ApoptosisApoptosis Regulatory ProteinsCaspasesCaspase 3Inhibitor of Apoptosis ProteinsProto-Oncogene Proteins c-bcl-2DNA FragmentationIn Situ Nick-End Labelingbcl-2-Associated X ProteinX-Linked Inhibitor of Apoptosis ProteinCell Line, TumorApoptosis Inducing FactorCell SurvivalSignal TransductionCASP8 and FADD-Like Apoptosis Regulating ProteinCaspase 9Caspase InhibitorsCaspase 8MitochondriaEnzyme ActivationFas Ligand ProteinTumor Suppressor Protein p53Cells, CulturedCytochromes cTumor Cells, Culturedbcl-X ProteinCell LineCell ProliferationBlotting, WesternAnnexin A5Intestinal MucosaAmino Acid Chloromethyl KetonesCysteine Proteinase InhibitorsProto-Oncogene ProteinsFlow CytometryCell CycleEpithelial CellsAntineoplastic AgentsPoly(ADP-ribose) PolymerasesCell DivisionTransfectionEnzyme InhibitorsTNF-Related Apoptosis-Inducing LigandReactive Oxygen SpeciesTumor Necrosis Factor-alphaJurkat CellsNF-kappa BMembrane GlycoproteinsRNA, Small InterferingCaspase 7HL-60 CellsDown-RegulationPhosphorylationRNA, MessengerUp-RegulationMembrane Potential, MitochondrialCell DeathDose-Response Relationship, DrugGenes, bcl-2Mice, Inbred C57BLTime Factorsbcl-2 Homologous Antagonist-Killer ProteinNecrosisCytochrome c GroupReverse Transcriptase Polymerase Chain ReactionMyeloid Cell Leukemia Sequence 1 ProteinBH3 Interacting Domain Death Agonist ProteinDNA DamageProto-Oncogene Proteins c-aktGene Expression RegulationMice, KnockoutStaurosporinebcl-Associated Death ProteinGene Expression Regulation, NeoplasticImmunohistochemistryAntineoplastic Agents, PhytogenicCeramidesReceptors, TNF-Related Apoptosis-Inducing LigandProtein-Serine-Threonine KinasesCarrier ProteinsCaspase 2HeLa CellsOxidative StressDrug SynergismFas-Associated Death Domain ProteinGene ExpressionNeoplasm ProteinsHT29 CellsCysteine EndopeptidasesRNA InterferenceApoptotic Protease-Activating Factor 1Mitogen-Activated Protein KinasesMembrane ProteinsDNA-Binding ProteinsReceptors, Tumor Necrosis FactorCaco-2 CellsMice, NudeCaspase 1Cell NucleusU937 Cells