• Furthermore, while overexpression of ITCH expression in breast cells is associated with increased incidence of mammary tumor formation and progression, its knockdown inhibited breast cancer cell tumorigenicity and metastasis. (oncotarget.com)
  • We further provided evidence that IL-37 inhibited effectively tumor metastasis in vitro and in vivo . (nature.com)
  • Given the crucial roles of Rac1 in tumor angiogenesis and metastasis, intracellular mature IL-37 might serve as a potential strategy for the control of Rac1 activity and tumor progression. (nature.com)
  • miR-139-5p overexpression inhibited CRC cell proliferation, migration and invasion in vitro , sensitized tumors to chemotherapy, and impaired tumor growth and metastasis in vivo . (thno.org)
  • Euphorbia helioscopia (madwoman's milk or ze qi) -- Like L. lucidum , E. helioscopia can stop tumor growth , induce cell death, and inhibit the metastasis of HCC in vivo. (naturalnews.com)
  • Other studies have shown that blueberries inhibit melanoma metastasis and proliferation. (newsmax.com)
  • Additionally, miR‑197‑3p markedly inhibited the metastasis of HCC cells in vitro and in vivo. (spandidos-publications.com)
  • HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. (lu.se)
  • Additionally, the use of simvastatin plus classII histone deacetylase (HDAC) inhibitor (MC1568) induced further overexpression of p27(KIP1) by inhibiting HDAC5 induction originated from downregulated EZH2 in CRC cells and synergistically led to considerable antiproliferative effects. (nih.gov)
  • The overexpression of Transgelin inhibits EMT in ESCC. (figshare.com)
  • SCARA5 overexpression significantly inhibited cell proliferation and induced apoptosis of CAL-27 and SCC-9 cells. (degruyter.com)
  • In the current study, we investigated the effects of pinealectomy on oral squamous cell carcinoma (OSCC) occurrence and progression in rats. (unesp.br)
  • Therefore, understanding the mechanisms underlying the initiation and progression of PC may assist the development of novel therapeutic strategies. (spandidos-publications.com)
  • Aberrantly expressed microRNAs contribute to the initiation and progression of human cancer. (oncotarget.com)
  • Indeed, the Jak2/STAT3 pathway is activated in human PCa specimens and cooperates with activated Kras to drive initiation and progression of PCa in murine models. (bmj.com)
  • In our research, we examined the influence of the administration of IL-27 and an anti-IL-27p28 antibody (anti-IL-27p28-Ab) on both the initiation and the progression of atherosclerosis. (hindawi.com)
  • In the groups (both the initiation and the progression) receiving recombinant IL-27 administration, the formation of atherosclerotic plaques was suspended, and the percentage of regulatory T cells (LAP + or Foxp3 + ) in the spleen and peripheral blood was increased. (hindawi.com)
  • Further studies have shown that Th1 cells promote atherosclerosis initiation and progression [ 6 , 7 ]. (hindawi.com)
  • In fact, these compounds can inhibit cancer in all of its stages - initiation, promotion, and progression. (newsmax.com)
  • Cytokines released during infection, inflammation, and immune responses can inhibit cancer initiation and progression. (thomasnet.com)
  • Unraveling the complex mechanisms associated with these events may provide insights into the initiation and progression of WC-Co-induced carcinogenesis. (cdc.gov)
  • In conclusion, SCARA5 inhibited the proliferation and EMT and induced the apoptosis of OSCC cells through the inhibition of STAT3 and PI3K/AKT signaling pathways, thereby exerting a tumor suppressor effect. (degruyter.com)
  • Both of these mechanisms prevent YAP and TAZ translocation to the nucleus and binding to TEAD transcription factors, thereby inhibiting transcription of downstream target genes implicated in proliferation, anti-apoptosis and EMT [ 9 ]. (oncotarget.com)
  • Blocking lactate generation in metformin-treated melanoma cells results in diminished cell proliferation and tumor progression in mice. (dcaguide.org)
  • Meanwhile IL-27 exerts proinflammatory effects by promoting Th1, CD8, natural killer (NK), T follicular helper (Tfh), and B cell proliferation/functions and by inhibiting Treg and Th2 cell generation in parasites infection [ 4 ]. (hindawi.com)
  • Zheng ZM, Wang YY, Chen M, Yang HL, Lai ZZ, Li MQ, Shao J. FBXO17 Inhibits the Wnt/β-Catenin Pathway and Proliferation of Ishikawa Cells. (medsci.org)
  • Hu D, Hu Y, Xu W, Yu H, Yang N, Ni S and Fu R: miR-203 inhibits the expression of collagen-related genes and the proliferation of hepatic stellate cells through a SMAD3-dependent mechanism. (spandidos-publications.com)
  • Intracellular mature form of IL-37, but not its extracellular form, markedly inhibited migration of multiple kinds of tumor cells through inhibiting Rac1 activation. (nature.com)
  • miR-205 expression in humans was validated by Landgraf et al ( 8 ), however, its role in tumor progression is contradictory ( 9 - 12 ). (spandidos-publications.com)
  • TGF- B 1 signaling also plays an important role in tumor progression and EMT. (naturalnews.com)
  • Novikova MV, Khromova NV and Kopnin PB: Components of the hepatocellular carcinoma microenvironment and their role in tumor progression. (spandidos-publications.com)
  • Anthocyanins from blueberry and black currant juices have also been shown to inhibit the growth of ovarian and cervical cancer, as well as melanomas. (newsmax.com)
  • anti-TNF-α has been shown to inhibit the progression of SAg-driven shock in mice and baboons ( 17 , 18 , 21 ). (cdc.gov)
  • Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
  • We further found that ADV significantly promoted APL cell differentiation and apoptosis, thereby restraining the progression of APL. (biomedcentral.com)
  • Most importantly, our study uncovered a novel mechanism of ADV prohibiting APL progression, which was mediated, at least in part, by inhibition of TRIB3 and degradation of the oncoprotein PML-RARA, therefore leading to APL cell differentiation and apoptosis. (biomedcentral.com)
  • Interestingly, inhibition of either LDH or complex I alone does not induce apoptosis, whereas inhibiting both together causes depletion in cellular ATP pool resulting in metabolic catastrophe induced apoptosis. (dcaguide.org)
  • Transgelin can inhibit the malignant progression of ESCC by inhibiting the occurrence of EMT. (figshare.com)
  • Duchesnea indica (mock strawberry or she mei) -- A recent study reported that D. indica extracts could inhibit highly metastatic lung adenocarcinoma cells by down-regulating EMT-related proteins. (naturalnews.com)
  • Factor Inhibiting HIF (FIH) Asparaginyl Hydroxylase Inhibitors inhibit the FIH pathway also catalyzed by Asparaginyl Hydroxylase inhibition. (wikipedia.org)
  • In summary, intraocular NO inhibits myopia dose-dependently and is obligatory for inhibition of myopia by atropine. (nih.gov)
  • Furthermore, CB treatment in a mouse model of collagen-induce arthritis resulted in a significant decrease in circulating inflammatory cytokine levels, immune cell infiltrates, joints erosion, and bone resorption, leading to a reduction in disease progression. (frontiersin.org)
  • These findings demonstrate that WC-Co nanoparticle s induce miR-21 generation, but inhibit PDCD4 production, which may be mediated through ROS, especially endogenous H2O2, and ERK pathways. (cdc.gov)
  • During growth, genes associated with protein ubiquitination/deubiquitination, cell cycle progression, and proteasomal degradation were affected, while genes linked to protein and carbohydrate catabolism were affected during early development. (frontiersin.org)
  • This article investigates the role of Transgelin (TAGLN) in the epithelial-mesenchymal transition (EMT) of esophageal squamous cell carcinomas (ESCC) and its possible mechanism of inhibiting the invasion of these cancers. (figshare.com)
  • Atropine inhibits myopia progression, but its mechanism is unknown. (nih.gov)
  • We observed functions of overexpressing miR-381-3p on glioma progression and explored corresponding functional mechanism which will provide a theoretical basis for miR-381-3p serving as a molecular target. (hindawi.com)
  • Results: The results demonstrated that both amentoflavone and PD98059 not only significantly reduced cell viability, NF-κB activation, and cell invasion, but also inhibited the expression of tumor progression-associated proteins. (tmu.edu.tw)
  • YGJDSJ also inhibited TGF- B 1 up-regulated Smad3 phosphorylation and Snail expression, as well as TGF- B 1-induced cell adhesion, migration, and invasion. (naturalnews.com)
  • Inhibiting angiogenesis has been shown to powerfully impede cancer growth, and can even lead to the death of cancers. (newsmax.com)
  • All of the berries exhibited this property, but the most powerful were bilberries and blueberries, which inhibited two compounds that drive angiogenesis - vascular endothelial growth factor (VEGF) and TNF-alpha. (newsmax.com)
  • Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models. (lu.se)
  • DRAIC interacted with subunits of the IκB kinase (IKK) complex to inhibit their interaction with each other, the phosphorylation of IκBα, and the activation of NF-κB. (bvsalud.org)
  • Based on these findings, the researchers concluded that YGJDSJ could inhibit TGF- B 1-induced EMT and mediates the metastatic potential of liver cancer cells by down-regulating Smad3 phosphorylation and Snail expression. (naturalnews.com)
  • Besides, the results suggested that FBXO17 may inhibit the Wnt/β-catenin signaling pathway and influence the expression of adhesion molecules, such as E-cadherin and N-cadherin in Ishikawa cells. (medsci.org)
  • In this study, we investigated the involvement of respiratory complex I and lactate dehydrogenase (LDH) in melanoma progression. (dcaguide.org)
  • As in the knockout mice, inhibiting the enzyme's action increased clearance of dysfunctional mitochondria and protected dopamine-producing neurons. (neurosciencenews.com)
  • Additionally, we administered daily intraperitoneal CB treatment to arthritic mice to evaluate its effects on circulating inflammatory cytokine levels, immune cell infiltrates, joints erosion, and bone resorption, as indicators of disease progression. (frontiersin.org)
  • ackground/Aim: A previous study indicated that amentoflavone inhibits tumor growth of breast cancer. (tmu.edu.tw)
  • In the second stage, we confirmed that the small molecule controls tumor growth as effectively as the antibodies - it inhibits PD-L1 in animals engineered to have human T cells. (scitechdaily.com)
  • Blueberry, currant, cranberry, and a few others significantly reduced the growth of these cancers by inhibiting the reproduction of the cancer cells (a process called cell-cycle arrest). (newsmax.com)
  • Taken together, our findings indicate the essential role of miRNA-187 in suppressing cervical cancer progression and indicate a novel link between miRNA-187 and human papillomavirus 16 E6 in cervical cancer. (oncotarget.com)
  • We identified miR-139-5p as a KRAS-responsive miRNA and demonstrated its involvement in CRC progression. (thno.org)
  • Our findings demonstrated that CXCR4 targeting with CB significantly inhibited the spontaneous and induced-production of key inflammatory cytokines by monocytes isolated from JIA patients. (frontiersin.org)
  • In one study, researchers examined the ability of red raspberries to inhibit inflammatory immune cells (called macrophages) taken from colitis-affected animals. (newsmax.com)
  • The findings open the door to the development of novel therapeutics targeting the enzyme that may slow or prevent the progression of Parkinson's disease in people-a major unmet need. (neurosciencenews.com)
  • High-grade prostate cancer, particularly the percentage presence of Gleason grades 4 and 5, is associated with adverse pathologic findings and disease progression. (medscape.com)
  • Long Noncoding RNA DRAIC Inhibits Prostate Cancer Progression by Interacting with IKK to Inhibit NF-κB Activation. (bvsalud.org)
  • Thus, DRAIC lncRNA inhibits prostate cancer progression through suppression of NF-κB activation by interfering with IKK activity. (bvsalud.org)
  • A cytoplasmic tumor -suppressive lncRNA interacts with and inhibits a major kinase that activates an oncogenic transcription factor in prostate cancer . (bvsalud.org)
  • Functional variants of the chitinase 3-like 1 gene are associated with clinicopathologic outcomes and progression of prostate cancer. (cdc.gov)
  • Signaling downstream of IL-6 is important in the genesis and progression of PCa. (bmj.com)
  • Mechanistically, intracellular mature IL-37 directly bound to the CAAX motif in the C-terminal hypervariable region of Rac1, and then inhibited Rac1 membrane translocation and subsequent downstream signaling. (nature.com)
  • We concluded that miR-381-3p and ANTXR1 were both important factors in modulating glioma progression. (hindawi.com)
  • Studies showed that miRNAs can regulate glioma progression. (hindawi.com)
  • Nonetheless, there is no research showing that miR-381-3p can modulate glioma progression. (hindawi.com)
  • The modern TCM formulation YGJDSJ is composed of different medicinal herbs, some of which have shown the ability to inhibit EMT in cancer cells in numerous experiments. (naturalnews.com)
  • We show that disease progression, during HIV-1, HIV-2 and dual infections, is accompanied by NK cells with elevated activation. (lu.se)
  • Researchers in the lab of senior author David K. Simon, MD, Ph.D., director of the Parkinson's Disease & Movement Disorders Center at BIDMC, in collaboration with colleagues at the University of Cambridge and Mission Therapeutics, performed complementary experiments showing that inhibiting a specific enzyme in a mouse model protects the dopamine-producing neurons that are normally lost as PD progresses, effectively halting the progression of the disease. (neurosciencenews.com)
  • In another study, researchers found that dried black raspberries inhibited oral, esophageal, and colon cancers in rodents. (newsmax.com)
  • They even isolated ferulic acid and beta-sitosterol as the active ingredients in the berries that inhibited the cancers. (newsmax.com)
  • Researchers discovered that inhibiting a specific enzyme, USP30, in a mouse model protects dopamine-producing neurons, which are typically lost as the disease progresses. (neurosciencenews.com)
  • In a new study, investigators at Beth Israel Deaconess Medical Center (BIDMC) have shed new light on key cellular processes involved in the progression of Parkinson's disease (PD). (neurosciencenews.com)
  • Our lab is focused on working out the origins of Parkinson's disease and it is our hope that-one day-we will be able to slow down or even prevent disease progression in patients," said first author Tracy-Shi Zhang Fang, Ph.D., an instructor in Simon's lab. (neurosciencenews.com)
  • A phytanic acid-restricted diet and combination docosahexaenoic acid and cholic acid therapy may inhibit disease progression. (medscape.com)
  • Riazalhosseini B, Mohamed R, Apalasamy YD, Langmia IM and Mohamed Z: Circulating microRNA as a marker for predicting liver disease progression in patients with chronic hepatitis B. Rev Soc Bras Med Trop. (spandidos-publications.com)
  • OBJECTIVE: Untreated perinatal HIV-1 infection is often associated with rapid disease progression in children with HIV (CWH), characterized by high viral loads and early mortality. (lu.se)
  • We performed a candidate gene association study of TRIM22 genotype and haplotypes with markers of disease progression and indicators of advanced disease. (lu.se)
  • METHODS: TRIM22 exons three and four were sequenced by Sanger sequencing and single nucleotide polymorphisms were associated with markers of disease progression (CD4+ T-cell count and HIV viral load) and clinical indicators of advanced HIV disease (presence of stunting and chronic diarrhoea). (lu.se)
  • CONCLUSION: TRIM22 genotype was not associated with markers of HIV disease progression markers or advanced disease in CWH. (lu.se)
  • Elevated level of iNKT and NK cell activation correlates with disease progression in HIV-1 and HIV-2 infections. (lu.se)
  • This study demonstrates that HIV-1 disease progression is inhibited by concomitant HIV-2 infection. (lu.se)
  • As an important member of the miRNA family, miR-381-3p also mediates tumor progression. (hindawi.com)
  • In other words, we have developed a molecule that can inhibit PD-1/PD-L1 binding and remind the immune system that it needs to attack the cancer. (scitechdaily.com)
  • Statins may inhibit tumor progression via an EZH2-mediated epigenetic alteration, which results in survival benefits after resected CRC. (nih.gov)
  • Previous studies have demonstrated that microRNAs (miRs) serve important roles in the progression of human cancer types, including pancreatic cancer (PC), a highly lethal malignancy. (spandidos-publications.com)
  • Melatonin may inhibit cancer progression caused by BPA replacements. (marksdailyapple.com)
  • This finding was confirmed by another study that used freeze-dried black raspberries, which inhibited esophageal cancer in rodents by 30 to 60 percent. (newsmax.com)
  • Even more impressive was the fact that they inhibited colon cancer by 80 percent. (newsmax.com)
  • Thus, host responses to cellular stress can influence various stages of cancer development and progression. (thomasnet.com)
  • Chemokines such as CXCL10 (IP-10) and CXCL9 may inhibit cancer development. (thomasnet.com)
  • Conclusion: The results of the present study suggest that amentoflavone down-regulates ERK-modulated tumor progression in HCC. (tmu.edu.tw)
  • and that HIF prolyl-hydroxylase inhibitors may only minimally inhibit FIH. (wikipedia.org)
  • adding NOS-inhibitors (L-NIO, L-NMMA) to atropine inhibited this effect dose-dependently, but adding D-NMMA did not. (nih.gov)
  • The study showed that inhibiting the USP30 enzyme protected dopamine-producing neurons in a Parkinson's mouse model. (neurosciencenews.com)
  • The aim of the present study was to verify the effect of amentoflavone on tumor progression in HCC. (tmu.edu.tw)
  • MicroRNAs (miRNAs) are usually dysregulated and play important regulatory roles in tumor progression. (thno.org)
  • The progression of liver injury to cirrhosis may occur over several weeks to years. (medscape.com)
  • Molecular features of these tumors have expanded our vision of tumorigenesis and progression and provided abundant specifically targeted pathways [ 5 ]. (hindawi.com)