• Although medical and surgical developments have extended the overall survival of patients, CRC still has a poor long-term prognosis, high recurrence rate, low five-year postoperative survival, and high tumor metastasis rate, which reduce therapeutic efficacy [ 3 ]. (hindawi.com)
  • The epithelial‑mesenchymal transition (EMT) serves vital roles in the angiogenesis, cell invasion and metastasis of various malignant tumors, including bladder cancer. (spandidos-publications.com)
  • Therefore, PPE and PPII may have antimetastatic effects and PPII may serve as a potential therapeutic option for inhibiting bladder cancer metastasis. (spandidos-publications.com)
  • Firstly, the transcriptome landscape of heterogeneous cell types in LUAD was analyzed and memory T cells, NK cells, and helper T cells were revealed to be the common immune cells in tumor, normal, and metastasis tissue, respectively. (aging-us.com)
  • Next, the results of cell-cell communication analysis suggested that pericytes interact with broad immune cells via MDK-NCL pathways in metastasis samples, MIF-(CD74+CXCR4) and MIF-(CD74+CC44) interaction especially occurred between different cell types in tumor and normal samples. (aging-us.com)
  • Abnormally activated Wnt/β-catenin signaling pathway plays a crucial role in promoting malignant tumor occurrence, development, recurrence, and metastasis, particularly in cancer stem cells. (frontiersin.org)
  • Malignant cells often have increased interactions with surrounding ECM 3 proteins, which provide linkages and signals that promote several aspects of metastasis (6) . (aacrjournals.org)
  • In particular, CVM-1118 possesses the novel mechanism of inhibiting a unique structure known as vasculogenic mimicry (VM), which is associated with metastasis and drug-induced resistance in malignant tumors. (bio-itworld.com)
  • As the most common endocrine tumor, PTC has a tendency to occur lymph node metastasis in the early stages of cancer, and 20%-30% of PTC patients already have cancerous lymph node involvement at the time of diagnosis [ 3 , 4 ]. (jcancer.org)
  • Meanwhile, PTC patients with lymph node metastasis have significantly higher tumor recurrence, distant metastasis and mortality rates than those without metastasis [ 5 , 6 ]. (jcancer.org)
  • We hypothesize that tumor-derived exosomes endow the fibroblasts in tumor microenvironment with invasive phenotype to the benefit of tumor metastasis. (dovepress.com)
  • It is confirmed that large variety of miRNAs in exosomes play important roles in tumor metastasis and invasion. (dovepress.com)
  • We found that SOX9 is upregulated in SWCNT-exposed cells, which is consistent with their abilities to induce tumor formation and metastasis in vivo. (cdc.gov)
  • Furthermore, SOX9 knockdown suppressed tumor metastasis and the expression of the stem cell marker ALDH1A1. (cdc.gov)
  • Consequently, these changes in gene expression can inhibit genetic regions related to tumor suppression, cell growth, DNA repair, intracellular binding, and inhibition of metastasis, among other processes. (bvsalud.org)
  • The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. (cancercentrum.se)
  • Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary. (cancercentrum.se)
  • Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? (cancercentrum.se)
  • Even though developed for AML patients, our pan-cancer analyses demonstrate a wider application of the IPRP signature for prognostic prediction and analysis of tumor-immune interplay also in multiple solid tumors. (nature.com)
  • Other malignancies have occurred, including skin cancers and other solid tumors. (drugs.com)
  • Why and how it is replacing past approaches in the management of solid tumors is the subject of this two-part overview. (cancernetwork.com)
  • The situation with solid tumors is considerably more complex, and the evolution of targeted therapies for these cancers is still in its infancy. (cancernetwork.com)
  • At present, and for some years to come, the treatment of most solid tumors will continue to rely on a patchwork of empirically derived and newly introduced molecularly targeted agents. (cancernetwork.com)
  • Another is SUSD4, which we recently showed to be bind and inhibit C1 and which we found on T cells infiltrating various solid tumors. (lu.se)
  • The usual CT image of E. multilocularis infection is that of indistinct solid tumors with central necrotic areas and perinecrotic plaque-like calcifications. (cdc.gov)
  • Therefore, OA may be a potentially new agent that can be used for the prevention and treatment of various malignant tumors, including glioma. (spandidos-publications.com)
  • Tavazoie et al pointed out that APOE may be involved in lymphocyte-mediated immune regulation, and that overexpression of APOE accelerated the biological processes of various malignant tumors [ 7 , 8 ]. (jcancer.org)
  • Glioma was one of the most common malignant brain tumors. (ijpsonline.com)
  • Malignant gliomas remain aggressive and lethal primary brain tumors in adults. (oncotarget.com)
  • This suggests that BK channel targeting might represent a novel approach to overcome radiation-induced spreading of malignant brain tumors during radiotherapy. (uni-regensburg.de)
  • In order to improve the tissue hypoxia in the tumor microenvironment, it is required to normalize very leaky and immature tumor vasculature. (nii.ac.jp)
  • The tumor microenvironment refers to the surrounding microenvironment in which tumor cells exist, including the surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, various signaling molecules, and extracellular matrix. (techscience.com)
  • Wang H , Han G , Chen J , . Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing. (aging-us.com)
  • Plenty of research had reported that the tumor immune microenvironment (TIME) impacts cancer progression and metastases, as well as affects patient prognoses and outcomes [ 6 , 7 ], which emphasizes the important role of immune cells, vital components of the tumor microenvironment, impacting on patient survival and tumor progression [ 8 , 9 ]. (aging-us.com)
  • Metastatic cells have acquired the abilities to break away from the primary tumor, translocate to distant sites in the body, and colonize a foreign microenvironment (4) . (aacrjournals.org)
  • 2 , 3 Tumor cell-derived exosomes carry particular molecular components originated from donor cells to mediate tumorigenesis and drive tumor progression by regulating tumor microenvironment. (dovepress.com)
  • Therefore, this study proves that Rh4 inhibits cancer cell proliferation by activating the ROS/p53 signaling pathway and activating autophagy to induce ferroptosis, which provides necessary scientific evidence of the great anticancer potential of Rh4. (hindawi.com)
  • Tumor-associated macrophages (TAMs) polarized to the M2 phenotype promote tumor cell proliferation and are associated with a poor prognosis in patients with high grade glioma. (spandidos-publications.com)
  • Furthermore, OA inhibited the proliferation of U373 human glioblastoma cells, and the activation of signal transducer and activator of transcription-3 (STAT3) in both human macrophages and glioblastoma cells. (spandidos-publications.com)
  • These results indicate that OA suppresses the M2 polarization of macrophages and tumor cell proliferation by inhibiting STAT3 activation. (spandidos-publications.com)
  • Fujiwara Y, Komohara Y, Kudo R, Tsurushima K, Ohnishi K, Ikeda T and Takeya M: Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3. (spandidos-publications.com)
  • It can inhibit the phosphorylation reaction through competing with adenosine triphosphate to bind to the catalytic region of the receptor tyrosine kinase, thereby blocking the down-proliferation signaling and inhibiting the activity of the tumor cell ligand-dependent HER-1/EGFR, thus achieving the inhibition of the proliferation of tumor cells. (lookchem.com)
  • This suggests the possibility that strictly regulated self-renewal mediated by Wnt signaling in cancer cells may be disturbed by the SUMOylation pathway to allow more malignant proliferation. (frontiersin.org)
  • Our previous studies have shown that the free fatty acid extract (FFAE) of krill oil inhibits the proliferation of both CRC and osteosarcoma cells, and induces the apoptosis of CRC cells [ 17 , 18 ]. (biomedcentral.com)
  • Chronic inflammation increases the risk of cancer and contributes to tumor development through the induction of oncogenic mutations, enhanced angiogenesis and early tumor promotion ( 7 ). (spandidos-publications.com)
  • The most common malignant glioma, known as glioblastoma (GBM), is characterized by necrosis, hypoxia, and extensive angiogenesis [ 2 ]. (oncotarget.com)
  • We describe areas where major inroads were initially achieved by targeting angiogenesis and by unraveling pathways in the heterogeneous tumors of mesenchymal origin-spurred by the identification of c-Kit-activating mutations in GIST and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec). (cancernetwork.com)
  • Here, in Part I, we describe areas where major inroads were initially achieved by targeting angiogenesis (central to the biology of renal cell carcinoma and hepatocellular cancer) and by unraveling pathways in the heterogeneous tumors of mesenchymal origin-spurred by the identification of c-Kit-activating mutations in gastrointestinal stromal tumors (GIST) and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec). (cancernetwork.com)
  • Literature suggests that the only known risk factor for extragonadal germ cell tumors (EGCTs) is Klinefelter syndrome (47XXY), which is associated with mediastinal nonseminomatous germ cell tumors. (medscape.com)
  • In extragonadal germ cell tumors, no evidence of a primary malignancy is present in either the testes or ovaries by radiologic imaging or physical examination. (medscape.com)
  • Extragonadal germ cell tumors produce a rich symptomatology and may reach large volumes if they arise in silent areas. (medscape.com)
  • Controversy remains regarding the origin of extragonadal germ cell tumors (EGGCTs). (medscape.com)
  • Some retroperitoneal extragonadal germ cell tumors may represent metastases from a testicular cancer , with subsequent spontaneous necrosis of the primary tumour. (medscape.com)
  • Pauniaho SL, Salonen J, Helminen M, Vettenranta K, Heikinheimo M, Heikinheimo O. The incidences of malignant gonadal and extragonadal germ cell tumors in males and females: a population-based study covering over 40 years in Finland. (cancercentrum.se)
  • Recent studies have identified overexpression of HER2 or epidermal growth factor receptor in some tumors and used this knowledge to develop successful approaches for therapeutic targeting of cancer cells (2) . (aacrjournals.org)
  • However, overexpression of HER2 and epidermal growth factor receptor is limited to a subset of tumors, which creates a need to identify other tyrosine kinases that are responsible for cancer progression and pathogenesis. (aacrjournals.org)
  • The epidermal growth factor receptor (EGFR) is frequently overexpressed in the most common malignant glioma, glioblastoma (GBM), and represents an important therapeutic target. (oncotarget.com)
  • Overexpression of the epidermal growth factor receptor (EGFR) associates with a range of cancers while downregulation of EGFR signalling can inhibit cancer growth. (biomedcentral.com)
  • Thus, treatment with L-Glu-L-Trp delayed aging rate and decreased spontaneous tumor incidence in rats. (nih.gov)
  • The incidence of primary malignant liver tumors per year is approximately 1.5 per million children in the United States. (medscape.com)
  • Abstract Non-small cell lung cancer (NSCLC) is a malignant tumor with high incidence worldwide. (techscience.com)
  • Incidence and occurrence of second primary tumors. (cancercentrum.se)
  • OBJECTIVE: Hepatoblastoma (HB) is the most common pediatric primary malignant liver tumor, its incidence has been increasing worldwide, but recent changes in incidence and outcomes with high population coverage are not well characterized. (cdc.gov)
  • Interestingly, stimulation of EphA2 reverses the malignant growth and invasiveness of EphA2-transformed cells. (aacrjournals.org)
  • Resveratrol, known as an anti-cancer agent, suppressed UV-induced malignant tumor progression in mice and resveratrol-inhibited invasiveness of human A431 SCC cells appears to occur, in part, through the Akt-mediated downregulation of TGF-beta2. (insidecosmeceuticals.com)
  • Sakashita K et al investigated the relationship between APOE and gastric cancer by immunohistochemistry and RT-PCR, and APOE overexpression in gastric cancer tissues exhibited stronger malignant invasiveness compared to cancer tissues with low APOE expression [ 10 ]. (jcancer.org)
  • Although several studies revealed the important role of immune cells and related marker genes impact on LUAD prognosis and process, a comprehensive understanding of TIME malignant and metastatic change in LUAD is still limited. (aging-us.com)
  • 8 , 9 The high-invasion and metastatic tendency of melanoma tumors complicates treatment of the malignancy. (dovepress.com)
  • However, malignant SFTs, which comprise 10%-15% of SFTs, not only aggressively infiltrate adjacent structures but are also capable of metastatic spread. (medscape.com)
  • In addition, ozone oxidizes the outer lipid layer of malignant cells and destroys them through cell lysis (break- down). (silvermedicine.org)
  • In terms of malignant transformation in cancer cells, interaction of cancer stem cells with endothelial cells or myofibroblasts as tumor microenvironmental cells was analyzed. (nii.ac.jp)
  • As a result, when tumor vasculature was focused, we found that cancer stem cells existing near myofibroblasts abundantly localizing at perivascular area show drug resistance. (nii.ac.jp)
  • Inhibiting LDH activity has an anti-proliferative effect on cancer cells (2). (rndsystems.com)
  • It may reverse the resistance of tumor cells to conventional chemo- and radiotherapy. (rndsystems.com)
  • Many cancers re-emerge after treatment, despite the sensitivity of the bulk of tumor cells to treatments. (mdpi.com)
  • This observation has led to the 'cancer stem cell' (CSCs) hypothesis, stating that a subpopulation of cancer cells survive therapy and lead to tumor relapse. (mdpi.com)
  • MiR mimics could inhibit proliferative, invasive migratory rates while promoting apoptotic rates of M4E and Hep2 cells. (hindawi.com)
  • The results demonstrated that PPII treatment significantly inhibited cancer cell migration and invasion, increased the expression level of E‑cadherin and decreased the levels of N‑cadherin, snail family transcriptional repressor 2, twist family bHLH transcription factor 1, matrix metallopeptidase (MMP) 2 and MMP9 compared with those in the control group (untreated cells). (spandidos-publications.com)
  • ECM gel can used with epithelial cells, endothelial cells, muscle cells, nerve cells and tumor cells. (sigmaaldrich.com)
  • ATO at non-cytotoxic level (1 μM) inhibited the migration and invasion of HNSCC cells by displacing zinc in the zinc finger motif of CLIP170, which is a key protein that controls microtubule dynamics. (nih.gov)
  • We also show that EphA2 overexpression is sufficient to confer malignant transformation and tumorigenic potential on nontransformed (MCF-10A) mammary epithelial cells. (aacrjournals.org)
  • When malignant cells metastasize to distant sites in the body, morbidity and mortality increase significantly (3) . (aacrjournals.org)
  • At the cellular level, malignant cells have overcome restraints on cell growth and migration that result from physical linkages and signals conveyed by cell-cell contacts (5) . (aacrjournals.org)
  • To identify tyrosine kinases that control tumor cell adhesion, we developed novel technologies to generate monoclonal antibodies against tyrosine kinases in cancer cells (8) . (aacrjournals.org)
  • GBM stem-like cells (GSCs) present in tumors are felt to be highly tumorigenic and responsible for tumor recurrence. (oncotarget.com)
  • GBM stem-like cells (GSCs) represent a subpopulation of the tumor which is responsible for tumor initiation, progression, and re-growth after chemoradiation [ 5 , 6 ], as well as supporting tumor vessel growth and function [ 7 ]. (oncotarget.com)
  • Concerning cancer etiology, it is widely held that the antigen structure of the tumor cells is the place where carcinogen works. (qigonginstitute.org)
  • However, it is certain that the antigen related to tumors is composed of cells and the product of cell metabolism, the affected cell membrane contains some antigens that do not possess strictly formulated particular embryos. (qigonginstitute.org)
  • 3. The anti-tumor mechanism of the human body is mainly performed by the immune function of the cells. (qigonginstitute.org)
  • In addition, U-87MG-Katushka cells were grown to solid glioblastomas in the right hemispheres of immunocompromised mice, fractionated irradiated (6 MV photons) with 5 x 0 or 5 x 2 Gy, and SDF-1, CXCR4, and BK protein expression by the tumor as well as glioblastoma brain infiltration was analyzed in dependence on BK channel targeting by systemic paxilline application concomitant to IR. (uni-regensburg.de)
  • APOE level was significantly correlated with tumor-infiltrating cells (B cells, CD8+ T cells, neutrophils, and dendritic) and immune biomarkers in PTC. (jcancer.org)
  • As has often been the case, hematologic malignancies have led the way in the introduction of this new generation of therapeutics-perhaps because of easy access to tumor samples for pharmacodynamics, and the narrow spectrum of cells of origin. (cancernetwork.com)
  • So tumor cells-derived exosomes. (dovepress.com)
  • 10 High expression of miR-21 in melanoma cells inhibits mRNA expression of crucial tumor suppressor proteins such as the tissue inhibitor of metalloproteinases 3 (TIMP3). (dovepress.com)
  • SOX9 depletion also suppressed the formation of cancer stem-like cells (CSCs), as determined by tumor sphere formation and aldehyde dehydrogenase (ALDH) activity (Aldefluor) assays. (cdc.gov)
  • This in turn attracts inflammatory cells that may be associated with malignant transformation but also with tumor regression. (lu.se)
  • function of several poorly characterized proteins expressed in tumor cells and which are structurally related to known complement inhibitors but also suggested to act as tumor suppressors. (lu.se)
  • The classic theory suggests that germ cell tumors (GCTs) in these areas are derived from local transformation of primordial germ cells misplaced during embryogenesis. (medscape.com)
  • Malignant transformation of germ cells is the result of a multistep process of genetic changes. (medscape.com)
  • Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. (cancercentrum.se)
  • Tumors fall into two categories: 'benign' tumors and ' malignant ,' or cancerous, tumors. (medicinenet.com)
  • 8 weeks, adults and adolescents must undergo nasopharyngeal examination to exclude malignant or benign tumors. (msdmanuals.com)
  • MiR-29a-3p was enriched in hBMSC-derived Exo, and the Exo from miR-29a-3p mimics transfected hBMSCs could inhibit laryngocarcinoma cell malignant phenotypes in vitro and prevent tumor progression in vivo . (hindawi.com)
  • NDV/Anh-EGFP can significantly inhibit hepatocarcinoma development in vitro and in vivo. (usda.gov)
  • Indeed, SOX9 knockdown inhibited anchorage-independent cell growth in vitro and lung colonization in vivo in a mouse xenograft model. (cdc.gov)
  • For each cancer discussed in the first part of our overview, as well as in Part II, which will deal with more common cancers, we briefly cover the tumor biology, how targeting was achieved, the introduction of immune modulation or immune-conjugates, and the impact these therapies are having in the disease. (cancernetwork.com)
  • Nonmesotheliomatous cancers of the pleura include an assortment of malignant neoplasms that primarily or secondarily involve pleura. (medscape.com)
  • More recently, the successes in the treatment of the notoriously refractory malignant melanoma via the targeting of a specific BRAF mutation and via immune activation represent an unprecedented achievement of this new therapeutic direction. (cancernetwork.com)
  • Malignant melanoma is a highly aggressive tumor type, in which Wnt signaling is essential. (lu.se)
  • Activation of the non-canonical Wnt signaling pathway via Wnt5a has been correlated with increased migration and invasion as well as a poor prognosis in malignant melanoma patients. (lu.se)
  • In this thesis, we investigate different processes downstream of Wnt5a that can lead to increased aggressiveness of malignant melanoma. (lu.se)
  • Our studies show that the secreted Wnt modulator, SFRP3 is down-regulated in malignant melanoma patients. (lu.se)
  • Using melanocyte and malignant melanoma cell lines, we demonstrate that the down-regulation is due to methylation. (lu.se)
  • Furthermore, by analyzing the effects of Wnt5a on the malignant melanoma proteome, we provide evidence for a cell context dependent reprogramming of cellular metabolism induced by Wnt5a. (lu.se)
  • This thesis highlights the complexity of Wnt signaling in general and Wnt5a signaling in melanoma in particular and extends our knowledge of the mechanisms behind progression of malignant melanoma. (lu.se)
  • We study how these proteins are related to tumor development in breast, prostate and melanoma cancer models. (lu.se)
  • For example, while TIPE is primarily associated with tumor progression and antitumor drug resistance, TIPE1 suppresses tumor progression in most instances. (techscience.com)
  • OA significantly inhibited the expression of CD163, one of the phenotype markers of M2 macrophages, as well as suppressed the secretion of IL-10, one of the anti-inflammatory cytokines preferentially produced by M2 macrophages, thus suggesting that OA suppresses the M2 polarization of macrophages. (spandidos-publications.com)
  • NDV/Anh-EGFP significantly inhibited liver cancer development both in cancer cell lines and in mice. (usda.gov)
  • Results: DMC significantly reduced tumor weights and volumes of HeLa cell xenografts in mice, indicating the suppression of growth of xenograft tumors. (iiarjournals.org)
  • According to the World Cancer Report, colorectal cancer (CRC) is one of the most dangerous malignant tumors in humans. (hindawi.com)
  • As a common malignant tumor in the upper respiratory tract, laryngocarcinoma accounts for approximately 25 to 30% of cancer cases worldwide [ 1 , 2 ]. (hindawi.com)
  • Hepatocellular carcinoma, known as liver cancer, is the most common life-killing tumors in the world. (usda.gov)
  • The cancer cell multiplies, and a cancerous or malignant tumor develops. (medicinenet.com)
  • Gefitinib is a kind of highly-specific anti-tumor targeted therapy drugs developed by the United Kingdom AstraZeneca, being the first molecular targeted drug for the treatment of non-small cell lung cancer. (lookchem.com)
  • Malignant gliomas remain a deadly form of brain cancer with a poor prognosis despite surgery, chemotherapy, and ionizing radiation [ 1 ]. (oncotarget.com)
  • This article presents a study on the unique effect of qigong in helping patients survive some difficult diseases, especially a study over the anti-tumor mechanism of qigong on the basis of a selection of 104 cases of different cancer patients, e.g. esophagus cancer, stomach cancer, rectum cancer, lung cancer, adenocarcinoma of breast, etc. (qigonginstitute.org)
  • however, the treatment of patients with cervical cancer depends on the cancer stage and tumor location according to diagnosis and characteristics of the patients ( 7 , 8 ). (iiarjournals.org)
  • Ovarian granulosa cell tumor and increased risk of breast cancer. (cancercentrum.se)
  • These data support a model whereby activating MLLT1 mutations early in renal development result in the development of Wilms tumour. (nature.com)
  • We report in-frame insertion/deletion MLLT1 mutations in FHWT that are absent in other TARGET paediatric tumour types. (nature.com)
  • We conclude that activating MLLT1 mutations accompanied by Wnt activation early in renal development result in the development of Wilms tumour. (nature.com)
  • Elevated levels of protein tyrosine phosphorylation contribute to a malignant phenotype, although the tyrosine kinases that are responsible for this signaling remain largely unknown. (aacrjournals.org)
  • Our results suggest that tumor-derived exosomes may facilitate stromal fibroblasts an aggressive phenotype to equip the tumor progression. (dovepress.com)
  • Ozone administered at a concentration of between 30 and 55 ug/cc causes the greatest increase in the production of interferon and the greatest output of tumor necrosis factor (TNF) and interleukin 2. (silvermedicine.org)
  • Abstract The multiple roles of the tumor necrosis factor (TNF)-α-inducible protein 8 (TNFAIP8), also named TIPE family of proteins have been shown in tumor and inflammation progression and regulation of cellular autophagy and apoptosis. (techscience.com)
  • This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
  • Therefore, cell pyroptosis is closely related to the immune process, but it is also essential for tumor development. (nature.com)
  • On the other hand, human immunity against tumor is mainly performed by the cell immune function in the body. (qigonginstitute.org)
  • Geng et al suggested that APOE modulated immune response by inhibiting antigen-activated lymphocytes [ 9 ]. (jcancer.org)
  • Also, complement is currently undergoing re-appreciation of its role in the immune surveillance of tumors. (lu.se)
  • Wilms tumour is an embryonal tumour of childhood that closely resembles the developing kidney. (nature.com)
  • Wilms tumour (WT), the most common embryonal neoplasm of the childhood kidney, has long intrigued investigators by its histologic similarity to the developing kidney 1 . (nature.com)
  • the full TARGET high-risk Wilms tumour data, including 125 tumours (both favourable histology and anaplastic tumours) and including verified variants present at lower frequencies, will be reported in full when these data become available. (nature.com)
  • Of these malignant tumors, hepatoblastoma (HB) and hepatocellular carcinoma (HCC) are the most common and account for over two thirds of all hepatic neoplasms. (medscape.com)
  • Is the Subject Area "Lung and intrathoracic tumors" applicable to this article? (plos.org)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • Although some mechanisms through which TP inhibits NSCLC are well understood, those that involve ribosomal proteins remain yet to be understood. (techscience.com)
  • The distinction among these various tumors is important both clinically and epidemiologically. (medscape.com)
  • Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary. (cancercentrum.se)
  • mdm2 sequesters p53 and inhibits its function as G1-S checkpoint controller and apoptosis inducer. (medscape.com)
  • It is known that arsenic trioxide (ATO) is able to inhibit the migration and invasion of solid malignant tumors, but its exact molecular mechanism remains unclear. (nih.gov)
  • Role of tumor-derived exosomal miR-21 in cell invasion was determined by qPCR. (dovepress.com)
  • Functional studies show that SFRP3 can inhibit Wnt5a signaling and induce a decrease in migration and invasion. (lu.se)
  • This yields a relative low rate for hepatic tumors (1.3% of all pediatric malignancies in children under the age of 19 years of age). (medscape.com)
  • Hematologic malignancies are frequently associated with mediastinal germ cell tumors. (medscape.com)
  • Mayr D, Hirschmann A, Marlow S, Horvath C, Diebold J. Analysis of selected oncogenes (AKT1, FOS, BCL2L2, TGFbeta) on chromosome 14 in granulosa cell tumors (GCTs): a comprehensive study on 30 GCTs combining comparative genomic hybridization (CGH) and fluorescence-in situ-hybridization (FISH). (cancercentrum.se)
  • CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)
  • Paragangliomas and pheochromocytomas are typically considered an undetermined tumor type, meaning they can be noncancerous (benign) or become cancerous (malignant) and spread to other parts of the body (metastasize). (medlineplus.gov)
  • According to this theory, the differences in phenotypes expressed by mediastinal germ cell tumors (MGCTs) and gonadal germ cell tumors may be explained by differences in the cellular environment between the gonad and the anterior mediastinum. (medscape.com)
  • In fungi, ozone inhibits cell growth at certain stages. (silvermedicine.org)
  • Hereditary paraganglioma-pheochromocytoma is an inherited condition characterized by the growth of tumors in structures called paraganglia. (medlineplus.gov)
  • Hemangiomas are the most common benign liver tumors in children and commonly occur within the first 6 months of life. (medscape.com)
  • It's up regulation is common in many malignant tumors. (rndsystems.com)
  • Hepatocellular carcinoma remains one of the most common malignant tumors in the world. (usda.gov)
  • Compared with solid tumor sampling, the bone marrow or peripheral blood of leukemia patients is easier to access, and therefore an accurate and practical prognostic signature for leukemia patients has potential for more direct clinical application. (nature.com)
  • 2014). genetic StudieS are carried out, uSing tuMour SaMPleS froM PatientS with excellent clinical data that have been collected at a PoPulation level or internationally, to Provide unique data coMbining the Pathology, geneticS, clinical featureS, and ePideMiology of tuMourS. (who.int)
  • Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. (cancercentrum.se)
  • Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. (cancercentrum.se)
  • In conclusion, hBMSC-derived Exo with upregulated miR-29a-3p inhibited laryngocarcinoma progression via regulating PTEN, providing a potential diagnostic and therapeutic target in this disease. (hindawi.com)
  • Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
  • The effect of dipeptide on survival, life span and spontaneous tumor development was studied in female rats. (nih.gov)
  • Benign liver tumors include hepatocellular adenomas (HCAs), hemangiomas , hamartomas, and focal nodular hyperplasia (FNH). (medscape.com)
  • Synovial sarcoma is a malignant soft-tissue neoplasm that most commonly affects the extremities near to, but not in continuity with, large joints. (medscape.com)
  • In this experiment, we found that apelin normalizes tumor vasculature, resulting in improvement of drug delivery and tumor immunity. (nii.ac.jp)
  • Tumors of the liver may be either malignant or benign. (medscape.com)
  • Most children with liver tumors present with abdominal distension, a palpable abdominal mass, or both. (medscape.com)
  • Benign lesions in children represent 30% of hepatic tumors and are most commonly vascular in origin (eg, hemangiomas, hemangioendotheliomas). (medscape.com)
  • The experimental evidence is being accumulated to show opposing roles of complement in tumor control. (lu.se)