regulatory factor 9 is critical for neointima formation following vascular injury. (rndsystems.com)
Proliferation10
The possible mechanism may involve serpina3c inhibition of ERK1/2 and JNK signaling in thrombin/PAR-1 system-mediated VSMC proliferation. (silverchair.com)
Stiffening of the vessel wall promotes abnormal migration and proliferation of VSMCs, causing neointima formation of the vessel wall," he explains. (buffalo.edu)
The researchers identified the stiffness-sensitive induction of survivin as a key mechanism for stimulating VSMC proliferation and migration, and found that survivin inhibition decreases the induction of major ECM proteins directly responsible for arterial stiffness. (buffalo.edu)
Of relevance, soluble Jagged1 has been shown to efficiently inhibit neointima formation after balloon injury by decreasing easy muscle mass cell proliferation and migration through inhibition of Notch signalling [5]. (rawveronica.com)
n\nMethods and Results-In the present study, we investigated the role of histone deacetylase (HDAC) inhibition in SMC proliferation and neointimal remodeling. (cret-signal.com)
Short interfering RNA-mediated knockdown of either HDAC 1, 2, or 3 and pharmacological inhibition of HDAC prevented mitogen-induced SMC proliferation. (cret-signal.com)
In conclusion, GGTase-I knockout efficiently blocked diabetes-accelerated atherosclerosis, and this protective effect must be related to the inhibition of VSMC proliferation. (hindawi.com)
To explore its molecular mechanism in regulating cell proliferation, we first showed that actinomycin D markedly reduced the SMC proliferation via the inhibition of BrdU incorporation at 80 nM. (tmu.edu.tw)
In this experimental study, we aimed to investigate the effects of cilostazol on smooth muscle cell proliferation and the formation of neointimal hyperplasia in surgical procedures in a rabbit carotid artery anastomosis model. (e-cvsi.org)
Histone deacetylase1
The 2.5 Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD + ) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition. (rndsystems.com)
Neointimal formation3
The present study aimed to investigate the ability and molecular mechanisms of methyl protodioscin (1), a steroidal saponin isolated from the root of Dioscorea nipponica, to inhibit neointimal formation. (tmu.edu.tw)
Actinomycin D has been regarded as a potential candidate to prevent balloon injury-induced neointimal formation. (tmu.edu.tw)
However, excessive inhibition of neointimal formation caused delayed vascular healing with incomplete endothelialization, which has been associated with an increased risk of late stent thrombosis (ST). (acc.org)
Atherosclerosis3
The association of ADAMTS7 with atherosclerosis suggests that inhibition of ADAMTS7 should be atheroprotective in humans. (wikipedia.org)
von Willebrand Factor Is Produced Exclusively by Endothelium, Not Neointima, in Occlusive Vascular Lesions in Both Pulmonary Hypertension and Atherosclerosis. (stanford.edu)
Available PH therapies consist of vasodilators that do not specifically target lesion formation or expansion and neither prevent progression nor reverse disease. (stanfordchildrens.org)
The cell dynamics and molecular signals driving neointimal lesion formation have been difficult to elucidate as classic mouse models of PH do not develop neointima. (stanfordchildrens.org)
In addition, inhibition of thrombin by dabigatran in serpina3c −/− mice reduced neointima lesion formation due to partial carotid artery ligation. (silverchair.com)
Thrombosis1
Platelet shape change is easily primed by diverse pro-thrombotic xenobiotics and stimuli, and its inhibition can modulate thrombosis, which can ultimately contribute to the development or prevention of thrombotic diseases. (koreascience.kr)
Thrombin1
The anticoagulant activity is mainly attributed to thrombin inhibition mediated by heparin cofactor II, with different effectiveness depending on the compound. (springer.com)
VSMC3
Yet, the molecular mechanisms by which pathological extracellular matrix (ECM) stiffness regulates VSMC growth and migration associated with pathological neointima formation are unclear. (buffalo.edu)
Using VSMCs, the study will first explore how vascular ECM stiffness impacts VSMC migration and growth at the single-cell level, and then determine how pathological ECM stiffness drives neointima formation altering the local mechanical environment of VSMCs in vitro. (buffalo.edu)
The new grant will enable, for the first time, the study of molecular and biophysical mechanisms by which surviving mediates stiffness-sensitive VSMC functions, and contributes to neointima formation and stiffening. (buffalo.edu)
Balloon injury1
A rat carotid artery balloon injury model indicated that neointima formation of the balloon-injured vessel was markedly reduced after extravascular administration of 1. (tmu.edu.tw)
Lesions1
This vascular remodeling, which includes thickening of the smooth muscle layer (an early finding) and formation of occlusive neointimal lesions (a late finding) in the pulmonary arteries, is a major driver of morbidity and mortality in PH. (stanfordchildrens.org)
Pulmonary1
Inhibition of chemokine receptor 4, the receptor for the stem cell mobiliser stromal-derived factor-1, significantly prevented and reversed hypoxia-induced pulmonary hypertension in neonatal mice [ 13 ]. (ersjournals.com)
Vivo1
Finally, we provide evidence that these observations are applicable in vivo by demonstrating that HDAC inhibition decreased neointima formation and expression of cyclin D1 in a murine model of vascular injury. (cret-signal.com)
TGF-1 proteins appearance localized predominantly towards the developing neointima and coincided with proclaimed suppression of endothelial TM appearance (162% of vein handles, P .03), a decrease in situ APC-generating capability (539% of vein handles, P=.001) and increased neighborhood thrombus development (3.70.8-fold increase more than vein controls, P .01). (aplarcongress.org)
MRNA1
Mature miRNAs bind to particular cognate sequences in the 3-UTRs of focus on transcripts, leading to either mRNA degradation or inhibition of translation (12). (cancer-ecosystem.com)
Mediates1
ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury. (uchicago.edu)
Mice2
In these mice, inhibition of the Notch pathway using an anti-Dll1 antibody, or GSI by intranasal administration, resulted in increased mortality, defective viral clearance, and decreased IFN- production in lungs [24]. (rawveronica.com)
To test the impact of glutamine uptake inhibition with V-9302, orthotopic E0771 tumors grown in immune-competent C57BL/6 female mice were treated daily with V-9302 (50 mg/kg) or vehicle beginning when tumors reached 100 mm3, equivalent to 11 days after tumor cell inoculation. (medkoo.com)
Vessel1
They found that anti-CD54 antibodies reduce neointima formation without influencing the number of monocytes/macrophages in the vessel walls ( 20 ). (iiarjournals.org)
Increases1
Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. (rndsystems.com)
Hyperplasia1
Finally, we investigated the result of TGF- inhibition for the advancement of VG neointimal and remodeling hyperplasia. (aplarcongress.org)
Proteins1
Systemic administration of 1D11 also avoided TM downregulation, preserved activated proteins C-generating capability and decreased regional thrombus in rabbit VGs without observable influence on neointima development and various other morphometric variables 6 weeks after implantation. (aplarcongress.org)
Growth2
A cytometric analysis suggested that 1 induced growth inhibition by arresting VSMCs at the G 1 phase of the cell cycle. (tmu.edu.tw)
A cytometric analysis suggested that 1 induced growth inhibition by arresting VSMCs at the G1 phase of the cell cycle. (tmu.edu.tw)
Expression2
As a result of this differential cell cycle-regulatory gene expression by HDAC inhibition, the retinoblastoma protein retains a transcriptional repression of its downstream target genes required for S phase entry. (cret-signal.com)
11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression. (uchicago.edu)
Model1
15 ] found limited evidence for a contribution of bone marrow-derived cells to the formation of the thickened media or the neointima in this model. (ersjournals.com)
Medicine1
Indeed, in an optical coherence tomography study by Jung-Sun Kim, MD, from Yonsei University College of Medicine in Seoul, and colleagues, most of the ZES struts (99.9%) were covered with neointima by 3 months, and late acquired malapposition was not seen. (acc.org)
Bone1
Non-contractile cells such as bone marrow or adult heart derivatives neither engraft long-term nor induce new muscle formation. (go.jp)
Confirm1
Many other publications confirm the importance of CD54 in neointima formation ( 15 - 17 ). (iiarjournals.org)
Control1
PCL and PCL+MSC significantly improve ultrasonographic (i.e., luminal diameter, wall-to-lumen ratio, and flow rate) and histologic (i.e., neointima-to-lumen ratio, neointima-to-media ratio) parameters compared to control, with PCL+MSC demonstrating further improvement in these parameters compared to PCL alone. (bvsalud.org)
Activity1
For anticoagulation potency, the formation of the SP/protease protein complex and the associated non-specific polar interaction between the negatively and positively charged groups in the polysaccharide and protein is responsible for anticoagulant activity. (springer.com)
Support1
The results demonstrate the utility of mechanical support loaded with MSCs at the outflow vein immediately after AVF formation to support maturation by minimizing NIH. (bvsalud.org)