• Re-replication and genome instability ensue if licensing occurs after DNA synthesis has started. (biorxiv.org)
  • Here, using quantitative microscopy, we show that Cdt1 inhibits DNA synthesis during an overlap period when cells fire origins while Cdt1 is still present. (biorxiv.org)
  • Cdt1 inhibits DNA synthesis by suppressing CMG helicase progression at replication forks through the MCM-binding domain of Cdt1, and DNA synthesis commences once Cdt1 is degraded. (biorxiv.org)
  • Thus, instead of separating licensing from firing to prevent re-replication in early S phase, cells separate licensing from DNA synthesis through Cdt1-mediated inhibition of CMG helicase after firing. (biorxiv.org)
  • Quinolones inhibit two enzymes that are required for bacterial DNA synthesis, i.e. (cdc.gov)
  • Azathioprine antagonizes purine metabolism and inhibits synthesis of DNA, RNA, and proteins. (medscape.com)
  • Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. (ebi.ac.uk)
  • These results show that membrane damage by NMDA is preceded by inhibition of phospholipid synthesis and not by phospholipid degradation in the early stages of the excitotoxic process, and that NMDA receptor overactivation decreases phosphatidylcholine and phosphatidylethanolamine synthesis by inhibiting choline-ethanolaminophosphotransferase activity. (jneurosci.org)
  • Inhibition of DNA synthesis by chromium compounds. (cdc.gov)
  • The effects of hexavalent and trivalent chromium (7440473) (Cr) on DNA synthesis were studied in-vitro. (cdc.gov)
  • The effects on DNA synthesis were evaluated by measuring uptake of tritium labeled thymidine. (cdc.gov)
  • The effects on DNA synthesis were determined as before. (cdc.gov)
  • Cr+6 caused a dose dependent inhibition of DNA synthesis in intact L-cells. (cdc.gov)
  • The inhibitory effect was irreversible as removal of the Cr+6 from the medium did not result in the level of DNA synthesis returning to the control value. (cdc.gov)
  • Cr+3 did not inhibit DNA synthesis. (cdc.gov)
  • Both Cr+3 and Cr+6 inhibited DNA synthesis to about the same extent in Triton-X-100 permeabilized cells. (cdc.gov)
  • Cr+3 inhibited DNA synthesis in the DNA/DNA-polymerase system biphasically. (cdc.gov)
  • Cr+6 caused a weak monophasic inhibition of DNA synthesis. (cdc.gov)
  • they inhibit bacterial DNA-dependent RNA polymerase, suppressing RNA synthesis. (msdmanuals.com)
  • by binding to the 50S subunit of the ribosome, they inhibit bacterial protein synthesis. (msdmanuals.com)
  • Their binding to DNA inhibits synthesis of nucleic acids. (bvsalud.org)
  • AVM induced the release of cleaved PARP and cleaved caspase‑3 caused apoptosis and inhibited the viability of these cells. (spandidos-publications.com)
  • It is thus concluded that AVM inhibits the activity of BCR/ABL and their subsequent molecular signals, including AKT and MAPK, resulting in cytotoxicity via apoptosis. (spandidos-publications.com)
  • This resulted in significantly decreased levels of BUN and creatinine in RKI mice , as well as reduced renal tubular and glomerular damage, lower apoptosis rate, decreased DNA damage index (8-OHdG), and increased levels of antioxidant factors associated with oxidative stress (SOD, CAT , GSH, GPx). (bvsalud.org)
  • The results demonstrated that TEOA inhibited proliferation and induced apoptosis in time-and dose-dependent manners. (figshare.com)
  • The aim of this study was to investigate whether resveratrol (RSV) could ameliorate ischemia- and hypoxia-associated cardiomyocyte apoptosis and injury via inhibiting senescence signaling and inflammasome activation. (hindawi.com)
  • RSV inhibited the expression of senescence markers (p53, p16, and p19), inflammasome markers (NLRP3 and Cas1 p20), and nuclear translocation of NF- κ B, hence alleviating infarction area, fibrosis, and cell apoptosis. (hindawi.com)
  • DNA damage caused by exposure of pBR322 to Cr(VI)-UV is markedly inhibited by both extracts in varying degrees. (vit.ac.in)
  • In addition, Jaxson cites a Swedish study of how researchers analyzed "key checkpoint proteins" in the BRCA1 and 53BP1 regeneration pathways and "found that the spike protein markedly inhibited both BRCA1 and 53BP1 foci formation. (mediaverse.news)
  • AA and the extracellular regulated protein kinase 1/2 (ERK1/2) blocker U0126 markedly inhibited migration, elevated smooth muscle 22 α (SM22 α ) expression, repressed VSMC proliferation, elevated miR-466f-3p and miR-425-3p expression, and suppressed miR-27a-5p and miR-128-5p expression in ox-LDL-induced VSMCs. (hindawi.com)
  • Two relevant DNA repair mechanisms involves enzymes that are compared to "repair workers" as in those pf nucleus of a cell. (mediaverse.news)
  • The targets of quinolone activity are the bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. (cdc.gov)
  • To prevent this, the DNA solution volume added to the reaction for these enzymes should be no more than 25% of total reaction volume. (neb.com)
  • Some enzymes may bind tightly to the substrate DNA. (neb.com)
  • Time-Saver qualified enzymes can cut substrate DNA in 5-15 minutes and safely digest overnight. (neb.com)
  • NEB began switching our BSA-containing reaction buffers in April 2021 to buffers containing Recombinant Albumin (rAlbumin) for restriction enzymes and some DNA modifying enzymes. (neb.com)
  • Recent studies have demonstrated the potential of pesticides to either inhibit or induce xenobiotic metabolizing enzymes in humans. (cdc.gov)
  • In previous research, the authors demonstrated that the methanol extract of Artemisia vulgaris (AVM) has the ability to inhibit chronic myeloid leukemia (CML) cell proliferation. (spandidos-publications.com)
  • Antineoplastic agents inhibit cell growth and proliferation. (medscape.com)
  • A substance that inhibits or prevents the proliferation of neoplasms. (ebi.ac.uk)
  • Our research showed that the migration, phenotypic transformation, and proliferation of ox-LDL-induced VSMCs were repressed by AA through inhibiting miR-128-5p by targeting the p21 gene, which may provide an effective option for the treatment of atherosclerosis. (hindawi.com)
  • Several studies have shown that miRNAs play multiple roles in the phenotypic transformation, migration, and proliferation of VSMCs by inhibiting ERK1/2 activation [ 11 , 12 ], partly by regulating the tissue inhibitor of metalloproteinases (TIMPs)-MMPs and p21-cyclins interactions [ 13 - 18 ]. (hindawi.com)
  • If an enzyme is sensitive to bacterial methylation you may need to grow the substrate DNA in a methylation-deficient bacterial strain. (neb.com)
  • This inhibits the formation of the membrane attack complex (C5b-C9), which prevents membrane damage and bacterial cell death. (medscape.com)
  • If a cell is treated with a substance that inhibits DNA polymerase activity, what stage of the cell cycle is most likely to be affected? (mcatquestionoftheday.com)
  • Here, we report positional cloning of Pairing homoeologous 2 (Ph2) and functional validation of the wheat DNA mismatch repair protein MSH7-3D as a key inhibitor of homoeologous recombination, thus solving a half-century-old question. (nature.com)
  • Here, by using an in vitro cell line, we report that the SARS-CoV-2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. (aquarius-technologies.de)
  • Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. (aquarius-technologies.de)
  • To provide a reasonable answer to this question, the authors "report that the SARS-CoV-2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. (mediaverse.news)
  • Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair," they wrote. (mediaverse.news)
  • Together, our work explains how Retro-2 prevents retrograde trafficking of toxins by inhibiting TA-protein targeting, describes a general CRISPR strategy for predicting the MOA of small molecules, and paves the way for drugging the TRC pathway to treat broad classes of viruses known to be inhibited by Retro-2. (elifesciences.org)
  • Protein activation and expression were analysed by western blotting, deoxyribonucleoside triphosphate levels by HPLC, ribonucleotide reductase activity by 14 C-cytidine incorporation into nascent DNA and cell-cycle distribution by FACS. (nature.com)
  • Scientists from two major Swedish universities recently released a worrisome paper that used a series of complex scientific techniques to look for the full-length coronavirus spike protein (the one the mRNA and DNA/AAV vaccines cause your body to produce) inside the nucleus of our cells. (techstartups.com)
  • As part of their research, they also examine how the spike protein might impact the repair of damaged DNA in the nucleus. (techstartups.com)
  • During their study, the two scientists found that the spike protein appeared to interfere with our own DNA repair proteins: "Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. (techstartups.com)
  • Together, these data demonstrate that the spike protein directly affects DNA repair in the nucleus . (techstartups.com)
  • Viruses are small particles of genetic material (either DNA or RNA) that are surrounded by a protein coat. (medicinenet.com)
  • A fundamental concept in eukaryotic DNA replication is the temporal separation of G1 origin licensing from S phase origin firing. (biorxiv.org)
  • DNA polymerase is the enzyme involved with bringing DNA nucleotides into place during DNA replication. (mcatquestionoftheday.com)
  • Alpha interferon inhibits hepatitis C virus replication in primary human hepatocytes infected in vitro. (microbiologyresearch.org)
  • Taken together, these data indicate that miR-31 suppresses medulloblastoma tumorigenesis by negatively regulating DNA replication via MCM2. (oncotarget.com)
  • Negative supercoiling of DNA by gyrase is inhibited in Salmonella enterica serovar Typhimurium during adaptation to acid stress. (jic.ac.uk)
  • Inhibiting ATP binding by DNA gyrase and topo IV with novobiocin enhanced the effect of low pH on DNA relaxation. (jic.ac.uk)
  • Bacteria expressing novobiocin-resistant (NovR) derivatives of gyrase or topo IV also exhibited DNA relaxation at acid pH, although further relaxation with novobiocin was not seen in the strain with NovRgyrase. (jic.ac.uk)
  • Thus, inhibition of the negative supercoiling activity of gyrase was the primary cause of enhanced DNA relaxation in drug-treated bacteria. (jic.ac.uk)
  • The Salmonella cytosol reaches pH 5-6 in response to an external pH of 4-5: the ATP-dependent DNA supercoiling activity of purified gyrase was progressively inhibited by lowering the pH in this range, as was the ATP-dependent DNA relaxation activity of topo IV. (jic.ac.uk)
  • We propose that DNA relaxation in Salmonella within macrophage is due to acid-mediated impairment of the negative supercoiling activity of gyrase. (jic.ac.uk)
  • DNA gyrase and topoisomerase IV. (cdc.gov)
  • DNA purification procedures that use spin columns can result in high salt levels, which can inhibit enzyme activity. (neb.com)
  • PCR components can inhibit enzyme activity. (neb.com)
  • Curcumol treatment was identified to increase miR‑30a‑5p expression and to activate the Hippo signaling pathway, which in turn inhibited the invasion and migration of CRC cells. (spandidos-publications.com)
  • DNA methyltransferases mediate DNA methylation on the DERARE, leading to reduced Hoxb cluster expression. (nih.gov)
  • CRISPR-Cas9-mediated specific DNA methylation at DERARE attenuated HOXB expression and alleviated leukemogenesis. (nih.gov)
  • Two nucleoside inhibitors of DNA methylation, azacitidine and decitabine, are now standard of care for the treatment of the myelodysplastic syndrome, a deadly form of leukemia. (aacrjournals.org)
  • These old drugs, developed as cytotoxic agents and nearly abandoned decades ago were resurrected by the renewed interest in DNA methylation. (aacrjournals.org)
  • The epigenetic potential of DNA methylation inhibitors may be limited by other epigenetic mechanisms that are also worth exploring as therapeutic targets. (aacrjournals.org)
  • Multiple mechanisms have evolved to perform these essential functions: DNA methylation, a bewildering array of histone modifications, RNA-based regulation, etc. (aacrjournals.org)
  • Specifically, Mason and his team found an increase in methylation, which involves slapping methyl groups onto stretches of DNA. (scientificamerican.com)
  • In summary, this study shows that Hcy can activate autophagy by inhibiting DNMT3b-mediated DNA methylation and upregulating TFEB expression. (lu.se)
  • Cytosine-phosphate-guanine oligodeoxynucleotides alleviate radiation-induced kidney injury in cervical cancer by inhibiting DNA damage and oxidative stress through blockade of PARP1/XRCC1 axis. (bvsalud.org)
  • CpG-ODNs may alleviate RKI by inhibiting DNA damage and oxidative stress levels. (bvsalud.org)
  • CpG-ODNs mediated the inhibition of PARP1, thereby suppressing DNA damage and oxidative stress response in vitro in HK-2 cells . (bvsalud.org)
  • Additionally, PARP1 promoted the formation of the PARP1 and XRCC1 complex by recruiting XRCC1, which in turn facilitated DNA damage and oxidative stress response in renal tubular cells . (bvsalud.org)
  • Overexpression of either PARP1 or XRCC1 reversed the inhibitory effects of CpG-ODN2006 on DNA damage and oxidative stress in the HK-2 cell model and RKI mouse model. (bvsalud.org)
  • CpG-ODNs may mitigate cervical cancer RKI by blocking the activation of the PARP1/XRCC1 signaling axis, inhibiting DNA damage and oxidative stress response in renal tubule epithelial cells . (bvsalud.org)
  • Here, we show that the genomic region surrounding human miR-31 at 9p21.3 is frequently deleted in many solid tumor cell lines, and reintroducing miR-31 into DAOY cells, a line of human medulloblastoma cells devoid of miR-31, strongly suppresses cell growth, causes cell cycle arrest at the G1/S boundary, and inhibits colony formation in vitro and xenograft tumorigenesis in nude mice. (oncotarget.com)
  • The study, titled "SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro," was published by the Department of Molecular Biosciences at Stockholm University. (mediaverse.news)
  • Our findings revealed that RSV protected against ischemia-induced mouse heart injury in vivo and hypoxia-induced NRCM injury in vitro via regulating Sirt1/p53-mediated cell senescence and inhibiting NLRP3-mediated inflammasome activation. (hindawi.com)
  • It was determined that IFN- α 2b specifically inhibited the translation of GFP mediated by IRES sequences from six major HCV genotypes in a concentration-dependent manner. (microbiologyresearch.org)
  • Myc proteins are basic helix-loop-helix/ leucine-zipper proteins that bind to specific DNA sequences. (uu.nl)
  • The Committee concluded that additional work may be needed to assess the viability of the stocks held in VECTOR, and that further molecular characterization of additional strains may be valuable in helping to identify strains from which further DNA sequences could be determined. (who.int)
  • Now, one of the reasons we do speculate on tap water as a source was a separate study that occurred in the Netherlands where they identified DNA sequences that indicated the same species as Mycobacterium franklinii from tap and shower water. (cdc.gov)
  • MTT, Transwell, scratch, western blotting and reverse transcription‑quantitative PCR assays were performed to examine how curcumol inhibited CRC cell viability, invasion and migration, and to detect the role of miR‑30a‑5p and curcumol in the invasion and Hippo signaling pathways of CRC cells. (spandidos-publications.com)
  • In previous research, the authors demonstrated that the methanol extract of A. vulgaris (AVM) has the ability to inhibit the viability of CML cells ( 10 ). (spandidos-publications.com)
  • Using a luciferase trasnfection assay, various cell lines were transfected with luciferase DNA in the presence or absence of Zot. (utmb.edu)
  • Vitamin C was analysed at each time point by HPLC, whereas H 2 O 2 -induced MNBC DNA damage was evaluated at 0, 3 and 24 h by means of the comet assay. (cambridge.org)
  • Exposure of human hepatocytes to doses of fipronil (5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl) sulfinyl]-1H-pyrazole-3-carbonitrile) ranging from 0.1 to 25 µM resulted in a dose dependent increase in CYP1A1 mRNA expression (3.5 to approximately 55-fold) as measured by the branched DNA assay. (cdc.gov)
  • False-negative results may be obtained for specimens containing low numbers of M. tuberculosis or substances inhibiting the assay. (cdc.gov)
  • Usurping these processes to deregulate functional pathways is likely simpler than generating mutations or chromosomal aberrations (unless DNA repair is deficient and genetic instability is present). (aacrjournals.org)
  • mutant of Max, named dMax, that inhibits sequence-specific DNA binding of Myc proteins. (uu.nl)
  • This prevents many different DNA-binding proteins from being present in the same reaction, competing for the same substrate. (neb.com)
  • and Fe3+, and in inhibiting lipid peroxidation. (vit.ac.in)
  • Here, our transcriptome and DNA methylome analyses revealed that Hoxb cluster and retinoid signaling genes are predominantly enriched in LT-HSCs, and this coordinate regulation of Hoxb expression is mediated by a retinoid-dependent cis-regulatory element, distal element RARE (DERARE). (nih.gov)
  • We demonstrate that miR-31 inhibits MCM2 expression via its 3'-untranslated region, that knockdown of MCM2 in DAOY cells leads to a degree of growth inhibition comparable to that by miR-31 restoration, and that overexpression of miR-31 reduces the chromatin loading of MCM2 at the point of G1/S transition. (oncotarget.com)
  • These data support the hypothesis that N-Myc affects neuroblastoma gene expression through the formation of a DNA-binding heterodimeric complex with Max in vivo. (uu.nl)
  • 410.4 cells showed a reduction in DNA expression either after pre- or post-treatment with Zot. (utmb.edu)
  • DU145, NIH 3T3, and Cos-7 cells lakced DNA expression only when Zot was adminsitered after DNA transfection. (utmb.edu)
  • RSV also inhibited expression of interleukin- (IL-) 1 β , IL-6, tumor necrosis factor- α , and IL-18 in vivo . (hindawi.com)
  • After inhibition of sirtuin 1 (Sirt1) by EX27, RSV failed to inhibit p53 acetylation and expression. (hindawi.com)
  • Moreover, the effect of Hcy on the expression of TFEB is regulated by hypomethylation of the TFEB promoter catalyzed by DNA methyltransferase 3b (DNMT3b). (lu.se)
  • It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
  • In occurs through the inhibition of DNA binding of cognate cis- hematopoiesis there exist several lineage branch points with regulatory motif while in the other case DNA binding is unaffected identified key transcription factors and external signals [3-5]. (lu.se)
  • DNA in intracellular Salmonella enterica serovar Typhimurium relaxes during growth in the acidified (pH 4-5) macrophage vacuole and DNA relaxation correlates with the upregulation of Salmonella genes involved in adaptation to the macrophage environment. (jic.ac.uk)
  • Wang et al ( 9 ) reported that miR-30a-5p upregulation can inhibit ovarian cancer epithelial-mesenchymal transition (EMT) and invasion. (spandidos-publications.com)
  • Notably, the former α-synuclein strain inhibited proteasome activity and co-precipitated with 26S proteasome complex. (elifesciences.org)
  • Any antiviral agent which inhibits the activity of coronaviruses. (ebi.ac.uk)
  • Metabolic labeling experiments in whole cells showed that NMDA receptor overactivation does not modify the activity of phosphocholine or phosphoethanolamine cytidylyltransferases but strongly inhibits choline-ethanolamine phosphotransferase activity. (jneurosci.org)
  • The developer defines antineoplastons as "substances produced by the living organism that protect it against development of neoplastic growth by a nonimmunological process which does not significantly inhibit the growth of normal tissues . (cancer.gov)
  • Imagine there are repair workers in our body, in our nucleus, that would rush to the place of a DNA break and go and fix it. (mediaverse.news)
  • Since the pandemic started over 18 months ago, health and medical experts have insisted that mRNA vaccines are NOT gene therapies because they supposedly have no impact on the nucleus of the cell and do not get inside the nucleus of the cell , where our DNA is stored. (techstartups.com)
  • DNA, serological detection of variola virus, antiviral agents and animal models of smallpox. (who.int)
  • Therefore, YAP-mediated EMT is considered to be a critical therapeutic target to inhibit YAP-promoted tumor invasion, and YAP may be a promising target for the treatment of CRC. (spandidos-publications.com)
  • Therefore, our result suggests that inhibiting neutropil elastase by administration of sivelestat is actually a promising therapeutic method to inhibit glial scar and promote functional recovery by upregulating angiopoietin-1 following spinal cord injury. (dna-alkylating.com)
  • However, as opposed to DNA vaccines, RNA vaccines only have to cross the plasma membrane, but not the nuclear envelope which may improve the probability of successful in vivo transfection. (techstartups.com)
  • Taken together, these results suggest that ROS mediated activation of the p38 MAPK signal pathway plays an important role in initiating TEOA-induced DNA damage. (figshare.com)
  • Furthermore, γH2AX foci staining and Western blot analysis showed that knockdown of UCHL3 increased IR-induced DNA damage. (aging-us.com)
  • Collectively, our study revealed that knockdown of UCHL3 enhanced the radio-sensitivity of NSCLC cells and increased IR-induced DNA damage via impairing HR repair. (aging-us.com)
  • In addition, "when our cells are dividing, there are strict mechanisms to make sure that the DNA is correctly repaired and correctly copied and there is no damage otherwise the cell will become a cancer cell," he said. (mediaverse.news)
  • Secondly, he called 53BP1 "the Guardian of the Genome," and referred to a 2018 study named "53BP1: A key player of DNA damage response with critical functions in cancer. (mediaverse.news)
  • TEOA induced DNA damage, increased the level of γ-H2AX, and the phosphorylation of CHK1 and CHK2. (figshare.com)
  • In addition, TEOA induced the activation of the p38 MAPK pathway and pretreated with p38 inhibitor SB20358 or ROS scavenger could block TEOA-induced DNA damage. (figshare.com)
  • The aim of the present investigation was to study the effect of the intake of a single portion of blood orange juice (BOJ, 300 ml, providing 150 mg vitamin C) on mononuclear blood cell (MNBC) DNA damage, compared with a drink supplemented with the same amount of vitamin C (C-drink) or sugars (S-drink). (cambridge.org)
  • As such, any environmental assault on the DNA in the form of chemicals or radiation may result in damage to the DNA. (techstartups.com)
  • To prevent an erroneous result, the scientists also use followed DNA damage treatments before conducting their study. (techstartups.com)
  • We showed previously that NMDA releases choline and inhibits incorporation of [ 3 H]choline into phosphatidylcholine before excitotoxic neuronal death. (jneurosci.org)
  • The results revealed that AVM inhibited the phosphorylation of BCR/ABL and their subsequent molecular signals including AKT and MAPK activation. (spandidos-publications.com)
  • While it's certainly true that drinking water is treated, the treatment is not something that will inhibit the survival of all microorganisms outside the treatment facility. (cdc.gov)
  • Nucleic acid amplification (NAA) tests, such as polymerase chain reaction (PCR) and other methods for amplifying DNA and RNA, may facilitate rapid detection of microorganisms. (cdc.gov)
  • However, an important challenge still facing breeders now is the ability to routinely perform DNA-introgression, a process by which distantly related chromosomes exchange genetic information that is passed onto progeny. (nature.com)
  • As we all know, DNA is the repository of genetic information in each living cell, its integrity and stability are essential to life. (techstartups.com)
  • This is accomplished mainly by inhibiting the activation or uptake of complement components, especially C3b. (medscape.com)
  • These observations have led to the conculsion that Zot may inhibit DNA experession due to its ability to modulate intracellular trafficking. (utmb.edu)
  • It works via 6-thioguanine to disrupt the making of RNA and DNA by cells. (wikipedia.org)
  • Liu M , Chen H , Chen X , Xiong J , Song Z , . Silencing UCHL3 enhances radio-sensitivity of non-small cell lung cancer cells by inhibiting DNA repair. (aging-us.com)
  • Others may act through activation of T-cells or by inhibiting the activation of helper cells. (ebi.ac.uk)
  • To prevent this, human cells have mechanisms to repair their own DNA. (techstartups.com)
  • Involved in signal transduction, cell cycle control and DNA repair. (lu.se)
  • Increasing the concentration of DNA-polymerase in the system reversed the inhibitory effect of Cr+6, but not that of Cr+3. (cdc.gov)
  • Plant phenolic oleuropein inhibits HT-29. (metu.edu.tr)