• MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
  • Long non-coding RNAs (lncRNAs) play an increasingly important role in some fundamental biological processes such as translational regulation, cell cycle regulation, epigenetic regulation, splicing, differentiation, and immune response [ 5 ]. (biomedcentral.com)
  • Let-7 Let-7 has an essential role in cell cycle and the differentiation of cell cycle terminals. (ukessays.com)
  • It inhibits cytokine production and cell proliferation/differentiation in various immune cells. (uwo.ca)
  • Caulobacter crescentus is an aquatic free-living Gram-negative bacterium whose cell cycle depends on cell differentiation. (usp.br)
  • We previously reported that mesenchymal stem cells (MSCs), through local injection upon testicular torsion-detorsion, restored the spermatogenesis without differentiation into sperm. (biomedcentral.com)
  • The purpose of this study is to identify cell cycle regulators involved in the differentiation of osteoblasts into osteocytes and determine their physiological significance. (lu.se)
  • The study uses IDG-SW3 cells as a model for the differentiation from osteoblasts to osteocytes. (lu.se)
  • Among the major cyclin-dependent kinases (Cdks), Cdk1 is most abundantly expressed in IDG-SW3 cells, and its expression is down-regulated during differentiation into osteocytes. (lu.se)
  • Inhibition of CDK1 activity reduces IDG-SW3 cell proliferation and differentiation into osteocytes. (lu.se)
  • Pthlh expression increases during differentiation, but inhibiting CDK1 activity reduces Pthlh expression. (lu.se)
  • miR-203 drives breast cancer cell differentiation. (medscape.com)
  • The results showed that Ganoderma lucidum inhibits cell growth and disruption of cell cycle progression via down regulation of cyclin D1. (greenmedinfo.com)
  • It helps in deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) and gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (novusbio.com)
  • Moreover, flowcytometry was applied to analyze the effects of miR-183 on the cell cycle progression. (nature.com)
  • MiR-183 can exert an oncogenic effect by promoting cell viability, migration, and cell cycle progression. (nature.com)
  • In the present study, the effect of miR-183 on cell viability, cell cycle progression, and migration was investigated, and the interaction between miR-183 and PTEN in BC cells was examined. (nature.com)
  • Transportation of LAPTM5 from Golgi to lysosome could be inhibited by deficiency of Nedd4, a key member of E3 ubiquitin ligase family overexpressing in invasive BCa and promoting its progression. (spandidos-publications.com)
  • T he presence and activity of various proteins are required in the cell cycle progression. (ukessays.com)
  • Senescent cells (SnCs) have been described to accumulate in osteoarthritis (OA) joint tissues in response to injury, thereby participating in OA development and progression. (aging-us.com)
  • Indeed, senescent cells (SnCs) are described to accumulate in joint tissues in response to injury and during aging, thereby participating in its development and progression [ 8 - 10 ]. (aging-us.com)
  • Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. (lsbio.com)
  • This specific project aims to identify sequences within caveolin involved in regulation of raft internalisation, cell cycle progression and anchorage-dependent cell growth. (europa.eu)
  • This objective integrates into a bigger project that also aims to identify molecular mechanisms by which caveolin regulates anchorage-dependent signalling pathways and cell cycle progression and to identify oncogenes that induce constitutive surface localization of rafts (and hence Rac), and/or changes in phosphocaveolin localization. (europa.eu)
  • Abnormalities in cell cycle regulation are reported to be strongly associated with tumorigenesis and progression of tumors. (biomedcentral.com)
  • We studied the effect of doxorubicin (Dox) on cell cycle progression and its correlation with DNA damage and cytotoxicity in p53-mutant P388 cells. (aspetjournals.org)
  • In untreated control P388 cells, p34cdc2 kinase localizes in the nucleus and cytoplasms, particularly in the centrosomes, and p34cdc2 kinase activity is dependent on cell cycle progression, with the enzyme activity increasing steadily from G1/S to G2/M and markedly declining thereafter. (aspetjournals.org)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • Several hallmarks of cellular senescence, such as cell cycle arrest, expression of cyclin-dependent kinase inhibitors, DNA damages, and senescence-associated secretory profile were evaluated. (aging-us.com)
  • It is inhibited by Cyclin-dependent kinase inhibitors (CKI). (biomedcentral.com)
  • We confirmed each of our cell lines expresses the RET fusion protein and assessed their sensitivity to RET inhibitors. (nih.gov)
  • These data highlight the utility of new RET+ models to elucidate differences in response to tyrosine kinase inhibitors and downstream signaling regulation. (nih.gov)
  • Our RET+ cell lines effectively recapitulate the interpatient heterogeneity observed in response to RET inhibitors and reveal opportunities for alternative or combination therapies. (nih.gov)
  • These data offer important insight into regulation of response to RET tyrosine kinase inhibitors and other potential therapeutic targets. (nih.gov)
  • The cyclin-dependent kinase (CDK) inhibitors p21 and p16 inhibit the activity of CDKs, such as CDK4. (medscape.com)
  • Another important class of tumor suppressor genes involved in cell cycle control and in the generation of human cancers is the cyclin-dependent kinase (CDK) inhibitors. (medscape.com)
  • In comparison, the other available flu antiviral medications, which are "neuraminidase inhibitors," do not directly interrupt replication within an infected cell, but instead work to prevent new copies of the virus from leaving the infected cell and spreading to healthy cells. (cdc.gov)
  • Regulated by guanine nucleotide exchange factors (GEFS) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (gaps) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. (lu.se)
  • It specifically negatively regulates the PI3K-AKT signaling pathway to induce cell cycle arrest. (medscape.com)
  • Modulation of intracellular free calcium concentration ([Ca 2+ ] i ) may be part of the signaling pathway by which both local environmental factors and cell autonomous developmental programs influence corticogenesis. (jneurosci.org)
  • However, THP-1 cells adaptively adjusted to LeTx and overrode cell cycle arrest by activating the PI3K/Akt signaling pathway. (uwo.ca)
  • si-Prok1 arrests cell cycle, induces apoptotic changes, and inhibits the proliferation of ovarian granulosa cells through a mechanism related to the regulation of Pi3k/Akt signaling pathway. (ajol.info)
  • Moreover, cell cycle arrest at G0/G1 phase was triggered by decreased LAPTM5 as well, which could lead to delayed BCa cell growth. (spandidos-publications.com)
  • Taken together, our results suggested that decreased LAPTM5 inhibited proliferation and viability, as well as induced G0/G1 cell cycle arrest possibly via deactivation of ERK1/2 and p38 in BCa cells. (spandidos-publications.com)
  • We have demonstrated that phenylacetate(PA)-induced cell cycle arrest in human prostate cancer is mediated by increase of p27. (iiarjournals.org)
  • This molecule also inhibits the androgen receptor, inhibits cell growth, and causes cell cycle arrest. (lktlabs.com)
  • 1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
  • induces growth arrest or apoptosis depending on the physiological circumstances and cell type. (lsbio.com)
  • In human monocytic cell lines U-937 and THP-1, LeTx induced cell cycle arrest in Go-Gi phase by rapid down-regulation of cyclin D1/D2 and checkpoint kinase 1 through MEK1 inhibition. (uwo.ca)
  • Recovery from cell cycle arrest was required before recovering from on-going MEK1 cleavage and suppression of TNF-a production. (uwo.ca)
  • Retroviral vectors expressing short hairpin RNAs (shRNAs) against CDC2 caused efficient deletion of CDC2, cellular G2/M arrest concluding in apoptosis and inhibition of proliferation in human glioma cells U251 and SHG-44 cell lines ex vivo. (biomedcentral.com)
  • Cell cycle-dependent cytotoxicity, G2/M phase arrest, and disruption of p34cdc2/cyclin B1 activity induced by doxorubicin in synchronized P388 cells. (aspetjournals.org)
  • Treatment of synchronized cells in early S phase with 1 microM Dox (2 x ID50) for 1 hr induced a marked cell arrest at G2/M phase at 6-12 hr after drug incubation. (aspetjournals.org)
  • Our results suggest that anthracycline-induced cytotoxicity is cell cycle dependent and is mediated, at least in part, by disturbance of the regulation of p34cdc2/cyclin B1 complex, thus leading to G2/M phase arrest. (aspetjournals.org)
  • Flow cytometry assay showed 5 μM OSI-027 induced cell cycle arrest in the G0/G1 phase in Panc-1 BxPC-3 and CFPAC-1 cells whereas RAPA had little effect on cell cycle. (globaltechbiz.com)
  • Activation of p21 or p16 therefore causes cell cycle arrest. (medscape.com)
  • The p19ARF protein, which is encoded by the same locus as p16, also leads to cell cycle arrest by inhibiting the ability of MDM2 to inactivate TP53. (medscape.com)
  • Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
  • Whole cell extracts (15 µg protein) from NIH3T3 cells transfected with non-targeting control siRNA (siCON) or siRNA targeting Ahr (siAhr) were resolved on a 4-12% Bis-Tris gel, transferred to PVDF and probed with 1.0 µg/mL (1:500 dilution) of Purified anti-AHR Antibody, clone W16012A, overnight at 4°C. Proteins were visualized by chemiluminescence detection using HRP goat anti-rat IgG antibody (Cat. (biolegend.com)
  • VES supplementation also decreases the expression of anti-apoptotic XIAP and Bcl-X(L) proteins and sensitizes androgen-dependent LNCaP cells to androgen deprivation. (positivehealth.com)
  • [1] In aerobic organisms , the citric acid cycle is involved in the chemical conversion of carbohydrates , fats and proteins into carbon dioxide and water to generate a form of usable energy. (citizendium.org)
  • Cell cycle proteins are altered in differently in HPV-positive and HPV-negative cancers, suggesting that treating these cancers should be treated according to their subtype. (cancer.gov)
  • 1 nM IC 50 ) to inhibition of two cell cycle-regulating proteins, polo-like kinase 1 and Aurora kinase A. Finally, we show that two of these cell lines, CUTO32 and CUTO42, successfully establish xenografted tumors in nude mice. (nih.gov)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. (lu.se)
  • HPV-negative tumors contained novel co-amplifications of 11q13 and 11q22, an event that likely promotes the interaction of BIRC2 and FADD , genes that together work to inhibit cell death. (cancer.gov)
  • We demonstrated that the RET inhibitor BLU-667 was effective at inhibiting tumor growth in CUTO42 tumors but had a much less profound effect in CUTO32 tumors, consistent with our in vitro experiments. (nih.gov)
  • Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA. (medscape.com)
  • This complex inhibits mammalian target of rapamycin (mTOR) kinase, a key protein in cells that regulate the gene translation responsible for cell-cycle regulation. (medscape.com)
  • The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. (antikoerper-online.de)
  • Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. (lsbio.com)
  • Also the enzymes citrate synthase, isocitrate dehydrogenase and alpha-ketoglutarate dehydrogenase, that regulate the first three steps of the TCA cycle, are inhibited by high concentrations of ATP. (citizendium.org)
  • The notion could be that unique cellular mechanisms are triggered in the breast cancer cells to stimulate BRCA2 gene expression as a temporary measure to regulate the growth of the breast cancer cells. (biomedcentral.com)
  • Receptors inside cells interact with hormones that regulate gene function (eg, corticosteroids, vitamin D , thyroid hormone). (msdmanuals.com)
  • Receptors on the cell surface bind with hormones that regulate enzyme activity or affect ion channels (eg, growth hormone, thyrotropin-releasing hormone). (msdmanuals.com)
  • Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
  • AMPK pathways inhibit biosynthetic pathways with energy consumption, such as protein, fatty acid and glycogen synthesis. (springer.com)
  • In addition, the expression of these fusions are no longer cell-cycle regulated, as well as GroEL synthesis in a strain which does not have the HrcA protein, the putative repressor that binds CIRCE, indicating that the CIRCE-HrcA system are involved in cell cycle regulation of groESL in C. crescentus. (usp.br)
  • The enzymatic steps of glycolysis and the subsequent synthesis of acetyl-CoA involve a linear sequence, whereas the oxidation of acetyl-CoA in the Krebs cycle is a cyclic sequence of reactions in which the starting substrate is subsequently regenerated with each turn of the cycle. (encyclopedia.com)
  • In whole cells, Dox treatment prevented p34cdc2 kinase dephosphorylation without altering its synthesis, and this effect was due to neither down-regulation of cdc25C nor inhibition of protein-tyrosine phosphatase activity. (aspetjournals.org)
  • In contrast, Dox treatment was found to induced cyclin B1 accumulation as a result of stimulating its synthesis and inhibiting its degradation. (aspetjournals.org)
  • Apart from its hypoglycemic properties, metformin also inhibits the cell cycle by restricting protein synthesis and cell proliferation via regulating the LKB1/AMPL pathway. (bmj.com)
  • Edu incorporation showed that OSI-027 also significantly inhibited DNA synthesis. (globaltechbiz.com)
  • The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation. (nih.gov)
  • HBP1 inhibits the development of type 2 diabetes mellitus through transcriptional activation of the IGFBP1 gene. (nih.gov)
  • In vitro studies and gene expression profiles showed that the transcriptional changes by the activated Ahr are ligand specific and are highly cell specific. (biolegend.com)
  • Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. (biolegend.com)
  • We identified Y134 as a raloxifene analog that activates AhR-mediated transcriptional activity and induces apoptosis in MDA-MB-231 human triple negative breast cancer cells. (oregonstate.edu)
  • Our studies also identified an analog of raloxifene that acts as a partial antagonist of the AhR, and is capable of inhibiting AhR agonist-induced transcriptional activity. (oregonstate.edu)
  • LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. (lsbio.com)
  • Evidence presented in this review implicated that Rhizoma coptidis exerted beneficial effects on various diseases by regulation of NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways, which support the clinical application of Rhizoma coptidis and offer references for future researches. (springer.com)
  • Suppression of proliferation and oxidative stress by extracts of Ganoderma lucidum in the ovarian cancer cell line OVCAR-3. (greenmedinfo.com)
  • It is a dietary plant phenol that has been shown to inhibit oxidative stress and chemical carcinogenesis. (cdc.gov)
  • The therapeutic effect of MSCs came from paracrine effect to inhibit testicular apoptosis, reduce intra-testicular oxidative stress, and maintain serum testosterone level. (biomedcentral.com)
  • At a fundamental level, cancer is caused by an accumulation of genetic changes that result in unregulated cell growth and proliferation. (medscape.com)
  • Other angiogenic growth factors that decorin inhibits are angiopoietin, hepatocyte growth factor (HGF) and platelet-derived growth factor (PDGF). (wikipedia.org)
  • Decorin has been shown to have anti-tumorigenic properties in an experimental murine tumor model and is capable of suppressing the growth of various tumor cell lines. (wikipedia.org)
  • mTOR also reduces the cell growth factors (eg, vascular endothelial growth factor) involved in new blood vessel development. (medscape.com)
  • Laboratory studies have shown that Ganoderma lucidum enhances immune functions and also inhibits growth of various cancer cells both in vitro and in vivo. (greenmedinfo.com)
  • In this study, we investigated whether Ganoderma lucidum elicits its anti-tumor effects by suppressing cell growth and inducing antioxidative/detoxification activity in human ovarian OVCAR-3 cells. (greenmedinfo.com)
  • Furthermore, we established a BCa cell model with downregulated LAPTM5, revealing a significantly delayed growth rate in the BCa cells with knockdown of LAPTM5. (spandidos-publications.com)
  • Selenium has been reported to inhibit the growth of prostate cancer cells in vitro. (positivehealth.com)
  • Caner is defined as the continuous uncontrolled growth of cells. (powershow.com)
  • These cancer cells need activation of the androgen receptor to divide, so drugs that drop testosterone levels block tumor growth. (lktlabs.com)
  • A conditional mutant was obtained by homologous recombination and in restrictive conditions growth is inhibited, DnaK levels are increased and the cells become filamentous, but no celllysis was observed. (usp.br)
  • Integrin signals mediate anchorage-dependence of cell growth, while growth of cancer cells is anchorage-independent. (europa.eu)
  • These studies will contribute to a better understanding of adhesion-dependent signalling and anchorage-dependence of cell growth, and therefore to the pathogenesis of the malignant disease. (europa.eu)
  • The expression of BRCA2 gene is silenced at the G0/G1 phase of cell growth and is de-silenced at the S/G2 phase. (biomedcentral.com)
  • In the G0/G1 growth phase ZAR2 is predominantly located inside the nucleus of the breast cells, binds to the BRCA2 promoter and inhibits the expression of BRCA2. (biomedcentral.com)
  • Downregulation of CDC2 could potentialy inhibit human gliomas cells growth ex vivo and in vivo. (biomedcentral.com)
  • Results showed crude water extracts of S. spectabilis inhibited growth of B. cereus (20-25 mm). (stuartxchange.org)
  • Figure3A) 3 suggesting that inhibition mTOR2 in PDAC may be a viable approach to inhibit cell growth. (globaltechbiz.com)
  • Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. (biolegend.com)
  • To determine the impacts of miR-183 on cell viability, the MTT assay was used. (nature.com)
  • Cell viability was determined by propidium iodide staining. (positivehealth.com)
  • The cell cycle is a complex process with myriad genes involved and elaborate and complex signaling mechanisms to allow for this critical cellular process. (biomedcentral.com)
  • Inactivation of tumor suppressor genes, whose products normally provide negative control of cell proliferation, contributes to malignant transformation in various cell types. (medscape.com)
  • TP53 activates the expression of genes involved in apoptosis, cell cycle regulation (p21), and MDM2. (medscape.com)
  • Ovarian granulosa cells from a rat model of PCOS were assigned to control and si-Prok1 groups, after cell culture. (ajol.info)
  • Anti-Müllerian hormone (AMH) or Müllerian-inhibiting substance, a dimeric glycoprotein secreted by granulosa cells of the preantral and small antral ovarian follicles. (cdc.gov)
  • Moreover, some studies demonstrated that LAPTM5 was highly expressed in malignant B lymphomas and involved in B cell malignancies ( 10 ), involving in negative regulation of cell surface T and B cell receptor by promoting lysosome degradation ( 6 ). (spandidos-publications.com)
  • Activated Akt inhibited GSK3 and prevented proteasome-mediated cyclin D1 degradation in LeTx-intoxicated THP-1 cells. (uwo.ca)
  • The Krebs cycle, first postulated in 1937 by Hans Krebs, is an efficient way for cells to produce energy during the degradation of energy-rich molecules. (encyclopedia.com)
  • The Ahr is well known to be involved in a variety of cellular processes, such as the cell cycle, epithelial barrier function, cell migration, and immune function. (biolegend.com)
  • It was revealed that cellular oncogenicity is positively regulated by miR-183 by inhibiting the expression of PTEN. (nature.com)
  • Cellular morphology, time-lapse imaging, and nuclear staining demonstrated that this activity occurred in mitotically active cells. (jneurosci.org)
  • This study demonstrated that modulation of PI3K/Akt/GSK3 signaling cascades can be beneficial for protecting or facilitating recovery from cellular LeTx intoxication in cells that depend on basal MEK1 activity for proliferation. (uwo.ca)
  • The citric acid cycle (also known as the tricarboxylic acid cycle , the TCA cycle, or the Krebs cycle ) is a series of chemical reactions of central importance in all living cells that utilize oxygen as part of cellular respiration . (citizendium.org)
  • The Krebs cycle, also called the citric acid cycle and tricarboxylic acid cycle, is the common pathway by which organic fuel molecules of the cell are oxidized during cellular respiration. (encyclopedia.com)
  • The Krebs cycle is part of the aerobic degradative process in eukaryotes known as cellular respiration, which is a process that generates adenosine triphosphate (ATP) by oxidizing energy-rich fuel molecules. (encyclopedia.com)
  • It is increasingly clear that DNA viruses exploit cellular epigenetic processes to control their life cycles during infection. (mdpi.com)
  • The mechanisms used by certain viruses to dysregulate the host cell through manipulation of epigenetic processes and the role of cellular cofactors such as BRD4 that are known to be involved in epigenetic regulation of host cell pathways will also be covered. (mdpi.com)
  • The term Langerhans cell histiocytosis is generally preferred to the older term, histiocytosis X. This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown ("X") because its cellular basis has now been clarified. (medscape.com)
  • Specifically, a variety of other cellular populations have been identified that possess phenotypic characteristics similar to Langerhans cells, including expression of CD207 and Birbeck granules. (medscape.com)
  • Therefore, in addition to epidermal Langerhans cells, other potential cellular origins for LCH include dermal langerin + dendritic cells, lymphoid tissue-resident langerin + dendritic cells, and monocytes that can be induced by local environmental stimuli to acquire a Langerhans cell phenotype. (medscape.com)
  • We discovered that our RET + cell lines had differential regulation of the mitogen-activated protein kinase and phosphoinositide 3-kinase/protein kinase B (AKT) pathways. (nih.gov)
  • Integrin-mediated retention of phosphorylated caveolin in focal adhesions inhibits raft internalisation, which occurs upon its recruitment to caveolae after cell detachment. (europa.eu)
  • During EMT, cells will undergo transformation from epithelial phenotype to mesenchymal phenotype ( 14 ) and many characteristics of cells will change including loss of cell-cell adhesion and acquisition of aggressive and metastatic ability ( 15 ). (spandidos-publications.com)
  • Forced expression of HOTAIR in epithelial cancer cells induces genome-wide Polycomb repression complex 2 (PRC2) to retarget to a more similar pattern of embryonic fibroblasts, leading to gene expression changes, and increase cancer invasion and metastasis. (biomedcentral.com)
  • Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells. (lsbio.com)
  • For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
  • The TP53 gene is also capable of stimulating apoptosis of cells containing damaged DNA. (medscape.com)
  • MDM2 binds to and inhibits TP53 activity. (medscape.com)
  • Arguments supporting the reactive nature of LCH include the occurrence of spontaneous remissions, the extensive elaboration of multiple cytokines by dendritic cells and T-cells (the so-called cytokine storm) in LCH lesions, and the good survival rate in patients without organ dysfunction. (medscape.com)
  • Herb-partitioned moxibustion may inhibit excessively activated autophagy and modulate the expression of immune-related factors by regulating the LKB1-mTOR-PI3KC signal transduction networks, thereby alleviating intestinal inflammation in CD rats. (hindawi.com)
  • Our transcriptome analysis revealed in bladder cancer (BCa) tissues a significant induction of lysosomal-associated multispanning membrane protein 5 (LAPTM5), a lysosomal membrane protein preferentially expressing in immune cells and hematopoietic cells. (spandidos-publications.com)
  • LAPMT5 is a lysosomal membrane protein preferentially expressed in immune cells ( 5 , 6 ) and hematopoietic cells ( 7 ), having a close interaction with the Nedd4 ( 8 ), a member of the E3 ubiquitin ligases family ( 8 ). (spandidos-publications.com)
  • During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
  • Next, the expression model, prognostic roles, potential biological functions and epigenetic regulation of tumor suppressor long noncoding RNAs were investigated and validated in the breast cancer and pancancer cohorts. (cancerindex.org)
  • This review will address epigenetic regulation in members of the polyomaviruses, adenoviruses, human papillomaviruses, hepatitis B, and herpes viruses. (mdpi.com)
  • For each type of virus, what is known about the roles of DNA methylation, histone modifications, nucleosome positioning, and regulatory RNA in epigenetic regulation of the virus infection will be discussed. (mdpi.com)
  • In step two of the Krebs cycle, citrate is isomerized to isocitrate by means of a dehydration reaction that yields cis -aconitate, followed by a hydration reaction that replaces the H + and OH- to form isocitrate. (encyclopedia.com)
  • Some hormones exert an effect on cells of the organ from which they were released (paracrine effect), some even on the same cell type (autocrine effect). (msdmanuals.com)
  • Then, control lentivirus and Prok1 siRNA lentivirus (50 μL each) were added to the cells to the groups, respectively. (ajol.info)
  • Effects of Raptor and Rictor on cell cycle in PDAC cells In order to confirm the role of mTOR pathway in the regulation of cell cycle we performed small interfering (si) RNA knock-out in Panc-1 BxPC-3 and CFPAC-1 cells and found that siRNA application successfully knocked down the expression of mTOR Raptor (mTOR1) and Rictor (mTOR2) in these cells. (globaltechbiz.com)
  • They found that in prostate cancer cell lines, CT7001 binds to CDK7. (lktlabs.com)
  • ZAR2 binds to BRCA2/ZAR2 bi-directional promoter in vivo and is responsible, at least in part, for the silencing of BRCA2 gene expression in the G0/G1 phase in human breast cells. (biomedcentral.com)
  • This mechanism for regulation is due to substrate inhibition by NADH of the enzymes that use NAD+ as a substrate. (citizendium.org)
  • After inhibition of RET, the CUTO42 cells had robust inhibition of phosphorylated AKT (pAKT), whereas CUTO22 and CUTO32 cells had sustained AKT activation. (nih.gov)
  • SIGNIFICANCE STATEMENT: We have derived and characterized three novel rearranged during transfection (RET) fusion non-small cell lung cancer cell lines and demonstrated that they have differential responses to RET inhibition as well as regulation of downstream signaling, an area that has previously been limited by a lack of diverse cell line modes with endogenous RET fusions. (nih.gov)
  • Standard techniques like cell synchronization by serum starvation, flow cytometry, N-terminal or C-terminal FLAG epitope-tagged protein expression, immunofluorescence confocal microscopy, dual luciferase assay for promoter evaluation, and chromatin immunoprecipitation assay were employed during this study. (biomedcentral.com)
  • Western Blotting was used to determine the level of expression of CDC2 protein as measure to quantify down regulation of CDC2 expression along with use of flow cytometry to investigate effect of shRNAs on cell cycles and detection of apoptosis. (biomedcentral.com)
  • Cell cycle ratio and apoptosis in the two groups were determined using flow cytometry, while Pi3k/Akt signal route-linked protein levels were assayed by immunoblot method. (ajol.info)
  • Previous researches completed by our team have also demonstrated that resveratrol inhibits the proliferation, invasion, and metastasis of colorectal cancer cells [ 5 ]. (hindawi.com)
  • Analysis of the changes of migration and invasion, showed significant reduced LAPTM5 suppressed cell metastasis. (spandidos-publications.com)
  • 1 2 Residing outside the sarcolemma but within the basal lamina of individual myofibers is a population of cells that are responsible for muscle repair and regeneration, the satellite cells. (arvojournals.org)
  • Human stem cell factor contributed the activation of Akt/GSK3 axis when sperm suffered from testicular torsion-detorsion-induced germ cell injury. (biomedcentral.com)
  • Although spontaneous changes of [Ca 2+ ] i have been examined in immature cortical neurons, the calcium dynamics of cortical precursor cells have received less attention. (jneurosci.org)
  • Using an intact cortical mantle and confocal laser microscopy, we examined the spatiotemporal patterns of spontaneous [Ca 2+ ] i fluctuations in neocortical ventricular zone (VZ) cells in situ . (jneurosci.org)
  • These results demonstrate distinct patterns of spontaneous [Ca 2+ ] i change in cortical precursor cells and raise the possibility that these dynamics may contribute to the regulation of neurogenesis. (jneurosci.org)
  • Testicular torsion-detorsion significantly decreased the amount of sperm, inhibited the motility, declined the F-actin expression, and reduced the content of ATP in sperm. (biomedcentral.com)
  • Decorin has been shown to either enhance or inhibit the activity of TGF-beta 1. (wikipedia.org)
  • Immunological parameters assessed included natural killer (NK) cell activity, cytotoxic T lymphocyte (CTL) activity, IgM antibody plaque forming cell (PFC) response, thymus, spleen, kidney, and liver mass, and total cellularity for the thymus and spleen. (cdc.gov)
  • Treatment with alpha-tocopherol succinate (VES) inhibits NF-kappaB but augments AP-1 activity, reduces expression of IL-6, IL-8, and VEGF, suppresses cell adhesion, ICAM-1 and gp130 expression in androgen-independent PC-3, DU-145, and CA-HPV-10 cells. (positivehealth.com)
  • In contrast, the loss of HOTAIR can inhibit cancer invasion, especially in cells with excessive PRC2 activity. (biomedcentral.com)
  • The majority of activity consisted of single cells that displayed independent [Ca 2+ ] i fluctuations. (jneurosci.org)
  • A third and infrequently encountered pattern of activity consisted of coordinated spontaneous increases in [Ca 2+ ] i in groups of neighboring VZ cells. (jneurosci.org)
  • In this study, molecular mechanisms of MSCs in regulating germ cell activity induced by testicular torsion-detorsion were investigated. (biomedcentral.com)
  • While studying the activity of BRCA2 gene promoter in breast cancer cells, we discovered that this promoter has bi-directional activity and the product of the reverse activity (a ZAR1-like protein, we named ZAR2) silences the forward promoter at the G0/G1 phase of the cell. (biomedcentral.com)
  • When the cells are in the dividing state (S/G 2 ), the forward activity of the promoter is 5-8 folds higher than the reverse activity. (biomedcentral.com)
  • In a cell-free system, Dox did not inhibit p34cdc2 kinase activity, indicating that is has no direct effect on the enzyme function. (aspetjournals.org)
  • Involved in negative regulation of lipid transport and negative regulation of reactive oxygen species biosynthetic process. (nih.gov)
  • Furthermore, previous studies suggested that knockdown of LAPTM4B , another important subtype of the LAPTM family inhibited proliferation of hepatocellular carcinoma ( 11 ), prostate ( 12 ) and breast cancer cells ( 13 ). (spandidos-publications.com)
  • Vitamin E succinate inhibits NF-kappaB and prevents the development of a metastatic phenotype in prostate cancer cells: implications for chemoprevention. (positivehealth.com)
  • In this study, we further investigated the mechanism of PA-induced p27 expression in prostate cancer cells (LNCaP, androgen-independent LNCaP [AIDL] and PC-3). (iiarjournals.org)
  • A striking decrease in Skp2 mRNA and protein expression and reciprocal increase in p27 protein level were observed in three PA-treated prostate cancer cells. (iiarjournals.org)
  • In vitro ubiquitination assay showed a decreased p27 ubquitination in PA-treated prostate cancer cells. (iiarjournals.org)
  • Our results suggest that PA attenuated Skp2 expression, thereby inhibiting ubiquitination and promoting p27 accumulation in all three prostate cancer cell lines. (iiarjournals.org)
  • To detect the effects of miR-183 on the migration of BC cell lines, wound healing was used along with a Trans-well migration assay. (nature.com)
  • Finally, EPB41L4A-AS2 inhibited breast cancer cell proliferation, migration and invasion and induced cell apoptosis in vitro. (cancerindex.org)
  • During this time, precursor cells undergo interkinetic nuclear migration ( Seymour and Berry, 1975 ) in which cells in the DNA synthetic S phase have their nuclei in the upper third of the VZ. (jneurosci.org)
  • Integrins are key regulators of gene expression, cell proliferation and migration. (europa.eu)
  • This type of negative regulation by ATP is by an allosteric mechanism. (citizendium.org)
  • The mutations of BRCA2 gene predispose the cells towards neoplastic development. (biomedcentral.com)
  • A nuclear protein, HDAC-9 belongs to the histone deacetylase family with several isoforms and is inhibited by Trichostatin A (TSA) and suberoylanilide hydroxamic acid. (novusbio.com)
  • Both active and passive stretch of the rectus muscles produced by strabismus surgery dramatically upregulated the processes of satellite cell activation, integration of new myonuclei into existing myofibers, and concomitant upregulation of immature myosin heavy chain isoforms. (arvojournals.org)
  • Resistance often involves cancer cells reactivating the androgen receptor without needing testosterone. (lktlabs.com)
  • The protein CDK7 is an attractive drug target because it is involved in both androgen receptor regulation and cell cycle regulation. (lktlabs.com)
  • Subchronic exposure to ellagic acid impairs cytotoxic T-cell function and suppresses humoral immunity in mice. (cdc.gov)
  • PTEN insufficiency promotes the PI3K/AKT path, which is a vital signal for the survival of cancer cells. (nature.com)
  • The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
  • The drug CT7001 inhibits CDK7, and shows promising experimental results in several other cancers. (lktlabs.com)
  • These membranes are made up of squamous cells and the head and neck cancers that grow in these cells are called squamous cell carcinomas. (cancer.gov)
  • 1 In 2010, about 36,000 Americans are estimated to have been diagnosed with head and neck cancers and an estimated 7,880 were expected have died of squamous cell carcinomas. (cancer.gov)
  • Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. (cdc.gov)
  • But these treatments, to some extent, easily produce side effects on normal cells, organs, and other tissues of the human body, thus accelerating the death process of cancer patients. (hindawi.com)
  • Through qRT-PCR analysis, miR-183 and PTEN mRNA levels in breast cancer cell lines were measured. (nature.com)
  • Cancer - Cancer When good cells go bad What is cancer? (powershow.com)
  • Head and Neck Squamous Cell Carcinoma Study was originally published by the National Cancer Institute. (cancer.gov)
  • We developed three novel RET fusion-positive ( RET +) patient-derived cancer cell lines, CUTO22 [kinesin 5B ( KIF5B )- RET fusion], CUTO32 ( KIF5B - RET fusion), and CUTO42 (echinoderm microtubule-associated protein-like 4- RET fusion), to study RET signaling and response to therapy. (nih.gov)
  • On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
  • We focus on the role of HPV in the increased incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer in which HPV is most commonly found ( 4 ). (cdc.gov)
  • These results suggest a strong link between ovulatory menstrual cycles and the risk of developing breast cancer, with progesterone playing an important role. (medscape.com)
  • Several enzymes are also negatively regulated when the level of reducing equivalents in a cell are high (high ratio of NADH/NAD+). (citizendium.org)
  • The first reference found related to the therapeutic use of the plant data from 2700 B.C. and is present in the pharmacopoeia of the Chinese Emperor Shen-Nung, where this plant was recommended in the treatment of malaria, rheumatic pain, in irregular and painful menstrual cycles. (bvsalud.org)
  • A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)