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  • pathway
  • Tyrosine phsphorylated receptors are coupled to several biochemical cascades, including the phosphoinositide-3-kinase (PI3K) pathway and the extracellular signal-regulated kinase (ERK), which belongs to the MAPK family. (nih.gov)
  • gastric
  • MicroRNA-495 Inhibits Gastric Cancer Cell Migration and Invasion Possibly via Targeting High Mobility Group AT-Hook 2 (HMGA2). (abcam.com)
  • formation
  • McNeill H & Reginensi A Lats1/2 Regulate Yap/Taz to Control Nephron Progenitor Epithelialization and Inhibit Myofibroblast Formation. (abcam.com)
  • specific
  • Accordingly, specific cyclin-CDK complexes persist in an active form for a very short period of time after translation, and are then degraded or inactivated by the time that particular phase of the cell cycle completes. (antibodies-online.com)
  • important
  • MicroRNAs, small RNAs that inhibit the translation of their target mRNAs ( 8 ), play important roles in cancer development. (aaccjnls.org)
  • therapy
  • Taken together, our data support the rationale for clinical development of the CDK4/6 inhibitor as a therapy for patients with aggressive thyroid cancer. (yonsei.ac.kr)
  • shown
  • Heterodimers of HER2/ErbB-2 and either EGFR/ErbB-1 or the kinase-defective ErbB-3/HER3 (note the letter X that symbolizes a defective cytoplasm-facing kinase domain) are shown, along with the growth factor ligands they bind. (nih.gov)