• PPARgamma and RB were shown to coimmunoprecipitate, and this PPARgamma-RB complex also contains the histone deacetylase HDAC3, thereby attenuating PPARgamma's capacity to drive gene expression and adipocyte differentiation. (epfl.ch)
  • In vitro, 5-ITu potently inhibited Haspin but not Aurora B. Consistently, 5-ITu counteracted the centromeric localization of the CPC without affecting the bulk of Aurora B activity in HeLa cells. (rupress.org)
  • Tsukahara T, Haniu H, Matsuda Y. Cyclic Phosphatidic Acid Inhibits Alkyl-Glycerophosphate-Induced Downregulation of Histone Deacetylase 2 Expression and Suppresses the Inflammatory Response in Human Coronary Artery Endothelial Cells. (medsci.org)
  • however, this effect was inhibited when HCAECs were cotreated with cPA or the synthetic peroxisome proliferator-activator receptor gamma (PPARγ) antagonist T0070907. (medsci.org)
  • By phosphorylating Thr3 of histone H3, Haspin promotes centromeric recruitment of the chromosome passenger complex (CPC) during mitosis. (rupress.org)
  • The hydroximic acid derivative BGP-15 is a small (350 Da) multi-target molecule, which intercalates into membranes and stabilizes their lipid rafts, reduces the levels of reactive oxygen species by enhancing mitochondrial efficiency, and inhibits both poly(adenosine 5′-diphosphate)-ribose]polymerase 1 (PARP-1) and tumour necrosis factor-α-induced pathways (Chung et al. (springer.com)
  • We previously demonstrated that the RNA polymerase II mediator components cyclin C - Cdk8p inhibit locus-specific H3Lys4 3me independently of Jhd2p . (g3journal.org)