogenesis activity, and an antimetastasis effect. (dovepress.com)
- I characterised the cellular effects of BET protein inhibition in pre-B ALL and showed this was associated with inhibition of cell cycle progression, downregulation of c-Myc protein, direct inhibition of DNA replication and induction of caspase-dependent apoptosis that was independent of p53 activity. (bham.ac.uk)
- Many mechanisms have been proposed for the inhibition of carcinogenesis by tea, including the modulation of signal transduction pathways that leads to the inhibition of cell proliferation and transformation, induction of apoptosis of preneoplastic and neoplastic cells, as well as inhibition of tumor invasion and angiogenesis. (indexindex.com)
- Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. (jcancer.org)
- The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)
- Tumor suppressive functions include inhibition of cell proliferation, induction of apoptosis and regulation of autophagy. (gla.ac.uk)
- May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. (lu.se)
Tumor4
- These data uncovered the IL32β/BAFF axis as a previously undescribed pathway involved in lymphoma-associated macrophage polarization and tumor survival, which could be counteracted through selective NIK inhibition. (haematologica.org)
- These multifactorial tumor influencing actions of TGFβ involve regulation of an increasing number of signal transduction pathways employing a diverse range of signaling molecules. (gla.ac.uk)
- Tumor suppressors are involved in regulating the cell cycle, ensuring that cells only divide when necessary and that the process is tightly controlled. (pharmiweb.com)
- Some tumor suppressor proteins are involved in maintaining cell adhesion, preventing cells from breaking away and spreading to other parts of the body (metastasis). (pharmiweb.com)
Pharmacological inhibition1
- Thus, pharmacological inhibition of BET proteins provides an alternative strategy by which to downregulate prosurvival signaling and target B-precursor ALL. (bham.ac.uk)
Vivo4
- Scientific Methods: In vitro growth inhibition assays were completed with AHCC alone and in combination with PLD in panel of human cancer cell lines and findings confirmed in vivo in an ovarian cancer xenograft mouse model. (researchgate.net)
- Furthermore, inhibition of ChoK shows a strong in vivo antitumor activity against human breast cancer xenografts. (aacrjournals.org)
- protects both peripheral and central neurons in vivo and in vitro through VEGFR2, MEK1/2, and inhibition of caspase-3 induction. (bris.ac.uk)
- In vivo augmentation of the cyclic nucleotide pathway by PDE inhibition may induce HbF slightly, but strikingly improves hemodynamic and functional status in SCD. (johnshopkins.edu)
Angiogenesis4
- Evidences suggest that Ca 2+ channels TRP and Orai participate in the intracellular Ca 2+ signaling involved the physiological angiogenesis processes [17]. (researchgate.net)
- New antitumor strategies using drugs targeted to intracellular signaling involved in cell proliferation and survival, angiogenesis, and metastasis have become promising in recent years. (researchgate.net)
- Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis. (creativebiomart.net)
- Through their production rates,competing Jagged-Notch and Delta-Notch dynamics determine the influence of lateral inhibition and lateral induction on the selection of cellular phenotypes, branching of blood vessels, anastomosis (fusion of blood vessels) and angiogenesis velocity. (uc3m.es)
Vitro1
- Major Findings: The in vitro growth inhibition assays demonstrated additive activity when AHCC is co-administered with PLD. (researchgate.net)
Progression1
- This editorial article gives insights for the inhibition of cancer progression. (researchgate.net)
Endothelial cells2
- VCAMs are involved in mediating the adhesion of leukocytes to vascular endothelial cells, facilitating the recruitment of immune cells during inflammation. (pharmiweb.com)
- PECAM-1 is expressed on the surface of platelets and endothelial cells and is involved in cell adhesion and signaling during immune responses. (pharmiweb.com)
Transcriptional3
- Most cells have intracellular sensors of viral za virus and appear partially responsible for the ability of products that, when activated, initiate a signaling cascade influenza viruses to infect multiple animal species, which likely contributes to the generation of new pandemic virus- that results in transcriptional induction of the IFN gene. (cdc.gov)
- Results obtained in our laboratory suggest that transcriptional upregulation of prosurvival pathways plays a key role in paediatric B-precursor ALL chemoresistance, thus providing a strong rationale for the inhibition of prosurvival gene transcription. (bham.ac.uk)
- Using microarray technology I confirmed BET protein inhibition involves transcriptional downregulation of prosurvival pathways and identified potential biomarkers predictive of JQ1 sensitivity. (bham.ac.uk)
Differentiation2
Metabolism5
- The aberrant metabolism of H 2 S is involved in the pathogenesis of several skin diseases, such as vascular disorders, psoriasis, ulcers, pigment disorders, and melanoma. (hindawi.com)
- They trigger processes such as autophagy (cellular recycling) , mitochondria biogenesis, stem cell activation, ketogenesis (production of ketone bodies), and the reduction of insulin-like growth factor 1 (IGF-1) levels, along with inhibiting the mechanistic target of rapamycin (mTOR) pathway, which is involved in cell growth and metabolism. (healthnews.com)
- Inhibition of calcitriol metabolism by 24-hydroxylase promotes growth inhibition effect of calcitriol. (jcancer.org)
- The enzymes involved in metabolism are present in many tissues but generally are more concentrated in the liver. (msdmanuals.com)
- Individual drug metabolism rates are influenced by genetic factors, coexisting disorders (particularly chronic liver disorders and advanced heart failure), and drug interactions (especially those involving induction or inhibition of metabolism). (msdmanuals.com)
Caspase-dependent1
- Further, we driven that LBH589 and KLF9 governed the appearance of pro- and anti- apoptotic protein, suggesting a system which involves the caspase-dependent apoptotic pathway. (immune-source.com)
Suppressive1
- Antitumor therapies targeted to reduce the induction, recruitment, or suppressive activities of the immune cells have been investigated. (researchgate.net)
Synthesis1
- GAD65 is involved in the synthesis, packaging, and release of GABA, whereas the other three play important roles in the induction of long-term depression (LTD). Thus, the auto-antibodies toward these synaptic molecules likely impair fundamental synaptic machineries involved in unique functions of the cerebellum, potentially leading to the development of cerebellar ataxias (CAs). (springer.com)
Endogenous1
- The endogenous nature of VEGF-A(165)b expression suggests that non-isoform-specific inhibition of VEGF-A (for antiangiogenic reasons) may be damaging to retinal and sensory neurons. (bris.ac.uk)
Selective2
- Finally, we demonstrated the efficacy of selective NIK/alternative-NFkB inhibition to counteract microenvironment-dependent induction of IL32β and BAFF-dependent survival of MCL cells. (haematologica.org)
- Due to the selective expression of UCK2 in malignancy cells, a selective inhibition of this important enzyme necessitates the discovery of its potential inhibitors for malignancy chemotherapy. (nanoker-society.org)
Mechanisms2
- Figure 1: Mechanisms of Alcohol Induction of Brain Innate Immune Genes. (unc.edu)
- this process often begins with mutations that inactivate normal cellular mechanisms for monitoring the fidelity of DNA replication, resulting in the rapid accumulation of mutations in genes involved in controlling the growth and death of cells. (ernolaszlo.com)
Activity5
- Indeed, the water deficit imposes itself as extrinsic factor that negatively influences the germination of seeds due to the essential and vital role of water in the induction of recovery of metabolic activity during germination process. (scirp.org)
- The objective was to define the mechanism of the growth inhibition of active hexose correlated compound (AHCC) alone and evaluate its activity in combination with pegylated liposomal doxorubicin (PLD). (researchgate.net)
- PMA caused about a 5-fold induction in MMP-9 promoter activity, which was also suppressed by apigenin treatment in Caski cells. (spandidos-publications.com)
- In this issue, we will discuss CYP2C19?an enzyme whose activity varies depending upon important genetic differences among people and also is involved in some clinically important drug interactions. (pharmacytimes.com)
- disables inhibition of NF-kappa-B DNA-binding activity. (lu.se)
Enzyme2
- The study suggests the possibility of MDM2 protein was downregulated and its suppression subsequently activates the expression of p53 during inhibition of UCK2 enzyme. (nanoker-society.org)
- Enzyme induction interactions may be hard to detect clinically, since reduced drug effect may be interpreted as simply a lack of patient drug response. (pharmacytimes.com)
Cells3
- Neural-immune communication involves the central and peripheral nervous systems, the endocrine system and innate immune signaling first discovered in white blood cells, particularly monocyte-like cells. (unc.edu)
- Second, these antibodies impair the induction of synaptic plasticity, rebound potentiation, and LTD, on Purkinje cells, resulting in loss of restoration and compensation of the distorted "internal models. (springer.com)
- Ig-superfamily CADMs are involved in mediating cell-to-cell adhesion, helping cells stick together and form tissues and organs. (pharmiweb.com)
Pathways involved2
- Here we describe the cellular pathways involved in the host response to experimental pneumococcal meningitis in specified disease states and brain regions. (biomedcentral.com)
- These data indicate glial expression of FGF9 can initiate a complex astrocyte-dependent response that contributes to two distinct pathogenic pathways involved in the development of multiple sclerosis lesions. (gla.ac.uk)
Mechanism1
- First, since chained inhibitory neurons shape the output signals through the mechanism of disinhibition/inhibition, impairments of GABA release and LTD distort the conversion process from the "internal model" to the output signals. (springer.com)
Drug interactions1
- it also is involved in important drug interactions. (pharmacytimes.com)
Genetic1
Inflammation4
- Cynaropicrin inhibits the activation of major adhesion molecules CD29 and CD98 involved in inflammation, but not CD43. (wikipedia.org)
- Exposure to chlorine gas (Cl2) causes occupational asthma that we hypothesized occurs through the induction of airway inflammation and airway hyperresponsiveness by oxidative damage. (cdc.gov)
- Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation. (creativebiomart.net)
- ICAMs are involved in immune responses and inflammation. (pharmiweb.com)
Plays1
- Inhibition of gastric emptying also plays a minor role in this property. (wikipedia.org)
Intracellular1
- Moreover, removing the membrane-bound CD59 did not affect insulin secretion, suggesting that intracellular CD59 is involved in this function. (lu.se)
Peripheral1
- VEGF-A(165)b may be therapeutically useful for pathologies that involve neuronal damage, including hippocampal neurodegeneration, glaucoma diabetic retinopathy, and peripheral neuropathy. (bris.ac.uk)
Regulation2
- We found that apigenin could inhibit PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), which was involved in the down-regulation of the expression of matrix metalloproteinase-9 (MMP-9) at mRNA levels. (spandidos-publications.com)
- Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover. (creativebiomart.net)
Contributes2
- Dr. Fulton Crews, John Andrews Distinguished Professor, Professor of Pharmacology and Psychiatry, and Director of UNC's Bowles Center for Alcohol Studies, has advanced the understanding of the role of innate immune signaling in the brain including the discovery that ethanol induction of innate immune signals contributes to the neurobiology of addiction. (unc.edu)
- The results suggest a crucial role of NF-kB in alcohol-induced brain damage and support the hypothesis that innate immune gene induction contributes to alcohol-induced frontal cortical damage that could underlie the loss of behavioral control associated with alcohol addiction (Fig. 2). (unc.edu)
Cellular processes1
- They are involved in various cellular processes, including tissue development, immune responses, and maintenance of tissue integrity. (pharmiweb.com)
Functions2
- Its γ-butyrolactone ring is involved in most of its biological functions. (wikipedia.org)
- Our data suggest that there are different structural requirements for separate functions of CD59, which are: MAC inhibition and insulin secretion. (lu.se)
Immune2
- In an animal model of binge alcohol drinking, Crews' group found that alcohol activated microglia and increased brain levels of the proinflammatory chemokines-cytokines, TNFa, IL-1 b , and MCP-1(CCL2), as well as oxidases and proteases involved in innate immune activation. (unc.edu)
- Crews hypothesized that the innate immune gene induction was not due to the brain damage, but rather, it was the cause of the binge drinking-induced brain damage. (unc.edu)
Molecules1
- Secretion of IFN/ results in the other cellular sensor molecules also likely participate in induction of a cellular antiviral response involving the the induction of IFN. (cdc.gov)
Viral1
- While some of these innate immunity, with particular emphasis on the IFN/ changes might be beneficial for viral replication, others rep- resent the induction of a host antiviral response. (cdc.gov)
Include1
- Relevant of mutagenicity and clastogenici- angiosarcomas of the liver, which carcinogens discussed in this chap- ty, including the induction of sister are rare tumours, were identified in ter do not include pharmaceutical chromatid exchange (SCE), chro- humans, rats, and mice exposed to drugs classified in Group 1, which mosomal aberrations (CA), and mi- vinyl chloride. (who.int)
Mice2
- After induction of EAE, C57BL/6 mice were fed on a HSD (4.0% NaCl) or normal diet (0.4% NaCl). (neurology.org)
- 1, 2 Moreover, susceptibility is largely intrinsic to the lung itself as shown by the classical experiments involving lung explants from sensitive and resistant mice. (bmj.com)
Substance1
- Sclerotherapy involves filling the seroma cavity with an irritating substance, which induces a fibrotic response to seal the dead space. (medscape.com)
Process1
Expression1
- Induction of glucotoxicity in primary, healthy human islets led to a significant decrease in IRIS-1 protein-level expression. (lu.se)
Response1
- Moreover, dsRNA binding is required for opti- stimulated response elements and stimulates the transcrip- mal inhibition of IFN production by NS1 ( 18 ). (cdc.gov)
Patients2
- Ces résultats semblent indiquer que l'utilisation de l'alun en tant qu'antiplaquettaire oral pourrait faire l'objet d'études complémentaires, en tenant compte des effets secondaires éventuels notamment chez les patients dont la fonction rénale est altérée. (who.int)
- Clinical practice involving these patients usually addresses the triumph of the act over the word, hence being designated pathologies of the act, difficult cases, or pathologies of emptiness. (bvsalud.org)
Active1
- The histological morphology of hair follicles demonstrated an active anagen phase with the induction of stem cell factor. (biomedcentral.com)
Biological2
- The biological material for the present study consisted of seeds of Triticum aestivum L. So, the major aim of the study has been to investigate whether phenolic compounds are involved in the inhibition of wheat seed germination under water stress simulated with PEG-6000. (scirp.org)
- Ig-superfamily CADMs are involved in a wide range of biological processes and are critical for the development and functioning of various tissues and organs in the body. (pharmiweb.com)
Multiple1
- This uncommon idiopathic syndrome is characterized by fibrosis involving multiple organ systems. (medscape.com)