Inhibition hyperthermia induced. Medical search. Frequent questions

Hyperthermia is an example of such a treatment-it inhibits a sub-pathway of the DDR, called homologous recombination (HR). It does so by inducing proteasomal degradation of BRCA2 -one of the key HR factors. (openrepository.com)
Understanding the precise mechanism that mediates this degradation is important for our understanding of how hyperthermia affects therapy and how homologous recombination and BRCA2 itself function. (openrepository.com)
The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination. (openrepository.com)
Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair. (openrepository.com)

Review on the Use of Modulated Electro-Hyperthermia as a Stand-Alone Therapy in a Palliative Setting: Potential for Further Research? (oncothermia-journal.com)
Electro-hyperthermia applied either alone or in combination with chemo- and/or radio-therapy is an advanced hyperthermia technique that has been used as adjuvant treatment for patients with malignant glioma. (thieme-connect.com)
The endpoint was the overall survival and the survival from the 1st electro-hyperthermia treatment. (thieme-connect.com)
The overall median survival time for patients with mostly advanced malignant glioma who received adjuvant electro-hyperthermia in this study was 20.4 months. (thieme-connect.com)
The median survival time from the first electro-hyperthermia treatment was 6.6 months. (thieme-connect.com)
Electro-hyperthermia was safe and well tolerated. (thieme-connect.com)
The presented results show the feasibility of the treatment and suggest a benefit of the electro-hyperthermia treatment for patients with advanced malignant glioma. (thieme-connect.com)

It also displayed strong antiinflammatory activity, the percentage of inhibition was near 60 %, and a dose of 5 mg/kg showed significant antipyretic activity. (sld.cu)
Experimental results in malignant hyperthermia susceptible swine show that prophylactic administration of intravenous or oral dantrolene prevents or attenuates the development of vital sign and blood gas changes characteristic of malignant hyperthermia in a dose related manner. (nih.gov)
1) Ohwada R, Ozeki Y, Saitoh Y*. High-dose ascorbic acid induces carcinostatic effects through hydrogen peroxide and superoxide anion radical generation-induced cell death and growth arrest in human tongue carcinoma cells. (pu-hiroshima.ac.jp)
Even so, from the existing studies, GR127935 had no result on 5 HT metabolic process in the raphe nuclei at a dose which appreciably enhanced metabolic process from the cortex and did not alter the electrically evoked release of 5 HT on this region when determined by speedy cyclic voltammetry, while inhibition of release was seen with sumatriptan. (gabasignaling.com)
In conclusion, we've shown that cisplatin induces dose depejfident emesis during the pigeon as a result of a serotonergic mechanism. (gabasignaling.com)

At therapeutic doses of metronidazole (4.98-24.86 μg/mL) significant inhibition of the production of reactive oxygen species was noted in both methods. (who.int)
Cu can also be used as a hydroxyl radical-generating agent with endogenous H2O2 in cancer cells mediated by Fenton-like reaction and it can reduce intracellular glutathione (GSH) levels leading to the inhibition of reactive oxygen species (ROS) scavenging. (sdlifesciences.com)

On the mechanism of hyperthermia-induced BRCA2 protein degradation. (openrepository.com)
In addition, mechanistic insight into the process of hyperthermia-induced BRCA2 degradation can yield new therapeutic strategies to enhance the effects of local hyperthermia or to inhibit HR. Here, we investigate the mechanisms driving hyperthermia-induced BRCA2 degradation. (openrepository.com)
Heat-induced BRCA2 degradation in human tumours provides rationale for hyperthermia-PARP-inhibitor combination therapies. (openrepository.com)

In the anesthetic-induced malignant hyperthermia syndrome, evidence points to an intrinsic abnormality of skeletal muscle tissue. (nih.gov)
Prazosin, an α 1 -antagonist (0.2 mg/kg i.p.), administered 30 min before MDMA significantly attenuated the MDMA-induced increase in rectal temperature, but had no effect on skeletal muscle temperature. (aspetjournals.org)
The mechanisms of thermogenesis induced by MDMA seem to result from an interaction between the hypothalamic-pituitary-thyroid axis and the sympathetic nervous system, wherein mechanisms leading to core and skeletal muscle hyperthermia after MDMA exposure seem to be differentially regulated by α 1 - and β 3 -adrenergic receptors. (aspetjournals.org)

chemotherapy/hyperthermia. (oslomet.no)
Hyperthermia induces high expression of HSPs, however, inhibition of HSPs by HSP inhibitors and silencing HSF1, did not enhance the cytotoxic effect of hyperthermic chemotherapy. (oslomet.no)
This results in the necessary therapeutic selectivity and, therefore, the corresponding tolerance of the body to the extreme whole-body hyperthermia and possible further treatment steps (e.g. chemotherapy and radiation therapy). (gisunt-klinik.de)

Though the mechanism via which 5 HT, receptor antagonists induce emesis continues to be controversial, evidence from this review displays that, as with cisplatin, a population of 5HT creating cells mediate the emetic effects of 5 HT, receptor antagonists. (gabasignaling.com)

Preliminary experience with the application of gadolinium-DTPA before MR imaging-guided laser-induced interstitial thermotherapy of brain tumors. (thieme-connect.com)

Here, we investigated the antinociceptive effect of PCW in complete freund's adjuvant (CFA)-induced mice and its possible mechanisms associated with opioid system and TRPV1 ion channel. (biomedcentral.com)
Further, involvements of TRPV1 in PCW antinociception were evaluated in CFA-induced TRPV1 −/− and TRPV1 +/+ C57BL/6 male mice, and in capsaicin-induced nociception ICR naive mice pretreated with nor-binaltorphimine (nor-BNI). (biomedcentral.com)
PCW significantly inhibited capsaicin-induced calcium influx in HEK293T-TRPV1 cells. (biomedcentral.com)
This effect may result from the activation of κ-opioid receptor via dynorphin release and the inhibition of TRPV1. (biomedcentral.com)

Metformin generates a mild and transient inhibition of the mTOR pathway, suggesting that ongoing therapy would be needed for best effects. (naturalmedicinejournal.com)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a tumor-selective apoptosis inducer that is expressed in natural killer cells, whose cytotoxicity is activated by interferon (IFN). (oncotarget.com)

This elevated myoplasmic calcium activates acute cellular catabolic processes that cascade to the malignant hyperthermia crisis. (nih.gov)
In this way, physiologic, metabolic, and biochemical changes associated with the malignant hyperthermia crisis may be reversed or attenuated. (nih.gov)
The efficacy of intravenous dantrolene in the treatment of human and porcine malignant hyperthermia crisis, when considered along with prophylactic experiments in malignant hyperthermia susceptible swine, lends support to prophylactic use of oral or intravenous dantrolene in malignant hyperthermia susceptible humans. (nih.gov)
Clinical experience has shown that early vital sign and/or blood gas changes characteristic of malignant hyperthermia may appear during or after anesthesia and surgery despite the prophylactic use of dantrolene and adherence to currently accepted patient management practices. (nih.gov)
These signs are compatible with attenuated malignant hyperthermia and respond to the administration of additional i.v. dantrolene (see DOSAGE AND ADMINISTRATION ). (nih.gov)
Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial. (thieme-connect.com)
The treatment of patients with high-grade malignant gliomas with RF-hyperthermia. (thieme-connect.com)
11 Hermisson M, Weller M. Hyperthermia enhanced chemosensitivity of human malignant glioma cells. (thieme-connect.com)

And PCW still manifested inhibitory effects in capsaicin-induced nociception with nor-BNI pretreatment. (biomedcentral.com)

In individuals with terminal cancer, methylphenidate can be used to counteract opioid-induced somnolence, to increase the analgesic effects of opioids, to treat depression, and to improve cognitive function. (wikipedia.org)
In normal cells, the DDR is extremely important for maintaining genome integrity, but in cancer cells these mechanisms counteract therapy-induced DNA damage. (openrepository.com)

17 Moran C J, Marchosky J A, Wippold 2nd F J, DeFord J A, Fearnot N E. Conductive interstitial hyperthermia in the treatment of intracranial metastatic disease. (thieme-connect.com)

Magnetic stimulation, used as a method that induces muscular activity, was verified in this study as being capable of retarding denervated muscular atrophy. (maxwellmagneticmeds.co.za)
PURPOSE: Postural imbalance can result from hyperthermia mediated muscular fatigue and is a major factor contributing to injuries from falling. (cdc.gov)

RON is activated in response to macrophage-stimulating protein (MSP), and then induces an invasive program ( 8 ) consisting of cell proliferation, migration, and invasion, all of which are important at multiple points during tumorigenesis. (spandidos-publications.com)
16 Ley-Valle A. [Non invasive intracranial hyperthermia with Electric Capacitive Transference -ECT- Intratumoral and cerebral thermometry results]. (thieme-connect.com)

15 Kurzen H, Schmitt S, Naher H, Mohler T. Inhibition of angiogenesis by non-toxic doses of temozolomide. (thieme-connect.com)

The IGF-1-induced effect was inhibited by pretreatment with IGF binding protein 3 (IGFBP3) or NVP-AEW541 (NVP, a selective inhibitor of type 1 IGF receptor tyrosine kinase, IGF1R TK). (bvsalud.org)
Without a doubt, the inhibition of 5 HT synthesis GABA receptor by pCPA, which has previously been shown to provide marked 5 HT and 5 HIAA depletion in unique locations on the pigeon brain, might blunt the emesis induced by 5 HT, receptor antagonists. (gabasignaling.com)
Indeed, all benzamidic form 5 Dizocilpine concentra HT, receptor antagonists utilized within this research may also be agonists at 5 HT4 receptors, and so they do not induce emesis or do so in element, though all indolic form 5 HT, receptor antagonists both have no affinity or are weak antagonists at S HT receptors, plus they all are emetogenic. (gabasignaling.com)
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. (bnwax.com)

Several national and international specialists have been researching hyperthermia for many years, which is a token of hyperthermia's value as a therapeutic tool. (gisunt-klinik.de)

Furthermore, we investigated the effect of hyperthermia to induces immunogenic cell death (ICD) by measuring extracellular HMGB1. (oslomet.no)
Whether hyperthermia (temperature, 400C), salicylates, acetaminophen or phenacetin has an adverse effect on polymorphonuclear leukocyte (PMNL) function was examined. (docksci.com)
In this paper the effect of hyperthermia (temperature, 400C) and the antipyretics mentioned above on polymorphonuclear leukocyte (PMNL) viability and function was ascertained. (docksci.com)
Radiosensitizers are chemical agents that have the potential to increase the lethal effect of radicals induced during irradiation [1-6].The extent of radiation damage to cells is dependent on the amount of oxygen available to the cell [1,2,7,8]. (who.int)
The objective of this study was to investigate the effect of exercise-induced hyperthermia and the impact of cooling on postural balance while wearing firefighters' protective clothing (FPC) in a hot environment. (cdc.gov)
Cooling resulted in a significant effect only on postural sway speed after exercise-induced hyperthermia. (cdc.gov)
This study investigated the effect of cooling on the physiological responses and probability of hyperthermia in subjects wearing FPC during exercise in a hot environment. (cdc.gov)
A logistic regression model was used to analyze the interaction effect of cooling on the probability of progression to hyperthermia (T(c) 38C). (cdc.gov)
The study purpose was to investigate the effect of hyperthermia and the effect of body cooling on sustained attention and response inhibition while wearing firefighters' personal protective ensembles after exercise in a hot environment. (cdc.gov)

1) Saitoh Y* , Yonekura N, Matsuoka D, Matsumoto A. Molecular hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide-induced increases in interleukin-1 alpha and interleukin-6 secretion in human gingival cells. (pu-hiroshima.ac.jp)

1) Saitoh Y* , Ohta H, Hyoudou S. Protective effects of polyvinylpyrrolidone-wrapped fullerene against intermittent ultraviolet-A irradiation-induced cell injury in HaCaT cells. (pu-hiroshima.ac.jp)

General Pharmacology and Cocaine-Induced Supersensitivity of Noninnerv. (erowid.org)

Since extreme hyperthermia is not selective enough for a systemic cancer therapy, the cancer cells are sensitized to temperature via hyperglycemia. (gisunt-klinik.de)
Thermoregulatory function, that is, heat dissipative responses such as skin blood flow (SkBF) and sweating to an increased body temperature, is critical during physical work or exercise in warm and hot conditions and during hyperthermia. (intechopen.com)

Cocaine may induce miscarriage, premature labor, placental abruption, or fetal toxicity, and modifications may be necessary for acute management. (medscape.com)
C. Obstetric complications polyhydramnios, pregnancy-induced hypertension, premature rupture of papillary muscles papillary muscles. (albionfoundation.org)

In this regard, CBD inhibition of 5-HT 3 receptors may contribute to its role in modulation of nociception and emesis, potentiation of GABA receptors may account for its anti-seizure, anxiolytic and analgesic effects, and potentiation of glycine receptors may be relevant for CBD anti-nociceptive actions [3,16, 22] . (researchgate.net)
Insulin-like growth factor-1 (IGF-1), interleukin-1ß (IL-1ß), monocyte chemoattractant protein-1 and lipocalin-2 produced hyperthermia, and the effects induced by IL-1ß (25 ng) and IGF-1 (5 µg) were sustainable and remarkable. (bvsalud.org)
MAO Inhibition and the Effects of Centrally Administered LSD Serotonin. (erowid.org)
1) Saitoh Y* , Tanaka A, Hyodo S. Protective effects of polyvinylpyrrolidone-wrapped fullerene against nitric oxide/peroxynitrite-induced cellular injury in human skin keratinocytes. (pu-hiroshima.ac.jp)

Inhibition of calcium release from the sarcoplasmic reticulum by dantrolene sodium reestablishes the myoplasmic calcium equilibrium, increasing the percentage of bound calcium. (nih.gov)

Microwave hyperthermia radiosensitized iridium-192 for recurrent brain malignancy. (thieme-connect.com)

A reflex technique to measure presynaptic inhibition in cerebral stroke. (mcmaster.ca)

It is well-known that activation of opioid receptors result in the inhibition of chronic inflammatory pain [ 3 ]. (biomedcentral.com)

A marked increase in IFN-induced DR4 protein expression after tocilizumab treatment was observed by immunohistochemical staining in the tumor from the mice xenograft model. (oncotarget.com)

At the same time, healthy tissues are stabilized by the hyperoxemia step by an oxygen supply adapted to the exposure to extreme hyperthermia in combination with the high supply of the energy carrier glucose. (gisunt-klinik.de)

Fenton-like reaction-associated chemodynamic therapy (CDT) and hyperthermia-inducing photothermal therapy (PTT)-combined crosslinked hydrogel systems were developed for loco-regional cancer therapy. (sdlifesciences.com)
We concluded that magnetic CZ nano/micro-particles could be evaluated for further application in cancer hyperthermia therapy and as anti-amyloidogenic agents. (nature.com)

MDMA (40 mg/kg s.c.) induced a significant increase in thyroxine levels 1 h post-treatment. (aspetjournals.org)

Inhibition of the DDR could therefore be used to increase the efficacy of anti-cancer treatments. (openrepository.com)

Finally, antipyretic activity was tested by inducing pyrexia with brewer's yeast in rats. (sld.cu)

This leads to the stimulation of glycolysis of the tumor cells and thus to a selective hyperacidity of the cancer tissue and inhibition of blood microcirculation therein. (gisunt-klinik.de)

The expression of DR4 induced by combination with IFN-α and tocilizumab was also examined by immunohistochemical staining using mice xenograft model. (oncotarget.com)

Physical restraint should be avoided if possible due to risks of rhabdomyolysis and hyperthermia. (medscape.com)

An acute and potentially life-threatening complication associated with the recreational use of the 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) is hyperthermia. (aspetjournals.org)

À des doses thérapeutiques de métronidazole (4,98-24,86 μg/mL), on a observé une inhibition significative de la production d'espèces réactives de l'oxygène avec les deux méthodes. (who.int)

The results indicate that when cooling was used each subject, on average, was 91% less likely to reach the lower threshold limit of hyperthermia. (cdc.gov)
Exercise in hot environments while wearing FPC results in significant physiological strain, which may lead to hyperthermia. (cdc.gov)

These findings suggested that IGF-1 produced hyperthermia, which was mediated, at least a part, through an increased IL-1ß concentration after activation of IGF1R TK in the POA, and the IGF-IGFBP system possibly participates in BT homeostasis in the POA. (bvsalud.org)

Geranylgeranylacetone is a very potent chemical that induces naturally made molecules inside cells (from bacteria to human) called heat shock proteins (HSP's). (barefacedtruth.com)

reduction, but addition of hyperthermia did not further decrease in cell viability. (oslomet.no)

Substance-induced/medication-induced anxiety disorder and anxiety due to another medical condition should always be considered when people present with significant anxiety. (msdmanuals.com)

The combination of prazosin and cyanopindolol resulted in an abolishment of MDMA-induced hyperthermia. (aspetjournals.org)

0.05) the thermal stress thereby reducing the probability of hyperthermia while exercising in hot and humid conditions. (cdc.gov)

Hyperthermia, antipyretics and function of polymorphonuclear leukocytes. (docksci.com)

04 Eikesdal H P, Bjorkhaug S T, Dahl O. Hyperthermia exhibits anti-vascular activity in the s.c. (thieme-connect.com)

NVP-induced inhibition was observed only in the early phase of IGF-1-induced hyperthermia. (bvsalud.org)

Anatomy2

Organisms3

Diseases16

Chemicals and Drugs23

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes16

Technology, Industry, Agriculture3

Health Care3

Homologous recombination4

Electro hyperthermia7

Dose5

Reactive oxygen2

BRCA23

Skeletal muscle3

Chemotherapy3

Cisplatin1

Thermotherapy1

TRPV14

Transient1

Apoptosis1

Malignant8

Capsaicin1

Counteract2

Metastatic1

Muscular2

Invasive2

Temozolomide1

Receptor4

Therapeutic1

Effect9

Suppresses1

Irradiation1

Pharmacology1

Temperature2

Premature2

Effects4

Calcium1

Recurrent1

Cerebral1

Receptors1

Protein1

Exposure1

Therapy2

Treatment1

Efficacy1

Rats1

Stimulation1

Expression1

Physical1

Acute1

Doses1

Results2

Findings1

Human1

Addition1

Significant1

Combination1

Thermal1

Function1

Activity1

Phase1