• Furthermore, while overexpression of ITCH expression in breast cells is associated with increased incidence of mammary tumor formation and progression, its knockdown inhibited breast cancer cell tumorigenicity and metastasis. (oncotarget.com)
  • In this study, clinical data from 84 patients showed that loss or reduced expression of IL-37 in lung adenocarcinoma tissues was significantly associated with tumor metastasis. (nature.com)
  • We further provided evidence that IL-37 inhibited effectively tumor metastasis in vitro and in vivo . (nature.com)
  • Given the crucial roles of Rac1 in tumor angiogenesis and metastasis, intracellular mature IL-37 might serve as a potential strategy for the control of Rac1 activity and tumor progression. (nature.com)
  • Overexpression of this gene is associated with tumor cell proliferation and metastasis. (cancerindex.org)
  • DRAM2 was preferentially upregulated in NSCLC tissues and higher expression of DRAM2 in NSCLC correlated with tumor node metastases stage and lymph node metastasis. (cancerindex.org)
  • Some tumor suppressor proteins are involved in maintaining cell adhesion, preventing cells from breaking away and spreading to other parts of the body (metastasis). (pharmiweb.com)
  • Recently we have demonstrated that one member of the class 3 semaphorins, Semaphorin 3F (SEMA3F), can inhibit human melanoma metastasis. (harvard.edu)
  • Together these results indicate that SEMA3F is a potent metastasis inhibitor that targets both tumor and stromal cells and raise the possibility of SEMA3F having therapeutic potential. (harvard.edu)
  • Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis. (ki.se)
  • The trial is the culmination of 15 years of research on the connection between the body's stress responses, immune functions, and tumor metastasis - the process of cancer cells spreading to new tissue. (eurekalert.org)
  • Through selection, similar to evolutionary processes, tumor cells have acquired a mechanism to synchronize the timing of their progression when the body is more vulnerable to metastasis. (eurekalert.org)
  • Prof. Ben-Eliyahu's clinical approach addresses this problem, hindering tumor metastasis by addressing the patient's anxiety and physiological stress responses to surgery. (eurekalert.org)
  • Proteases play a key role in tumor cell invasion and metastasis by digesting the basement membrane and ECM components. (drrathresearch.org)
  • Strong clinical and experimental evidence demonstrates association of elevated levels of uPA and MMPs with cancer progression, metastasis and shortened patient survival. (drrathresearch.org)
  • Matrix metalloproteinases (MMPs) secreted by cervical and ovarian cancer, especially MMP-2 and MMP-9, play crucial roles in tumor invasion and metastasis. (drrathresearch.org)
  • Previous researches completed by our team have also demonstrated that resveratrol inhibits the proliferation, invasion, and metastasis of colorectal cancer cells [ 5 ]. (hindawi.com)
  • We have previously shown that apo-10'-lycopenoic acid, a derivative of lycopene through cleavage by carotenoid cleavage enzyme, inhibits tumor progression and metastasis in both liver and lung cancer animal models. (usda.gov)
  • Additionally, apo-10'-lycopenoic acid functions as a natural activator to a cell nuclear receptor (called peroxisome proliferator-activated receptor-gamma), which is involved in controlling angiogenesis, tumor progression and metastasis. (usda.gov)
  • We hypothesized that ALA inhibits cancer cell motility and angiogenesis by up-regulating peroxisome proliferator-activated receptor gamma (PPARgamma) which is involved in controlling angiogenesis, tumor progression and metastasis. (usda.gov)
  • Noninvasive prediction of axillary lymph node breast cancer metastasis using morphometric analysis of nodal tumor microvessels in a contrast-free ultrasound approach. (medscape.com)
  • HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. (lu.se)
  • Myo1b promotes tumor progression and angiogenesis by inhibiting autophagic degradation of HIF-1α in colorectal cancer. (nih.gov)
  • Angiogenesis, the acquisition of new blood vessels, is an important step in tumor progression. (harvard.edu)
  • Therefore, drugs aimed at inhibiting angiogenesis are actively being investigated. (harvard.edu)
  • SEMA3F may inhibit angiogenesis and lymphangiogenesis by a novel mechanism, which is the repulsion of vascular and lymphatic endothelial cells (EC) expressing NRP2 similar to the way SEMA3F repels neurons. (harvard.edu)
  • By inhibiting these receptors' function, lenvatinib has the potential to inhibit pathogenic angiogenesis, tumor growth, and cancer progression. (pharmacytimes.com)
  • Cruciferous vegetables, which contain phytochemicals, inhibit a wide range of cancer-promoting cellular processes, including angiogenesis (new blood vessel growth), which is needed for tumor growth and fat tissue growth. (drfuhrman.com)
  • Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. (jcancer.org)
  • The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)
  • Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)
  • The PxIxIT motif of the RCAN3 Inhibits angiogenesis and tumor progression in Triple Negative Breast Cancer in Immunocompetent Mice. (amedeo.com)
  • In the present study, we present evidence that apo-10'-lycopenoic acid, is effective at inhibiting angiogenesis, migration and invasion of human cancer cells. (usda.gov)
  • In conclusion, apo-10'-lycopenoic acid inhibits cancer cell motility and angiogenesis, which could be one of the potential mechanisms for apo-10'-lycopenoic acid protecting against tumor progression. (usda.gov)
  • Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models. (lu.se)
  • Analysis of immune biomarkers will focus on Jak2/STAT3 driven processes such as the percentage of MDSC, T cell subset analysis and inflammatory cytokines both systemically and in the tumor microenvironment. (bmj.com)
  • In order to improve the tissue hypoxia in the tumor microenvironment, it is required to normalize very leaky and immature tumor vasculature. (nii.ac.jp)
  • While GB tumors are frequently infiltrated by natural killer (NK) cells, these are actively suppressed by the GB cells and the GB tumor microenvironment. (frontiersin.org)
  • Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
  • Nevertheless, the composition of the immunologic tumor microenvironment undergoes changes upon radiotherapy, chemotherapy, or even after anti-angiogenic therapy ( 6 ). (frontiersin.org)
  • Mar. 28, 2023 Cancer-associated fibroblasts (CAFs) are key factors in the tumor microenvironment, which have been implicated in cancer cell progression. (sciencedaily.com)
  • Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
  • Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
  • Endometrial carcinoma (EC) in combination with pembrolizumab for the treatment of patients with advanced EC that is not microsatellite instability-high or mismatch repair deficient, who have disease progression following prior systemic therapy, and are not candidates for curative surgery or radiation. (pharmacytimes.com)
  • In autoimmune disease, highly cytotoxic T cells that drive disease progression express KLRG1. (businesswire.com)
  • Assessment of serum IL-10 levels in HCV patients may provide a possible predictive marker for disease progression. (who.int)
  • In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
  • Glioma was one of the most common malignant brain tumors. (ijpsonline.com)
  • Glioma brain tumors carry a very poor prognosis due to their fast growth and invasive migration. (montclair.edu)
  • In terms of malignant transformation in cancer cells, interaction of cancer stem cells with endothelial cells or myofibroblasts as tumor microenvironmental cells was analyzed. (nii.ac.jp)
  • Glioblastoma (GB) is the most frequent malignant primary brain tumor in adults, without any curative treatment options available at present. (frontiersin.org)
  • In recent years, the utilization of Chinese native medicine and other plant extracts in the treatment of diseases has attracted extensive attention, especially in the area of malignant tumors. (hindawi.com)
  • With the changes of the diet types and the bad living habits, malignant tumors have gradually developed into a serious threat to human health and life. (hindawi.com)
  • Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA. (medscape.com)
  • Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
  • Malignant melanoma is a highly aggressive tumor type, in which Wnt signaling is essential. (lu.se)
  • This thesis highlights the complexity of Wnt signaling in general and Wnt5a signaling in melanoma in particular and extends our knowledge of the mechanisms behind progression of malignant melanoma. (lu.se)
  • Autophagy, an evolutionarily conserved catabolic process, has a crucial role in tumor initiation and progression. (spandidos-publications.com)
  • Alteration of beta-catenin expression in hepatocellular carcinomas (HCCs) may play an important role in tumor progression by stimulating cell proliferation. (nih.gov)
  • In this study, we found that in vitro FCHO1560-571 inhibits cell proliferation via PKB/ERK/SMAD4 pathways in KRAS-mutated A549 lung cancer cells . (bvsalud.org)
  • In vitro, SEMA3F inhibits tumor cell adhesion to fibronectin by inhibiting beta 1 integrin levels, inhibits tumor cell motility, and inhibits tumor cell invasion through matrigel. (harvard.edu)
  • According to a previous study, NS5A inhibits cell apoptosis in vivo and in vitro ( 4 ). (spandidos-publications.com)
  • Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)
  • Results: The results demonstrated that both amentoflavone and PD98059 not only significantly reduced cell viability, NF-κB activation, and cell invasion, but also inhibited the expression of tumor progression-associated proteins. (tmu.edu.tw)
  • Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
  • We will discuss three key proteins that function as tumor suppressors implicated in the development of pediatric (and some adult) cancers: pRB, p53, and PTEN. (medscape.com)
  • Tumor suppressor genes code for proteins that inhibit cell division and growth, acting as a control mechanism to prevent excessive cell proliferation. (pharmiweb.com)
  • Many tumor suppressor proteins play a role in DNA repair, helping to correct genetic mutations and maintain the stability of the genome. (pharmiweb.com)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • Driver events in pediatric malignancies can occur through loss of function in tumor suppressor genes or gain of function in proto-oncogenes. (medscape.com)
  • Tumor suppressor genes can promote cellular senescence, a state in which cells stop dividing, preventing the replication of damaged DNA. (pharmiweb.com)
  • In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
  • This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
  • Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
  • Additionally, the use of simvastatin plus classII histone deacetylase (HDAC) inhibitor (MC1568) induced further overexpression of p27(KIP1) by inhibiting HDAC5 induction originated from downregulated EZH2 in CRC cells and synergistically led to considerable antiproliferative effects. (nih.gov)
  • Intracellular mature form of IL-37, but not its extracellular form, markedly inhibited migration of multiple kinds of tumor cells through inhibiting Rac1 activation. (nature.com)
  • Glioma is the most frequent primary central nerve tumor, which originates from glial progenitor cells [ 1 ]. (hindawi.com)
  • As a result, when tumor vasculature was focused, we found that cancer stem cells existing near myofibroblasts abundantly localizing at perivascular area show drug resistance. (nii.ac.jp)
  • NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
  • Cells are potent to go under abnormal growth processes and finally lead to tumor/cancer. (pharmiweb.com)
  • Tumor suppressors are involved in regulating the cell cycle, ensuring that cells only divide when necessary and that the process is tightly controlled. (pharmiweb.com)
  • There are two main routes by which tumor cells disseminate, through blood vessels (hematogenous spread) and through lymphatic vessels (lymphogenous spread). (harvard.edu)
  • July 27, 2023 Investigators have designed an innovative RNA-based strategy to activate dendritic cells--which play a key role in immune response -- that eradicated tumors and prevented their recurrence in mouse models of melanoma. (sciencedaily.com)
  • July 5, 2023 A new vaccine boosts the response of engineered CAR-T cells and helps the immune system generate T cells that target other tumor antigens. (sciencedaily.com)
  • June 23, 2023 B cells are thought to play a critical role in innate and adaptive immunity, but their exact role in anti-tumor immunity remains unknown. (sciencedaily.com)
  • Feb. 16, 2023 Cancer immunotherapy involves using activated T cells to destroy tumors, but it doesn't work for all patients. (sciencedaily.com)
  • And just when the body is lowering its defenses, tumor cells are shifting into high gear. (eurekalert.org)
  • Autophagy provides energy to tumor cells for survival and metabolic reprogramming, in order to accommodate rapid cell growth and proliferation ( 8 ). (spandidos-publications.com)
  • Increasing amounts of evidence indicate that autophagy is induced by a number of stressors in tumor cells, such as starvation, growth factor deprivation, hypoxia, damage stimulation and therapeutic drugs, and is an important survival mechanism in response to cellular stress ( 9 ). (spandidos-publications.com)
  • The major cytokines released from antigen-presenting cells and T cells after activation by SAgs are tumor necrosis factor alpha (TNF-α), tumor necrosis factor beta (TNF-β), interleukin (IL)-1, and IL-2 ( 11 - 14 ). (cdc.gov)
  • 18-21 These vegetables are known for their characteristic (and eye-irritating) organosulfur compounds, which slow tumor growth and kill cancer cells. (drfuhrman.com)
  • In one fascinating study, women were given flaxseeds daily after being diagnosed with breast cancer and reduced growth and increased death of their tumor cells was found after just 4-5 weeks. (drfuhrman.com)
  • The notion of controlling tumor growth through a naturally occurring biochemical mechanism in the body that directs cancer cells into normal channels of differentiation is one of the theoretical foundations of antineoplaston therapy. (cancer.gov)
  • It is suggested that curcumin can selectively kill tumor cells through its multifaceted metabolic effects, that culminate in its anti-oxidant and anti-inflammatory activities ( Hewlings and Kalman, 2017 ). (frontiersin.org)
  • Decoy receptor 3 (DcR3) is highly expressed in various cancer cells and plays a significant role in immune suppression and tumor progression. (academicjournals.org)
  • Conversely, in cancer, tumor cells expressing ligands that bind to the KLRG1 receptor inhibit effector T cells and natural killer (NK) cells and downregulate anti-tumor immunity. (businesswire.com)
  • Methods and results: ALA treatment, in dose-dependent manner, was effective at inhibiting migration and invasion of liver and lung cancer cells (HuH7 and A549) in both Transwell and wound-healing models, as well as suppressing actin remodeling and ruffling/lamellipodia formation in HuH7 and immortalized lung BEAS-2B cells. (usda.gov)
  • These changes can be inherited and are, therefore, found in every cell, but more often, they are somatically acquired and restricted to tumor cells. (medscape.com)
  • Development of most solid tumors is characterized by an increase in secretion and activation of matrix metalloproteinases (MMPs) produced by either the tumor cells or tumor-associated fibroblasts. (bvsalud.org)
  • Study IV showed that tamoxifen inhibited the proliferation, disrupted the cell cycle progression, and inhibited the ECM adhesion capacity of healthy breast epithelial cells. (lu.se)
  • A potential mechanism for the role of calcium in prostate cancer development and progression is that intracellular calcium controls the growth of prostate cancer cells and the process of apoptosis (9). (cdc.gov)
  • 1,25-dihydroxyvitamin D (1,25[OH]2D) (10), which promotes the differentiation and inhibits the proliferation of prostate cells (11). (cdc.gov)
  • Pinealectomized rats showed higher mean number of tumor-associated macrophages and eosinophils in the invasive front of OSCC. (unesp.br)
  • Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages. (lu.se)
  • More importantly, we show that MESF treatment leads to significant inhibition of tumor growth and a 3-fold increase in the life span of tumor bearing animals compared to untreated tumor mice. (nature.com)
  • ackground/Aim: A previous study indicated that amentoflavone inhibits tumor growth of breast cancer. (tmu.edu.tw)
  • In addition, FCHO1560-571, at effective doses of 15 and 30 mg/kg, significantly suppressed tumor growth and decreased the size and weight of tumors in A549- xenograft mice . (bvsalud.org)
  • Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
  • Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)
  • Hence, the adipocyte, as a major constituent of the mammary tumor stroma ( 3 ), is a likely contributor to tumor growth. (jci.org)
  • BK channels potentiate cell proliferation, and their blockers are used to inhibit glioma cell growth. (montclair.edu)
  • This NIH funded project studies how ASICs function as endogenous inhibitors of glial cell growth through inhibition of BK and how dysregulation of this interaction may lead to increased proliferation of glia and tumor growth. (montclair.edu)
  • Lenvatinib inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1-3, fibroblast growth factor (FGF) receptors FGFR1-4, platelet-derived growth factor receptor alpha (PDGFR⍺), stem cell factor receptor (KIT) and rearranged during transfection (RET). (pharmacytimes.com)
  • The developer defines antineoplastons as "substances produced by the living organism that protect it against development of neoplastic growth by a nonimmunological process which does not significantly inhibit the growth of normal tissues . (cancer.gov)
  • TARGETING ONCOLOGY contains research on new cancer treatments emerging that target molecular pathways and inhibit tumor growth and progression. (periodicals.com)
  • D and thereby promote tumor growth. (cdc.gov)
  • In this experiment, we found that apelin normalizes tumor vasculature, resulting in improvement of drug delivery and tumor immunity. (nii.ac.jp)
  • The melatonin suppression caused by the pinealectomy might contribute to oral cancer development by acting on ERK1/2 and p53 pathways and regulating tumor inflammation. (unesp.br)
  • Molecular features of these tumors have expanded our vision of tumorigenesis and progression and provided abundant specifically targeted pathways [ 5 ]. (hindawi.com)
  • These findings demonstrate that WC-Co nanoparticle s induce miR-21 generation, but inhibit PDCD4 production, which may be mediated through ROS, especially endogenous H2O2, and ERK pathways. (cdc.gov)
  • Indeed, the Jak2/STAT3 pathway is activated in human PCa specimens and cooperates with activated Kras to drive initiation and progression of PCa in murine models. (bmj.com)
  • Unraveling the complex mechanisms associated with these events may provide insights into the initiation and progression of WC-Co-induced carcinogenesis. (cdc.gov)
  • Together, our results reveal that ITCH pro-tumorigenic functions in breast cancer are mediated, at least in part, through inactivation of the Hippo tumor suppressor pathway. (oncotarget.com)
  • A tumor suppressor gene, also known as anti-onco gene, is an essential component of the body's defense against cancer. (pharmiweb.com)
  • 1975 Munson shows anti cancer effects of cannabis in Lewis Lung Tumors. (greenmedinfo.com)
  • In the broader scheme of health and healthcare systems, we can help save lives and a lot of money," he notes, pointing out that with this drug treatment, governments and individuals will spend less on the long-term care of cancer patients, with fewer numbers experiencing tumor recurrence. (eurekalert.org)
  • substances that inhibit the production of estrogen, which can reduce breast cancer risk. (drfuhrman.com)
  • SOCS1 acts as a ferroptosis driver to inhibit the progression and chemotherapy resistance of triple-negative breast cancer. (amedeo.com)
  • Pan-cancer analysis of G6PD carcinogenesis in human tumors. (amedeo.com)
  • POP1 promotes the progression of breast cancer through maintaining telomere integrity. (amedeo.com)
  • Correction to: SOX8 acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer. (amedeo.com)
  • Ehm2 transcript variant 1 inhibits breast cancer progression and increases E-cadherin stability. (amedeo.com)
  • Correction to: tRNA-derived fragment tRFLys-CTT-010 promotes triple-negative breast cancer progression by regulating glucose metabolism via G6PC. (amedeo.com)
  • Recent studies demonstrated that the tumor suppressor gene programmed cell death 4 (PDCD4) and its upstream regulator miR-21 have been considered as oncogenes for novel cancer prevention or anticancer therapies. (cdc.gov)
  • SCR-6852, an oral and highly brain-penetrating estrogen receptor degrader (SERD), effectively shrinks tumors both in intracranial and subcutaneous ER + breast cancer models. (medscape.com)
  • Correction: Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy. (medscape.com)
  • Functional variants of the chitinase 3-like 1 gene are associated with clinicopathologic outcomes and progression of prostate cancer. (cdc.gov)
  • An important development in cancer research over the past 2 decades has been the recognition that genetic changes drive the pathogenesis of tumors of both adulthood and childhood. (medscape.com)
  • One such disease process is the development and progression of cancer. (lu.se)
  • Requests for reprints: Sofia K. Gruvberger-Saal, Institute for Cancer Genetics, tumors in the adjuvant or metastatic setting. (lu.se)
  • Environmental factors such as diet are thought to influence prostate cancer development and progression. (cdc.gov)
  • In the current study, we investigated the effects of pinealectomy on oral squamous cell carcinoma (OSCC) occurrence and progression in rats. (unesp.br)
  • Targeting MYO1B impairs tumorigenesis via inhibiting the SNAI2/cyclin D1 signaling in esophageal squamous cell carcinoma. (nih.gov)
  • Functional studies show that SFRP3 can inhibit Wnt5a signaling and induce a decrease in migration and invasion. (lu.se)
  • Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)
  • Escape from immune surveillance is thought to contribute to the development and progression of GB. (frontiersin.org)
  • peptide, a PKB kinase motif, inhibits tumor progression. (bvsalud.org)
  • FCHO1 560-571 peptide, a PKB kinase motif, inhibits tumor progression. (bvsalud.org)
  • PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
  • The cyclin-dependent kinase (CDK) inhibitors p21 and p16 inhibit the activity of CDKs, such as CDK4. (medscape.com)
  • To assess this phenomenon, we established tumor myofibroblasts cell line and analyzed the up-regulating genes in myofibroblasts upon exposure with hypoxia and/or serum starvation. (nii.ac.jp)
  • Tumor specimens from 259 NSCLC patients were collected and analyzed. (cancerindex.org)
  • The two-drug cocktail, which includes a generic version of a beta-adrenergic antagonist and a COX2 inhibitor- used to treat hypertension and anxiety, and to inhibit inflammation and pain - will be administered to patients over a twenty day period before, during and after surgery. (eurekalert.org)
  • Currently, use of cannabinoids is limited to improve adverse effects of chemotherapy and their palliative administration during treatment is curiously concomitant with improved prognosis and regressed progression in patients with different tumor types. (frontiersin.org)
  • Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
  • In study III, we showed that FGFR1 expression was upregulated in almost 60% of tumor tissues versus tumor-adjacent tissues from the same patients. (lu.se)
  • 2014). genetic StudieS are carried out, uSing tuMour SaMPleS froM PatientS with excellent clinical data that have been collected at a PoPulation level or internationally, to Provide unique data coMbining the Pathology, geneticS, clinical featureS, and ePideMiology of tuMourS. (who.int)
  • [ 9 ] In a cohort study including 671 patients, progression to bone demineralization was observed in 28% of the patients over a median of 2.5 years. (medscape.com)
  • The factors responsible for response to tamoxifen in 5% to 10% of patients with ERa-negative tumors are not clear. (lu.se)
  • ExperimentalDesign: We investigated ERh by immunohistochemistry in 353 stage II primary breast tumors from patients treated with 2 years adjuvant tamoxifen, and generated gene expres- sion profiles for a representative subset of 88 tumors. (lu.se)
  • Patients with tumors lacking ERa in general do not charges. (lu.se)
  • The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
  • Moreover, we uncovered a novel mechanism by which IL-37 suppressed tumor cell migration via its intracellular mature form (amino acids 46-218). (nature.com)
  • We observed functions of overexpressing miR-381-3p on glioma progression and explored corresponding functional mechanism which will provide a theoretical basis for miR-381-3p serving as a molecular target. (hindawi.com)
  • The two-hit hypothesis has now been adopted as a key mechanism for the loss of function of tumor suppressors leading to oncogenesis. (medscape.com)
  • In vivo, mock-transfected tumors are circumscribed with many large, open-lumened lymphatic vessels and contain intratumoral lymphatic vessels as well, while tumors overexpressing SEMA3F do not contain lymphatic vessels or have dilated surrounding lymphatics. (harvard.edu)
  • In our earlier in vivo studies, the nutrient mixture significantly, reduced tumor weight and tumor burden of ovarian and cervical cancers. (drrathresearch.org)
  • We have previously reported that auraptene (AUR), an antioxidant agent isolated from citrus fruit, effectively inhibits chemically induced hepatocarcinogenesis in rats. (nih.gov)
  • Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and currently incurable. (frontiersin.org)
  • In studies the drug has been shown to significantly inhibit the tumor's further development. (bayer.com)
  • By 5 weeks of age, Brca1-KPC mice have adenocarcinoma with 100% penetrance, pSTAT3 in the tumor and stroma, high levels of MDSC, and increased plasma IL-6. (bmj.com)
  • At 5-6 weeks of age, mice (n = 5/group) were imaged by bioluminescent imaging (BLI) to confirm tumor burden and were then treated with vehicle or BMS-911543 by oral gavage daily for 14 days. (bmj.com)
  • PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice. (sigmaaldrich.com)
  • anti-TNF-α has been shown to inhibit the progression of SAg-driven shock in mice and baboons ( 17 , 18 , 21 ). (cdc.gov)
  • Tumors that developed in mice deficient in INK4A were enhanced by the topical application of carcinogens and ultraviolet light. (medscape.com)
  • RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
  • [ 1 ] His prediction was subsequently supported by the cloning of the retinoblastoma tumor suppressor gene ( RB1 ) and by functional studies of the retinoblastoma protein, Rb. (medscape.com)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
  • Slows tumor progression in mouse xenograft models. (tocris.com)
  • Besides, administration of concentrated extracts of Morinda citrifolia in tumor containing animals increased the immune response of the animals with a concomitant reduction in tumor burden 7 . (nature.com)
  • Bristol-Myers Squibb) would elicit anti-tumor activity against PCa and decrease immune suppressive features of the disease. (bmj.com)
  • Physiological and psychological stresses caused by the surgery itself can inhibit the body's immune responses, heightening vulnerability to tumor progression and spreading. (eurekalert.org)
  • The psychological stress and anxiety surrounding the surgery itself is obvious, but physiological processes that occur due to the surgical removal of the primary tumor also cause the body to release stress hormones that markedly inhibit the functioning of the immune system. (eurekalert.org)
  • Signaling downstream of IL-6 is important in the genesis and progression of PCa. (bmj.com)
  • Mechanistically, intracellular mature IL-37 directly bound to the CAAX motif in the C-terminal hypervariable region of Rac1, and then inhibited Rac1 membrane translocation and subsequent downstream signaling. (nature.com)
  • In tumor-induced osteomalacia, tumor-secreted FGF-23 inhibits enzyme 1α-hydroxylase and subsequently results in decreased 1,25(OH) 2 D synthesis. (medscape.com)
  • negative tumors do seem to be sensitive to tamoxifen (5 - 7). (lu.se)
  • Here, we have described a cleavage product of the COL6α3 chain, endotrophin (ETP), which serves as the major mediator of the COL6-mediated tumor effects. (jci.org)
  • [ 5 ] Targeted disruption of TP53 in the mouse leads to the development of various tumors. (medscape.com)
  • MDM2 binds to and inhibits TP53 activity. (medscape.com)