• In this study, the anti-biofilm activity of previously fabricated polyamino-phenolic ligands and polyamidoamine dendrimers was investigated against legionella mono-species and multi-species biofilms formed by L. pneumophila in association with other bacteria that can be found in tap water ( Aeromonas hydrophila , Pseudomonas aeruginosa , Escherichia coli , Klebsiella pneumoniae ). (frontiersin.org)
  • Cultures were exposed 48 h to 6 and 12 ng ml -1 of gold nanoparticles coated with mannose generation 0 polyamidoamine dendrimer. (elsevierpure.com)
  • Specifically, the polyamidoamine (PAMAM) dendrimer is a small molecule that targets the largest family of pore-forming virulence proteins that are found in a variety of bacterial plant pathogens belonging to Erwinia spp. (duke.edu)
  • While Macrophen and Double Macrophen were the most active substances among polyamino-phenolic ligands, dendrimers were overall twofold more effective than all other compounds with a reduction up to 85 and 73% of legionella and multi-species biofilms, respectively. (frontiersin.org)
  • These data suggest that the studied compounds, especially dendrimers, could be considered as novel molecules in the design of research projects aimed at the development of efficacious anti-biofilm disinfection treatments of water systems in order to minimize legionellosis outbreaks. (frontiersin.org)
  • Dendrimers and dendrons are monodisperse and usually highly symmetric, spherical compounds. (wikipedia.org)
  • Of the hit compounds identified, the dendrimer SB105-A10 was the most potent inhibitor of RSV infectivity, with IC50 values equal to 0.35 μM and 0.25 μM measured in Hep-2 and A549 cells, respectively. (mattek.com)
  • Therefore, this protein is an interesting therapeutic target, suitable for inhibition by carbohydrate-based compounds. (dissem.in)
  • The mannose-spin labeled functionalized dendrimers were further studied to determine effects of the spin label in hemagglutination inhibition assays. (montana.edu)
  • The interaction between galactoside derivatives and PA-IL was investigated by several biophysical methods, including hemagglutination inhibition assay, isothermal titration calorimetry, analytical ultracentrifugation, and surface plasmon resonance. (dissem.in)
  • The first dendrimers were made by divergent synthesis approaches by Fritz Vögtle in 1978, R.G. Denkewalter at Allied Corporation in 1981, Donald Tomalia at Dow Chemical in 1983 and in 1985, and by George R. Newkome in 1985. (wikipedia.org)
  • Dendrimers are also classified by generation, which refers to the number of repeated branching cycles that are performed during its synthesis. (wikipedia.org)
  • For example, if a dendrimer is made by convergent synthesis (see below), and the branching reactions are performed onto the core molecule three times, the resulting dendrimer is considered a third generation dendrimer. (wikipedia.org)
  • Synthesis of glucosamine funtionalized dendrimers was undertaken unsuccessfully. (montana.edu)
  • Recent advances in click chemistry applied to dendrimer synthesis. (innovareacademics.in)
  • Efficient synthesis of carbazole core diblock dendrimer by double click chemistry. (innovareacademics.in)
  • Soto Castro D, Magana Vergara NE, Farfan N, Santillan R. Synthesis of steroidal dendrimers modified by 'click chemistry with PAMAM dendrons as unimolecular micelles. (innovareacademics.in)
  • A previously-published 16-step and a new 9-step concise synthesis of BNM-III-170 bis TFA salt, a small molecule CD4 mimetic compound targeting toward the inhibition of the HIV-1 entry which has the potential to eliminate the infected cell and the HIV cell, is reported. (upenn.edu)
  • The first structure that can be interpreted as a dendrimer was first reported in the published paper by Fritz Vogtle and coworkers and the process was referred to as cascade synthesis. (upenn.edu)
  • The concentration of the chemicals tested as anti-biofilm agents was chosen based on cytotoxicity assays: the highest non-cytotoxic chemical concentration was used for biofilm inhibition assays, with dendrimer concentration 10-fold higher than polyamino-phenolic ligands. (frontiersin.org)
  • Two-directional arborols are synthetic bolaform amphiphilic dendrimers. (lsu.edu)
  • Synonymous terms for dendrimer include arborols and cascade molecules. (wikipedia.org)
  • Fedeli E, Lancelot A, Serrano JL, Calvo P, Sierra T. Self-assembling amphiphilic Janus dendrimers: mesomorphic properties and aggregation in water. (innovareacademics.in)
  • Mannose-functionalized dendrimers with varying concentrations of saccharides on the dendrimer surface were synthesized. (montana.edu)
  • Our results suggest that the NO release from the dendrimer occurs in a controlled fashion, keeping the anti-inflammatory effect of NO even at high concentrations. (mpg.de)
  • A solubility study was conducted with various solvents and surfactants at 40 ◦C. An in vitro antimicrobial assay was performed against bacterial and fungal strains to determine the zone of inhibition and minimum inhibitory concentrations. (docslib.org)
  • The surface modification of dendrimers can reduce their innate toxicity problems and increase the therapeutic efficacy of brain disorders. (innovareacademics.in)
  • Among the various nanocarriers, dendrimers owing to their unique physical and chemical characteristics, represent a potential therapeutic tool in biomedical and pharmaceutical science. (innovareacademics.in)
  • Potent and selective inhibition of HIV and SIV by prostratin interacting with viral entry. (neb.com)
  • Dendrimers are highly ordered, branched polymeric molecules. (wikipedia.org)
  • Dendrimers, an established polymeric nanocarrier system of the time, can deliver both drugs and genetic material and are being extensively studied to target the brain. (innovareacademics.in)
  • IUPAC definition Dendrimer Substance composed of identical dendrimer molecules. (wikipedia.org)
  • Lower generations can be thought of as flexible molecules with no appreciable inner regions, while medium-sized (G-3 or G-4) do have internal space that is essentially separated from the outer shell of the dendrimer. (wikipedia.org)
  • Also we measured maximum inhibitory concentration (MIC) of dendrimer against isolated bacteria. (ac.ir)
  • The difference between dendrons and dendrimers is illustrated in the top figure, but the terms are typically encountered interchangeably. (wikipedia.org)
  • Dendrimer molecule Molecule consisting of one or more dendrons emanating from a single constitutional unit. (wikipedia.org)
  • The first category includes dendrimers and dendrons, and the latter includes dendronized polymers, hyperbranched polymers, and the polymer brush. (wikipedia.org)
  • 22 have a relatively low stability and delivery efficacy compared to polyethyleneimine (PEI),dendrimer, and liposome. (hifsignaling.com)
  • ABSTRACT The inhibition of Phosphodiesterase 5A (PDEA5) has the potential to modulate pulmonary arterialhypertension and cardiovascular diseases. (biruni.edu.tr)
  • Cationic dendrimers such as poly(propyleneimine) (PPI), poly(amidoamine) (PAMAM), poly(L-Lysine) (PLL) and carbosilane are able to form complexes with siRNA through charge interactions and shielding it from RNases. (polymerfactory.com)
  • In this paper we report the first catalytic Cu(II)-PAMAM dendrimer complexes that catalyze aerobic oxidative polymerization of DMP in water with significantly high catalytic efficiency ([monomer]/[catalyst]=2000). (lwgsw.com)
  • First, it is the first example that Cu(II)-PAMAM dendrimer complexes are used as catalysts. (lwgsw.com)
  • The low PPO yield at lower [Cu(II)]/[PAMAMG3] ratio could be ascribed to the dispersed state of copper complexes which do not have concentration effect, and might also be duo to inhibition of polymerization by uncoordinated nitrogen sites. (lwgsw.com)
  • In this study we evaluated and compared nanostructure macromolecules called Poly (amidoamine) dendrimer generation 4 (PAMAM-G4) with conventional antibiotics in relation to resistance of isolated bacteria from water resources. (ac.ir)
  • Dendrimers represent a new means of creating three dimensional macromolecules where there is a tree like branching of symmetry in the arrangement of atoms within the molecule. (ivoryresearch.com)
  • Poly(amidoamine), or PAMAM, is perhaps the most well known dendrimer. (wikipedia.org)
  • 5205. C.Z. Chen, N.C. Beck-Tan, P. Dhurjati, T.K. van Dyk, R.A. LaRossa, S.L. Cooper, "Quaternary ammonium functionalized poly(propylene imine) dendrimers as effective antimicrobials: structure-activity studies," Biomacromolecules 1(Fall 2000):473-480. (nanomedicine.com)
  • siRNA mediates the inhibition of gene expression and has become a major tool for vitro analysis of protein function. (polymerfactory.com)
  • Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle. (neb.com)
  • Also, it is possible to make dendrimers water-soluble, unlike most polymers, by functionalizing their outer shell with charged species or other hydrophilic groups. (wikipedia.org)
  • Because pore-forming virulence factors are produced by many bacterial, fungal and oomycete pathogens, this technology, based on the concept of inhibition of microbial pores, has potential to be used to treat many other plant (and animal/human) pathogens in addition to fire blight and kiwi bacterial canker disease. (duke.edu)
  • Amino-functional bis-MPA dendrimers of generation 1 to 4 (G1 to G4) have been investigated as a non-viral vector for siRNA delivery in primary neurons, astrocytes, glioma, and glioblastoma cell lines. (polymerfactory.com)
  • There is no clear explanation for the low percentage of protein inhibition by siRNA. (polymerfactory.com)
  • Alternatively, it might also due to a strong charge-interaction between dendrimer and siRNA which inhibits the release of siRNA. (polymerfactory.com)
  • Since this is the first study on bis-MPA dendrimers as a potential non-viral carrier for siRNA delivery, the results are relatively promising and more studies are required to understand the system better and potentially discover ways to take measures to improve the existing protein knockdown rate. (polymerfactory.com)
  • Dendrimers are tree-like branched structures that are unimolecular in nature and are synthesized in a sequential manner. (upenn.edu)
  • Surface functionalized dendrimers are being used for several applications including the study of protein-carbohydrate interactions. (montana.edu)
  • The properties of dendrimers are dominated by the functional groups on the molecular surface, however, there are examples of dendrimers with internal functionality. (wikipedia.org)
  • Background and Aim: Dendrimers have antibacterial properties and can be used against microbial infections as alternative antibacterial agents with minimal side effects. (ac.ir)
  • In this work, we synthesized a nitrate-terminated dendrimer and evaluated its anti-inflammatory properties. (mpg.de)
  • In this study, the globotriose and 3'-sialyllactose carbohydrate head groups found on two GSL were covalently attached to a dendrimer core to produce two types of unique multivalent carbohydrates (MVC). (psu.edu)
  • Each successive generation results in a dendrimer roughly twice the molecular weight of the previous generation. (wikipedia.org)
  • Higher generation dendrimers also have more exposed functional groups on the surface, which can later be used to customize the dendrimer for a given application. (wikipedia.org)
  • Fluorescence microscopy experiment also suggested efficient endo-lysosomal escape with distinct mitochondrial subcellular localisation for all generation dendrimers. (polymerfactory.com)
  • The generation of PAMAM strongly influences the catalytic efficiency of Cu(II)-PAMAM dendrimer catalyst. (lwgsw.com)
  • This review article is an attempt to update on the potential of dendrimers explored in the past five years as a drug delivery avenue that can be considered as a promising solution in the management of a wide range of disorders affecting the central nervous system, including neoplastic, degenerative, and ischemic conditions. (innovareacademics.in)
  • The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (cancerindex.org)
  • Resistance of isolated species to amoxicillin, erythromycin, tetracycline and ciprofloxacin antibiotics was determined by measuring zones of inhibition and then compared to the resistance of these species to PAMAM-G4 dendrimer as an antibacterial agent. (ac.ir)
  • Gram-negative species revealed high resistance to PAMAM-G4 dendrimer based on the measurement of zones of inhibition. (ac.ir)
  • Gram-positive species showed a good response to PAMAM-G4 dendrimer, so that the MIC's for Staphylococcus aureus and Bacillus subtilis were 1 and 2.5 µg/ml, respectively. (ac.ir)
  • Typically, dendrimers are symmetric about the core, and often adopt a spherical three-dimensional morphology. (wikipedia.org)
  • however, inhibition of algal growth and photosynthetic activity was found only in the wild type. (elsevierpure.com)
  • Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives. (neb.com)
  • Investigation of the NO-releasing profiles from monomer and dendrimer using real-time NO analyzer NOA confirmed the slow release of NO from the dendrimer. (mpg.de)
  • PAMAM-G4 dendrimer didn't have any effect on inhibition of the growth of Enterobacter and Pseudomonas. (ac.ir)
  • The newly synthesized multivalent galactoclusters proved to be significantly better ligands than simple d-galactose for lectin PA-IL and as a result, two representatives of the dendrimers were able to decrease adhesion of P. aeruginosa to bronchial cells to approximately 32% and 42%, respectively. (dissem.in)
  • Inhibition of Env-mediated membrane fusion by MVC was also observed using a dye-transfer assay. (psu.edu)