Inhibit prostate tumor cell tumor cells cultured. Medical search. Frequent questions

UCN-01, a protein kinase C (PKC) inhibitor, induces growth arrest and apoptosis in cancer cells and was recently introduced in a phase I clinical trial. (karger.com)
ET-1 participates to a wide range of cancer relevant process, such as cell proliferation, inhibition of apoptosis, matrix remodeling, bone deposition, and metastases. (biomedcentral.com)
Firstly, the overexpression of miRNA‑375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
It affects cell proliferation, differentiation and inhibits apoptosis, and its role in tumor development has received attention ( 9 ). (spandidos-publications.com)
Overexpression of IGF-1 in serum and tissue alters the growth of normal cells and causes uncontrolled proliferation, inhibits differentiation and reduces apoptosis, resulting in the incidence and development of malignant tumors ( 10 ). (spandidos-publications.com)
Potential synergistic effects of various combinations including these compounds were tested by measuring cancer cell proliferation and apoptosis. (frontiersin.org)
For apoptosis (programmed cell death), eyeballing the graph in the paper I estimate the IC 50 of around 75-100 μM. (scienceblogs.com)
Comparison of the results showed that the combination of S.chinensis and CQ10 was more effective compared with CQ10 alone, ie, the ability of S.chinensis combined with CQ10 in improving cardiac function, inhibiting cardiomyocyte apoptosis and reducing inflammatory response lies in the synergistic effect of PI3K/AKT signaling pathway. (bvsalud.org)
Recently, increasing evidences elucidated that miRNAs was involved in the cancer pathogenesis, including cell proliferation, metastasis, and apoptosis [ 6 ]. (hindawi.com)
Also, in gastric cancer, miR-455 inhibited human cell proliferation and invasion and promoted cell apoptosis [ 12 ]. (hindawi.com)
In addition, miR-455 inhibited cell viability, while it induced cell apoptosis in colorectal cancer [ 13 ]. (hindawi.com)
Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. (jcancer.org)
The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)
Although KLF6 overexpression in human cancer cells inhibits cell proliferation, induces apoptosis, and attenuates cell migration, the effects of KLF6 on oral cancer remains poorly elucidated. (medsci.org)
KLFs regulate a wide range of cellular functions, including cell proliferation, apoptosis, differentiation, and neoplastic transformation, by binding to GC-rich promoter regions [ 1 , 2 ]. (medsci.org)
however, forced KLF6 expression in lung cancer cell lines can trigger cells to undergo apoptosis and reduce colony formation ability [ 6 ]. (medsci.org)
In a preclinical study, the combination of AZD5991 and Capivasertib (AZD5363) synergistically inhibited proliferation and induced apoptosis in a triple-negative breast cancer cell line and hormone-receptor positive breast cancer cell line each harboring a PTEN inactivating mutation in culture and inhibited tumor growth in cell line xenograft models ( PMID: 36241868 ). (jax.org)
Flow cytometry was used to examine apoptosis, cell cycle distribution, and accumulation of reactive oxygen species (ROS). (jcancer.org)
Moreover, it induced cell cycle arrest in the G0/G1 phase, apoptosis, and ROS generation in these cells. (jcancer.org)
Silibinin considerably reduced the development of oral cancer cells by inducing apoptosis, G 0 /G 1 arrest, ROS generation, and activation of the JNK/c-Jun pathway. (jcancer.org)
Ibudilast showed modest anti-proliferative activity however, when combined with TMZ, significant synergism was observed, resulting in cell cycle arrest and apoptosis. (nature.com)
Traditionally, cell death has been divided into apoptosis and necrosis. (nature.com)
It does not have the morphological characteristics of typical necrosis, such as swelling of the cytoplasm and organelles and rupture of the cell membrane, nor does it have the characteristics of traditional cell apoptosis, such as cell shrinkage, chromatin condensation, formation of apoptotic bodies and disintegration of the cytoskeleton. (nature.com)
AKT regulates an array of oncogenic procedures including cell development proliferation and apoptosis through phosphorylation of various other proteins kinases transcription elements and signaling modulators. (researchhunt.com)
Promoting PTEN expression in CRC cell lines will stop the activation of the phosphatidylinositol-3-kinase ( PI3K )/sinkserine/threonine kinase ( Akt ) signaling pathway, which affects CRC cell growth, promotes apoptosis, and improves sensitivity to targeted therapy, immunotherapy, and conventional therapy. (aging-us.com)

Physical exercise has been linked to delayed progression and improved survival in prostate cancer patients. (medicalnewstoday.com)
In addition, epidemiological studies have linked physical exercise to a lower risk of disease progression and longer survival after a prostate cancer diagnosis. (medicalnewstoday.com)
The demonstration of ET-1 as an important mediator in the progression of many tumors clearly identifies the ET axis as a potential therapeutic target. (biomedcentral.com)
Currently, use of cannabinoids is limited to improve adverse effects of chemotherapy and their palliative administration during treatment is curiously concomitant with improved prognosis and regressed progression in patients with different tumor types. (frontiersin.org)
Recent studies demonstrated that piperine potentiates curcumin's inhibitory effect on tumor progression via enhancing its delivery and therapeutic activity. (frontiersin.org)
The current aim was to further characterize biological responses and mechanisms underpinning CXCL8-promoted progression of PTEN-depleted prostate cancer, focusing on characterizing the potential interplay between CXCL8 and other disease-promoting chemokines resident within the prostate tumor microenvironment. (oncotarget.com)
The team, led by Karen E. Knudsen, Ph.D., Professor in the Departments of Cancer Biology, Urology, & Radiation Oncology at Thomas Jefferson University, found that functions of PARP-1 not only include DNA damage repair but also androgen receptor (AR) regulation in advanced prostate cancer growth and progression. (sciencedaily.com)
Recent reports have implicated that BEX2 is involved in tumor development and progression in several types of cancer, such as glioblastoma, glioma and breast cancer [ 7 - 9 ]. (ijbs.com)
The loss of KLF6 expression is also correlated with cancer progression, tumor recurrence, and short survival time in head and neck carcinomas [ 7 ]. (medsci.org)
The availability of a sophisticated genetic tool box makes Drosophila an excellent genetic model well suited to studying the biology of Lunasin and its effect on tumor progression in an in vivo model organism. (weeksmd.com)
Collectively, these results indicated that miR‑320 acts as a tumor suppressor in breast cancer tumorigenesis and progression. (spandidos-publications.com)
A previous study demonstrated that various proteins are dysregulated in primary tumors, and are associated with breast cancer development and progression ( 2 ). (spandidos-publications.com)
SOX4 has been revealed to induce EMT, a key process during organ development and the progression of epithelial tumors to metastatic cancers ( 9 ), via its activation of the Wnt and transforming growth factor β signaling pathways in cancer cells ( 10 , 11 ). (spandidos-publications.com)
Given progression occurs in MGMT promoter methylated tumors 4 , this indicates that other pathways must be activated to escape from TMZ treatment, however acquired resistance mechanisms to TMZ are not well understood. (nature.com)
PTEN can inhibit cell cycle progression and induce cell death to stimulate angiogenesis [ 6 ]. (aging-us.com)
Our study uncovered a novel molecular mechanism of lncRNA SNHG4 in driving prostate cancer progression and enzalutamide resistance, revealing the critical roles and therapeutic potential of RREB1, SNHG4, RRM2 and let-7 miRNAs in anticancer therapy. (biomedcentral.com)

Thus, the pivotal roles of miR-455 in cell viability and metastasis in HCC still needed to be explored. (hindawi.com)
In summary, our findings suggest that BEX2 negatively modulates the hedgehog signaling pathway by retaining Zic2 in the cytoplasm in colorectal cancer cells, thereby inhibiting migration and metastasis of colorectal cancer cells. (ijbs.com)
These results indicate that CTCDOs recapitulate several features of colorectal CTCs and may be used to investigate the features of metastatic CRC cells, to identify new prognostic biomarkers and to devise new potential strategies for metastasis prevention. (biomedcentral.com)
Circulating tumor cells (CTCs) contain the physical elements responsible for tumor dissemination and metastasis. (biomedcentral.com)
Our study is the first to provide demonstrate that KLF6 functions as a tumor suppressor gene and prevents the metastasis of oral cancer cells. (medsci.org)
Ma Z, Gibson SL, Byrne MA, Zhang J, White MF and Shaw LM (2006) Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. (scielo.br)
They added capsaicin to lab cultures of lung cancer cells and found that it inhibited cancer cell invasion, the first step of metastasis. (911weknow.com)
Prostate cancer bone metastasis is still not fully understood, and increased knowledge could aid in the development of better treatment options for patients in the future. (lu.se)
Using cell culture, animal and patient studies, we investigated the biological role of microRNA-96 (miR-96) and microRNA-379 (miR-379) in prostate cancer bone metastasis. (lu.se)
In Paper II, we performed an in vivo anti-miRNA library screen, and identified miR-379 as a suppressor of prostate cancer bone metastasis. (lu.se)
Downregulation of miR-379 enhanced incidence of bone metastasis in mice, increased colony formation potential in osteoblast-conditioned media, and increased cell growth. (lu.se)
In bone metastasis samples from prostate cancer patients, miR-379 was frequently downregulated. (lu.se)
Using this method, we could reveal that unedited, but not edited, miR-379 was frequently downregulated in prostate cancer patients with metastasis, treatment resistance, and shorter overall survival. (lu.se)
Overall, this thesis reports multiple findings and tools that can help us better understand the process of prostate cancer bone metastasis and the role that miRNAs play in this process. (lu.se)

In addition, most prostate cancers depend on androgens and androgen receptors for their growth. (medicalnewstoday.com)
Cancers that develop resistance to androgen deprivation therapy are referred to as castration-resistant prostate cancer (CRPC). (medicalnewstoday.com)
Impaired PTEN function is a genetic hallmark of aggressive prostate cancers (CaP) and is associated with increased CXCL8 expression and signaling. (oncotarget.com)
In other words, it helps halt tumor growth by stopping DNA repair in various cancers. (sciencedaily.com)
Nordihydroguaiaretic acid (NDGA) is an inhibitor of the IGF-1 receptor (IGF-1R) in breast and other cancers, and concomitantly inhibits tumor growth both in cultured cells and animals. (elsevierpure.com)
miR-455 usually played the role of a tumor suppressor in multiple cancers. (hindawi.com)
Numerous epidemiological and preclinical studies support a role of vitamin D compounds in cancer prevention and treatment in colorectal, breast, prostate, ovarian, bladder, lung and skin cancers and leukemia ( 1 , 5 , 6 ). (jcancer.org)
Low levels of plasma 25(OH)D 3 are associated with higher cancer incidence and mortality in men in colorectal, breast, lung and prostate cancers ( 7 - 10 ). (jcancer.org)
However, BEX2 appears to exhibit diverse expression patterns and functions in different types of tumors, with conflicting evidence regarding the role of BEX2 in different cancers. (ijbs.com)
Differential expression of miRNAs has been widely described in breast cancers, and suggests that certain miRNAs, including miR-206 ( 19 ), miR-129 ( 20 ), miR-200 ( 21 ) and miR-34 ( 22 ), may function as oncogenes or tumor suppressors in breast cancer. (spandidos-publications.com)
Wet-lab experiments confirm the accuracy of an earlier computational discovery that three drug-like compounds successfully penetrate micro-tumors of advanced cancers to aid chemo in destroying the cancer. (smu.edu)
Researchers at Southern Methodist University have discovered three drug-like compounds that successfully reverse chemotherapy failure in three of the most commonly aggressive cancers - ovarian, prostate and breast. (smu.edu)
They can be used to treat all kinds of cancers because they inhibit not just the P-gp pump, but also the breast cancer protein pump. (smu.edu)
We wanted to make sure when using these really aggressive cancers that if we do knock out the pump, that the chemotherapy goes in there and causes the cell to die, so it doesn't just stop it temporarily," Wise said. (smu.edu)
Well, the recent experiments have also shown that capsaicin has the ability to make lung cancer cells vulnerable to chemotherapeutic agents, so one day capsaicin could be used in combination with chemotherapy to treat a variety of lung cancers. (911weknow.com)
The polypeptide component of telomerase (TERT) is an attractive candidate for a broadly expressed tumor rejection antigen because telomerase is silent in normal tissues but is reactivated in more than 85% of cancers. (nova.edu)
Single drugs may cure selected cancers (eg, choriocarcinoma, hairy cell leukemia). (msdmanuals.com)

BN80927 shows high efficiency in vivo in tumor xenograft studies using human androgen-independent prostate tumors PC3 and DU145. (aacrjournals.org)
Both mice model with xenograft prostate tumor model and canine model were used. (hindawi.com)
MLN8054 also shows similar antitumor activity in the PC-3 tumor xenograft in nude mice. (xcessbio.com)
In the HCT-116 xenograft-bearing animals, MLN8054 induces DNA and tubulin staining of tumor tissue in nuclear and cell body area, consistent with a senescent phenotype by increasing senescence-associated beta-galactosidase activity. (xcessbio.com)
We have established an experimental model of CTCs-derived organoids (CTCDOs) obtained from circulating cancer cells spontaneously generated in an orthotopic CRC xenograft model derived from one CRC patient. (biomedcentral.com)
In a preclinical study, XL147 inhibited PI3K signaling, growth, and migration of a human prostate adenocarcinoma cell line harboring a PTEN inactivating mutation in culture, and inhibited tumor growth and vascularization in xenograft models ( PMID: 25637314 ). (jax.org)
Therefore we investigated the antitumor effects of DMC on a HeLa cell xenograft model in nude mice in this study. (iiarjournals.org)
Results: DMC significantly reduced tumor weights and volumes of HeLa cell xenografts in mice, indicating the suppression of growth of xenograft tumors. (iiarjournals.org)
Silibinin significantly inhibited xenograft tumor growth in nude mice, with no obvious toxicity. (jcancer.org)
Importantly, silibinin effectively suppressed xenograft tumor growth in nude mice. (jcancer.org)

This study is the first to examine skeletal muscle-secreted molecules (myokines) in patients with metastatic castrate-resistant prostate cancer (mCRPC).This work supports an acute myokine response to exercise in patients with advanced cancer and that the serum of these patients after acute exercise has a growth-suppressive effect. (medicalnewstoday.com)
Circulating PSA-positive cells are also strongly associated with metastatic prostate cancer [ 8 ]. (hindawi.com)
BEX2 has been reported to be involved in tumor development in several types of cancer, but its role in metastatic colorectal cancer remains largely undefined. (ijbs.com)
Herein, we demonstrated that BEX2 knockout resulted in enhanced migratory and metastatic potential in colorectal cancer cells both in vitro and in vivo, and re-expression of BEX2 in knockout cells could reverse the enhanced migratory capacity. (ijbs.com)
Circulating tumor cells (CTCs) are responsible for the metastatic dissemination of colorectal cancer (CRC) to the liver, lungs and lymph nodes. (biomedcentral.com)
CTCs analysis through liquid biopsies provides not only a full repertoire of tumor biological material (including proteins, lipids, sugars and nucleic acids) but also a sample of living tumor cells endowed with metastatic ability [ 3 ]. (biomedcentral.com)
Further experiments with mice showed that animals who were fed capsaicin had fewer metastatic cancer cells compared to mice that didn?t take the compound. (911weknow.com)

Preclinical data reported here show that BN80927 retains Topo I poisoning activity in cell-free assay (DNA relaxation) as well as in living cells, in which in vivo complexes of topoisomerase experiments and quantification of DNA-protein-complexes stabilization, have confirmed the higher potency of BN80927 as compared with the Topo I inhibitor SN38. (aacrjournals.org)
Although virus-based gene therapy is a promising strategy to combat advanced prostate cancer, its current effectiveness is limited partially due to inefficient cellular transduction in vivo . (hindawi.com)
In this study, we have analyzed and compared three prostate-specific promoters (PSA, probasin, and MMTV LTR) for their specificity and activity both in vitro and in vivo . (hindawi.com)
Using various in vitro and in vivo model systems, the researchers found that PARP-1 activity is required for AR function and is increased in castrate-resistant prostate cancer. (sciencedaily.com)
Lgr5 resides in Wnt receptor complexes and mediates signaling of the Wnt-agonistic R-spondins (31), explaining the unique dependence of Lgr5 stem cells on secreted R-spondins in vivo and in vitro. (hubrecht.eu)
miR-455 suppressed cell proliferation in vitro and in vivo, and it inhibited the abilities of cell invasion and EMT in HCC. (hindawi.com)
Background/Aim: Demethoxycurcumin (DMC), a derivate of curcumin from natural plants, exerts antitumor effects on various human cancer cells in vitro and in vivo. (iiarjournals.org)
Nevertheless, no reports have disclosed whether DMC can affect the growth of human cervical cancer cells in vivo. (iiarjournals.org)
NK activation was evaluated, and its tumoricidal activity was assessed using in vitro and in vivo tumor models. (weeksmd.com)
In addition, NK cells stimulated with lunasin plus cytokines displayed higher tumoricidal activity than those stimulated with cytokines alone using in vitro and in vivo tumor models. (weeksmd.com)
In vitro and in vivo experiments showed that SNHG4 overexpression markedly enhanced cell resistance to enzalutamide. (biomedcentral.com)
In vitro T cell-mediated killing assays and in vivo syngeneic mouse models were used to investigate the functional roles of circIGF2BP3 and its downstream target PKP3 in antitumor immunity in NSCLC. (biomedcentral.com)

Almost 40 percent of men with prostate cancer progress into an advanced stage, termed castrate-resistant prostate cancer, where chemotherapy and other therapies have little to no effect. (sciencedaily.com)

Wnt signaling intimately interacts with the BMP and Notch cascades to drive proliferation and inhibit differentiation in intestinal crypts and adenomas (17, 20). (hubrecht.eu)
Krüppel-like factors can bind to specific DNA motifs and regulate various cellular functions, such as metabolism, cell proliferation, and differentiation. (medsci.org)
The SRY-box 4 (SOX4) gene, which is located on chromosome 6p22.3, encodes a 47-kDa protein that is a member of the sex-determining region Y-related high-mobility group-box transcription factor family and has functions in embryonic development and cell differentiation ( 3 , 4 ). (spandidos-publications.com)

In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)
Here we show that immunization against TERT induces immunity against tumors of unrelated origin. (nova.edu)

Since hypoxia activates hypoxia-inducible factor (HIF-1)-dependent transcription in cancer cells that, in a paracrine fashion, drive tumor angiogenesis, we investigated the effects of UCN-01 on HIF-1-responsive promoter constructs. (karger.com)
Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)

Physical exercise can modulate the circulating levels of growth factors, hormones, and cytokines, a class of proteins that can modulate inflammation levels, that are involved in sustaining the growth of cancer cells. (medicalnewstoday.com)
These molecules that can suppress cancer cell growth include myokines, which are cytokines and other proteins secreted by the skeletal muscle fibers during physical activity. (medicalnewstoday.com)
In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)
The adenovirus early region 1 (E1) gene, which comprises E1a and E1b, encodes the viral early proteins that are necessary for adenoviral replication and the consequent oncolysis of permissive host cells. (hindawi.com)
BEX proteins have been reported to be involved in transcriptional regulation and signaling pathways in neurodegeneration, cell cycle and tumor growth [ 5 - 8 ]. (ijbs.com)
Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)
Furthermore, silibinin inhibited the migration and invasion abilities of YD10B and Ca9-22 cells by regulating the expression of proteins involved in the epithelial-mesenchymal transition. (jcancer.org)
Herein, frozen tumors from 36 MGMT methylated patients grouped according to overall survival were extracted and proteins were profiled using surface-enhanced laser desorption/ionization (SELDI) with time-of flight (TOF) proteomics to identify low molecular weight proteins that associated with poor survival outcomes. (nature.com)
In addition to ligand-regulated degradation of β-catenin, Wnt signaling is antagonized by extracellular factors that inhibit the ability of Wnt ligands to bind to Fzd and initiate signaling, such as the secreted frizzled-related proteins (SFRP1, WNT inhibitory factor (WIF) and dickkopf (DKK) [3] . (plos.org)
Key to cancer cell resistance are often certain proteins typically found in all cells - cancerous or otherwise - that are outfitted with beneficial mechanisms that pump away toxins to ensure a cell's continued survival. (smu.edu)

Thus, E1 protein expression will be confined strictly to the prostate tissues and render this a conditional oncolytic virus (CRAD) within the prostate. (hindawi.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
In mammals, physiological Wnt signaling is intimately involved with the biology of adult stem cells and self-renewing tissues (18,19). (hubrecht.eu)
These epithelial organoid cultures are genetically and phenotypically extremely stable, allowing transplantation of the cultured offspring of a single stem cell, as well as disease modeling by growing organoids directly from diseased patient tissues (32, 47, 53). (hubrecht.eu)
The expression of miR-455 was lower in HCC tissues and cell lines than in nontumor tissues and normal cell line, and downregulation of miR-455 was connected with worse outcome of HCC patients. (hindawi.com)
RAB18 was upregulated in HCC tissues and cell lines, and the expression of RAB18 was regulated by miR-455. (hindawi.com)
Bioinformatic analyzing approaches were used to identified the over-expressed genes in prostate cancer tumor tissues from three GEO datasets. (biomedcentral.com)
The editing frequency of miR-379 was higher in prostate cancer tissues compared to benign tissues. (lu.se)

HPV promotes latency and consequently does not cause a disease phenotype following initial infection by an immune evasion response reaction, featuring binding to epithelial cells and integrating into the host genome, resulting in the proliferation of epidermal cells containing the viral genome and neovascularization ( 3 ). (spandidos-publications.com)
These cells represent the epithelial stem cells of the small intestine and colon (23), the hair follicle (24), the stomach (28) and many other tissue stem cell types. (hubrecht.eu)

Materials and Methods: Twenty-four nude mice were subcutaneously injected with HeLa cells. (iiarjournals.org)

We found that unedited miR-379 increased cell growth in androgen-independent cell lines, but inhibited cell growth in androgen-sensitive cell lines. (lu.se)

A new study explains how a single bout of high-intensity exercise can boost tumor-suppressing mechanisms even in advanced prostate cancer. (medicalnewstoday.com)
Previous research has shown that blood taken from patients with advanced prostate cancer who followed a high-intensity exercise program for a few months could suppress the growth of cultured tumor cells. (medicalnewstoday.com)
These results suggest that regular exercise could help suppress tumor cell proliferation in patients with advanced prostate cancer, and each additional bout of exercise could potentially further enhance this tumor-suppressive effect. (medicalnewstoday.com)
Previous research has shown that serum from advanced prostate cancer patients who followed a supervised high-intensity exercise program (HIIT) for 6 months showed elevated myokine levels and a greater ability to suppress the growth of tumor cells. (medicalnewstoday.com)
In a follow-up study published in Prostate Cancer and Prostatic Diseases , the same researchers have now shown that serum samples collected immediately after a single bout of physical exercise from exercise-trained advanced prostate cancer patients also showed elevated myokine levels and enhanced tumor suppressive effects than before exercise. (medicalnewstoday.com)
In other words, a single bout of exercise further enhanced the already existing anticancer effects of serum due to exercise training in these advanced prostate cancer patients. (medicalnewstoday.com)
As a result, androgen deprivation therapy , involving drugs or surgery to reduce the synthesis of androgens, is used as a treatment for advanced prostate cancer. (medicalnewstoday.com)
A newly discovered function of PARP-1 could be the key to more effective therapeutics to treat advanced prostate cancer patients, a recent preclinical study suggests. (sciencedaily.com)

KLF6 functions as a tumor suppressor gene and increases p21 expression via p53-independent pathway [ 3 ]. (medsci.org)
this evidence suggests that miR-320 functions as a tumor suppressor ( 24 - 29 ). (spandidos-publications.com)

Oral cancer is one of the most prevalent malignant tumors worldwide. (jcancer.org)

Our data show that PARP-1 plays a major role in controlling AR function and that, when suppressed with inhibitors, enhanced anti-tumor effects of castration and delayed onset to castration resistance. (sciencedaily.com)

We conclude that UCN-01, at clinically relevant concentrations, exerts an anti-neovascularization effect by blocking two important steps in vessel formation: (1) the response of cancer cells to hypoxia, and (2) endothelial cell proliferation. (karger.com)
However, mutations in prostate cancer cells can lead to the development of resistance to androgen deprivation therapy. (medicalnewstoday.com)
Consistent with this, studies have shown that serum collected immediately after a bout of exercise from patients with breast or colon cancer can inhibit the proliferation of cultured cancer cells. (medicalnewstoday.com)
The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
The overexpression of miRNA‑375 significantly suppressed the levels of protein expression of ubiquitin‑protein ligase E3A (UBE3A) and Insulin‑like growth factor‑1 receptor (IGF‑1R) in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
To conclude, it was identified that the probable anti‑CA mechanism of miRNA‑375 modulates HPV through the UBE3A and IGF‑1R pathway in cervical cancer cells. (spandidos-publications.com)
UBE3A is associated with cervical cancer and may combine with the E6 proto-oncogene encoded by HPV16 within cervical cancer cells to form the E6/E6-AP protein complex through the ubiquitin proteasome pathway ( 4 ). (spandidos-publications.com)
The efficacy and specificity of CRAD on prostate cancer cells were examined in cell culture and animal models. (hindawi.com)
It is said that the sugar in the molasses bings the cancer cells out and the baking soda then attacks it. (earthclinic.com)
CXCL12-induced migration of PC3 cells and CCL2-induced proliferation of prostate cancer cells were dependent upon intrinsic CXCL8 signaling within the prostate cancer cells. (oncotarget.com)
Combined inhibition of both CXCL8 and CXCL12 signaling was more effective in inhibiting fibroblast-promoted cell motility while repression of CXCL8 attenuated CCL2-promoted proliferation of prostate cancer cells. (oncotarget.com)
We conclude that tumor-derived CXCL8 signaling from PTEN-deficient tumor cells increases the sensitivity and responsiveness of CaP cells to stromal chemokines by concurrently upregulating receptor expression in cancer cells and inducing stromal chemokine synthesis. (oncotarget.com)
Today, PARP-1 is seen as a valuable target because of its involvement in DNA damage repair for cancer cells. (sciencedaily.com)
With this new role defined, PARP inhibitors targeting both functions could sensitize prostate cancer cells to DNA damage, and potentially improve the efficacy of AR-directed therapies in these patients, the researchers suggest in the paper. (sciencedaily.com)
Geibel said he initially tested capsaicin on breast cancer cells in a culture to determine the dose and the best way to deliver it. (scienceblogs.com)
Capsaicin can indeed inhibit the growth of breast cancer cells, but it requires a high concentration. (scienceblogs.com)
The current study evaluates the effect of NDGA on the androgen-stimulated growth of human prostate cancer cells. (elsevierpure.com)
LAPC-4 prostate cancer cells in tissue culture were androgen starved for 3 days, 1 nM dihydrotestosterone (DHT) and other androgens were then added for up to 7 days, and cell proliferation measured. (elsevierpure.com)
NDGA blocks the DHT-induced growth of LAPC-4 prostate cancer cells by several mechanisms including rapid inhibition of the IGF-1R kinase, and a dose-dependent inhibition of androgen stimulation of IGF-1R expression. (elsevierpure.com)
The Tcf4-driven target gene program in colorectal cancer cells is the malignant counterpart of a physiological gene program in selfrenewing crypts (13, 14). (hubrecht.eu)
NK cells kill cancer cells, viruses, fungus and bacteria. (alternative-cancer-care.com)
moreover, the hedgehog signaling inhibitors, GANT61 and GDC-0449 could reverse the migratory enhancement of BEX2-/- colorectal cancer cells. (ijbs.com)
Gene therapy has attracted attention for its potential to specifically and efficiently target cancer cells with minimal toxicity to normal cells. (weeksmd.com)
Numerous vectors have been engineered for the sole purpose of killing cancer cells, and some have successfully suppressed malignant tumours. (weeksmd.com)
To investigate the effects of silibinin on the growth of oral cancer cells, cell proliferation and anchorage-independent colony formation tests were conducted on YD10B and Ca9-22 oral cancer cells. (jcancer.org)
The effects of silibinin on the migration and invasion of oral cancer cells were evaluated using transwell assays. (jcancer.org)
Western blotting revealed that silibinin downregulated SOD1 and SOD2 and triggered the JNK/c-Jun pathway in oral cancer cells. (jcancer.org)
Preclinical data indicate that metformin may chemosensitize ovarian cancer cells to platinum therapy. (naturalmedicinejournal.com)
In this study we assessed the effects of the phytocompounds garcinol and curcumin on histone and p53 modification in cancer cells, focussing on the breast tumour cell line MCF7. (biomedcentral.com)
In summary, although garcinol and curcumin can both inhibit histone acetyltransferase activities, our results show that these compounds have differential effects on cancer cells in culture. (biomedcentral.com)
To uncover genetic dependencies in breast cancer cells that harbor active β-catenin signaling, we performed RNAi-based loss-of-function screens in breast cancer cell lines in which we had characterized β-catenin activity. (plos.org)
Here we identify CSNK1E , the gene encoding casein kinase 1 epsilon (CK1ε) as required specifically for the proliferation of breast cancer cells with activated β-catenin and confirm its role as a positive regulator of β-catenin-driven transcription. (plos.org)
Furthermore, we demonstrate that breast cancer cells that harbor activated β-catenin activity exhibit enhanced sensitivity to pharmacological blockade of Wnt/β-catenin signaling. (plos.org)
Nature designs all cells with survival mechanisms, and cancer cells are no exception," said Vogel, a professor in the SMU Department of Biological Sciences and director of SMU's Center for Drug Discovery, Design and Delivery . (smu.edu)
So it was incredibly gratifying that we were able to identify molecules that can inhibit that mechanism in the cancer cells, thereby bolstering the effectiveness of chemotherapeutic drugs. (smu.edu)
We saw the drugs penetrate these resistant cancer cells and allow chemotherapy to destroy them. (smu.edu)
Cancer cells initially treated with chemotherapy drugs ultimately evolve to resist the drugs. (smu.edu)
In the case of cancer cells on the first round of treatment, these pumps are typically not produced in high levels in the cells, which allows chemotherapy to enter most of the cells in the tumor. (smu.edu)
Unfortunately, in the cancer cells that don't die, the chemotherapeutic often changes the cell, which then adapts to protect itself by aggressively multiplying the production of its defensive pumps. (smu.edu)
They effectively bring the cancer cells back to a sensitivity as if they'd never seen chemotherapy before," said Vogel. (smu.edu)
Test tube studies show that these compounds can inhibit the growth of human prostate cancer cells. (kssct.org)
Experiments revealed that capsaicin suppresses cancer cells? (911weknow.com)
Similar experiments with breast cancer cells have been conducted before. (911weknow.com)
As for the surviving cancer cells, they lost the ability to move quickly which reduced their ability to spread. (911weknow.com)
Other studies have achieved promising results when they tested the effects of capsaicin in gut tumours, prostate cancer cells and even a rare form of non-Hodgkin?s lymphoma. (911weknow.com)
Hence, it is of great importance to investigate the mechanisms that induce enzalutamide resistance in prostate cancer cells. (biomedcentral.com)
In Paper IV, we compared the biological functions of unedited and edited miR-379 in prostate cancer cells. (lu.se)
The ideal drug would target only cancer cells and have no adverse effects on normal cells. (msdmanuals.com)
Cytotoxic drugs damage DNA and kill many normal cells as well as cancer cells. (msdmanuals.com)
In contrast, other drugs (eg, DNA cross-linkers, also known as alkylating agents) have a linear dose-response relationship, killing more cancer cells at higher doses. (msdmanuals.com)

Combined chemokine targeting may be required to inhibit their multi-faceted actions in promoting the invasion and proliferation of aggressive CaP. (oncotarget.com)
Cell viability and invasion were measured by CCK8 and Transwell assays. (hindawi.com)
RAB18 reversed partial roles of miR-455 on cell viability and invasion in HCC. (hindawi.com)
miR-455 inhibited cell viability and invasion by directly targeting the 3′-UTR of RAB18 mRNA of hepatocellular carcinoma. (hindawi.com)
However, miR-455 promoted cell invasion and migration in triple-negative breast cancer [ 14 ]. (hindawi.com)
BEX2 can also promote cell migration and invasion in glioma [ 7 ]. (ijbs.com)
KLF6 overexpression attenuated the migration and invasion of oral cancer SAS cells. (medsci.org)
In addition, knockdown of miR‑320 in breast cancer cell lines promoted cell proliferation and invasion in vitro, whereas miR‑320 overexpression had the opposite effect. (spandidos-publications.com)
Liu Y , Sun M , Zhang B , Zhao W , . KIF18A improves migration and invasion of colorectal cancer (CRC) cells through inhibiting PTEN signaling. (aging-us.com)
In addition, the scratch wound assay and Transwell assay were conducted to detect the effect of KIF18A on the migration and invasion of CRC cells. (aging-us.com)
The results of Western blot illustrated that KIF18A could forward the migration and invasion of CRC cells, and inhibit PTEN , which promoted the activation of PI3K/Akt signaling pathway, thus bringing about the expression of MMP2 and MMP9 . (aging-us.com)
Because colorectal cancer's migration and invasion are one of main factors to the severity of the disease, exploring the molecular mechanisms of proliferation, migration and invasion of CRC cells will contribute to the development of targeted therapy [ 5 ]. (aging-us.com)

Furthermore, a Dual‑Luciferase reporter assay indicated that SRY‑box 4 (SOX4) is a direct target of miR‑320, and the restoration of SOX4 in miR‑320‑overexpressing cells attenuated the tumor‑suppressive effects of miR‑320. (spandidos-publications.com)

PTEN gene is considered an established tumor suppressor gene in different types of cancer including breast cancer. (cancerindex.org)

Moreover, a Topo I-altered cell line (KBSTP2), resistant to SN38, remains sensitive to BN80927, suggesting that a part of the antiproliferative effects of BN80927 are mediated by a Topo I-independent pathway. (aacrjournals.org)
Triple treatment showed synergism in terms of exhibiting anti-tumorigenic effects by activating the Hippo YAP signaling pathway in the HCT116 cell line. (frontiersin.org)
Results: Network pharmacology combined with experimental validation suggests that the mechanism of action of S.chinensis combined with CQ10 in the treatment of heart failure may involve CQ10, Citral, Schisandrone, Schisanhenol B, Gomisin O, Schisandrin C and other components, which may synergistically inhibit the PI3K-AKT signaling pathway and affect the expression of AKT1, PIK3CG and other targets on this pathway. (bvsalud.org)
We also demonstrated that the nuclear translocation of Zic2 after BEX2 silencing could activate the hedgehog signaling pathway, while Zic2 knockdown abrogated the migratory enhancement of BEX2-/- cells and inhibited the hedgehog signaling pathway. (ijbs.com)
The Wnt/β-catenin pathway plays a critical role in embryonic development, maintenance of multipotent progenitor cell populations and proliferation of many tissue types [1] , [2] . (plos.org)
Conclusion: In conclusion, KIF18A can further the activation of PI3K/Akt signaling pathway by means of inhibiting PTEN transcription. (aging-us.com)
Therefore, targeting drugs molecules in the PTEN signaling pathway may be another strategy to suppress tumor cells by inhibiting tumor activity [ 7 , 8 ]. (aging-us.com)
Ewing sarcomas are thought to derive from cells of the neural crest, possibly mesenchymal stem cells, via a pathway that might include postganglionic cholinergic neurons. (medscape.com)

Enzalutamide remains the first-line drug for castration-resistant prostate cancer, however, tumors inevitably become resistant to enzalutamide. (biomedcentral.com)
However, most PCa patients inevitably develop castration-resistant prostate cancer (CRPC), which is a fatal form of PCa that is difficult to confront [ 6 ]. (biomedcentral.com)

In cell growth assays, BN80927 is a very potent antiproliferative agent as shown by IC 50 values consistently lower than those of SN38 in tumor cell lines as well as in their related drug-resistant lines. (aacrjournals.org)
CTCs-derived organoids (CTCDOs) were characterized through proteome profiling, immunohistochemistry, immunofluorescence, flow cytometry, tumor-forming capacity and drug screening assays. (biomedcentral.com)
Cell viability/proliferation assays, cell cycle analysis by flow cytometry, immunodetection of specific histone and p53 acetylation marks, western blotting, siRNA and RT-qPCR. (biomedcentral.com)
Tumor RNA-transfected DC were used as surrogate targets in the CTL assays, obviating the difficulties in obtaining tumor cells from cancer patients. (nova.edu)
CCK-8, plate colony formation and EdU assays were performed to assess the cell proliferation. (biomedcentral.com)

PB, a rat prostate protein, is also expressed selectively in prostate [ 10 ]. (hindawi.com)
It is suggested that curcumin can selectively kill tumor cells through its multifaceted metabolic effects, that culminate in its anti-oxidant and anti-inflammatory activities ( Hewlings and Kalman, 2017 ). (frontiersin.org)
In addition, MLN8054 selectively inhibits Aurora A over Aurora B in cultured cells, and inhibits cell proliferation by promoting G2/M accumulation and spindle defects in multiple cultured human tumor cells lines. (xcessbio.com)
One such peptide, Lunasin , has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. (weeksmd.com)

Therefore, strategies to use conditional oncolytic virus, or the so-called attenuated replication-competent viruses, to specifically target prostate tissue have been developed [ 2 - 4 ]. (hindawi.com)
40-fold more selective inhibitory activity for Aurora A compared with Aurora B. In vitro, MLN8054 exhibits the activity of growth inhibition across various cell lines from diverse tissue origins with IC50 values ranging from 0.11 μM to 1.43 μM. (xcessbio.com)
What if, he posited, after a surgeon has removed a malignant tumor from a breast, the doctor can "coat the underlying tissue area with a capsaicin-based preparation to prevent any residual cells" from reproducing? (scienceblogs.com)
The Organoid group, previously Clevers group, studies the molecular mechanisms of tissue development and cancer of various organs using organoids made from adult Lgr5 stem cells. (hubrecht.eu)
We derive HPAd from human subcutaneous and heart adipose tissue and cryopreserve these fibroblast-like precursor cells at the end of primary culture. (cellapplications.com)

However, the regulatory mechanisms of HPV infection and consequent immune escape reaction, persistent infection and cell proliferation and the regulatory mechanisms of vascular proliferation are poorly understood and require additional investigation ( 4 ). (spandidos-publications.com)
HPAd from Cell Applications, Inc. have been used in multiple studies investigating the cellular basis of diabetes and obesity, as well as mechanisms of action of various drug candidates. (cellapplications.com)
How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and specific molecular mechanisms of ferroptosis still need to be further explored. (nature.com)
An in-depth understanding of immune evasion mechanisms in tumors is crucial to overcome resistance and enable innovative advances in immunotherapy. (biomedcentral.com)
For chemotherapy drugs, one of the best characterized resistance mechanisms is overexpression of MDR1 , a cell membrane transporter that causes efflux of certain drugs (eg, vinca alkaloids, taxanes, anthracyclines). (msdmanuals.com)

With the goal of further improving cytokine-based immunotherapy, we examined the effects of a soybean peptide called lunasin that synergistically works with cytokines on natural killer (NK) cells. (weeksmd.com)

Cell cycle was measured by flow cytometry. (biomedcentral.com)

A number of PSPs have been defined over the years that include, but not limited to, promoters of prostate-specific antigen (PSA), probasin (PB), mouse mammary tumor virus (MMTV LTR), prostate-specific membrane antigen (PSMA), human glandular kallikrein 2 (hK2), and prostatic steroid-binding protein C3. (hindawi.com)
Transgenic mice bearing PB promoter fused to simian virus 40 large tumor antigen gene all consistently develop prostate adenocarcinoma [ 13 ]. (hindawi.com)
PSA antigen reading started at 4.2 (I have prostate cancer) and dramatically dropped to 2.01 at the end of the month. (alternative-cancer-care.com)

People with grade IV glioma (glioblastoma or GBM) face a poor prognosis and inevitable tumor recurrence. (nature.com)
Overview of Cancer Therapy Curing cancer requires eliminating all cells capable of causing cancer recurrence in a person's lifetime. (msdmanuals.com)

Preclinical studies suggest that these myokines can suppress the growth of tumor cells. (medicalnewstoday.com)
PARP inhibition in various models was found to suppress AR activity, which fuels prostate growth. (sciencedaily.com)

Non-small-cell lung cancer (NSCLC), which primarily comprises lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), is the major type of primary lung cancer [ 2 ]. (biomedcentral.com)
Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)

We demonstrate that UCN-01, at concentrations lower than those necessary to inhibit cancer cell growth, inhibit proliferation of human endothelial cells in vitro. (karger.com)

The rat PB gene promoter (454 bp) contains ARE [ 11 ] and directs a hormonal and developmental regulated expression, of a heterologous gene, specifically to the prostate in transgenic mice [ 12 ]. (hindawi.com)
In the HCT-116 tumor-bearing mice, MLN8054, administered orally at 3 mg/kg, 10 mg/kg, and 30 mg/kg once a day, leads to dose-dependent tumor growth inhibition (TGI: 76% and 84% for 10 mg/kg and 30 mg/kg). (xcessbio.com)
A chemist in South Korea claimed he injected mice with prostate cancer then cured them with Allicin. (alternative-cancer-care.com)
The experimental design for the demethoxycurcumin (DMC) treatments in human cervical HeLa cell-bearing mice. (iiarjournals.org)
Immunization of mice with TERT RNA-transfected dendritic cells (DC) stimulated cytotoxic T lymphocytes (CTL), which lysed melanoma and thymoma tumor cells and inhibited the growth of three unrelated tumors in mice of distinct genetic backgrounds. (nova.edu)

GLA inhibits these destructive enzymes, thus impeding the ability of AA to convert to detrimental inflammatory molecules (like leukotriene B4). (lifeextension.com)
The aptamer is a kind of short DNA or RNA sequence that can specifically bind to target molecules, and could be widely used as the active targeting agents of nanoplatforms to achieve active-targeted therapy of tumors. (bvsalud.org)
Drug-like molecules that can reprogram selected histone PTMs in tumour cells are therefore of interest as potential cancer chemopreventive agents. (biomedcentral.com)
Thus, drug-like molecules that target chromatin modifying enzymes to reprogram selected histone PTMs in tumour cells may have potential as cancer chemopreventive agents. (biomedcentral.com)
A number of natural and synthetic molecules that inhibit histone acetyltransferase (HAT) or histone deacetylase (HDAC) activities have been described. (biomedcentral.com)
The computational discovery was confirmed in the Wise-Vogel labs at SMU after aggressive micro-tumors cultured in the labs were treated with a solution carrying the molecules in combination with a classic chemotherapy drug. (smu.edu)

In addition, BN80927 inhibits Topo II-mediated DNA relaxation in vitro but without cleavable-complex stabilization, thus indicating catalytic inhibition. (aacrjournals.org)
Auora kinase inhibitor MLN8054 binds to and inhibits Aurora kinase A, resulting in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregration, and inhibition of cell proliferation. (xcessbio.com)
Inhibition of AKT activity by wortmannin or over-expression of dominating negative AKT clogged arsenic-induced MLN0128 cyclin D1 manifestation and transformation [5 6 Short-term exposure to numerous concentrations of arsenite (5-50 μM) raises phosphorylation of p70-KDa ribosomal protein S6 kinase (p70S6K) in human being prostate DU145 cells [7]. (researchhunt.com)

Recombinant Kinesin Family, Member 18A ( KIF18A ) belongs to Recombinant Kinesin Family [ 9 ], which is highly expressed in tumors and associated with poor prognosis [ 10 , 11 ]. (aging-us.com)

2004) Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. (scielo.br)

Prostate cancer is dependent on AR activity for growth and survival, and is largely resistant to standard chemotherapy. (sciencedaily.com)
Well, here we have an estimated IC 50 of close to μM for capsaicin for the endpoint of cell survival. (scienceblogs.com)
For example, reduced levels of acetylated H4K16 and trimethylated H4K20 are associated with high tumour grade and poor survival in breast cancer. (biomedcentral.com)
We took an unbiased approach by selecting human GBM tumors that were MGMT methylated, responded initially to TMZ treatment, and grouped them according to patient survival. (nature.com)

Autocrine CXCL8-stimulation (i) increased expression of CXCR1 and CXCR2 in PTEN-deficient CaP cells suggesting a self-potentiating signaling axis and (ii) induced expression of CXCR4 and CCR2 in PTEN-wild-type and PTEN-depleted CaP cells. (oncotarget.com)

In this study, we investigated a plausible therapeutic synergism of a triple combination of CBD/CBG, curcumin, and piperine in the colon adenocarcinoma using HCT116 and HT29 cell lines. (frontiersin.org)
Active-targeted nanoplatforms could specifically target tumors compared to normal cells, making them a promising therapeutic agent. (bvsalud.org)
To improve the therapeutic effect of the tumor, the anticancer drug doxorubicin (DOX) was loaded into PCN-224 to form DOX@PCN-224 for tumor combination therapy. (bvsalud.org)
In vitro, experimental results indicated that DOX@PCN@Apt-M exhibited enhanced combined therapeutic effect and active targeting efficiency under 808 nm laser irradiation for MCF-7 tumor cells. (bvsalud.org)
Immunostimulatory cytokines can enhance anti-tumor immunity and are part of the therapeutic armamentarium for cancer treatment. (weeksmd.com)

Induction of cytotoxic T cell responses and tumor immunity against unr" by S K Nair, A Heiser et al. (nova.edu)
Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells. (nova.edu)
Functionally, elevated circIGF2BP3 inactivated cocultured T cells in vitro and compromised antitumor immunity in an immunocompetent mouse model, and this effect was dependent on CD8 + T cells. (biomedcentral.com)

The tumor suppressor protein APC forms the core of a cytoplasmic complex which binds ß-catenin and targets it for degradation in the proteasome. (hubrecht.eu)
Recently, immune checkpoint blockade therapies (ICBs) blocking programmed cell death protein 1 (PD-1) and its ligand (PD-L1) have shown tremendous benefit for the treatment of advanced NSCLC [ 4 ]. (biomedcentral.com)

Luciferase reporter assay was performed to verify that miR-455 directly binds to the 3′-noncoding region (UTR) of RAB18 mRNA in Huh7 cells. (hindawi.com)
Zymography assay demonstrated that KLF6 inhibited the activities of matrix metalloproteinase 9 (MMP-9) and weakened the expression of mesenchymal markers, such as snail, slug, and vimentin. (medsci.org)
Senescence-associated β-Gal assay was used to detect the cell senescence level. (biomedcentral.com)
γ-H2AX staining assay was performed to assess the DNA damages of PCa cells. (biomedcentral.com)

PMID:21684805 oncoprotein in HPV 16-positive cells. (who.int)

Why not any number of other drugs used against breast cancer, like paclitaxel or compounds that are known to slow down or stop brast cancer tumors in a dish? (scienceblogs.com)
Although treatment with curcumin, garcinol or the garcinol derivative LTK-14 hampered MCF7 cell proliferation, differential effects of these compounds on histone modifications were observed. (biomedcentral.com)
Researchers in the field have searched unsuccessfully for compounds to inhibit the pumps that could be used in the clinic as well. (smu.edu)
Moringa leaves and seeds are rich in sulfur compounds that may have anti-cancer properties-meaning they can help in treating prostate cancer. (kssct.org)
For example, they tested similar compounds, such as capsiate and capsiconiate and found that the first was also able to block the cancerous cells? (911weknow.com)

Metz H, Busch SE, Hanke ML, Kargl J, Kim KH and Houghton M (2014) Insulin receptor substrate-1 regulates immune cell content in lung adenocarcinoma. (scielo.br)

By using an expression vector, a 680 bp PSA promoter isolated from a prostate cancer patient demonstrated the prostate-specific expression of the reporter gene [ 9 ]. (hindawi.com)
We were the first to link Wnt signaling with adult stem cell biology, when we showed that TCF4 gene disruption leads to the abolition of crypts of the small intestine (8), and that TCF1 gene knockout severely disables the stem cell compartment of the thymus (2). (hubrecht.eu)
Amongst the intestinal Wnt target genes (13), we found the Gpr49/Lgr5 gene to be unique in that it marks small cycling cells at crypt bottoms. (hubrecht.eu)
The Wnt target gene encoding the transcription factor Achaete scute-like 2 controls intestinal stem cell state (26). (hubrecht.eu)
The underlying mechanism responsible for the effects of lunasin on NK cells is likely due to epigenetic modulation on target gene loci. (weeksmd.com)
This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. (lu.se)

Earlier studies have shown capsaicin's ability "to slow down or even stop the machinery of (cell) division," he said, pointing to one in which capsaicin stopped the growth of prostate colonic tumors in a dish. (scienceblogs.com)
Calcium helps by binding to the fatty acids and bile, forming an insoluble soap, which is less irritating to colonic cells. (ironmanmagazine.com)

Zr-based porphyrinic nanoscale metal organic framework PCN-224 was synthesized through a one-pot reaction, which could produce cytotoxic 1O2 for efficient treatment of tumor cells. (bvsalud.org)

Arsenite may be the predominant type of arsenic within contaminated drinking water and may be the type mainly related to the induction of individual malignancies including lung epidermis bladder and liver organ cancer tumor [1]. (researchhunt.com)
Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)

Previous studies have identified that UBE3A exhibits abnormal expression in numerous tumor cells, including prostate, cervical and breast cancer ( 6 , 7 ). (spandidos-publications.com)
Another paper found roughly the same thing for a number of breast cancer cell lines, an IC 50 ranging between 50 and 200 μM. (scienceblogs.com)
Granted, it did a reasonable job inhibiting the growth of breast cancer xenografts. (scienceblogs.com)
Although mutations in these same genes have not been observed as recurrent genetic events in breast tumors, there is strong evidence implicating Wnt/β-catenin activity in breast tumorigenesis. (plos.org)

The National Cancer Institute states: "Protective (cancer) effects from garlic may arise from its anti-bacterial properties, or from its ability to block the formation of cancer-causing substances, halt the activation of cancer-causing substances, enhance DNA repair, reduce cell proliferation, or induce cell death. (alternative-cancer-care.com)

On the contrary, in primary glioma, BEX2 is epigenetically silenced and exhibits extensive promoter hypermethylation, and re-expression of BEX2 results in significantly suppressed tumor proliferation [ 10 ]. (ijbs.com)

Accumulating evidences have elucidated connection between the expression of GTPases members and several diseases, including colorectal cancer, lung cancer, and prostate cancer [ 16 - 18 ]. (hindawi.com)
Lung cancer is divided into two major groups: non small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). (scielo.br)
2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. (scielo.br)
However, much remains unknown regarding whether circRNAs impact immune escape in non-small-cell lung carcinoma (NSCLC). (biomedcentral.com)

Anatomy16

Organisms9

Diseases90

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment53

Phenomena and Processes43

Disciplines and Occupations1

Information Science4

Health Care7

Apoptosis25

Progression16

Metastasis14

Cancers17

Xenograft10

Metastatic7

Vivo12

Castrate-resistant prostate cancer1

Differentiation3

Induces2

Angiogenesis2

Proteins11

Tissues8

Epithelial2

Nude mice1

Androgen-independent1

Advanced prostate cancer8

Functions as a tumor2

Malignant tumors1

Anti-tumor effects1

Cancer cells50

Invasion12

Suppressive effects1

Suppressor gene1

Pathway8

Castration-resistant prostate cancer2

Assays5

Selectively4

Tissue5

Mechanisms5

Synergistically1

Flow cytometry1

Antigen3

Recurrence2

Suppress2

Squamous Cell Carc2

Endothelial cells1

Mice5

Molecules6

Inhibition3

Prognosis1

Phosphorylation1

Survival4

PTEN1

Therapeutic5

Immunity3

Protein2

Assay4

PMID1

Compounds5

Adenocarcinoma1

Gene6

Colonic2

Cytotoxic1

Bladder2

Breast4

Induce cell death1

Significantly suppressed1

Lung4