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  • vitro
  • We conclude that the firing rate of SNr neurones is under tonic inhibition by GABA in vitro, which can be relieved by antagonists of GABAA, but not GABAB receptors, and enhanced by blockade of GABA reuptake. (google.com)
  • decrease
  • This type of inhibition causes V max to decrease (maximum velocity decreases as a result of removing activated complex) and K m to decrease (due to better binding efficiency as a result of Le Chatelier's principle and the effective elimination of the ES complex thus decreasing the K m which indicates a higher binding affinity). (wikipedia.org)
  • Inhibition of VEGF activity results in a decrease of microvessel density, which increases hypoxia in the target tissue. (utsouthwestern.edu)
  • No decrease in iron absorption occurred when coffee was consumed 1 h before a meal, but the same degree of inhibition as with simultaneous ingestion was seen when coffee was taken 1 h later. (nih.gov)
  • This would decrease the cell requirements for ATP (thus, decreasing the rate of glycolysis) by reduction in the activity of the ATPases or inhibition of phophofructokinase, pyruvate kinase or pyruvate carboxylase in the glycolytic pathway (13, 14). (springer.com)
  • kinetic
  • The exclusive extrasynaptic presence of the delta subunit-containing receptors, together with their kinetic properties, suggests that tonic inhibition could be mediated mainly by extrasynaptic alpha6beta2/3delta receptors, whereas phasic inhibition is attributable to the activation of synaptic alpha1beta2/3gamma2, alpha6beta2/3gamma2, and alpha1alpha6beta2/3gamma2 receptors. (google.com)
  • This reaction is inhibited by bilirubin, and initial kinetic studies suggest that the inhibition is due in part to a competition between protoporphyrin and the bile pigment. (sciencemag.org)
  • Activity
  • Expression of conformationally constrained adhesion peptide in an antibody CDR loop and inhibition of natural killer cell cytotoxic activity by an antibody antigenized with the RGD motif," EMBO Journal , vol. 12, no. 11, pp. 4375-4384, 1993. (hindawi.com)
  • occurs
  • In Inhibitions, Symptoms and Anxiety (1925), Sigmund Freud discussed the anxiety that occurs when so-called "ego-alien" impulses (impulses unacceptable to the individual) threaten to manifest themselves in the individual's thinking or behavior. (hubpages.com)
  • Symptoms
  • But actually, our results suggest that loss of inhibition might represent a useful compensation that the brain is doing, or might be unrelated to disease symptoms. (news-medical.net)
  • He is continuing his studies to determine what other effects lowered inhibition have that could explain autism symptoms. (news-medical.net)
  • Brain
  • These inhibitions, transmitted from the brain by the spinal cord and peripheral nerves, are involuntary signals stopping or retarding the contractions of the appropriate muscle groups. (hubpages.com)
  • Many groups are searching for ways to increase inhibition in the brain, either through drugs or through gene therapy, on the assumption that increasing inhibition will restore the brain back to normal,' said study leader Daniel Feldman, a UC Berkeley professor of molecular and cell biology and member of the Helen Wills Neuroscience Institute. (news-medical.net)
  • The finding should send researchers back to the lab to determine what is actually causing the decreased inhibition and increased excitation, and what role these changes play, if any, in the brain, he said. (news-medical.net)
  • prevention
  • An example of non-drug related competitive inhibition is in the prevention of browning of fruits and vegetables. (wikipedia.org)
  • In neobehaviorist psychology, "inhibition" refers to the prevention of an action, "repression" to the prevention of a thought or feeling. (hubpages.com)
  • content
  • In each case the inhibition increases in proportion to the similarity in form and dissimilarity in content of the materials learned. (hubpages.com)
  • effects
  • Tonic inhibition of striatal dopamine transmission: effects of benzodiazepine and GABAA receptor antagonists on extracellular dopamine levels. (google.com)
  • But decreased inhibition may have unwanted secondary effects that impair other aspects of neural information processing, such as the tuning each neuron has to specific stimuli. (news-medical.net)
  • response
  • These hypotheses predict that presenting the same prepulse before a reflex blink-evoking stimulus to a normal or an abnormal reflex blink circuit should produce short-lasting excitation and long-lasting inhibition of the reflex response, regardless of the state of the reflex circuit. (jneurosci.org)
  • type
  • Two types of GABAA receptor-mediated inhibition (phasic and tonic) have been described in cerebellar granule cells, although these cells receive GABAergic input only from a single cell type, the Golgi cell. (google.com)
  • Test
  • He chose four well-validated mouse models, each with a single genetic defect mimicking one found in humans, and investigated synapse properties and neuron firing to systematically test the excitation-inhibition balance theory. (news-medical.net)
  • result
  • Anxiety is a signal of danger, and when it is suppressed by inhibition the result may be an obliviousness to danger and an incapacity to deal with it. (hubpages.com)
  • important
  • GABA tonic inhibition is a very important factor in my hypothetical understanding of behavior, but that's an awful lot of references. (google.com)
  • The term "inhibition" is more important in personality theory, where it denotes a mental restraint functioning to protect the individual from anxiety. (hubpages.com)
  • example
  • Walking, for example, requires the coordinated inhibitions of certain muscle groups at particular times and in particular sequence. (hubpages.com)