• Furthermore, overexpression of fibulin-5 in H460 lung cancer cells inhibited metastasis in mice. (aacrjournals.org)
  • Collectively, these results suggest that epigenetic silencing of fibulin-5 promotes lung cancer invasion and metastasis by activating MMP-7 expression through the ERK pathway. (aacrjournals.org)
  • Across three different murine models of human prostate and breast cancer, KBU2046 inhibits metastasis, decreases bone destruction, and prolongs survival at nanomolar blood concentrations after oral administration. (nature.com)
  • We have previously shown that apo-10'-lycopenoic acid, a derivative of lycopene through cleavage by carotenoid cleavage enzyme, inhibits tumor progression and metastasis in both liver and lung cancer animal models. (usda.gov)
  • We hypothesized that ALA inhibits cancer cell motility and angiogenesis by up-regulating peroxisome proliferator-activated receptor gamma (PPARgamma) which is involved in controlling angiogenesis, tumor progression and metastasis. (usda.gov)
  • Ethanol consumption inhibits metastasis of melanoma in mice, but the mechanism is not well understood. (iiarjournals.org)
  • Results: In mice, ethanol consumption inhibited experimental pulmonary metastasis. (iiarjournals.org)
  • Lastly, ethanol increased the expression of Kiss1 metastasis-suppressor and the metastasis suppressor Nm23/nucleoside diphosphate kinase. (iiarjournals.org)
  • The mesenchymal phenotype is associated with high expression levels of Snai1, a zinc-finger transcription factor that regulates metastasis by down-regulating the expression of genes such as E-cadherin ( 17 ). (iiarjournals.org)
  • Moreover, miR-139-5p inhibited cellular metastasis through inhibition of matrix metalloproteinases (MMP)-7 and MMP-9. (oncotarget.com)
  • Taken together, our results demonstrated that miR-139-5p plays a pivotal role in lung cancer through inhibiting cell proliferation, metastasis, and promoting apoptosis by targeting oncogenic c-Met. (oncotarget.com)
  • Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (cancerindex.org)
  • Also AFAP1-AS1 knock-down inhibited tumor metastasis-associated genes expression in terms of EMT. (biomedcentral.com)
  • M-CSF binds to the M-CSF receptor, which is promote the proliferation and differentiation of OC and the continuous expression of RANK. (frontiersin.org)
  • NF-κB controls the expression of an array of genes involved in multiple features of cancer, including proliferation, survival angiogenesis and invasion. (spandidos-publications.com)
  • Although KLF6 overexpression in human cancer cells inhibits cell proliferation, induces apoptosis, and attenuates cell migration, the effects of KLF6 on oral cancer remains poorly elucidated. (medsci.org)
  • AA and the extracellular regulated protein kinase 1/2 (ERK1/2) blocker U0126 markedly inhibited migration, elevated smooth muscle 22 α (SM22 α ) expression, repressed VSMC proliferation, elevated miR-466f-3p and miR-425-3p expression, and suppressed miR-27a-5p and miR-128-5p expression in ox-LDL-induced VSMCs. (hindawi.com)
  • The miR-128-5p mimic promoted the migration and proliferation of VSMCs and suppressed p21, p27, and SM22ɑ expression. (hindawi.com)
  • The inhibitor increased p21, p27, and SM22ɑ expression and repressed the migration, phenotypic transformation, and proliferation of VSMCs. (hindawi.com)
  • miR-128-5p directly targeted the 3′UTR-binding sequences of the p21 gene, negatively regulated p21 expression, and supported the proliferation of VSMCs. (hindawi.com)
  • Our research showed that the migration, phenotypic transformation, and proliferation of ox-LDL-induced VSMCs were repressed by AA through inhibiting miR-128-5p by targeting the p21 gene, which may provide an effective option for the treatment of atherosclerosis. (hindawi.com)
  • EIF5B promotes HCC proliferation and invasion by increasing ASAP1 expression [ 5 ]. (techscience.com)
  • EGCG (epigallocatechin-3-gallate) is a potent tea flavonoid that specifically inhibits endothelial cell proliferation stimulated by bFGF. (ppt-health.com)
  • Genistein is an isoflavonoid found in soybeans, has antiangiogenic activity including angiogenesis inhibition, induction of apoptosis, inhibition of bFGF- and VEGF-driven cell proliferation, PDGF, G2, c-fos expression, NF-κB activation and growth factor signaling pathways. (ppt-health.com)
  • Red wine polyphenol extracts and fractions were reported to delay tumor onset in transgenic mice, inhibit azoxymethane (AOM) induced intestinal carcinogenesis by modulation of gene expression, inhibit epidermal growth factor induced the proliferation of transformed colon epithelial cells by modulation of activation of mitogen-activated protein kinases and show selective cytotoxicity against MCF-7 breast cancer cells. (orlpedia.gr)
  • We identified 98 candidate genes containing rare variation that in aggregate show association with SLE many of which have recognized immunological function, but also function and expression related to relevant tissues such as the joints, skin, blood or central nervous system. (frontiersin.org)
  • miR-128-5p targets the tissue inhibitor of metalloproteinases (TIMPs), silent information regulator 2 (SIRT2), peroxisome proliferator-activated receptor (PPAR), and p21 genes, which are linked to the behaviours of VSMCs. (hindawi.com)
  • Red wines contain a large array of polyphenolic constituents that have been shown to block carcinogenesis and to inhibit the growth of tumors in whole animals, or in cell culture by altering the activity of certain enzymes or the expression of specific genes. (orlpedia.gr)
  • An up-regulation of several key genes known to be important in cell invasion, notably matrix metalloproteinase-2 (MMP-2), was observed in the exposed mesothelial cells as determined by real-time PCR. (cdc.gov)
  • From experimentally validated target genes of these 86 miRNAs, pan-sensitive and pan-resistant genes with concordant mRNA and protein expression associated with in-vitro drug response to 19 NCCN-recommended breast cancer drugs were selected. (cdc.gov)
  • The mRNA expression patterns of these 26 genes were validated using RT-PCR analyses of independent tissue samples (n = 77) and blood samples (n = 48). (cdc.gov)
  • The mRNA and protein expression of the 26 genes was associated with sensitivity or resistance to 18 NCCN-recommended drugs for treating breast cancer. (cdc.gov)
  • In this study, we established ATAD2 knockdown in colorectal cancer cell lines by RNA interference and found that silencing of ATAD2 inhibited the migration and invasion ability of Caco-2 and SW-480 cells. (elis.sk)
  • In the present study, we present evidence that apo-10'-lycopenoic acid, is effective at inhibiting angiogenesis, migration and invasion of human cancer cells. (usda.gov)
  • Methods and results: ALA treatment, in dose-dependent manner, was effective at inhibiting migration and invasion of liver and lung cancer cells (HuH7 and A549) in both Transwell and wound-healing models, as well as suppressing actin remodeling and ruffling/lamellipodia formation in HuH7 and immortalized lung BEAS-2B cells. (usda.gov)
  • Diallyl sulfide, diallyl disulfide, and diallyl trisulfide inhibit migration and invasion in human colon cancer colo 205 cells through the inhibition of matrix metalloproteinase-2, -7, and -9 expressions," Environ Toxicol. (doctorshealthpress.com)
  • In colorectal cancer cells, myricetin inhibited the activity of matrix metalloproteinase-2 [11]. (orlpedia.gr)
  • Piperine increases bioavailability of many drugs and nutrients by inhibiting various metabolising enzymes. (researchgate.net)
  • If you choose to take turmeric/curcumin (traditionally, curcumin has been much more widely recognized, but newer research suggests the whole herb has more advantages), look for a product that contains piperine or Bioperine (black pepper extract), which inhibits the enzymes that break down most supplements and medicines in the gut. (blogspot.com)
  • TGF-β favors accumulation of collagen and noncollagen basement membrane components by direct stimulation of production and by inhibiting matrix degradation enzymes such as collagenases and metalloproteinases. (medscape.com)
  • Free Bcl-XL directly binds to BAK, downregulates the dimerization level of BAK and inhibits the activation of BAK. (researchsquare.com)
  • Although Bcl-XL and Bax do not bind directly in platelets, they may inhibit Bax activation by reducing the translocation of Bax from cytoplasm to mitochondria through some indirect effects. (researchsquare.com)
  • In nucleated cells, Akt activation inhibits their pro-apoptotic activity through flow acidification. (researchsquare.com)
  • ALA treatment resulted in suppression of angiogenesis in both tube formation and aortic ring assays and inhibition of matrix metalloproteinase-2 expression and activation in both HuH7 and A549 cells. (usda.gov)
  • However, abnormal expression or aberrant activation of these molecules may convert normal growth signals to undesirable signals inducing overgrowth, becoming an important contributor to a variety of human cancers. (medsci.org)
  • The changes in TNF-α, pro-IL-1β, AP-1, NF-κB p65, pRIPK1, pTAK1 and TAK1 expression and astrocyte and microglia activation in the hippocampus were assessed. (imperial.ac.uk)
  • Recent findings have demonstrated potent anticancer-promoting activity for myricetin, which mainly targeted MEK signaling and inhibited COX-2 expression by blocking the activation of NF-κB. (orlpedia.gr)
  • Lethal or sublethal injury to renal cells leads to expression of new local antigens, inflammatory cell infiltration, and activation of proinflammatory and chemoattractant cytokines. (medscape.com)
  • Trouw L., Nilsson S., Goncalvez I., Landberg G. and Blom A. M. (2005) C4b-binding protein binds to necrotic cells and DNA, which limits DNA release and inhibits complement activation. (lu.se)
  • The expression of P2Y12 increased in OA cartilage tissue, and P2Y12 inhibited apoptosis. (researchsquare.com)
  • Matrix metalloproteinases -8 and -9 and tissue inhibitor of metalloproteinase-1 in burn patients. (uni-bielefeld.de)
  • A set of 26-gene mRNA expression profiles were used to identify invasive ductal carcinomas from histologically normal tissue and benign lesions and to select those with a higher potential for future cancer development (ADHC) in the breast associated with atypical ductal hyperplasia (ADH). (cdc.gov)
  • The expression-defined model achieved an overall accuracy of 94.05% (AUC = 0.96) in classifying invasive ductal carcinomas from histologically normal tissue and benign lesions (n = 185). (cdc.gov)
  • It is generally orchestrated by higher levels of TGF‑β1 14 , simultaneously inhibiting ECM degradation by suppressing metalloproteinase, especially MMP-2 and MMP-9 20 . (bvsalud.org)
  • however, forced KLF6 expression in lung cancer cell lines can trigger cells to undergo apoptosis and reduce colony formation ability [ 6 ]. (medsci.org)
  • Immunohistochemistry and Western blot were used to observe the expression of P2Y12, MMP13, COL2 and other cartilage degeneration and apoptosis related indexes. (researchsquare.com)
  • NF-κB then translocates to the nucleus followed by p65 phosphorylation and binding to specific response elements in the DNA, which subsequently activates target gene expression ( 5 ). (spandidos-publications.com)
  • The quantitative real-time PCR (qRT-PCR) was used to quantitatively analyze the gene expression changes in human dermal fibroblasts (HDFs) by hydroxytyrosol. (researchgate.net)
  • KLF6 functions as a tumor suppressor gene and increases p21 expression via p53-independent pathway [ 3 ]. (medsci.org)
  • KLF6 downregulation enhances MDM2 gene expression that deregulates the p53 pathway [ 9 ]. (medsci.org)
  • MicroRNAs (miRNAs) are small noncoding sequences involved in the negative regulation of gene expression. (hindawi.com)
  • Gene expression analysis suggested that matrix metalloproteinase synthesis was inhibited in cells expanded in 2% oxygen. (ox.ac.uk)
  • This gene exhibits elevated expression levels in multiple human cancers. (cancerindex.org)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Expression of epithelial-mesenchymal transition (EMT)-related gene expression was determined using western blot. (biomedcentral.com)
  • Knockdown of MMP-2 in CNT and asbestos-exposed cells by shRNA-mediated gene silencing effectively inhibited the aggressive phenotypes. (cdc.gov)
  • There is currently no gene expression assay that can assess if premalignant lesions will develop into invasive breast cancer. (cdc.gov)
  • Based on this gene expression signature, the VEGFR inhibitor ZM-306416 was discovered as a new drug for treating breast cancer. (cdc.gov)
  • Conclusion: Thus, the results suggest that L-PRP not only induces an intense fibrosis rich in collagen III, which is not degraded, but also suppresses MMP-2 and -9 expressions, mimicking a similar pathological event as that of a cleft-palate or cranial suture. (bvsalud.org)
  • It inhibited lung cancer cell invasion and down-regulated matrix metalloproteinase-7 (MMP-7), which promoted lung cancer cell invasion. (aacrjournals.org)
  • The loss of KLF6 expression is also correlated with cancer progression, tumor recurrence, and short survival time in head and neck carcinomas [ 7 ]. (medsci.org)
  • In conclusion, apo-10'-lycopenoic acid inhibits cancer cell motility and angiogenesis, which could be one of the potential mechanisms for apo-10'-lycopenoic acid protecting against tumor progression. (usda.gov)
  • This chemical is one of my favorites because it has been shown to inhibit cancer growth in various cell lines. (doctorshealthpress.com)
  • however, as cancer cells gain the ability to metastasize, E-cadherin expression is significantly reduced, which allows the cancer cells to disseminate to form distant metastases ( 18 ). (iiarjournals.org)
  • Matrix metalloproteinases MMP-2 and -9 are known to be overexpressed in ultraviolet B (UVB)-irradiated skin tissues and contribute to the acceleration of photoaging and the development of skin cancer. (sinica.edu.tw)
  • It has also been demonstrated that myricetin exerted protective effects against two-stage skin tumorigenesis [9] and inhibited the growth of A549 lung cancer cells [10]. (orlpedia.gr)
  • Six miRNAs had concordant expression in both tumors and breast cancer patient blood samples compared with the normal control samples. (cdc.gov)
  • The protein expression of PBX2 and RAD52 assessed with immunohistochemistry were prognostic of breast cancer survival outcomes. (cdc.gov)
  • OB release bone matrix rich in collagen type I and participate in the hydroxyapatite crystal formation in collagen fiber deposition process, namely bone mineralization process, eventually forming new bone. (frontiersin.org)
  • Here, the company observed coumestrol could inhibit the expression of matrix metalloproteinase-1, in turn maintaining collagen in the skin and improving skin elasticity and wrinkles. (skininc.com)
  • Introduction and Objective: Because L-PRP constitutes an important source of growth factor that is associated with osteogenesis and fibrogenesis, the aim of this study was to evaluate the effect of L-PRP on the presence of collagen III and MMP-2 and MMP-9, while comparing these results by means of a histomorphometric analysis of bone matrix and fibrous deposition on bone repair. (bvsalud.org)
  • Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. (caplancannabis.com)
  • The expression levels of fibulin-5 and MMP-7 were inversely correlated in lung tumors. (aacrjournals.org)
  • lipid carriers (C-D-NLC) inhibited the growth of LLC tumors in mice and reduced drug toxicity. (ajol.info)
  • Twelve miRNAs showed concordant expression in tumors vs. normal breast tissues and patient survival (n = 1093), with seven as potential tumor suppressors and five as potential oncomiRs. (cdc.gov)
  • Chronic exposure to carbon nanotube s induces invasion of human mesothelial cells through matrix metalloproteinase-2. (cdc.gov)
  • Therefore, the aim of the present work was to evaluate the effect of NAC on interleukin-8 (IL-8) and matrix metalloproteinase-9 (MMP-9) production as well as intercellular cell adhesion molecule-1 (ICAM-1) expression by BAL cells from interstitial lung diseases. (nih.gov)
  • Additionally, ALA dose-dependently increased the mRNA expression and protein levels of PPARgamma in human THLE-2 liver cells. (usda.gov)
  • Conclusion: In both animal and in cell culture conditions, ethanol inhibited the metastatic ability of B16-BL6 melanoma cells. (iiarjournals.org)
  • Relative expression of AFAP1-AS1 in CRC tissues and CRC cells lines was determined using quantitative real-time PCR (qRT-PCR). (biomedcentral.com)
  • During EMT, epithelial cell lose its E-cadherin expression, which contributes to intercellular adhesion and enables cells with migratory and invasive properties. (biomedcentral.com)
  • Sufferers and strategies: The expression ranges of DRAIC and miR-18a-3p in gastric most cancers cells have been measured by quantitative polymerase chain response (qPCR). (sebov-detection.com)
  • Moreover, norbixin reduces protein kinase B (AKT) phosphorylation, NF-κB and AP-1 transactivation and mRNA expression of the inflammatory interleukins (IL) -6 and -8 and of vascular endothelial growth factor (VEGF) enhanced by A2E. (sorbonne-universite.fr)
  • TAK1 inhibition exacerbated surgery-induced pRIPK1 expression, neuroinflammation and cognitive dysfunction in young rats, and this effect was reversed by a RIPK1 inhibitor. (imperial.ac.uk)
  • By coupling efficient chemical synthesis routes to multiple upfront in parallel phenotypic screens, we identify that KBU2046 inhibits cell motility and cell invasion in vitro. (nature.com)
  • 9'-cis-norbixin, a di-apocarotenoid is also a ligand of these nuclear receptors (NR). Norbixin inhibits PPAR and RXR transactivation induced by A2E. (sorbonne-universite.fr)
  • Selective PPAR-α, -β/δ and -γ antagonists inhibit the expression of IL-6 and IL-8 while only the antagonist of PPAR-γ inhibits the transactivation of NF-κB following A2E exposure. (sorbonne-universite.fr)
  • Altogether, A2E's deleterious biological effects could be inhibited through PPAR and RXR regulation. (sorbonne-universite.fr)
  • Knockdown of fibulin-5 was sufficient to stimulate cell invasion and MMP-7 expression. (aacrjournals.org)
  • These findings suggest that P2Y12 has the potential to regulate cell death, but its expression in lumbar facet joint osteoarthritis and its possible role remain unclear. (researchsquare.com)
  • In the present study, we investigated the expression profile and prognostic potential of EIF5B in HCC tissues and cell lines. (techscience.com)
  • In cell culture, ethanol inhibited B16-BL6 cell motility, invasion, and anchorage-independent growth. (iiarjournals.org)
  • Ectopic expression of miR-139-5p in NSCLC cell lines significantly suppressed cell growth through inhibition of cyclin D1 and up-regulation of p57(Kip2). (oncotarget.com)
  • Relative expression of AFAP1-AS1 was significantly elevated in CRC tissues and CRC HCT116 and SW480 cell lines. (biomedcentral.com)
  • Production of IL-8 and MMP-9 was evaluated by specific enzyme-linked immuno-sorbent assays and ICAM-1 expression was studied by immunohistochemistry. (nih.gov)
  • Western blot and enzyme activity assays confirmed the increased expression and activity of MMP-2. (cdc.gov)
  • Here, we show that in primary human femoral head osteoarthritic and normal bovine chondrocytes, TWHF partially or completely inhibited mRNA and protein expression of tumor necrosis factor-α, interleukin (IL)-1, and IL-17-inducible MMP-3 and MMP-13. (aspetjournals.org)
  • This agent also inhibited cytokine-stimulated MMP-3 protein expression in human synovial fibroblasts. (aspetjournals.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • For attenuation of chronic UVB irradiation damage to skin, inhibition of MMP-2 and -9 protein expression was detected using immunohistochemistry analysis. (sinica.edu.tw)
  • In this study, we will compare expression of AFAP1-AS1 in CRC tissues and paired adjacent non-cancerous tissues for purpose of identification of abnormal expression of AFAP1-AS1 in relation to tumorigenesis of CRC. (biomedcentral.com)
  • Zymography assay demonstrated that KLF6 inhibited the activities of matrix metalloproteinase 9 (MMP-9) and weakened the expression of mesenchymal markers, such as snail, slug, and vimentin. (medsci.org)
  • Conversely, genetic TAK1 overexpression attenuated surgery-induced pRIPK1 expression, neuroinflammation and cognitive dysfunction in old rats. (imperial.ac.uk)
  • Results: In contrast to the results of the L-PRP-free groups, the histomorphometric results of the L-PRP groups demonstrated intense fibrotic deposition along with hindered bone matrix deposition. (bvsalud.org)
  • CONCLUSION: Ageing-related decreases in TAK1 expression may contribute to surgery-induced RIPK1 overactivation, resulting in neuroinflammation and cognitive impairment in old rats. (imperial.ac.uk)
  • In conclusion, NAC inhibits production of factors playing a key role in the etiopathogenesis of interstitial lung diseases, thus suggesting its possible therapeutic potency in the treatment of these disorders. (nih.gov)
  • Instead, TWHF partially inhibited DNA binding capacity of cytokine-stimulated activating protein-1 (AP-1) and nuclear factor-κB (NF-κB) transcription factors. (aspetjournals.org)
  • In addition, nuclear factor (NF)‑κB and matrix metalloproteinase (MMP) expression was examined by western blotting, and MMP‑2/‑9 activities were determined by gelatin zymography. (spandidos-publications.com)
  • NAC exerted a dose-dependent inhibitory effect on IL-8 and MMP-9 release and ICAM- expression by BAL macrophages and lymphocytes from patients with IPF and sarcoidosis. (nih.gov)
  • Since EMPD is a skin adenocarcinoma of apocrine gland origin that expresses high levels of RANKL and matrix metalloproteinase (MMP) 7, and EMPD is associated with the presence of RANK + M2 macrophages, we hypothesized that tumor-associated macrophages (TAMs) in adenocarcinomas such as PCAC might also express RANKL and MMP7. (iiarjournals.org)
  • To examine the anti-inflammatory effect of hydroxytyrosol in UV exposed HDFs, the expression of inflammatory interleukins IL-1β, IL-6, and IL-8 were analyzed. (researchgate.net)
  • The loss of KLF6 expression has been observed in several human cancers [ 4 - 7 ]. (medsci.org)
  • Also, the elevated expression of MMP-1 and MMP-3 by UVA were decreased by hydroxytyrosol in a dose-dependent manner. (researchgate.net)
  • But the specific molecular mechanisms that can control or interfere with the expression and regulation of these MMP-2 and -9 activities in skin are not clearly understood. (sinica.edu.tw)
  • The expression and transcription of alkaline phosphatase (ALP) and BSP promote the maturation and mineralization of OB ( 5 ). (frontiersin.org)