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  • tumor
  • Interestingly, Hsp90 inhibitors accumulate in cancerous tissue when compared to healthy control tissue [ 13 , 14 ], and accumulation in disease tissue appears to be caused by an increase in active Hsp90 protein complexes in tumor tissue, which have a greater affinity for ATP and thusly inhibitor binding [ 15 ]. (impactjournals.com)
  • Background: Vascular endothelial growth inhibitor (VEGI) is a member of the tumor necrosis factor superfamily, identified as an anti-angiogenic cytokine. (cf.ac.uk)
  • Conclusion: Our findings indicate that VEGI174 prevents progression and tumor metastasis through inhibiting EMT in RCC in vivo. (cf.ac.uk)
  • complexes
  • The broad range of cellular functions for p97 is thought to derive from its ability to unfold proteins or disassemble protein complexes, but the detailed mechanism of how p97 works and is linked to specific cellular processes remains largely unknown. (pnas.org)
  • genes
  • 1. the RAG genes and RSSs were originally a transposon, and the RAG proteins had transposase activity. (antievolution.org)
  • Genes encoding proteins underlying host-pathogen co-evolution and which are selected for new resistance specificities frequently are under positive selection, a process that maintains diversity. (biomedcentral.com)
  • Molecular evolution analyses of genes involved in pattern triggered immunity (PTI) and effector triggered immunity (ETI) have shown that those encoding proteins involved in host-pathogen interactions frequently have a higher proportion of non-synonymous to synonymous substitutions. (biomedcentral.com)
  • ubiquitin
  • The mechanochemical activity of p97 is linked to substrate proteins by an array of 13 UBX (ubiquitin regulatory X) domain adapters that bind the N-terminal domain of p97 ( 17 ), as well as the non-UBX domain adaptors Ufd1 and Npl4 ( 18 ). (pnas.org)
  • Whereas all UBX proteins interact with p97, only those containing a ubiquitin-associated domain associate with ubiquitin conjugates ( 19 ). (pnas.org)
  • hepatic
  • Effective at lowering low-density lipoprotein-cholesterol (LDL-C), these inhibitors also elevate liver enzymes and induce hepatic steatosis in animals and humans. (aspetjournals.org)
  • When coadministered with tyloxapol, SLx-4090 did not inhibit the secretion of hepatic triglycerides (TG), consistent with the absence of systemic exposure. (aspetjournals.org)
  • inflammatory
  • The Rel/nuclear factor-κB (Rel/NF-κB) proteins comprise a family of transcription factors, which is conserved from Drosophila to humans and regulates a variety of physiological aspects of immune and inflammatory responses. (bloodjournal.org)
  • Interactions
  • This led us to the idea that expression of this protein in potato plants may alter the host: pathogen interactions through binding to the host cellulose molecules, proving a potential shield from pathogen endoglucanases, or conversely, binding to Phytophthora hyphae, providing a shield from host endoglucanases. (biomedcentral.com)
  • The N- and C-terminal regions are the least conserved, and may be involved in interactions with different protein partners. (ebi.ac.uk)
  • HCNP
  • Other PEBP-like proteins that show strong structural homology to PEBP include Escherichia coli YBHB and YBCL, the Rattus norvegicus (Rat) neuropeptide HCNP, and Antirrhinum majus (Garden snapdragon) protein centroradialis (CEN). (ebi.ac.uk)
  • interaction
  • Although the p38 inhibitor PD169316 did not directly kill MM cells, it potentiated the apoptotic effect of SN50, suggesting an interaction between the p38 and NF-κB pathways. (bloodjournal.org)
  • In most cell types, NF-κB is present constitutively in the cytosol in a latent, inactive form where it is retained through its interaction with inhibitory IκB (inhibitor of NF-κB) proteins, masking its nuclear localization sequence. (bloodjournal.org)
  • Centromere-associated protein-E (CENP-E) is a kinetochore-associated mitotic kinesin that is thought to function as the key receptor responsible for mitotic checkpoint signal transduction after interaction with spindle microtubules. (pnas.org)
  • Unlike these KSP inhibitors, which block release of ADP and destabilize motor-microtubule interaction, GSK923295 inhibited release of inorganic phosphate and stabilized CENP-E motor domain interaction with microtubules. (pnas.org)
  • catalytic
  • Protein kinases are a group of enzymes that possess a catalytic subunit that transfers the gamma (terminal)phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. (slideshare.net)
  • shows a three-domain protein in which the catalytic domain is the middle one. (ebi.ac.uk)
  • progression
  • Here, we investigated the function of FBL17 (F BOX-LIKE17), an Arabidopsis thaliana F-box protein previously shown to govern the progression through the second mitosis during pollen development. (plantcell.org)
  • homologues
  • as for the SH2-containing proteins, i should point out that homologues for syk and ZAP70 have been discovered in organisms as distant as hydra , and as similar (to tunicates) as sea urchin . (antievolution.org)
  • Cell
  • Regulator of G protein signaling 20 enhances cancer cell aggregation, migration, invasion and adhesion. (semanticscholar.org)
  • This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. (wikipedia.org)
  • Altogether, these data indicate that the F-box protein FBL17 acts as a master cell cycle regulator during the diploid sporophyte phase of the plant. (plantcell.org)
  • Within the CBD families, there are a few examples of CBDs that are present as independent proteins, often associated with the cell wall. (biomedcentral.com)
  • The P. infestans CBD 1 protein is found tightly associated with the cellulose-containing hyphal cell wall, and may play a role in assembly and/or integrity of the cell wall. (biomedcentral.com)
  • family
  • MTP and apoB belong to the vitellogenin family of lipid transfer proteins. (aspetjournals.org)
  • Protein fold of the peptidase unit for members of this family resembles that of thermolysin, the type example for clan MA. (ebi.ac.uk)
  • In comparison to smaller families encoding pathogenesis-related (PR) proteins under positive selection, DEFLs are involved in a wide variety of processes that altogether might pose structural and functional trade-offs to their family-wide pattern of evolution. (biomedcentral.com)