QuercetinAlkaloidsCompoundsVitroSilicoPhenolicsAntioxidant activityInhibitorsPharmacologicalAnti-inflammatory effectsEnzyme inhibitionSignificant inhibitionAglyconesPlantExtractsBioavailabilityFlavonolActivityDietary1997ConcentrationAnthocyaninsExtract showedRemarkableNaturallyWidely distributedBiologicalSynthesisNaringinInhibitorApoptosisLeavesAlterationExperimentalTotalMechanismsChemicalBeveragesPropertiesContentFruitStudies have shown
Quercetin6
- Flavonols such as quercetin and kaempferol showed a biphasic effect on vincristine efflux, causing inhibition or enhancement depending on their concentration. (aspetjournals.org)
- leaves extract showed the flavonoid content (0.49±0.02 mg quercetin equivalent/g of dry extract) among the three samples studied, respectively. (nepjol.info)
- Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. (prostate.net)
- Quercetin is a flavonoid - a compound that gives color to a variety of vegetables and fruits, including grapes. (medscape.com)
- The authors then examined the concentration of quercetin glucuronide to achieve various inhibitions of ALDH, as you can see in this graph here. (medscape.com)
- The ethanolic extracts of the plant were examined for the presence of bioactive components and their total flavonoid content, with focusing on quercetin detection using thin layer bioautography (TLB) and brine shrimp lethality assay (BSLA) for cytotoxicity. (who.int)
Alkaloids6
- The most common flavonoid alkaloids contain a nitrogen heterocycle such as a pyridine or piperidine which is covalently bonded to the A-ring of a chromone. (wikipedia.org)
- The synthesis of flavonoid alkaloids has been achieved A number of flavonoid alkaloids have been discovered that possess diverse pharmacological activity that may have application in the treatment of a range of diseases. (wikipedia.org)
- Flavonoid alkaloids were also found to present alpha-glucosidase inhibitory activity through artificial organic synthesis. (wikipedia.org)
- Synthesis of novel flavonoid alkaloids as α-glucosidase inhibitors. (wikipedia.org)
- Phytochemical analysis of the extract revealed the presence of some bioactive substances such as alkaloids, tannins, flavonoids, saponins, etc. (ac.be)
- The phytochemical analysis of different extracts of G. lancifolia leaf, stem and fruit revealed the presence of tannins, saponins, flavonoids, terpenoids, alkaloids and cardiac glycosides. (ijpsonline.com)
Compounds11
- Multiple structure-activity relationships were identified among active compounds such as enrichment of galloylated flavonoids and biflavones, including multiple biflavone analogs of apigenin. (covidnewscast.com)
- Among the compounds tested, 14b showed a dose-response inhibition of PGE2 production with an IC50 value of 2.1 lM. (iium.edu.my)
- Although they are a rich source of bioactive compounds, especially flavonoids, corn husks are usually disposed of or used as animal feed. (mdpi.com)
- Flavonoids are a large family of polyphenolic plant compounds. (oregonstate.edu)
- The compounds showed good inhibition of seed germination, especially at 50 mg.L-1, but little fungistatic activity. (scielo.br)
- Plants contain a broad range of bioactive compounds such as phenolics, terpenoids, carotenoids, anthocyanins and flavonoids. (ijpsonline.com)
- This study showed the leaves and seeds extracts of these two medicinal plants are found rich in phenolic and flavonoid compounds. (nepjol.info)
- The full range of antioxidants found in the body include vitamins C and E, carotenes, glutathionine, uric acid, taurine, and plant flavonoids and flavonoid derivatives, and some other compounds. (positivehealth.com)
- This article considers only the flavonoids, which are small compounds synthesised by plants, but not animals, so must be taken in our diet. (positivehealth.com)
- Study yielded eleven pure compounds including four flavonoids and five steroids. (stuartxchange.org)
- Both had a similar chemical constitution, the glycerin being more efficient in concentrating phenolic compounds and flavonoids. (bvsalud.org)
Vitro5
- Yet no comprehensive in vitro testing of flavonoid activity against SARS-CoV-2 Mpro has heretofore been performed. (covidnewscast.com)
- Flavonoids have been shown to exhibit antiinflammatory, antithrombogenic, antidiabetic, anticancer, and neuroprotective activities through different mechanisms of action in vitro and in animal models. (oregonstate.edu)
- In-vitro metabolic inhibition studies using rat and human liver microsomes and intestinal absorption studies of riluzole in a rat everted gut-sac model were conducted to elucidate the mechanism of interaction. (researchgate.net)
- In-vitro metabolism studies demonstrated significant inhibition of riluzole metabolism when it was co-incubated with ciprofloxacin or grapefruit juice. (researchgate.net)
- Inhibition of OATP1A2 transport by flavonoids in grapefruit (naringin) and orange (hesperidin) was conducted in vitro. (nih.gov)
Silico2
- The SARS-CoV-2 main protease (Mpro) has been implicated as a target for flavonoids in silico. (covidnewscast.com)
- Further in silico study was performed to explain the binding mode between flavonoid pyranoside or galactoside and flavonoid aglycone in the 15-LOX cavity and their amino acid residues interaction. (ui.ac.id)
Phenolics2
- lower amounts of total phenolics and flavonoids and a different quantitative phenolic profile) and samples sold in packages. (unboundmedicine.com)
- Indeed, under the global optimal MAE conditions ( t = 20 min, T = 180 °C, Et = 47.4% and S/L = 45 g/L), QWERT and colleagues reported that it was possible to obtain an extraction yield of 75.5% and ingredients with high levels of sugars, proteins, phenolics, and flavonoids, and interesting antioxidant properties - as measured by ABTS + scavenging activity and oxidative haemolysis inhibition assay (OxHLIA). (nutraingredients.com)
Antioxidant activity2
Inhibitors1
- Plant-based flavonoids have been evaluated as inhibitors of β-coronavirus replication and as therapies for COVID-19 on the basis of their safety profile and widespread availability. (covidnewscast.com)
Pharmacological3
- Valenzuela A, Garrido A. Biochemical bases of the pharmacological action of the flavonoid silymarin and of its structural isomer silibinin. (springer.com)
- The above findings are potentially significant because flavonoids are widely present in vegetables, fruits, and beverages ( Herrmann, 1988 ) and are known to have a wide range of biochemical and pharmacological effects. (aspetjournals.org)
- Scutellarin is an herbal flavonoid glucuronide with multiple pharmacological activities. (cdc.gov)
Anti-inflammatory effects1
- Certain naturally occurring flavonoids, such as luteolin, have anti-oxidant and anti-inflammatory effects, including inhibition of activated peripheral blood leukocytes from MS patients. (tufts.edu)
Enzyme inhibition2
- The α-amylase enzyme inhibition activity was performed to evaluate the antidiabetic property of plant extracts. (nepjol.info)
- was found potent towards α-amylase enzyme inhibition activity of IC 50 16.05±0.24 μg/mL whereas E. robusta Sm. (nepjol.info)
Significant inhibition2
Aglycones1
- We also showed that aglycones of several flavonoids inhibited P-gp function in a concentration-dependent manner, whereas their glycosides were inactive (Y. Mitsunaga, H.T., H.M., M. Naito, T. Tsuruo, H.O., and Y.S., submitted). (aspetjournals.org)
Plant3
- Plant flavonoid inhibition of SARS-CoV-2 main protease and viral replication. (covidnewscast.com)
- These studies will advance the development of plant-based flavonoids-including widely available natural products-to target β-coronaviruses. (covidnewscast.com)
- Apigenin has special interest for the development of chemopreventive agents against cancer because it is a widely distributed plant flavonoid that has antitumor properties. (spandidos-publications.com)
Extracts4
- Determination of Total Phenolic and Flavonoid Content, Antidiabetic, and Antioxidant Activities of Leaves and Seeds Extracts of Eucalyptus robusta Sm. (nepjol.info)
- Extracts of treated fruit showed enhanced inhibition of A549 cell and HL-60 cell proliferation and induced the apoptosis of HL-60 cells. (cdc.gov)
- Thus, this study demonstrated for the first time that the glycolic extracts of C. pachystachya have promising chemical and biological characteristics for the development of a multifunctional cosmetic with antioxidant and tyrosinase-inhibition activities. (bvsalud.org)
- L. egeregia was regarded as the prototype of the anticancer species due to its profound flavonoid concentration (85.40 µg/mL) and cytotoxicity (9.46 µg/mL) compared to other extracts. (who.int)
Bioavailability1
- High intakes of dietary flavonoids are generally regarded as safe, especially because of their low bioavailability. (oregonstate.edu)
Flavonol1
- This group of flavonoids, flavonol, could be investigated further to discover the common mechanisms of inhibition of dengue virus replication. (who.int)
Activity4
- Moreover, the DPPH and ABTS scavenging capacity of FS, as well as α-glucosidase inhibition activity, that resulted about 20-fold higher than commercial Acarbose, were retained during nanoencapsulation process. (uniss.it)
- An important preventive antifungal effect was observed after 7 days of storage (100% of inhibition), although this activity decreased after 14 and 21 days (85.71 and 57.14% of inhibition, respectively). (ac.be)
- A slight curative antifungal activity was observed only after 7 days of storage (14.29% of inhibition). (ac.be)
- It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
Dietary3
- Dietary flavonoids are naturally occurring in fruit, vegetables, chocolate, and beverages like wine and tea. (oregonstate.edu)
- Since the 1990s, there has been a growing interest in dietary flavonoids due to their likely contribution to the health benefits of fruit- and vegetable-rich diets. (oregonstate.edu)
- Flavonoids are classified into 12 major subclasses based on chemical structures, six of which, namely anthocyanidins, flavan-3-ols, flavonols, flavones, flavanones, and isoflavones ( Table 1 and Figures 1-9 ) are of dietary significance. (oregonstate.edu)
19971
- Miyagi, Y., Miwa, K. and Inoue, H. (1997) Inhibition of Human Low Density Lipoprotein Oxidation by Flavonoids in Red Wine and Grape Juice. (scirp.org)
Concentration1
- The suppression upon PGE2 secretion was not due to cell death since 14b did not reduce the cell viability in close proximity to the PGE2 inhibition concentration. (iium.edu.my)
Anthocyanins1
- The results of small-scale randomized controlled trials suggest that consumption of flavonoid-rich food and beverages containing anthocyanins or flavan-3-ols may improve vascular endothelial function. (oregonstate.edu)
Extract showed1
- The extract showed a remarkable inhibition zone against the pathogen in agar well diffusion assays carried out in Petri plates. (ac.be)
Remarkable1
- The result showed no remarkable inhibition of bacterial growth. (ishs.org)
Naturally1
- Naturally occurring flavonoids have long been utilized as essential templates for the development of novel drugs and as critical ingredients for functional foods. (frontiersin.org)
Widely distributed1
- Glycosylated flavonols (bound to at least one sugar molecule) are the most widely distributed flavonoids in the diet (2, 3) . (oregonstate.edu)
Biological2
- Many of the biological effects of flavonoids appear to be related to their ability to modulate a number of cell-signaling cascades. (oregonstate.edu)
- The present study aimed at the determination of total phenolic and flavonoid content and biological activities of Eucalyptus robusta (Sm. (nepjol.info)
Synthesis2
- In this Letter, we report the synthesis of a series of minor prenylated chalcones and flavonoids which was found to be significantly active in suppressing the PGE2 production secreted by lipopolysaccharide-induced mouse macrophage cells (RAW 264.7). (iium.edu.my)
- microRNAs (miRNAs) are important regulators of target messenger RNA translation by binding mainly to complementary sequences of the 3′ untranslated region of target messenger RNA transcripts thereby leading to RNA degradation and/or inhibition of protein synthesis [ 4 ]. (hindawi.com)
Naringin1
- Naringin and hesperidin's half-maximal inhibitions were 3.6 and 2.7 microM, respectively. (nih.gov)
Inhibitor2
- Inhibition of the Ras-MAPK pathway by expression of the dominant-negative Ras mutant HRasN17 or by addition of the MAPK kinase (MEK) inhibitor PD98059 reduced several of these parameters but failed to block transformation. (embl.de)
- Similarly, inhibition of the PI3K-mTOR pathway by addition of the PI3K inhibitor 2-[4-morpholinyl]-8-phenyl-4H-1-benzopyran-4-one (LY294002) or the mTOR inhibitor rapamycin, although reducing several parameters of transformation, also failed to block transformation. (embl.de)
Apoptosis1
- Growth inhibition, cell-cycle dysregulation, and induction of apoptosis by green tea constituent (-)-epigallocatechin-3-gallate in androgen-sensitive and androgen-insensitive human prostate carcinoma cells. (prostate.net)
Leaves2
- We recently have isolated flavonoids from the leaves of Carya cathayensis Sarg. (hindawi.com)
- The total flavonoids (TFs) were extracted from the leaves of Carya cathayensis Sarg. (hindawi.com)
Alteration2
- CYP1A2 inhibition can cause alteration of the metabolism of many important drugs like theophylline, clozapine, olanzapine, and caffeine [27]. (researchgate.net)
- Transformation was assessed by the standard parameters of morphological alteration, increased hexose uptake, loss of density inhibition, and anchorage-independent growth. (embl.de)
Experimental1
- Moreover, luteolin and structurally similar flavonoids can inhibit experimental allergic allergic encephalomyelitis (EAE), an animal model of MS in rodents. (tufts.edu)
Total5
- Our previous studies have shown that the total flavonoids (TFs) from Rosa laevigata Michx fruit has various activities, however, there were no papers reporting the role of the TFs against renal IRI. (mdpi.com)
- Total Flavonoids from Carya cathayensis Sarg. (hindawi.com)
- This study aimed to investigate whether the total flavonoids (TFs) from Carya cathayensis Sarg. (hindawi.com)
- with 40% ethanol and enriched total flavonoids by polyamide [ 27 ]. (hindawi.com)
- The total phenolic (TPC) and flavonoid content (TFC) were quantified by the Folin-Ciocalteu phenol reagent and aluminium chloride colorimetric method. (nepjol.info)
Mechanisms1
- Because it promotes the lightening of pigment spots, tyrosinase inhibition is one of the mechanisms of depigmenting cosmetic products. (bvsalud.org)
Chemical1
- Study of aqueous extract yielded twelve types of major chemical constituents: six flavonoids, two homocyclic peptides, two long chain aliphatic amides, one tannin and one nitrogen heterocyclic compound. (stuartxchange.org)
Beverages1
- They have more antioxidants or flavonoids than any other alcoholic beverages. (rejuvalife.md)
Properties2
- Inhibition properties of some flavonoids. (anadolu.edu.tr)
- The flavonoid silymarin and one of its structural components, silibinin, are substances with documented hepatoprotective properties. (springer.com)
Content1
- Blackberries treated with MJ (0.01 and 0.1 mM) had higher soluble solids content, and lower titratable acids than untreated fruit as well as enhanced content of flavonoids and increased antioxidant capacity. (cdc.gov)
Fruit1
- There has been much interest in the potential health benefits of flavonoids associated with fruit- and vegetable-rich diets. (oregonstate.edu)
Studies have shown1
- Numerous studies have shown that flavonoids can prevent cardiovascular disease [ 16 - 19 ]. (hindawi.com)