• These cytokines strongly stimulate the proliferation and maturation into CIK cells. (wikipedia.org)
  • It develops imetelstat, a telomerase inhibitor that is in Phase 3 clinical trials, which inhibits the uncontrolled proliferation of malignant stem and progenitor cells in hematologic myeloid malignancies for the treatment of low or intermediate-1 risk myelodysplastic syndromes and intermediate-2 or high-risk myelofibrosis. (numfin.com)
  • We found that the expanded cells possessed significantly improved immune effector functions, including proliferation, differentiation, and cancer cell killing, both in vitro and in the humanized mouse model. (nature.com)
  • 4 Muhammad Noman Khan,Bing Wang,Jing Wei,etc.CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis[J].Oncotarget.2015,6(25): 21315-21327. (sbjbio.com)
  • Long non-coding RNA LINC00707, a prognostic marker, regulates cell proliferation, apoptosis, and EMT in esophageal squamous cell carcinoma. (e-century.us)
  • The ovarian microenvironment affects the proliferation and differentiation of OGSCs, and immune cells and related cytokines are important components of the microenvironment. (biomedcentral.com)
  • With increasing time, the fluorescence intensity of cells gradually increased, and the cytokines IL-2 and TNF-α significantly promoted the proliferation of OGSCs. (biomedcentral.com)
  • It was found that ovoid cells in the epithelial layer of the ovary simultaneously expressed the germ cell specific marker MVH and the proliferation of cell marker BrdU using double-immunofluorescence staining. (biomedcentral.com)
  • It is worth noting that the proliferation and differentiation of stem cells cannot be separated from the surrounding microenvironment, and immune system related cells are an important part of the microenvironment of the OGSCs nest [ 14 ]. (biomedcentral.com)
  • It has been shown that lymphocytes, when exposed to interferon-gamma, anti-CD3 antibody, interleukin-1 and interleukin 2, are capable of lysing fresh, non-cultured cancer cells, both primary and metastatic. (wikipedia.org)
  • Different primitive and metastatic TNBC cancer mouse models were established in mice, and the treatment CIK cells plus cetuximab significantly restrained primitive tumor growth in mice, either in patient-derived tumor xenografts or MDA-MB-231 cell line models. (wikipedia.org)
  • Even though the effects of anti-VEGF ased therapy is usually transitory (62), VEGF still represents a target for pharmacologically controlling and inhibiting neoangiogenesis and metastatic diffusion (63,64), therefore the previously unknown capacity of CIK cells to secrete this pro-angiogenic factor is relevant (65). (squalene-epoxidase.com)
  • Typically, immune cells detect major histocompatibility complex (MHC) presented on infected cell surfaces, triggering cytokine release, causing lysis or apoptosis. (wikipedia.org)
  • IPA functional analysis of gene expression information from CIK cells discovered unique inhibited/activated processes according to the expression pattern of regulatory molecules: (A) chemotaxis, (B) phagocytosis, (C) apoptosis of B lymphocyte, (D) cytotoxicity. (squalene-epoxidase.com)
  • 8 Jian'an Bai,He Na,Xiumei Hua,etc.A retrospective study of NENs and miR-224 promotes apoptosis of BON-1 cells by targeting PCSK9 inhibition[J].Oncotarget.2017,8(4): 6929-6939. (sbjbio.com)
  • 3. Expression of Bmi-1 gene in esophageal carcinoma cell EC9706 and its effect on cell cycle, apoptosis and migration. (whocc.org.cn)
  • Moreover, γδ T cells can directly kill target cells without the involvement of dendritic cells (DCs) and perform dual functional roles in antitumor and anti-infective immunity. (nature.com)
  • Researchers collected ovarian cancer patient menstrual blood samples to acquire mononuclear cells and isolated dendritic cell (DC)-cytokine-induced killer (CIK) cells in vitro . (stemcellsciencenews.com)
  • 10. Comparative study on anti-tumor immune response of autologous cytokine-induced killer (CIK) cells, dendritic cells-CIK (DC-CIK), and semi-allogeneic DC-CIK. (whocc.org.cn)
  • Cytokine-induced killer cells (CIK) cells are a group of immune effector cells featuring a mixed T- and natural killer (NK) cell-like phenotype. (wikipedia.org)
  • These NK cells referred to as cytokine induced memory-like natural killer cells are induced using cytokines, most commonly a mix of IL-12, IL-15, and IL-18. (wikipedia.org)
  • They were given the name "cytokine-induced killer" because cultivation with certain cytokines is mandatory for the maturation into terminally differentiated CIK cells. (wikipedia.org)
  • As a special feature, terminally differentiated CD3+CD56+ CIK cells possess the capacity for both MHC-restricted and MHC-unrestricted anti-tumor cytotoxicity. (wikipedia.org)
  • Indeed, the engagement of CD16a on CD3+CD56+ cells led to a potent antibody-dependent cell-mediated cytotoxicity (ADCC) both in vitro and in vivo against ovarian cancer. (wikipedia.org)
  • This unique combination of T-cell and NK-cell capabilities exerts a potent and widely MHC-unrestricted anti-tumor cytotoxicity against a broad range of cancer cells. (wikipedia.org)
  • Up to now the exact mechanisms of tumor recognition and targeted cytotoxicity of CIK cells is not fully understood. (wikipedia.org)
  • We further demonstrated that reduced recognition of NKG2D ligands significantly alters NK cell anti-tumor cytotoxicity in human primary NK cells and in the NK cell line NK-92. (bvsalud.org)
  • After completed maturation CIK cells are transfused to the donor in autologous settings or to different recipients in allogeneic settings. (wikipedia.org)
  • In addition, autologous CD44 + /CD133 + ovarian cancer stem cells were isolated and used as target cells. (stemcellsciencenews.com)
  • Primary tumor material (P) derived from patients undergoing surgery for head and neck squamous cell carcinoma (HNSCC) or glioblastoma multiforme (GBM) was transplanted subcutaneously into NMRI Foxn1 nu/nu mice. (europdxworkshop.eu)
  • The authors investigated the role of p38 MAPK in maintenance of CSC phenotype, therapy resistance and DNA damage repair and response in head and neck squamous cell carcinoma. (stemcellsciencenews.com)
  • A new subclass of NK cells have been created both in vitro and in vivo. (wikipedia.org)
  • In vitro T cell-mediated killing assays and in vivo syngeneic mouse models were used to investigate the functional roles of circIGF2BP3 and its downstream target PKP3 in antitumor immunity in NSCLC. (biomedcentral.com)
  • Functionally, elevated circIGF2BP3 inactivated cocultured T cells in vitro and compromised antitumor immunity in an immunocompetent mouse model, and this effect was dependent on CD8 + T cells. (biomedcentral.com)
  • To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy, the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized, and clinical safety and efficacy also need to be proven. (nature.com)
  • Research has revealed that human cancer cells in breast, lung and uterine tumors are inhibited by O3 therapy in vitro. (valenciaclinicofintegrativeoncology.com)
  • The antigen-specific mAb favored tumor and metastasis tissue infiltration by CIK cells, and led to an enrichment of the CD16a+ subset. (wikipedia.org)
  • We demonstrated that circIGF2BP3 (hsa_circ_0079587) expression was increased in NSCLC and negatively correlated with CD8 + T cell infiltration. (biomedcentral.com)
  • Buyang huanwu decoction (BYHWD) alleviates sepsis-induced myocardial injury by suppressing local immune cell infiltration and skewing M2-macrophage polarization. (e-century.us)
  • Recently, it has been demonstrated the efficacy of a combined approach (CIK + Cetuximab) against triple negative breast cancer (TNBC), an aggressive tumor that still requires therapeutic options. (wikipedia.org)
  • Non-small-cell lung cancer (NSCLC), which primarily comprises lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), is the major type of primary lung cancer [ 2 ]. (biomedcentral.com)
  • furthermore, the expanded γδ T cells were adoptively transferred into late-stage liver and lung cancer patients. (nature.com)
  • Among these 132 patients, 8 liver cancer patients and 10 lung cancer patients who received ≥5 cell infusions showed greatly prolonged survival, which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy. (nature.com)
  • Paraspeckle component 1 (PSPC1) promoted tumorigenesis, epithelial-to-mesenchymal transition (EMT), stemness and metastasis in multiple cell types and in spontaneous mouse cancer models. (stemcellsciencenews.com)
  • Scientists established novel animal models to investigate early tumor adaptation in brain metastases by introducing both patient-derived and cell line-derived CSC-enriched brain metastasis tumorsphere cells into mice. (stemcellsciencenews.com)
  • 11 It is believed that tumor cells with mutations in certain genes, such as TP53 and ARID1A, exhibit aggressive behaviors with increased vascular invasion, metastasis, and epithelial-to-mesenchymal transition. (xiahepublishing.com)
  • 14 Peng-Tao Ren,Yuan Zhang,etc.Comparative investigation of the effects of specific antigen-sensitized DC-CIK and DC-CTL cells against B16 melanoma tumor cells[J].Mol Med Rep. 2017,15(4):1533-1538. (sbjbio.com)
  • 16 Yucai Chen,Tianyi Yuan,Huifang Zhang,etc.Activation of Nrf2 Attenuates Pulmonary Vascular Remodeling via Inhibiting Endothelial-to-Mesenchymal Transition: an Insight from a Plant Polyphenol[J].Int J Biol Sci.2017,13(8):1067-1081. (sbjbio.com)
  • Most BMPs play roles in the regulation of embryonic development, stem cell differentiation, tumor growth and some cardiovascular and cerebrovascular diseases. (bvsalud.org)
  • This can hopefully represent a brand new approach to enhance their efficiency against neoplastic cells and/or contribute for the establishment of a micro-environment of unfavorable conditions for cancer growth. (squalene-epoxidase.com)
  • 12 Geng Tian,Linlin Cheng,Xuewei Qi,etc.Transgenic Cotton Plants Expressing Double-stranded RNAs Target HMG-CoA Reductase (HMGR) Gene Inhibits the Growth, Development and Survival of Cotton Bollworms[J].Int J Biol Sci. (sbjbio.com)
  • 5. Low dosage 5-fluorouracil increases the transfection efficiency of Ad/VEGF-A in mouse lung carcinoma cell line LA795 and inhibits tumor growth. (whocc.org.cn)
  • This is because it has been proven that ozone has an oxygenating effect on cancer cells, thus delaying the growth of neoplasms. (valenciaclinicofintegrativeoncology.com)
  • They are generated by ex vivo incubation of human peripheral blood mononuclear cells (PBMC) or cord blood mononuclear cells with interferon-gamma (IFN-γ), anti-CD3 antibody, recombinant human interleukin (IL)-1 and recombinant human interleukin (IL)-2. (wikipedia.org)
  • Peripheral blood mononuclear cells or cord blood mononuclear cells are extracted from either peripheral blood or cord blood, e.g. by simple blood draw. (wikipedia.org)
  • 15 Ming Ma,Lian-mei Zhao,Xing-xiao Yang,etc.p-Hydroxylcinnamaldehyde induces the differentiation of oesophageal carcinoma cells via the cAMP-RhoA-MAPK signalling pathway[J].Scientific reports.2016(6):1-13. (sbjbio.com)
  • TSF/FHA induces osteogenic differentiation of Mc3t3 cells via Pygo2 dependent Wnt/β-catenin signaling pathway. (e-century.us)
  • These NK cells are activated by these cytokines to stimulate an infection and induce an adaptive immune response. (wikipedia.org)
  • The mechanism of CIK cells is distinctive from that of natural killer cells or LAK cells because they can lyse cells that NK cells and LAK cells cannot. (wikipedia.org)
  • As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)
  • E discovered to become optimal for binding to peripheral blood B-cells (Fig. S7, ESI). (squalene-epoxidase.com)
  • γδ T cells, specifically the Vγ9Vδ2 subset, which is the dominate subset among γδ T cells in human peripheral blood, recognize target cells in a human leukocyte antigen (HLA)-independent manner. (nature.com)
  • Furthermore, it has been shown that CIK cells have a relevant expression of FcγRIIIa (CD16a), which can be exploited in combination with clinical-grade mAbs to redirect their activity in an antigen-specific manner. (wikipedia.org)
  • Data highlight the potentiality of this novel immunotherapy strategy where a nonspecific cytotoxic cell population can be converted into tumor-specific effectors with clinical-grade antibodies, thus providing not only a therapeutic option for TNBC but also a valid alternative to more complex approaches based on chimeric antigen receptor-engineered cells. (wikipedia.org)
  • Clinical cancer research is mainly based on the use of cell line derived xenografts. (europdxworkshop.eu)
  • Due to their HLA-independent mode of action, allogeneic Vγ9Vδ2 T cells can be considered for clinical application. (nature.com)
  • Furthermore, a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells. (nature.com)
  • Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy, which will inspire further clinical investigations and eventually benefit cancer patients. (nature.com)
  • In the past decade, many clinical trials have been investigating anti-CTLA-4 as well as anti-programmed cell death protein 1 (PD-1) therapies in various solid tumors, including HCC. (stanford.edu)
  • Niikura [ 5 ] and others observed germ cells expressing Stra8 (stimulated by retinoic acid gene 8) in the ovarian surface epithelium, indicating that there may be germ cells with meiotic function in the ovary. (biomedcentral.com)
  • Using models of human-derived melanoma and glioblastoma tumors, we demonstrated that NKG2D ligands are downregulated in tumor cells post-reovirus-infection due to the impaired translation of these ligands in reovirus-infected cells. (bvsalud.org)
  • However, CIK cells have the ability to recognize infected or even malignant cells in the absence of antibodies and MHC, allowing for a fast and unbiased immune reaction. (wikipedia.org)
  • Vγ9Vδ2 T cells recognize pyrophosphates secreted by many microbes or overproduced by malignant cells in the context of butyrophilin 3A1 molecules. (nature.com)
  • Here, we identified the zebrafish bmp4 ortholog, whose expression is up-regulated through challenge with grass carp reovirus (GCRV) or its mimic poly(I:C). The overexpression of bmp4 in epithelioma papulosum cyprini (EPC) cells significantly decreased the viral titer of GCRV-infected cells. (bvsalud.org)
  • Moreover, we showed that downregulation of NKG2D ligands significantly impaired the binding of NKG2D to infected tumor cells. (bvsalud.org)
  • 8. A novel sesquiterpene Hirsutanol A induces autophagical cell death in human hepatocellular carcinoma cells by increasing reactive oxygen species. (whocc.org.cn)
  • In recent years, the discovery of ovarian germ stem cells (OGSCs) has provided a new research direction for the treatment of female infertility. (biomedcentral.com)
  • Androgens have been reported to stimulate production of red blood cells by enhancing production of erythropoietic stimulation factor. (medlibrary.org)
  • Studies have shown that reovirus can directly stimulate natural killer (NK) cells, but how reovirus affects cellular ligands on tumor cells, which are ultimately key to tumor recognition and elimination by NK cells, has not been investigated. (bvsalud.org)
  • It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and herpes simplex virus type 1 (HSV-1). (frontiersin.org)
  • 7. Establishment and biological characteristics of oxaliplatin-resistant human colon cancer cell lines. (whocc.org.cn)
  • These properties, inter alia, rendered CIK cells attractive as a potential therapy for cancer and viral infections. (wikipedia.org)
  • 5. Hormones: The stimulation of estrogen to breast gland's epithelial cell to hyperplasia is a substantial reason in causing breast cancer. (asiancancer.com)
  • Gastric cancer (GC) is a common malignant tumor originating from gastric mucosa epithelial cells, and its onset is relatively insidious. (frontiersin.org)
  • Unfortunately, patients are already in the terminal stage at this time, and the cancer cells have already invaded the surrounding organs or metastasized far away, which leads to the loss of the curative chance for most patients ( 1 ). (frontiersin.org)
  • In this respect, the introduction of checkpoint inhibitors to unleash the activity of tumor-reactive T cells has been a milestone in cancer immunotherapy. (nature.com)
  • Researchers examined the relationship between long non-coding RNA (lncRNA) X inactive specific transcript (XIST) and miR-200c and assessed their functions in the regulation of the stemness properties and tumorigenicity of human bladder cancer stem cell-like cells. (stemcellsciencenews.com)
  • In addition, the expression of let-7c in cancer stem cells was evaluated and the effect of let-7c on stemness characteristics were assessed. (stemcellsciencenews.com)
  • Visit our reviews page to see a complete list of reviews in the cancer stem cell research field. (stemcellsciencenews.com)
  • An immunogenic cell death-related classification predicts response to immunotherapy and prognosis in triple-negative breast cancer. (e-century.us)
  • for example, there are inconsistent views 24 on the intratumoral γδ T-cell signature as the most favorable prognostic biomarker 25 of cancers and discussions on the pro- and antitumor activities of γδ T cells. (nature.com)
  • Besides recognition via TCR/CD3, NK-cell-like tumor recognition is mediated by cell-cell contact-dependent NKG2D, DNAM-1 and NKp30. (wikipedia.org)
  • We tested how reovirus infection affects the binding of the NK Group-2 member D (NKG2D) receptor, which is a dominant mediator of NK cell anti-tumor activity. (bvsalud.org)
  • 6 Xiaoyue Shen,Wenkui Sun,Yi Shi,etc.Altered Viral Replication and Cell Responses by Inserting MicroRNA Recognition Element into PB1 in Pandemic Influenza A Virus (H1N1) 2009[J].Mediators Inflamm.2015:1-12. (sbjbio.com)
  • 10 Meng-Chen Lu,Jian-Ai Ji,Yong-Lin Jiang,etc.An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis[J].Scientific reports. (sbjbio.com)
  • Ginger extract also protects skin collagen by inhibiting collagen that would otherwise break down collagen. (beaute-pacifique.lv)
  • COnCLUsiOn In this report we analyzed the secretory panel of human CIK cells laying a foundation for future research on modulation of CIK secretome. (squalene-epoxidase.com)
  • Scientists revealed that junctional adhesion molecule 3 (JAM3) is highly enriched in both mouse and human leukemia-initiating cells. (stemcellsciencenews.com)
  • Ribosomal proteins are blood biomarkers and associated with CD4+ T cell activation in Alzheimer's disease: a study based on machine learning strategies and scRNA-Seq data validation. (e-century.us)
  • 7 Chun \Tao Lei,Hua Su,Chen Ye,etc.The classic signalling and trans-signalling of interleukin \6 are both injurious in podocyte under high glucose exposure[J].J Cell Mol Med.2018,22(1):251-260. (sbjbio.com)
  • 13 Siyuan Cui,Lili Men,Yu Li,etc.Selenoprotein S Attenuates Tumor Necrosis Factor-α-Induced Dysfunction in Endothelial Cells[J].Mediators Of Inflamm.2018:1-16. (sbjbio.com)
  • This discovery invalidated the "fixation theory of primordial follicle pool" and suggested for the first time the hypothesis that germ stem cells also exist in the ovary. (biomedcentral.com)
  • During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). (medlibrary.org)
  • 2 Juan Zhang,Meng Cao,Wenwen Yang,etc.Inhibition of Glucose-6-Phosphate Dehydrogenase Could Enhance 1,4-Benzoquinone-Induced Oxidative Damage in K562 Cells[J].Oxid Med Cell Longev.2016:1-11. (sbjbio.com)
  • Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. (nature.com)
  • However, little is known about how reovirus infection affects the tumor microenvironment and immune response towards infected tumor cells. (bvsalud.org)
  • Recently, immune checkpoint blockade therapies (ICBs) blocking programmed cell death protein 1 (PD-1) and its ligand (PD-L1) have shown tremendous benefit for the treatment of advanced NSCLC [ 4 ]. (biomedcentral.com)
  • The transcription of bcRIOK3 varied in host cells in response to the stimulation of spring viremia of carp virus (SVCV), poly (I:C), and LPS. (bvsalud.org)
  • Several sources also call them natural killer cell-like T cells due to their close relationship to NK cells. (wikipedia.org)
  • Intervallerne mellem forbindingsskift skal baseres pa en fortsat evaluering af sarets tilstand samt patientens kliniske standing frem for et fast skema [url=https://activecareeducation.com/mod/order-cheap-zanaflex/] spasms left abdomen order zanaflex 4mg line[/url]. (ehd.org)
  • Others propose to classify CIK cells as subset of NKT cells. (wikipedia.org)
  • If cocultured with target cells such as tumor targets, these NK cells have memory-like abilities and are more adapt and effective at mounting a defense. (wikipedia.org)